J. Obniska

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Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.

K. Kieć‐Kononowicz, J. Łuszczki, G. Latacz, 2015, Bioorganic & medicinal chemistry.

SYNTHESIS AND 5-HT 1 A / 5-HT 2 A RECEPTOR ACTIVITY OF NEW N-[ 3-( 4-PHENYLPIPERAZIN-1-YL )-PROPYL ] DERIVATIVES OF 3-SPIRO-CYCLOHEXANEPYRROLIDI-NE2 , 5-DIONE AND 3-SPIRO-- TETRALONEPYRRO-LIDINE-2 , 5-DIONE

E. Tatarczyńska, J. Obniska, B. Duszyńska, 2003 .

Lipophilicity characterization of new N-phenylamino-azaspiranes as potential anticonvulsant agents.

K. Kamiński, J. Obniska, 2006, Biomedical chromatography : BMC.

Synthesis and Anticonvulsant Properties of New N‐Mannich Bases Derived from 3,3‐Diphenyl‐ and 3‐Ethyl‐3‐methyl‐pyrrolidine‐2,5‐diones. Part III

J. Karolak-Wojciechowska, K. Kamiński, J. Obniska, 2013, Archiv der Pharmazie.

Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.

A. Siwek, E. Pękala, A. Rapacz, 2019, European journal of pharmacology.

Antiallodynic and antihyperalgesic activity of new 3,3‐diphenyl‐propionamides with anticonvulsant activity in models of pain in mice

A. Gryboś, A. Siwek, E. Pękala, 2018, European journal of pharmacology.

The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.

M. Pawłowski, A. Bojarski, Jean Martínez, 2009, European journal of medicinal chemistry.

Synthesis, anticonvulsant activity and 5-HT1A, 5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione.

M. Kołaczkowski, A. Bojarski, J. Obniska, 2006, European journal of medicinal chemistry.

Synthesis, anticonvulsant properties and 5-HT1A/5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane and [4.5]decane-1,3-dione derivatives.

M. Kołaczkowski, A. Bojarski, J. Obniska, 2005, Pharmacological reports : PR.

Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione.

M. Kołaczkowski, M. Pawłowski, E. Tatarczyńska, 2003, Polish journal of pharmacology.

SYNTHESIS AND 5-HT 1A /5-HT 2A RECEPTOR ACTIVITY OF NEW N-(3-(4-PHENYLPIPERAZIN-1-YL)-PROPYL) DERIVATIVES OF 3-SPIRO-CYCLOHEXANEPYRROLIDI- NE-2,5-DIONE AND 3-SPIRO--TETRALONEPYRRO-

E. Tatarczyńska, J. Obniska, B. Duszyńska, 2003 .

Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives

K. Kamiński, J. Obniska, Beata Wiklik, 2015, Medicinal Chemistry Research.

Antinociceptive properties of N-Mannich bases derived from 3-substituted pyrrolidine-2,5-dione in the formalin model of persistent pain in mice.

T. Librowski, A. Rapacz, K. Sałat, 2015, Pharmacological reports : PR.

Synthesis, Anticonvulsant Properties, and SAR Analysis of Differently Substituted Pyrrolidine‐2,5‐diones and Piperidine‐2,6‐diones

K. Kamiński, J. Obniska, Beata Wiklik, 2014, Archiv der Pharmazie.

Synthesis, Physicochemical, and Anticonvulsant Properties of New N‐Mannich Bases Derived from Pyrrolidine‐2,5‐dione and Its 3‐Methyl Analog

A. Rapacz, K. Kamiński, J. Obniska, 2014, Archiv der Pharmazie.

Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.

K. Kamiński, J. Obniska, Iwona Chlebek, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological properties of new N-Mannich bases derived from 3-methyl-3-phenyl- and 3,3-dimethyl-succinimides. Part V.

E. Pękala, K. Kamiński, J. Obniska, 2013, European journal of medicinal chemistry.

Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.

