K. Metwally

发表

Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors.

M. Soliman, D. Kletsas, H. Pratsinis, 2017, Future medicinal chemistry.

Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity.

D. Kletsas, H. Pratsinis, K. Metwally, 2007 .

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

D. Kletsas, H. Pratsinis, A. Mitschler, 2018, European journal of medicinal chemistry.

The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3

D. Kletsas, H. Pratsinis, K. Metwally, 2015, Medicinal Chemistry Research.

Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.

F. Avilés, J. Lorenzo, J. Farrés, 2019, Chemico-biological interactions.

Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity.

D. Kletsas, H. Pratsinis, K. Metwally, 2007, European journal of medicinal chemistry.

1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.

A. Gamal-Eldeen, O. Aly, K. Metwally, 2015, Anti-cancer agents in medicinal chemistry.

Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents.

K. Metwally, M. Husseiny, L. Abdel-Aziz, 2006, Bioorganic & medicinal chemistry.

Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.

R. Glennon, M. Teitler, M. Dukat, 1998, Journal of medicinal chemistry.

Synthesis and biological activity of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-one derivatives.

O. Aly, Abhijit Banerjee, K. Metwally, 2007, Bioorganic & medicinal chemistry.

Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.

M. El-Sadek, K. Metwally, El-Sayed M. Lashine, 2007, European journal of medicinal chemistry.

2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations

S. El-Adl, Abdalla E A Hassan, K. Metwally, 2020 .

Profiling the physiological pitfalls of anti‐hepatitis C direct‐acting agents in budding yeast

Ahmed A. Abdelmoaty, Z. Storchová, R. Almeer, 2021, Microbial biotechnology.

Synthesis, in‐vitro Cytotoxicity, and a Preliminary Structure‐Activity Relationship Investigation of Pyrimido[4,5‐c]quinolin‐1(2H)‐ones

D. Kletsas, H. Pratsinis, A. Khalil, 2010, Archiv der Pharmazie.

Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study.

C. La Motta, M. Soliman, Vito Coviello, 2017, Bioorganic & medicinal chemistry letters.

Neuroprotective Effects of Phytochemicals against Aluminum Chloride-Induced Alzheimer’s Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 Pathways with Physical and Mental Activities in a Rat Model

Z. A. Abd Elmageed, H. Salem, K. Metwally, 2022, Pharmaceuticals.

Synthesis and anticancer activity of novel quinazolinone-based rhodanines

D. Kletsas, H. Pratsinis, K. Metwally, 2017, Chemistry Central Journal.

Novel 2,4- thiazolidinediones: Synthesis, in vitro cytotoxic activity, and mechanistic investigation.

D. Kletsas, H. Pratsinis, K. Metwally, 2017, European journal of medicinal chemistry.

Structure–activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones

D. Kletsas, H. Pratsinis, Asmaa A. Sallam, 2013, Medicinal Chemistry Research.

Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation

L. Baillie, C. Simons, S. El-Adl, 2016 .

The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3

D. Kletsas, H. Pratsinis, K. Metwally, 2015, Medicinal Chemistry Research.

Synthesis, in‐vitro Cytotoxicity, and a Preliminary Structure‐Activity Relationship Investigation of Pyrimido[4,5‐c]quinolin‐1(2H)‐ones

D. Kletsas, H. Pratsinis, A. Khalil, 2010, Archiv der Pharmazie.

Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.

R. Glennon, M. Teitler, M. Dukat, 2002, Current topics in medicinal chemistry.

The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)’s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19

G. Yahya, Mahmoud A. A. Ibrahim, K. Metwally, 2023, Molecules.

A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs.

Rafael V. C. Guido, M. Castilho, T. Q. Froes, 2020, Future medicinal chemistry.

Design and Synthesis of Novel Quinazolinone-Chalcone Hybrids as Potential Apoptotic Candidates Targeting Caspase-3 and PARP-1: In Vitro, Molecular docking, and SAR Studies

D. Kletsas, H. Pratsinis, A. A. Al-karmalawy, 2022, New Journal of Chemistry.

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials

G. Yahya, M. Popoviciu, S. Cavalu, 2023, International journal of molecular sciences.

Diabetes Mellitus Secondary to Endocrine Diseases: An Update of Diagnostic and Treatment Particularities

G. Yahya, M. Popoviciu, S. Cavalu, 2023, International journal of molecular sciences.

Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi

G. Yahya, K. Krukiewicz, S. Cavalu, 2023, Microbial biotechnology.

Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors

G. Yahya, S. Cavalu, K. Metwally, 2024, Journal of inflammation research.