G. Showell

发表

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor.

P. Leeson, I. Collins, M. Rowley, 1998, Bioorganic & medicinal chemistry.

Selective thyromimetics. Cardiac-sparing thyroid hormone analogues containing 3'-arylmethyl substituents.

J. C. Emmett, P. Leeson, H. D. Prain, 1989, Journal of Medicinal Chemistry.

Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.

S. Freedman, S. Patel, A. Macleod, 1991, Journal of medicinal chemistry.

Derives de benzodiazepine

V. Matassa, S. Fletcher, K. Moore, 1993 .

The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3)

K. Wada, T. Arai, E. Wada, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry.

J. Montana, Louise M. Walsh, G. Showell, 2007, Bioorganic & medicinal chemistry letters.

Exploitation of silicon medicinal chemistry in drug discovery

G. Showell, J. Mills, 2004, Expert opinion on investigational drugs.

Chemistry challenges in lead optimization: silicon isosteres in drug discovery.

Graham A Showell, John S Mills, G. Showell, 2003, Drug discovery today.

Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.

T. Hamilton, J. M. Evans, G. Showell, 1983, Journal of medicinal chemistry.

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

S. Freedman, L. Street, A. Macleod, 1990, Journal of medicinal chemistry.

Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry.

J. Montana, G. Showell, M. J. Barnes, 2007, Bioorganic & medicinal chemistry letters.

Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization

J. Montana, R. Tacke, C. Burschka, 2006 .

(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis.

J. Montana, R. Tacke, G. Showell, 2006, Bioorganic & medicinal chemistry letters.

Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

J. Montana, H. Gronemeyer, D. Ivanova, 2005 .

Silicon Analogues of the Nonpeptidic GnRH Antagonist AG‐045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization

J. Montana, P. Muniandy, A. Hendrick, 2011, ChemMedChem.

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

P D Leeson, P. Leeson, D. O'connor, 1998, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

S. Freedman, L. Street, A. Macleod, 1990, Journal of medicinal chemistry.

X-ray surface dose measurements using TLD extrapolation.

P. Metcalfe, T. Wong, T. Kron, 1993, Medical physics.

2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists.

R. Snow, S. Freedman, E. Harley, 1988, Journal of medicinal chemistry.

High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.

J. Kemp, J. G. Neduvelil, S. Freedman, 1994, Journal of medicinal chemistry.

Synthesis, physicochemical and conformational properties of (3R,4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane, a novel M1 selective muscarinic partial agonist

R. Hargreaves, S. Freedman, K. Hoogsteen, 1992 .

L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.

L. Iversen, N. Newberry, S. Freedman, 1992, European journal of pharmacology.

Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].

J. Salamone, J. Springer, J. Hirshfield, 1987, Journal of medicinal chemistry.

Thyroid hormone analogues. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart.

J. C. Emmett, P. Leeson, D. Ellis, 1988, Journal of medicinal chemistry.

Collaborative Approaches to Lead Generation

Fabrizio Giordanetto, Anna Karawajczyk, Graham A. Showell, 2016 .

C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists

V. Matassa, J. G. Neduvelil, S. Freedman, 1995 .

Design strategies for building drug-like chemical libraries.

T Mitchell, G A Showell, T. Mitchell, 2001, Current opinion in drug discovery & development.

Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.

Jorge Sanchez-Quesada, Fabrizio Giordanetto, Anna Karawajczyk, 2015, Bioorganic & medicinal chemistry.

Synthesis, crystal structure analysis, and pharmacological characterization of desmethoxy-sila-venlafaxine, a derivative of the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine

J. Montana, R. Tacke, C. Burschka, 2006 .