Mathew Njoroge

发表

Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor.

K. Chibale, P. Denti, E. Sturrock, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

K. Chibale, G. Basarab, G. Robertson, 2022, Antimicrobial agents and chemotherapy.

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

K. Chibale, Dale Taylor, T. Ioerger, 2020, ACS infectious diseases.

Azaaurones as Potent Antimycobacterial Agents Active against MDR‐ and XDR‐TB

K. Chibale, R. Moreira, F. Lopes, 2019, ChemMedChem.

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

G. Drewes, C. Harris, Markus Boesche, 2017, Journal of medicinal chemistry.

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

Paul W Smith, K. Chibale, Dale Taylor, 2015, Journal of medicinal chemistry.

In vitro metabolism of tetrazole aminoquinolines and derivatives of metergoline and fusidic acid

Mathew Njoroge, 2014 .

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.

K. Chibale, Dale Taylor, M. Witty, 2015, Journal of medicinal chemistry.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

E. Winzeler, S. Meister, K. Chibale, 2015, Journal of medicinal chemistry.

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

M. Bogyo, D. Fidock, M. Vanaerschot, 2018, Journal of the American Chemical Society.

Semisynthetic Antimycobacterial C-3 Silicate and C-3/ C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma and Mycobacterium tuberculosis culture.

K. Chibale, Dale Taylor, John Okombo, 2019, ACS infectious diseases.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-Hydroxylation

H. Gohlke, K. Chibale, T. Kurz, 2022, Pharmaceuticals.

Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.

J. Gut, P. Rosenthal, K. Chibale, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents.

K. Chibale, Peter J. Smith, V. Mizrahi, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

K. Chibale, Matshawandile Tukulula, Stefan Louw, 2020, Molecules.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile artemisinin-based anti-malarial drugs using a QTRAP® mass spectrometer.

K. Chibale, Stefan Louw, Mathew Njoroge, 2012, Rapid communications in mass spectrometry : RCM.

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

K. Chibale, Peter J. Smith, John Okombo, 2017, Bioorganic & medicinal chemistry letters.

Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.

K. Chibale, A. Nzila, C. Masimirembwa, 2012, Future medicinal chemistry.

Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites

K. Chibale, D. Warner, N. M. Njuguna, 2014 .

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

K. Chibale, T. Egan, John Okombo, 2019, Journal of medicinal chemistry.

, 2 ‐ a ] benzimidazoles Which Are E ffi cacious in an in Vivo Mouse Model of Malaria

K. Chibale, T. Egan, John Okombo, 2019 .

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

K. Chibale, T. Egan, John Okombo, 2017, Journal of medicinal chemistry.

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis.

Kelly Chibale, Paul W Smith, K. Chibale, 2014, Chemical reviews.

Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.

K. Chibale, Peter J. Smith, K. Land, 2016, Dalton transactions.

Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.

Paul W Smith, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.

K. Chibale, T. Egan, Dale Taylor, 2022, Journal of medicinal chemistry.

Synthesis of fusidic acid bioisosteres as antiplasmodial agents and molecular docking studies in the binding site of elongation factor-G

K. Chibale, Peter J. Smith, S. Wittlin, 2015 .

Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies.

K. Chibale, Dale Taylor, Mathew Njoroge, 2023, ACS infectious diseases.

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.

K. Chibale, G. Dziwornu, L. Birkholtz, 2021, Journal of medicinal chemistry.

Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches.

K. Chibale, Stefan Louw, Grace Mugumbate, 2013, Drug metabolism letters.

Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

K. Chibale, Dale Taylor, G. Basarab, 2018, Antimicrobial Agents and Chemotherapy.

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin

K. Chibale, L. Wiesner, J. Louw, 2017, Molecules.

Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies.

K. Chibale, John Okombo, G. Dziwornu, 2019, ACS infectious diseases.

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2.

J. Gut, P. Rosenthal, K. Chibale, 2015, European journal of medicinal chemistry.

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

K. Chibale, T. Egan, C. Masimirembwa, 2015, Bioorganic & medicinal chemistry.

Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro.

K. Chibale, Dale Taylor, L. Birkholtz, 2021, ACS medicinal chemistry letters.

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

J. Keiser, K. Chibale, T. Egan, 2017, ACS infectious diseases.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

E. Winzeler, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.