K. Kamiński, J. Obniska, S. Rzepka, 2012, Bioorganic & medicinal chemistry.

Synthesis and anticonvulsant activity of new N-Mannich bases derived from 5-cyclopropyl-5-phenyl- and 5-cyclopropyl-5-(4-chlorophenyl)-imidazolidine-2,4-diones.

M. Pawłowski, K. Kamiński, J. Obniska, 2011, Bioorganic & medicinal chemistry.

Synthesis and Anticonvulsant Activity of New N‐Mannich Bases Derived from 5‐Cyclopropyl‐5‐phenyl‐hydantoins

K. Kamiński, J. Obniska, A. Czopek, 2011, Archiv der Pharmazie.

Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.

J. Karolak-Wojciechowska, M. Pawłowski, M. Szczesio, 2010, Bioorganic & medicinal chemistry.

Synthesis, physicochemical and anticonvulsant properties of new N-phenylamino derivatives of 2-azaspiro[4.4]nonane- and [4.5]decane-1,3-diones: part V.

K. Kamiński, J. Obniska, M. Dybała, 2008, European journal of medicinal chemistry.

Synthesis, Physicochemical and Anticonvulsant Properties of New N‐4‐Arylpiperazin‐1‐yl Amides of (2‐Aza‐1,3‐dioxospiro[4.4]non‐2‐yl)‐ and [4.5]dec‐2‐yl)‐propionic Acid

K. Kamiński, J. Obniska, Lukasz Hondo, 2007, Archiv der Pharmazie.

Synthesis, Physicochemical and Anticonvulsant Properties of New N‐(Pyridine‐2‐yl) Derivatives of 2‐Azaspiro[4.4]nonane and [4.5]decane‐1,3‐dione. Part II

A. Zagórska, K. Kamiński, J. Obniska, 2006, Archiv der Pharmazie.

Impact of aromatic substitution on the anticonvulsant activity of new N-(4-arylpiperazin-1-yl)-alkyl-2-azaspiro[4,5]decane-1,3-dione derivatives.

E. Tatarczyńska, K. Kamiński, J. Obniska, 2006, Pharmacological reports : PR.

Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part I.

J. Karolak-Wojciechowska, P. Zajdel, A. Zagórska, 2005, Farmaco.

Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione.

A. Zagórska, J. Obniska, 2003, Farmaco.

Synthesis, physicochemical and anticonvulsant properties of new N-pyridyl derivatives of 3-phenyl- and 3,3-diphenyl-succinimides.

J. Karolak-Wojciechowska, J. Obniska, A. Zejc, 1999, Farmaco.

Synthesis, physicochemical and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)alkyl]-3-phenyl- and 3-(3-methyl-phenyl)-pyrrolidine-2,5-diones.

K. Kamiński, J. Obniska, Iwona Chlebek, 2009, Acta poloniae pharmaceutica.

Synthesis and anticonvulsant properties of new N-phenylamino derivatives of 2-azaspiro[4.4]nonane, 2-azaspiro[4.5]decane-1,3-dione and 3-cyclohexylpyrrolidine-2,5-dione. Part IV.

K. Kamiński, J. Obniska, 2006, Acta poloniae pharmaceutica.

Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.

A. Rapacz, K. Sałat, P. Żmudzki, 2016, Bioorganic & medicinal chemistry.

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione

M. Głuch-Lutwin, B. Mordyl, A. Rapacz, 2020, International journal of molecular sciences.

Synthesis and anticonvulsant activity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 3-phenyl-pyrrolidine-2,5-dione.

K. Kamiński, J. Obniska, Joanna Pichór, 2009, European journal of medicinal chemistry.

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione

E. Pękala, A. Rapacz, K. Sałat, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid.

E. Pękala, A. Rapacz, P. Żmudzki, 2015, European journal of medicinal chemistry.

Evaluation of mutagenic and antimutagenic properties of new derivatives of pyrrolidine-2,5-dione with anti-epileptic activity, by use of the Vibrio harveyi mutagenicity test.

