Liezl Gibhard

发表

Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice

R. Hayeshi, L. Wiesner, H. Swai, 2015, International journal of nanomedicine.

Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor.

K. Chibale, P. Denti, E. Sturrock, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

K. Chibale, G. Basarab, G. Robertson, 2022, Antimicrobial agents and chemotherapy.

The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells

B. Loos, L. Wiesner, S. Mapolie, 2019, Cell Death Discovery.

Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether

L. Wiesner, H. Wong, R. Haynes, 2021, Antimicrobial agents and chemotherapy.

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

E. Winzeler, G. Drewes, M. Bantscheff, 2022, Science Translational Medicine.

The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

K. Chibale, L. Wiesner, Matshawandile Tukulula, 2014, Malaria Journal.

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

K. Batty, L. Wiesner, L. Birkholtz, 2021, Pharmaceutics.

Development and validation of a LC-MS/MS method for the quantitation of lumefantrine in mouse whole blood and plasma.

L. Wiesner, L. D. du Plessis, Liezl Gibhard, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

D. Taramelli, L. Wiesner, L. Birkholtz, 2018, Antimicrobial Agents and Chemotherapy.

The effect of Pheroid™ technology on the bioavailability of quinoline–based anti–malarial compounds in primates

Liezl Gibhard, 2012 .

Ozone autohaemotherapy protects against Ketamine hydrochloride® induced liver and muscle damage in baboons

Liezl Gibhard, M. Meyer, H. Kotze, 2009 .

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

K. Chibale, T. Egan, John Okombo, 2019, Journal of medicinal chemistry.

, 2 ‐ a ] benzimidazoles Which Are E ffi cacious in an in Vivo Mouse Model of Malaria

K. Chibale, T. Egan, John Okombo, 2019 .

The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria

L. Wiesner, Richard M. Beteck, R. Haynes, 2022, Frontiers in Pharmacology.

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.

K. Chibale, T. Egan, Dale Taylor, 2022, Journal of medicinal chemistry.

Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model

L. Wiesner, N. Dambuza, Liezl Gibhard, 2015, Malaria Journal.

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

T. Egan, Jill M Combrinck, Peter J. Smith, 2015, Malaria Journal.

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.

K. Chibale, G. Dziwornu, L. Birkholtz, 2021, Journal of medicinal chemistry.

Integrating Pharmacokinetic–Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study

K. Chibale, M. Mulubwa, Liezl Gibhard, 2023, Antimicrobial agents and chemotherapy.

Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

K. Chibale, Dale Taylor, G. Basarab, 2018, Antimicrobial Agents and Chemotherapy.

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells

B. Loos, L. Wiesner, S. Mapolie, 2019, Cell Death Discovery.

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

J. Keiser, K. Chibale, T. Egan, 2017, ACS infectious diseases.

In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102

L. Wiesner, Liezl Gibhard, Peter Smith, 2016, Antimicrobial Agents and Chemotherapy.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

E. Winzeler, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.