K. Hidaka

发表

Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.

Y. Kiso, Y. Hayashi, H. Yasui, 2010, Bioorganic & medicinal chemistry.

beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.

Kazuki Saito, Y. Kiso, Y. Hamada, 2006, Bioorganic & medicinal chemistry letters.

Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.

E. Freire, Y. Kiso, R. F. de Freitas, 2014, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Y. Kiso, Y. Hamada, S. Ishiura, 2014, Bioorganic & medicinal chemistry letters.

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Y. Kiso, Y. Hamada, S. Ishiura, 2012, Bioorganic & medicinal chemistry letters.

BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors

E. Freire, Y. Kiso, Y. Hayashi, 2009, Bioorganic & Medicinal Chemistry Letters.

Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.

Y. Kiso, Y. Hayashi, H. Yasui, 2011, Bioorganic & medicinal chemistry.

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.

B. Szabó, Y. Kiso, Tooru Kimura, 2003, Bioorganic & medicinal chemistry letters.

High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.

Jun Liu, D. Goldberg, E. Freire, 2003, Biochemistry.

Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles.

Y. Kiso, Tooru Kimura, J. Nguyen, 2011, Bioorganic & medicinal chemistry letters.

Characterziation of JC polyomavirus derived from COS-IMRb cells.

S. Sugiura, T. Takegami, M. Kameoka, 2020, Japanese journal of infectious diseases.

Active site-directed plasmin inhibitors: Extension on the P2 residue.

Y. Tsuda, K. Gohda, N. Teno, 2016, Bioorganic & medicinal chemistry.

Establishment of COS‐JC cells persistently producing archetype JC polyomavirus

S. Sugiura, T. Takegami, M. Kameoka, 2018, Microbiology and immunology.

Exploration of Active Site-Directed Plasmin Inhibitors: Beyond Tranexamic Acid

Y. Tsuda, Y. Okada, K. Hojo, 2021, Processes.

Development of [Ile40]HTLV‐I protease inhibition assay using novel fluorogenic and chromogenic substrate

Y. Kiso, Tooru Kimura, Y. Hayashi, 2011, Journal of peptide science : an official publication of the European Peptide Society.

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.

J. Whisstock, R. Norton, R. Law, 2017, Blood advances.

Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.

Y. Kiso, Y. Hamada, Tooru Kimura, 2011, Bioorganic & medicinal chemistry.

Novel non-peptidic and small-sized BACE1 inhibitors.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.

Y. Kiso, Y. Hamada, Tooru Kimura, 2008, Journal of medicinal chemistry.

How Much Binding Affinity Can be Gained by Filling a Cavity?

E. Freire, E. Freire, V. Lafont, 2010, Chemical biology & drug design.

Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.

Y. Kiso, Y. Hamada, Tooru Kimura, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.

Kazuki Saito, Y. Kiso, Y. Hamada, 2006, Bioorganic & medicinal chemistry letters.

A Fluorogenic Probe for γ‐Glutamyl Cyclotransferase: Application of an Enzyme‐Triggered O‐to‐N Acyl Migration‐Type Reaction

Taku Yoshiya, Y. Kiso, Y. Tsuda, 2013, Chembiochem : a European journal of chemical biology.

Biosynthesis of glutamate in photosynthetic bacteria.

K. Shigesada, H. Katsuki, S. Tanaka, 1966, Biochimica et biophysica acta.

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.

Y. Kiso, Y. Hamada, Tooru Kimura, 2005, Bioorganic & medicinal chemistry letters.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2007, Bioorganic & medicinal chemistry letters.

Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2011, Biochemistry.

Evaluation of novel protease inhibitors against darunavir‐resistant variants of HIV type 1

M. Kameoka, K. Hidaka, M. Inoue, 2016, FEBS open bio.

Search for substrate‐based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II

E. Freire, Y. Kiso, Tooru Kimura, 2004, Journal of peptide science : an official publication of the European Peptide Society.

Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases

E. Freire, Y. Kiso, Tooru Kimura, 2004, Biological chemistry.

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2011, Journal of structural biology.

Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.

Y. Kiso, Tooru Kimura, J. Nguyen, 2011, Bioorganic & medicinal chemistry letters.

Analysis of Amide Bond Formation with an α-Hydroxy-β-amino Acid Derivative, 3-Amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone

Y. Kiso, Tooru Kimura, Y. Hayashi, 2001 .

Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.

E. Freire, Y. Kiso, Tooru Kimura, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2003, Bioorganic & medicinal chemistry letters.

Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.

A. Molla, D. Kempf, R. Kuroki, 2009, Journal of medicinal chemistry.

Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.

E. Freire, Y. Kiso, Tooru Kimura, 2010, Bioorganic & medicinal chemistry letters.

Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: Racemization studies and water-based synthesis of histidine-containing peptides

J. Wade, H. Ichikawa, Y. Tsuda, 2014, Amino Acids.

7-Aminocoumarin-4-acetic Acid as a Fluorescent Probe for Detecting Bacterial Dipeptidyl Peptidase Activities in Water-in-Oil Droplets and in Bulk

W. Ogasawara, Y. Tsuda, A. Nakamura, 2021, Analytical chemistry.

Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights

A. Wlodawer, S. Sen, A. Gustchina, 2018, The FEBS journal.

Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation.

Y. Tsuda, M. Adachi, K. Hidaka, 2019, Bioconjugate chemistry.

Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: Racemization studies and water-based synthesis of histidine-containing peptides

J. Wade, H. Ichikawa, Y. Tsuda, 2014, Amino Acids.

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.

D. Kempf, R. Kuroki, Y. Kiso, 2018, Journal of medicinal chemistry.

Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography

Yusuke Mori, Hiroaki Adachi, Kazuo Kurihara, 2009, Proceedings of the National Academy of Sciences.

Oligomerization of neutral peptides derived from the JC virus agnoprotein through a cysteine residue

Y. Tsuda, K. Hojo, K. Hidaka, 2015, Amino Acids.

Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.

Tooru Kimura, Yoshio Hayashi, Robert McKenna, 2006, Acta crystallographica. Section D, Biological crystallography.

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

E. Freire, Y. Kiso, Tooru Kimura, 2008, Bioorganic & medicinal chemistry.

Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.

Y. Kiso, Y. Hamada, Tooru Kimura, 2007, Bioorganic & medicinal chemistry letters.

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

E. Freire, Y. Kiso, Tooru Kimura, 2008, Bioorganic & medicinal chemistry.

Evaluation of Malarial Protease Plasmepsin Inhibitors Containing Hydroxymethylcarbonyl Isostere

E. Freire, Y. Kiso, Tooru Kimura, 2006 .

Tetrapeptides, as small‐sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1

Y. Kiso, Y. Hamada, Tooru Kimura, 2010, Journal of peptide science : an official publication of the European Peptide Society.