J. V. Van Brocklyn

发表

Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk*

S. Spiegel, D. Beitner-Johnson, D. Leroith, 1997, The Journal of Biological Chemistry.

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death.

Joseph B. Williams, J. V. Van Brocklyn, 2012, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.

M. Caligiuri, O. Abdel-Wahab, R. Levine, 2013, Blood.

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

K. Palanichamy, J. V. Van Brocklyn, A. Estrada-Bernal, 2012, Neuro-oncology.

Immunosuppressive human anti‐lymphocyte autoantibodies specific for the type 1 sphingosine 1‐phosphate receptor

M. Wabl, E. Goetzl, J. Liao, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.

S. Spiegel, O. Cuvillier, A. Olivera, 1998, Biochemistry. Biokhimiia.

Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions.

K. Coggeshall, S. Tridandapani, J. V. Van Brocklyn, 1997, Journal of immunology.

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.

J. P. Hobson, S. Spiegel, M. Lipp, 2000, Blood.

Ganglioside GM1 Activates the Mitogen‐Activated Protein Kinase Erk2 and p70 S6 Kinase in U‐1242 MG Human Glioma Cells

A. Yates, J. Vandenheede, R. Fertel, 1997, Journal of neurochemistry.

Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.

S. Spiegel, A. Porcelli, M. Rugolo, 2000, Archives of biochemistry and biophysics.

Gangliosides Inhibit Platelet‐Derived Growth Factor‐Stimulated Growth, Receptor Phosphorylation, and Dimerization in Neuroblastoma SH‐SY5Y Cells

A. Yates, M. O'dorisio, D. L. Hynds, 1995, Journal of neurochemistry.

Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61

D. Pearl, J. V. Van Brocklyn, N. Young, 2009, Molecular Cancer Research.

Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.

E. Remold-O’Donnell, J. V. Van Brocklyn, D. Kenney, 1992, Blood.

Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors.

N. H. Lee, B. Behbahani, J. V. Van Brocklyn, 2002, Biochimica et biophysica acta.

FTY720 (Gilenya) Phosphate Selectivity of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) G Protein-coupled Receptor Requires Motifs in Intracellular Loop 1 and Transmembrane Domain 2*

Y. Fujiwara, A. Parrill, R. Bittman, 2011, The Journal of Biological Chemistry.

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

S. Spiegel, T. Hla, O. Cuvillier, 1998, The Journal of cell biology.

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

C. H. Liu, S. Spiegel, T. Hla, 1998, Science.

Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.

A. Parrill, M. Naor, G. Tigyi, 2007, Journal of molecular graphics & modelling.

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218*

S. Spiegel, R. Schmidt, J. V. Van Brocklyn, 1999, The Journal of Biological Chemistry.

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

S. Spiegel, O. Cuvillier, B. Kleuser, 1998, Biochemistry.

Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.

N. Lehman, B. Kaur, D. A. Kellough, 2014, Cancer research.

The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells

S. Lawler, M. Nowicki, J. V. Van Brocklyn, 2011, Journal of Neuro-Oncology.

Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer.

Jian-xin Gao, Rulong Z. Shen, Yiqing Xu, 2009, International journal of clinical and experimental pathology.

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

J. P. Hobson, S. Milstien, S. Spiegel, 1999, The Journal of Biological Chemistry.

Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.

C. H. Liu, S. Spiegel, T. Hla, 1999, Molecular biology of the cell.

Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors*

James I. Fells, Y. Fujiwara, A. Parrill, 2008, Journal of Biological Chemistry.

MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.

Michael C. Ostrowski, Jeff Palatini, Agnieszka Bronisz, 2010, Molecular cell.

Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.

J. V. Van Brocklyn, N. Young, 2007, Experimental cell research.

Type 1 sphingosine 1‐phosphate G protein‐coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino‐terminal tyrosines

E. Goetzl, C. Fieger, Mei‐Chuan Huang, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors*

Sylvia Wong, S. Milstien, S. Spiegel, 2001, The Journal of Biological Chemistry.

Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors

J. V. Van Brocklyn, N. Young, 2006, TheScientificWorldJournal.

Identification of the Hydrophobic Ligand Binding Pocket of the S1P1 Receptor*

Y. Fujiwara, A. Parrill, K. Liliom, 2007, Journal of Biological Chemistry.

Binding of sphingosine 1-phosphate to cell surface receptors.

S. Spiegel, J. V. Van Brocklyn, 2000, Methods in enzymology.

Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.

S. Spiegel, F. Wang, V. Nava, 1999, Cancer research.

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate*

S. Spiegel, D. Baker, A. Parrill, 2000, The Journal of Biological Chemistry.

Human Cytomegalovirus Regulates Bioactive Sphingolipids*

A. Merrill, Samuel L. Kelly, W. Waldman, 2008, Journal of Biological Chemistry.

Sphingosine Kinase-1 Expression Correlates With Poor Survival of Patients With Glioblastoma Multiforme: Roles of Sphingosine Kinase Isoforms in Growth of Glioblastoma Cell Lines

Thomas W Prior, D. Pearl, T. Prior, 2005, Journal of neuropathology and experimental neurology.

Cellular Metabolic Rate Is Influenced by Life-History Traits in Tropical and Temperate Birds

Joseph B. Williams, A. G. Jimenez, M. Wortman, 2014, PloS one.

Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.

James R Van Brocklyn, Nicholas Young, Rosemary Roof, 2003, Cancer letters.

Gangliosides inhibit platelet-derived growth-factor-stimulated increases in intracellular calcium in Swiss 3T3 cells.

B. Stokes, A. Yates, Z. Guan, 1992, Biochimica et biophysica acta.

An IgM-kappa rat monoclonal antibody specific for the type 1 sphingosine 1-phosphate G protein-coupled receptor with antagonist and agonist activities.

E. Goetzl, Mei‐Chuan Huang, J. V. Van Brocklyn, 2004, Immunology letters.

Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta.

T. Prior, P. Snyder, J. V. Van Brocklyn, 2002, Cancer letters.

Sphingolipid signaling pathways as potential therapeutic targets in gliomas.

J. V. Van Brocklyn, 2007, Mini reviews in medicinal chemistry.

Structural Features of EDG1 Receptor‐Ligand Complexes Revealed by Computational Modeling and Mutagenesis

S. Spiegel, D. Baker, A. Parrill, 2000, Annals of the New York Academy of Sciences.