C. Patten

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Optimizing Donor Number for Consistent Pooled Human Liver Microsomes Application Note 465

E. Francis, C. Crespi, C. Patten, 2013 .

CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis

M. Zollinger, A. Zimmerlin, C. Patten, 2011, Drug Metabolism and Disposition.

Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

W. Völkel, W. Lutz, J. Zarn, 2006, Toxicology.

Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.

C. S. Yang, S. Murphy, T. Smith, 1996, Archives of biochemistry and biophysics.

Role of cytochromes P450 in the metabolism of methyl tert -butyl ether in human livers

Jun-yan Hong, F. Bondoc, Chung S. Yang, 1997, Archives of Toxicology.

Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible.

S. D. Turner, S. Dehal, D. Stresser, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Glucuronides of tea catechins: enzymology of biosynthesis and biological activities.

Chi-Tang Ho, S. Sang, Xiaofeng Meng, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS

W. Völkel, W. Lutz, Eva R Trösken, 2004, Journal of the American Society for Mass Spectrometry.

Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase.

L. Peterson, S. Murphy, C. Patten, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.

S. Amin, F. Guengerich, S. Hecht, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.

C. M. Yates, I. Uings, E. Stewart, 2010, Journal of medicinal chemistry.

Acetone-inducible cytochrome P-450: purification, catalytic activity, and interaction with cytochrome b5.

A. Y. Lu, C. S. Yang, S. Ning, 1986, Archives of biochemistry and biophysics.

Nature of N-nitrosodimethylamine demethylase and its inhibitors.

D. Wade, C. S. Yang, J. Yoo, 1987, Cancer research.

Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals.

C. S. Yang, J. Yoo, S. Ning, 1987, Cancer research.

Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.

Y. Hah, C. S. Yang, H. Gelboin, 1987, Cancer research.

Induction, purification, and characterization of cytochrome P450IIE.

C. S. Yang, J. Yoo, H. Ishizaki, 1991, Methods in enzymology.

Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology.

J. Trill, I. Rioja, P. Wooley, 2004, Arthritis and rheumatism.

Comparison of species differences of P-glycoproteins in beagle dog, rhesus monkey, and human using Atpase activity assays.

C. Xia, G. Xiao, L. Gan, 2006, Molecular pharmaceutics.

A high-throughput screen to identify inhibitors of aromatase (CYP19).

S. D. Turner, D. Stresser, P. Stocker, 2000, Analytical biochemistry.

ASSESSING PREGNANCY RISKS OF AZOLE ANTIFUNGALS USING A HIGH THROUGHPUT AROMATASE INHIBITION ASSAY

S. D. Turner, D. Stresser, C. Crespi, 2002, Endocrine research.

Characterization of Recombinant Human Carboxylesterases: Fluorescein Diacetate as a Probe Substrate for Human Carboxylesterase 2

E. T. Williams, Y. Wong, Jie Wang, 2011, Drug Metabolism and Disposition.

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism.

D. Greenblatt, L. V. von Moltke, C. Patten, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.

F. Guengerich, P. Thomas, F. Gonzalez, 1993, Chemical research in toxicology.

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

D. Greenblatt, J. Miners, P. Mackenzie, 2001, The Journal of pharmacology and experimental therapeutics.

IN VITRO INHIBITION OF UDP GLUCURONOSYLTRANSFERASES BY ATAZANAVIR AND OTHER HIV PROTEASE INHIBITORS AND THE RELATIONSHIP OF THIS PROPERTY TO IN VIVO BILIRUBIN GLUCURONIDATION

Donglu Zhang, W. Humphreys, S. Dehal, 2005, Drug Metabolism and Disposition.

Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells.

F. Gonzalez, T. Aoyama, C. S. Yang, 1992, Archives of biochemistry and biophysics.

Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

Jeffrey P. Jones, D. Scadden, D. Rock, 2001, The Journal of biological chemistry.

Enzymatic mechanisms in the metabolic activation of N-nitrosodialkylamines.

C. S. Yang, J. Yoo, M. Lee, 1987, IARC scientific publications.

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.

C. S. Yang, S. Murphy, T. Smith, 1997, Carcinogenesis.

Monoclonal antibodies to ethanol induced cytochrome P-450 that inhibit aniline and nitrosamine metabolism.

C. S. Yang, H. Gelboin, S. S. Park, 1986, Biochemical pharmacology.

Evidence for cytochrome P 450 2 A 6 and 3 A 4 as major catalysts for N 9-nitrosonornicotine α-hydroxylation by human liver microsomes

C. S. Yang, S. Murphy, T. Smith, 1997 .

Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system.

C. S. Yang, T. Smith, C. Patten, 1997, Archives of biochemistry and biophysics.

Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.

Laishun Chen, E. Wang, C. S. Yang, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Isoniazid Mediates the CYP2B6*6 Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6

D. Greenblatt, U. Zanger, K. Klein, 2014, Antimicrobial Agents and Chemotherapy.

ROLE OF CYP4F IN THE METABOLIC CLEARANCE OF FTY720 ‐ PREDICTION OF LOW DRUG TO DRUG INTERACTION POTENTIAL.: Abstract# 300 Poster Board #‐Session: P147‐I

A. Zimmerlin, C. Patten, 2000 .

Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice.

Chung S. Yang, K. Reuhl, E. Wang, 1996, Journal of biochemical toxicology.

CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis

M. Zollinger, A. Zimmerlin, C. Patten, 2011, Drug Metabolism and Disposition.

Cytochrome P-450 That Metabolizes Aniline and Nitrosamines Monoclonal Antibodies to Ethanol-induced Rat Liver

Christopher, Chung S. Yang, Y. Hah, 2006 .