G. Węgrzyn, A. Węgrzyn, E. Pękala, 2013, Mutation research.

CO…HC interactions as packing motifs in crystals: Part 3. Impact of chloro-substituents on the structures of N-(chloro)-benzyl-3-spirocycloalkylopyrrolidine-2,5-diones

J. Obniska, J. Karolak‐Wojciechowska, A. Dzierżwska-Majewska, 2008 .

CO…HC interactions as packing motifs in the crystals: Part 4. Intermolecular interactions in the structures of N-[(4-arylpiperazin-1-yl)-alkyl]2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione derivatives

J. Obniska, A. Mrozek, J. Karolak‐Wojciechowska, 2008 .

CO…H–C interactions as packing motifs in crystals. Part 1. Structure and conformation of N-(methyl)-benzyl-3-spiro-cycloalkylopyrrolidine-2,5-diones

J. Obniska, Agnieszka Dzierżawska-Majewska, J. Karolak‐Wojciechowska, 2006 .

Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice.

A. Rapacz, K. Sałat, J. Obniska, 2016, European journal of pharmacology.

Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain

A. Rapacz, K. Kamiński, J. Obniska, 2022, International journal of molecular sciences.

Synthesis and anticonvulsant properties of new 1-phenyl and 1-phenylamino-3-phenylpyrrolidine-2,5-dione derivatives.

A. Zagórska, J. Obniska, A. Zeic, 2002, Acta poloniae pharmaceutica.

New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.

J. Łuszczki, M. Andres-Mach, M. Zagaja, 2016, Bioorganic & medicinal chemistry.

Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs.

D. Atamanyuk, K. Kamiński, J. Obniska, 2011, European journal of medicinal chemistry.

Synthesis, anticonvulsant, and antinociceptive activity of new 3‐(3‐methyl‐2,5‐dioxo‐3‐phenylpyrrolidin‐1‐yl)propanamides and 3‐phenyl‐butanamides

M. Jakubiec, A. Rapacz, K. Sałat, 2020, Archiv der Pharmazie.

Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core.

A. Zagórska, A. Rapacz, K. Sałat, 2019, Bioorganic & medicinal chemistry letters.

Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre-screening of 5-HT1A ligands.

M. Pawłowski, A. Bojarski, Jean Martínez, 2003, Biomedical chromatography : BMC.

Synthesis and Anticonvulsant Properties of New 3,3‐Diphenyl‐2,5‐dioxo‐pyrrolidin‐1‐yl‐acetamides and 3,3‐Diphenyl‐propionamides

A. Rapacz, P. Żmudzki, K. Kamiński, 2017, Archiv der Pharmazie.

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

E. Pękala, A. Rapacz, P. Koczurkiewicz, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis and anticonvulsant activity of new N-mannich bases derived from benzhydryl- and isopropyl-pyrrolidine-2,5-dione

A. Rapacz, P. Żmudzki, J. Obniska, 2016, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides.

A. Rapacz, K. Kamiński, J. Obniska, 2016 .

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from 3-(1-phenylethyl)- and 3-benzyl-pyrrolidine-2,5-dione.

A. Rapacz, A. Furgala, P. Żmudzki, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.

K. Kamiński, J. Obniska, S. Rzepka, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones.

K. Kamiński, J. Obniska, 2008, Bioorganic & medicinal chemistry.

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs.

A. Rapacz, P. Żmudzki, J. Obniska, 2017, Bioorganic & medicinal chemistry letters.

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione

E. Pękala, A. Rapacz, K. Sałat, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Relationships Between the Lipophilicity and Anticonvulsant Activity of N-Benzyl-2-azaspiro[4.4]nonane- and [4.5]decane-1,3-dione Derivatives

K. Kamiński, J. Obniska, 2005, JPC – Journal of Planar Chromatography – Modern TLC.

Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives

E. Pękala, A. Rapacz, P. Żmudzki, 2017, ChemMedChem.

Anticonvulsant properties of N-(4-methylpiperazin-1-yl)- and N-[3-(4-methyl-piperazin-1-yl)propyl] derivatives of 3-aryl- and 3-spirocycloalkyl-pyrrolidine-2,5-dione.

E. Tatarczyńska, K. Stachowicz, K. Kamiński, 2005, Pharmacological reports : PR.

Synthesis, 5-HT1A and 5-HT2A receptor affinity of new 1-phenylpiperazinylpropyl derivatives of purine-2,6- and pyrrolidine-2,5-diones.

