J. Laitila

发表

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

P. Neuvonen, M. Niemi, J. Backman, 2011, European Journal of Clinical Pharmacology.

Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

P. Neuvonen, J. Backman, M. Neuvonen, 2013, Drug Metabolism and Disposition.

Autoinhibition of CYP 3 A 4 Leads to Important Role of CYP 2 C 8 in Imatinib Metabolism : Variability in CYP 2 C 8 Activity May Alter Plasma Concentrations and Response s

P. Neuvonen, J. Backman, M. Neuvonen, 2012 .

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Anne M. Filppula, J. Laitila, A. Filppula, 2011 .

Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.

P. Neuvonen, J. Backman, J. Laitila, 2005, Basic & clinical pharmacology & toxicology.

Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro.

P. Neuvonen, J. Backman, Jun-sheng Wang, 2006, Basic & clinical pharmacology & toxicology.

Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride

P. Neuvonen, M. Niemi, J. Backman, 2001, Clinical pharmacology and therapeutics.

Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.

P. Neuvonen, J. Backman, J. Laitila, 2004, British journal of clinical pharmacology.

Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors.

P. Neuvonen, J. Backman, J. Laitila, 2006, Basic & clinical pharmacology & toxicology.

The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism‐based Inhibition of CYP2C8 In Vivo

M. Niemi, J. Backman, M. Neuvonen, 2008, Clinical pharmacology and therapeutics.

Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans

P. Neuvonen, M. Niemi, J. Backman, 2009, Pharmacogenetics and genomics.

Effect of rifampicin on the pharmacokinetics of pioglitazone.

P. Neuvonen, J. Backman, M. Neuvonen, 2006, British journal of clinical pharmacology.

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma.

P. Neuvonen, M. Niemi, M. Neuvonen, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions

E. Kalso, M. Niemi, T. Lilius, 2016, European journal of pain.

Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.

P. Neuvonen, J. Backman, M. Neuvonen, 2006, British journal of clinical pharmacology.

Voriconazole greatly increases the exposure to oral buprenorphine

P. Neuvonen, J. Backman, K. Laine, 2018, European Journal of Clinical Pharmacology.

Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats

E. Kalso, T. Lilius, H. Viisanen, 2020, Journal of neuroscience research.

Autoinhibition of CYP3A4 Leads to Major Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

P. Neuvonen, J. Backman, M. Neuvonen, 2012 .

Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2

P. Neuvonen, J. Backman, J. Laitila, 2005, Clinical pharmacology and therapeutics.

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

P. Neuvonen, J. Backman, K. Laine, 2016, Pharmacology research & perspectives.

Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

P. Neuvonen, J. Backman, Pertti J. Neuvonen, 2003, Clinical pharmacology and therapeutics.

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

P. Neuvonen, M. Niemi, J. Backman, 2012, European Journal of Clinical Pharmacology.

Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients.

P. Neuvonen, K. Raaska, J. Laitila, 2004, Basic & clinical pharmacology & toxicology.

Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate

P. Neuvonen, J. Backman, M. Neuvonen, 2001, Clinical pharmacology and therapeutics.

Voriconazole greatly increases the exposure to oral buprenorphine

P. Neuvonen, J. Backman, K. Laine, 2018, European Journal of Clinical Pharmacology.

Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively.

P. Neuvonen, J. Backman, X. Wen, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations

P. Neuvonen, J. Backman, M. Neuvonen, 2000, Clinical pharmacology and therapeutics.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

P. Neuvonen, J. Backman, K. Laine, 2016, European Journal of Clinical Pharmacology.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

P. Neuvonen, J. Backman, K. Laine, 2016, European Journal of Clinical Pharmacology.

Cyclosporine markedly raises the plasma concentrations of repaglinide

P. Neuvonen, M. Niemi, J. Backman, 2005, Clinical pharmacology and therapeutics.

Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

M. Niemi, P. Neuvonen, T. Karonen, 2010, Clinical pharmacology and therapeutics.

Potent mechanism‐based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

P. Neuvonen, J. Backman, P. Neuvonen, 2012, British journal of pharmacology.

TRIMETHOPRIM AND SULFAMETHOXAZOLE ARE SELECTIVE INHIBITORS OF CYP 2 C 8 AND CYP 2 C 9 , RESPECTIVELY

P. Neuvonen, J. Backman, X. Wen, 2002 .

Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations

Janne T. Backman, P. Neuvonen, J. Backman, 2011, Drug Metabolism and Disposition.

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

P. Neuvonen, M. Niemi, J. Backman, 2003, Diabetologia.

Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants

V. Fellman, P. Neuvonen, K. Raivio, 1999, European Journal of Clinical Pharmacology.

Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine

E. Kalso, M. Niemi, T. Lilius, 2017, Basic & Clinical Pharmacology & Toxicology.

DISPOSITION ral contraceptives containing ethinyl estradiol nd gestodene markedly increase plasma oncentrations and effects of tizanidine by nhibiting cytochrome P 450 1 A 2

J. Backman, J. Laitila, 2005 .

Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.

P. Neuvonen, J. Backman, M. Neuvonen, 2004, British journal of clinical pharmacology.

Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8.

P. Neuvonen, J. Backman, M. Pasanen, 2005, Basic & clinical pharmacology & toxicology.

The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone

P. Neuvonen, K. Kivistö, J. Laitila, 1998, European Journal of Clinical Pharmacology.

Effect of rifampicin on the pharmacokinetics of pioglitazone

P. Neuvonen, J. Backman, M. Neuvonen, 2005 .

Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine

E. Kalso, M. Niemi, Tuomas O. Lilius, 2017, Basic & clinical pharmacology & toxicology.

Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

P. Neuvonen, J. Backman, M. Neuvonen, 2013, Drug Metabolism and Disposition.

Autoinhibition of CYP3A4 Leads to Major Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

P. Neuvonen, J. Backman, M. Neuvonen, 2012 .

Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

P. Neuvonen, M. Niemi, J. Backman, 2010, Clinical pharmacology and therapeutics.

Autoinhibition of CYP3A4 Leads to Major Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

M. Neuvonen, Anne M. Filppula, J. Laitila, 2012 .