J. Hazeldine

发表

Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation

D. Kavanagh, N. Kalia, J. Lord, 2019, Haematologica.

Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock

Paul J. Harrison, M. Midwinter, D. Naumann, 2018, The journal of trauma and acute care surgery.

Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system

J. Lord, A. Acharjee, D. Naumann, 2021, Burns & trauma.

Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

J. Lord, C. Greig, J. Hazeldine, 2019, Burns & Trauma.

A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT

J. Lord, K. Brock, C. Greig, 2021, BMJ Open.

Altered neutrophil phenotype and function in non-ICU COVID-19 patients correlated with disease severity

E. Sapey, D. Thickett, J. Hazeldine, 2021, medRxiv.

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways.

J. Lord, P. Hampson, J. Hazeldine, 2015, Injury.

The impact of trauma on neutrophil function.

J. Lord, P. Hampson, J. Hazeldine, 2014, Injury.

Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease

J. Lord, P. Hampson, J. Hazeldine, 2013, Current opinion in hematology.

Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis

M. Strnad, V. Kryštof, P. Pechan, 2012, PloS one.

Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease

C. Weston, L. Gathercole, G. Lavery, 2016, Endocrinology.

The Impact of Age on Neutrophil Extracellular Trap Formation

J. Lord, J. Hazeldine, 2019, Handbook of Immunosenescence.

Immunesenescence and Compromised Removal of Senescent Cells: Implications for Health in Old Age

J. Lord, J. Hazeldine, 2021, Healthy Ageing and Longevity.

Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury

M. Midwinter, E. Kirkman, S. Watts, 2019, The British journal of surgery.

Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study

J. Lord, M. Midwinter, D. Naumann, 2017, PloS one.

Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality

J. Lord, W. Arlt, P. Hampson, 2017, European journal of endocrinology.

Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury

A. Logan, A. Belli, D. Davies, 2017, Scientific Reports.

Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation

J. Lord, P. Harrison, J. Hazeldine, 2019, Front. Immunol..

of Birmingham Traumatic injury and exposure to mitochondrial-derived damage associated molecular patterns suppresses neutrophil extracellular trap formation

J. Lord, J. Hazeldine, P. Harrison, 2019 .

Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia

E. Sapey, D. Thickett, S. Lugg, 2022, Cells.

Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study

J. Lord, M. Midwinter, A. Belli, 2017, Shock.

University of Birmingham Endotheliopathy of trauma is an on-scene phenomenon, and is associated with multiple organ dysfunction syndrome

J. Lord, J. Midwinter, M. Midwinter, 2017 .

Changes in the pattern of plasma extracellular vesicles after severe trauma

A. Belli, G. Nash, P. Hampson, 2017, PloS one.

Exacerbated hepatic inflammatory response to diet-induced non-alcoholic fatty liver disease in 1 male 11β-HSD1 knockout mice 2

C. Weston, L. Gathercole, P. Stewart, 2016 .

Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis

S. Shen-Orr, A. Acharjee, N. Duggal, 2022, Immunity & Ageing.

Characteristics of L-PRP preparations for treating Achilles tendon rupture within the PATH-2 study

K. Willett, S. Lamb, P. Hulley, 2020, Platelets.

The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review

J. Lord, P. Hampson, J. Hazeldine, 2016, Burns & Trauma.

Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?

J. Lord, J. Hazeldine, 2020, Frontiers in Immunology.

Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study

J. Lord, N. Moiemen, P. Hampson, 2017, Annals of surgery.

Heparin resistance in severe thermal injury: a prospective cohort study

J. Lord, N. Moiemen, P. Harrison, 2021, Burns & trauma.

Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus

J. Lord, A. Belli, J. Hazeldine, 2015, Front. Neurol..

University of Birmingham The impact of ageing on natural killer cell function and potential consequences for health in older adults

J. Lord, J. Hazeldine, 2017 .

Innate immunesenescence: underlying mechanisms and clinical relevance

J. Hazeldine, J. M. Lord, J. Lord, 2014, Biogerontology.

The impact of ageing on natural killer cell function and potential consequences for health in older adults

J. Lord, J. Hazeldine, 2013, Ageing Research Reviews.

Mechanisms underlying innate immunesenescence

J. Hazeldine, 2013 .

Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury : A prospective cohort

Paul J. Harrison, J. Lord, A. Belli, 2019 .

Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction

G. Gkoutos, J. Lord, A. Acharjee, 2019, Scientific Data.

Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets

J. Lord, J. Hazeldine, 2021, Frontiers in Immunology.

Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial

E. Sapey, D. Thickett, P. Newby, 2019, American journal of respiratory and critical care medicine.

University of Birmingham Simvastatin improves neutrophil function and clinical outcomes in pneumonia

E. Sapey, D. Thickett, P. Newby, 2019 .

Multicentre, longitudinal, observational cohort study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries: a protocol for the Scientific Investigation of the Biological Pathways Following Thermal Injury-2 (SIFTI-2) study

J. Lord, N. Moiemen, Y. Wilson, 2021, BMJ Open.

Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient

J. Lord, P. Hampson, J. Hazeldine, 2015, Ageing Research Reviews.

MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury.

A. Logan, A. Belli, M. Ragusa, 2017, Journal of neurotrauma.

Reduced release and binding of perforin at the immunological synapse underlies the age‐related decline in natural killer cell cytotoxicity

J. Lord, P. Hampson, J. Hazeldine, 2012, Aging cell.

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

Elizabeth Sapey, E. Sapey, J. Lord, 2014, Aging cell.

Genetic Deletion of the Lipid Raft Protein Caveolin-1 Leads to Worsening Renal Fibrosis

J. Hazeldine, S. Chand, Smith Sw, 2018, Journal of Clinical Nephrology and Renal Care.

Changes in novel haematological parameters following thermal injury: A prospective observational cohort study

J. Lord, N. Moiemen, P. Hampson, 2017, Scientific Reports.

University of Birmingham Changes in novel haematological parameters following thermal injury:

J. Hazeldine, J. Lord, J. Bishop, 2017 .

Dehydroepiandrosterone as a regulator of immune cell function

J. Lord, W. Arlt, J. Hazeldine, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin

E. Sapey, J. Lord, D. Thickett, 2017, American journal of respiratory and critical care medicine.

University of Birmingham Pulmonary infections in the elderly lead to impaired neutrophil targeting, improved by Simvastatin

E. Sapey, D. Thickett, P. Nightingale, 2017 .

University of Birmingham Neutrophil dysfunction, immature granulocytes, and cell-free DNA are early biomarkers of sepsis in burn-injured patients

J. Lord, N. Moiemen, P. Hampson, 2016 .

Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury.

G. Gkoutos, J. Lord, A. Acharjee, 2021, Metabolites.

Innate Immunosenescence and Its Impact on Health in Old Age

J. Lord, J. Hazeldine, Mohammad A. Tariq, 2017 .

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Paul J. Harrison, Gary F. Simons, A. L. Tan, 2023, The Lancet Regional Health - Europe.

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Gary F. Simons, A. L. Tan, L. Wain, 2023, eClinicalMedicine.

Innate immunesenescence: underlying mechanisms and clinical relevance

J. Lord, J. Hazeldine, 2015, Biogerontology.

Detection of tissue factor–positive extracellular vesicles using the ExoView R100 system

T. Luther, N. Mackman, J. Hazeldine, 2023, Research and practice in thrombosis and haemostasis.

Differential benefits of steroid therapies in adults following major burn injury.

J. Lord, A. Acharjee, N. Moiemen, 2022, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

The immune suppressive properties of damage associated molecular patterns in the setting of sterile traumatic injury

J. Lord, J. Hazeldine, E. Horner, 2023, Frontiers in immunology.

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Paul J. Harrison, Gary F. Simons, A. L. Tan, 2023, The Lancet Respiratory Medicine.

Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study

J. Lord, A. Belli, N. Duggal, 2017, PLoS medicine.

Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study.

M. Midwinter, D. Naumann, S. Hutchings, 2019, Clinical Hemorheology and Microcirculation.

Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury

A. Logan, A. Belli, L. Hill, 2017, Scientific Reports.

University of Birmingham Traumatic injury and exposure to mitochondrial-derived damage associated molecular patterns suppresses neutrophil extracellular trap formation

J. Lord, J. Hazeldine, P. Harrison, 2019 .

The impact of trauma on neutrophil function.

J. Lord, P. Hampson, J. Hazeldine, 2014, Injury.

University of Birmingham Immunesenescence

J. Hazeldine, Janet M. Lord, 2022 .

of Birmingham Impaired neutrophil extracellular trap formation : a novel defect in the innate immune system of aged individuals

J. Hazeldine, H. Greenwood, Amy Livesey, 2022 .

University of Birmingham Impaired neutrophil extracellular trap formation : a novel defect in the innate immune system of aged individuals

J. Lord, I. Chapple, J. Hazeldine, 2014 .

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging

J. Hazeldine, Yung-Yi Chen, Janet M. Lord, 2024, Experimental Gerontology.