M. Pawłowski, J. Obniska, M. Mokrosz, 2000, Farmaco.

Synthesis and 5-HT1A/5-HT2A receptor activity of N-(4-arylpiperazin-1-yl)alkyl derivatives of 2-azaspiro([4.4]nonane and [4.5]decane-1,3-dione.

E. Tatarczyńska, J. Obniska, A. Nikiforuk, 2006, Pharmacological reports : PR.

Synthesis, 5‐HT1A and 5‐HT2A Receptor Affinity of New 1‐Phenylpiperazinylpropyl Derivatives of Purine‐2,6‐ and Pyrrolidine‐2,5‐diones.

M. Pawłowski, J. Obniska, M. Mokrosz, 2001 .

Synthesis and Anticonvulsant Properties of New Mannich Bases Derived from 3,3‐Disubstituted Pyrrolidine‐2,5‐diones. Part IV

K. Kamiński, J. Obniska, Iwona Chlebek, 2012, Archiv der Pharmazie.

RPTLC Determination of the Lipophilicity of Some New N-[(4-Arylpiperazin-1-yl)alkyl] spirosuccinimides

K. Kamiński, J. Obniska, 2005, JPC – Journal of Planar Chromatography – Modern TLC.

Synthesis, anticonvulsant activity and 5-HT_1A/5-HT_7 receptors affinity of 1-[(4-arylpiperazin-1-yl)-propyl]-succinimides

A. Bojarski, G. Satała, K. Kamiński, 2012, Pharmacological reports : PR.

Synthesis and anticonvulsant activity of new fluorinated N-phenyl- and N-benzyl-2-azaspiro[4.4]nonane- and [4.5]decane-1,3-dione derivatives: Part III

Janina Karolak-Wojciechowska, Krzysztof Kamiński, A. Zagórska, 2006 .

Synthesis, Anticonvulsant Properties, and SAR Analysis of Differently Substituted Pyrrolidine‐2,5‐diones and Piperidine‐2,6‐diones

K. Kamiński, J. Obniska, Beata Wiklik, 2014, Archiv der Pharmazie.

Synthesis and Anticonvulsant Activity of New Fluorinated N‐Phenyl‐ and N‐Benzyl‐2‐azaspiro[4.4]nonane‐ and [4.5]Decane‐1,3‐dione Derivatives. Part 3.

A. Zagórska, K. Kamiński, J. Obniska, 2006 .

Electronic conditions for anticonvulsant activity of diphenylsuccinimides: Crystal and molecular structure of 1,1-diphenyl-N-(2-pyridyl)-succinimide

J. Obniska, M. Błaszczyk, A. Zejc, 1997 .

3-(m-Bromophenyl)-1-(3-methyl-2-pyridyl)pyrrolidin-2,5-dione

J. Obniska, A. Zejc, J. Karolak‐Wojciechowska, 1996 .

Structures of three N-pyridyl-2-phenylsuccinimides and structural evidence for substituent effects on anticonvulsant properties.

J. Obniska, A. Zejc, J. Karolak‐Wojciechowska, 1990, Acta Crystallographica Section C: Crystal Structure Communications.

Impact of aromatic substitution on the anticonvulsant activity of new N-(4-arylpiperazin-1-yl)-alkyl-2-azaspiro[4,5]decane-1,3-dione derivatives.

E. Tatarczyńska, K. Kamiński, J. Obniska, 2006, Pharmacological reports : PR.

Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione.

A. Zagórska, J. Obniska, 2003, Farmaco.

Synthesis and anticonvulsant properties of some arylsuccinate methylpyridylimides.

M. Witkowska, J. Obniska, M. Rutkowska, 1990, Polish journal of pharmacology and pharmacy.

Synthesis and anticonvulsant properties of N-methylpyridyl derivatives of m- and p-bromophenylsuccinimides.

B. Wiczyńska, E. Tatarczyńska, J. Obniska, 1987, Polish journal of pharmacology and pharmacy.