M. Ribadeneira

发表

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.

Diansong Zhou, S. Grimm, Mark A. Smith, 2012, British journal of clinical pharmacology.

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.

R. Magolda, M. Covington, C. Decicco, 2001, Journal of medicinal chemistry.

Inhibition of fatty acid synthase with FT‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two early‐phase randomized trials

M. Hellerstein, P. Schroeder, L. Morrow, 2020, Diabetes, obesity & metabolism.

Development and SAR of functionally selective allosteric modulators of GABAA receptors.

E. Christian, C. Alhambra, J. Arriza, 2011, Bioorganic & medicinal chemistry.

Differential Bile Acid Detection in Refractory GERD Patient Saliva Using a Simple and Sensitive Liquid Chromatography Tandem Mass Spectrometry Approach

K. Chambert, M. Currie, Yan Chen, 2021, Journal of clinical gastroenterology.

Resistance of the stromal cell in murine long-term bone marrow cultures to damage by ionizing radiation.

R. Rhodes, K. Zuckerman, C. W. Prince, 1986, Experimental hematology.

Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

E. Wilker, A. Drake, P. Schroeder, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.

J. Duan, M. Garneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.

Xiaohua He, John Roderick, J. Trzăskos, 2004, Bioorganic & medicinal chemistry letters.

A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.

J. Trzăskos, Xiao-tao Chen, K. Vaddi, 2007, Bioorganic & medicinal chemistry letters.

Assessment of CYP3A‐mediated drug–drug interaction potential for victim drugs using an in vivo rat model

J. Duan, M. Garneau, N. Rioux, 2013, Biopharmaceutics & drug disposition.

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.

Liang-Shang Gan, Patrick Koch, Andrew Parkinson, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT‐4202), an Allosteric Activator of Pyruvate Kinase‐R, in Healthy Adults: A Randomized, Placebo‐Controlled, Double‐Blind, First‐in‐Human Phase 1 Trial

P. Schroeder, D. Konstantinidis, M. Ribadeneira, 2022, Clinical pharmacology in drug development.

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

M. Telen, P. Malik, P. Schroeder, 2020, Blood.

Sl/Sld mouse bone marrow stroma in vitro contains an active radiation-sensitive inhibitor of normal hemopoiesis.

K. Zuckerman, M. Ribadeneira, C. Prince, 1986, Blood.

Phase 1 Dose Escalation and Expansion Study to Determine Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the BET Inhibitor FT-1101 As a Single Agent in Patients with Relapsed or Refractory Hematologic Malignancies

G. Garcia-Manero, R. Paquette, M. Grunwald, 2019, Blood.

Direct visualization of the isolated and perfused macula densa.

K. Kirk, M. Ribadeneira, D. Barfuss, 1985, The American journal of physiology.

KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Ming-Hu Han, Allyson K Friedman, Rachael L Neve, 2016, Nature Communications.

Effects of Structural Modifications on the Intestinal Permeability of Angiotensin II Receptor Antagonists and the Correlation of In Vitro, In Situ, and In Vivo Absorption

Shiew-Mei Huang, Charles J. Eyermann, C. Eyermann, 1996, Pharmaceutical Research.

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.

R. Magolda, J. Trzăskos, K. Vaddi, 2004, Bioorganic & medicinal chemistry letters.

EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABA(Aα2/3)-positive allosteric modulators at nonsedating anxiolytic doses.

M. Quirk, E. Christian, J. Doherty, 2015, Journal of neurophysiology.

A strategy to reduce biliary clearance in early drug discovery.

J. Duan, M. Garneau, N. Rioux, 2013, Journal of pharmacological and toxicological methods.

A membrane vesicle-based assay to enable prediction of human biliary excretion

J. Duan, F. Colombo, N. Rioux, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

M. Telen, P. Malik, A. Drake, 2019, Blood.