Christopher Sarko

发表

Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.

M. Hao, K. Qian, N. Moss, 2006, Bioorganic & medicinal chemistry letters.

M. Yus, F. Alonso, Christopher Sarko, 2014 .

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

D. Kass, H. Bian, S. Weldon, 2019, Proceedings of the National Academy of Sciences.

A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat

Hong Wang, R. Fryer, Kathleen A. Lincoln, 2016, The Journal of Pharmacology and Experimental Therapeutics.

A 4 Identification and characterization of positive allosteric modulators of the natriuretic peptide receptor-A

R. Fryer, F. Levy, A. Cataliotti, 2017 .

DABIGATRAN ANTICOAGULANT ACTIVITY IS NEUTRALIZED BY AN ANTIBODY SELECTIVE TO DABIGATRAN IN IN VITRO AND IN VIVO MODELS

Rachel Kroe-Barrett, Sanjaya Singh, N. Hauel, 2011 .

Antidotes aux anticoagulants

Sanjaya Singh, N. Hauel, T. Litzenburger, 2012 .

Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.

M. Hao, K. Qian, N. Moss, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)

F. Supek, M. Barrett, H. Cheung, 2022, Journal of medicinal chemistry.

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

J. Chiba, M. Yokoyama, J. Baldwin, 2006, Bioorganic & medicinal chemistry.

A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 rat Authors:

R. Fryer, Kathleen A. Lincoln, T. Bosanac, 2015 .

Discovery and optimization of pyrazole amides as antagonists of CCR1.

D. White, M. Brown, A. Swinamer, 2019, Bioorganic & medicinal chemistry letters.

BCl3- and TiCl4-Mediated Reductions of β-Hydroxy Ketones

Christopher Sarko, M. DiMare, Scott E Collibee, 1996 .

Chelation-controlled protocol for the diastereoselective reduction of ketones

Christopher Sarko, M. DiMare, Ian C. Guch, 1994 .

Microwave-assisted synthesis of a [3+2] cycloaddition library

Christopher Ronald Sarko, Noel S. Wilson, G. Roth, 2001 .

Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.

Noel S. Wilson, C. Cywin, G. Roth, 2007, Bioorganic & medicinal chemistry letters.

TADDOL-Based Titanium Catalysts and Their Adducts: Understanding Asymmetric Catalysis of Diels-Alder Reactions

Christopher Sarko, M. DiMare, C. Haase, 1995 .

Microwave-assisted synthesis of 2-aminoquinolines

Christopher Ronald Sarko, Noel S. Wilson, G. Roth, 2002 .

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

J. Chiba, M. Yokoyama, J. Baldwin, 2005, Bioorganic & medicinal chemistry letters.

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

G. Bonamy, V. Sasseville, Yen-Liang Chen, 2021, Science Translational Medicine.

A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.

Younggi Choi, N. Moss, D. Skow, 2009, Bioorganic & medicinal chemistry letters.

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

F. Gamo, E. Fang, Yen-Liang Chen, 2022, Journal of medicinal chemistry.

Discovery and optimization of p38 inhibitors via computer-assisted drug design.

Angela Berry, Jinhua J. Song, Ming-Hong Hao, 2007, Journal of medicinal chemistry.

Efficient stereoselective synthesis of the epoxyacid fragment of the azinomycins

R. S. Coleman, Christopher Sarko, J. P. Gittinger, 1997 .

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Jordi Villà-Freixa, Peter Sandner, Bernd J. Pichler, 2017, BMC Pharmacology and Toxicology.

Synthesis of a Potent Pan-Serotype Dengue Virus Inhibitor Having a Tetrahydrothienopyridine Core

B. Yeung, Lei Zhang, F. Yokokawa, 2020, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

A soluble guanylate cyclase activator protects from diabetic nephropathy beyond standard of care in the ZSF1 rat

R. Fryer, Kathleen A. Lincoln, S. Pullen, 2015, BMC Pharmacology and Toxicology.

Indole RSK inhibitors. Part 1: discovery and initial SAR.

J. Madwed, M. Kashem, R. Snow, 2012, Bioorganic & medicinal chemistry letters.

Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β: Part I: Hit-to-Lead Strategies

C. Homon, C. Cywin, Jiang-Ping Wu, 2006 .

The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease

R. Fryer, M. McHugh, Kathleen A. Lincoln, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

Charles A. Wartchow, Remo S. Schmidt, M. Barrett, 2023, Science.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

James C. Campbell, Dong I. Lee, M. Zaccolo, 2017, BMC Pharmacology and Toxicology.

2 – Analysis of a Combinatorial Library Synthesized Using a Split-and-Pool Irori MicroKan Method for Development and Production

Heewon Lee, Christopher Ronald Sarko, Heewon Lee, 2004 .

Indole RSK inhibitors. Part 1: discovery and initial SAR.

J. Madwed, M. Kashem, R. Snow, 2012, Bioorganic & medicinal chemistry letters.

Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.

C. Homon, C. Cywin, Jiang-Ping Wu, 2006, Journal of medicinal chemistry.