Jubo Wang

发表

Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.

Zhiyu Li, Jinlei Bian, Tizhi Wu, 2020, Journal of medicinal chemistry.

Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders.

Qiuyu Chen, Xi Xu, Zhiyu Li, 2020, European journal of medicinal chemistry.

Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion.

Jie Ren, H. Ding, Zhiyu Li, 2020, European journal of medicinal chemistry.

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity.

Yajing Wang, Jie Ren, Xi Xu, 2018, Bioorganic chemistry.

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles.

Xi Xu, Di Zhang, J. Kou, 2022, European journal of medicinal chemistry.

Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents.

Tinghan Li, Zhiyu Li, Jinlei Bian, 2017, Bioorganic & medicinal chemistry letters.

Current knowledge on the nucleotide agonists for the P2Y2 receptor.

Zhiyu Li, Jinlei Bian, Jubo Wang, 2018, Bioorganic & medicinal chemistry.

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Zhiyu Li, Jinlei Bian, Zhixia Qiu, 2020 .

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, The Journal of organic chemistry.

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

Tinghan Li, Zhiyu Li, T. Weng, 2017 .

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists.

Xi Xu, Qianming Du, Zhiyu Li, 2020, European journal of medicinal chemistry.

Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.

C. Luo, H. Ding, Xi Xu, 2019, Journal of medicinal chemistry.

Synthesis and biological evaluation of baicalein derivatives as potent antitumor agents.

N. Lu, Q. You, Q. Guo, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

Xi Xu, Zhiyu Li, Jinlei Bian, 2019, Organic Chemistry Frontiers.

Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti-prostate cancer agents.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, European journal of medicinal chemistry.

Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy.

Jinlei Bian, Zhiyu Li, Jinlei Bian, 2018, European journal of medicinal chemistry.

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.

H. Ding, Tinghan Li, Zhiyu Li, 2019, European journal of medicinal chemistry.

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro.

Xi Xu, Zhiyu Li, Jinlei Bian, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives.

Wei-Chang Fu, N. Lu, Q. You, 2012, Bioorganic & medicinal chemistry letters.

Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, Journal of medicinal chemistry.

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Q. Guo, Jian Liu, Ye Xu, 2021, Autophagy.

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening.

Kaixian Chen, Hualiang Jiang, C. Luo, 2020, Bioorganic chemistry.

A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.

Zhiyu Li, Jinlei Bian, Yifan Feng, 2019, Bioorganic & medicinal chemistry.

Discovery of imidazopyrrolopyridines derivatives as novel and selective inhibitors of JAK2.

Jie Ren, Zhiyu Li, Jinlei Bian, 2021, European journal of medicinal chemistry.

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site.

Xi Xu, J. Kou, Zhiyu Li, 2021, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group.

Xi Xu, Di Zhang, Jinlei Bian, 2023, European journal of medicinal chemistry.

Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.

N. Lu, Q. You, Q. Guo, 2012, Bioorganic & medicinal chemistry letters.

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

Q. Guo, H. Hui, Hui Li, 2021, Cell death & disease.

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Zhiyu Li, Jinlei Bian, Dechun Huang, 2021, Acta Pharmaceutica Sinica B.

Microwave-assisted unprotected Sonogashira reaction in water for the synthesis of polysubstituted aromatic acetylene compounds

Zhiyu Li, Jinlei Bian, Tizhi Wu, 2020 .

A patent review of selective CDK9 inhibitors in treating cancer

R. Chen, Zhiyu Li, Jinlei Bian, 2023, Expert opinion on therapeutic patents.

Identification of novel androgen receptor degrading agents to treat advanced prostate cancer.

Jie Ren, Zhiyu Li, Jinlei Bian, 2021, European journal of medicinal chemistry.

Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia.

Ting Yu, Jing Zhang, Zhiyu Li, 2023, European journal of medicinal chemistry.

An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

Zhiyu Li, Ning Li, Di Zhao, 2019, Molecules.

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

Xi Xu, Jinlei Bian, Jubo Wang, 2024, Medicinal research reviews.

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy.

Xi Xu, Jinlei Bian, Zekun Du, 2023, European journal of medicinal chemistry.

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression.

H. Ding, Xi Xu, Zhiyu Li, 2022, Journal of medicinal chemistry.

Inhibitors and PROTACs of CDK2: challenges and opportunities.

Jubo Wang, Zhiyu Li, Yangjie Zeng, 2024, Expert opinion on drug discovery.

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions.

Xi Xu, Jinlei Bian, Jubo Wang, 2024, European journal of medicinal chemistry.