I. Kimura

发表

Analysis of Chemical-Structure-Activity Relationships to Identify New Pro-Drugs with Unique Mechanisms of Actions in Kampo Medicines and Other Natural Products

H. Nojima, I. Kimura, M. Kimura, 2000 .

Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins.

R. Unno, I. Kimura, L. R. Pancho, 1989, Japanese journal of pharmacology.

Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion.

T. Hibi, H. Ishii, Jing-yu Fan, 2008, Pharmacology & therapeutics.

Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.

S. Kobayashi, I. Kimura, M. Kimura, 1995, Biological & pharmaceutical bulletin.

Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.

S. Kobayashi, M. Kimura, S Kobayashi, 1989, Endocrinologia japonica.

Accelerated desensitization of nicotinic receptor channels and its dependence on extracellular calcium in isolated skeletal muscles of streptozotocin‐diabetic mice

H. Nojima, H. Tsuneki, I. Kimura, 1995, British journal of pharmacology.

Intracellular Ca2+ and Mg2+ regulation for insulin-stimulated glucose uptake into mouse diaphragm muscles.

S. Kobayashi, I. Kimura, M. Kimura, 1991, Japanese journal of pharmacology.

Diabetic state-induced modification of Ca, Mg, Fe and Zn content of skeletal, cardiac and smooth muscles.

S. Kobayashi, M. Kimura, I. Kimura, 1989, Endocrinologia japonica.

Diabetes mellitus-induced hypersensitivity of mouse skeletal muscles to acetylcholine and succinylcholine.

H. Nojima, M. Muroi, I. Kimura, 1986, Japanese journal of pharmacology.

Hypersensitivity of acetylcholine receptor in diabetic skeletal muscle to neuromuscular blockers: the effect of myotubes cultured with spinal cord or its extract.

H. Nojima, M. Kimura, I. Kimura, 1986, Journal of pharmacobio-dynamics.

Developmentally delayed sensitivity of acetylcholine receptor in myotubes of nerve-muscle cocultures from genetically diabetic mouse embryos.

M. Kimura, I. Kimura, M. Fujihara, 1986, Journal of pharmacobio-dynamics.

Diabetic state-induced modifications of succinylcholine binding mode in the microsomal fractions of mouse skeletal muscles.

I. Kimura, M. Fujihara, N. Hoshino, 1988, Life sciences.

Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.

T. Matsui, I. Kimura, M. Kimura, 1988, Japanese journal of pharmacology.

Full and partial relaxing CCK-C-terminal fragments in hog duodenal circular muscle.

T. Kondoh, I. Kimura, M. Kimura, 1986, European journal of pharmacology.

Alkaloids Indolizidine 235B′, Quinolizidine 1-epi-207I, and the Tricyclic 205B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors

J. A. Dani, T. Sasaoka, N. Toyooka, 2004, Molecular Pharmacology.

Alkaloids Indolizidine 235 B , Quinolizidine 1-epi-207 I , and the Tricyclic 205 B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors

J. A. Dani, T. Sasaoka, N. Toyooka, 2004 .

Effects of tryptamine on plasma glucagon levels in mice

Y. Sugimoto, J. Yamada, I. Kimura, 2004, Neurochemical Research.

Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema sylvestre Leaves in Streptozotocin-Diabetic Mice

H. Nojima, H. Matsuda, M. Yoshikawa, 2000, Journal of Asian natural products research.

Progressive Bone Loss due to Androgen Deprivation Therapy for Prostate Cancer

H. Origasa, H. Tsuneki, I. Kimura, 2005 .

[Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice].

I. Kimura, Fu Chen, M. Kimura, 1995, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

β-Eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation

Min-wei Wang, Mingyu Xia, H. Tsuneki, 2008, Journal of Asian natural products research.

Histamine release as the basis for morphine action on bile duct and sphincter of Oddi.

I. Kimura, S. Ehrenpreis, M. Kimura, 1987, Life sciences.

Mutual dependence of calcitonin-gene related peptide and acetylcholine release in neuromuscular preparations.

H. Nojima, I. Kimura, M. Okazaki, 1997, European journal of pharmacology.

Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle.

T. Kondoh, H. Tsuneki, I. Kimura, 1991, The Journal of pharmacology and experimental therapeutics.

Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscles

H. Nojima, I. Kimura, Tsunehiko Sasaki, 2000, Brain Research.

The evidence of accelerative interaction between cAMP-dependent protein kinase and external calcium for the desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscle cells

H. Nojima, I. Kimura, M. Kimura, 1994, Neuroscience Letters.

Diabetic state-modified macrophages in GK rat release platelet-derived growth factor-BB for tube formation of endothelial cells in rat aorta.

S. Kobayashi, I. Kimura, M. Kimura, 1996, Immunopharmacology.

Competence effect of basic fibroblast growth factor on cell cycle in subcultured endothelial cells of rat aorta by flow cytometry.

M. Okabe, I. Kimura, M. Kimura, 1996, Japanese journal of pharmacology.

Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells.

T. Sasaoka, T. Wada, T. Okamoto, 2007, European journal of pharmacology.

Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells.

T. Sasaoka, T. Wada, T. Okamoto, 2013, European journal of pharmacology.

Can Coenzyme Q10 Lead to Improvement of Essential Hypertension?: A Long-Term Case Study

T. Sasaoka, H. Tsuneki, I. Kimura, 2008 .

Suppression by high glucose concentration of insulin receptor up-regulation in diaphragm and flexor digitorum brevis muscles from diabetic KK-CAy and streptozotocin-diabetic mice.

T. Nakadate, S. Kobayashi, I. Kimura, 1992, Journal of pharmacobio-dynamics.

Hyperglucagonemia induced in mice by tryptamine: involvement of the peripheral 5-HT2 receptors.

Y. Sugimoto, J. Yamada, I. Kimura, 1992, European journal of pharmacology.

Salivary peptide P-C modulates both insulin and glucagon release from isolated perfused rat pancreas.

I. Kimura, M. Kimura, N. Nakashima, 1990, Japanese journal of pharmacology.

Diabetic state-induced modification of insulin-stimulated, glucose uptake into and kinase activity in, the diaphragm muscle of genetically diabetic KK-CAy mice.

S. Kobayashi, I. Kimura, T. Naitoh, 1992, Journal of pharmacobio-dynamics.

Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice.

T. Sasaoka, T. Wada, H. Tsuneki, 2002, European journal of pharmacology.

Dual modes of action of platelet-derived growth factor and its inhibition by trichostatin-A for DNA synthesis in primary cultured smooth muscle cells of rat aorta.

M. Kimura, M. Okabe, T. Beppu, 1994, Biological & pharmaceutical bulletin.

Inhibitory effect of nifedipine on tumor necrosis factor alpha-induced neovascularization in cultured choroidal explants of streptozotocin-diabetic rat.

Miho Suzuki, H. Tsuneki, I. Kimura, 2005, Biological & pharmaceutical bulletin.

The antihyperglycaemic blend effect of traditional Chinese medicine Byakko‐ka‐ninjin‐to on alloxan and diabetic KK‐CAy mice

M. Kimura, I. Kimura, M. Kimura, 1999, Phytotherapy research : PTR.

Effects of prostaglandin E2 and cyclooxygenase inhibitors on clustering and level of nicotinic acetylcholine receptor in mouse myotubes co-cultured with spinal cord explant

S. Kobayashi, I. Kimura, M. Nakagawa, 1991, International Journal of Developmental Neuroscience.

Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases.

F. Nagashima, H. Tsuneki, I. Kimura, 2022, Pharmacology & therapeutics.

Synthesis of Poison-Frog Alkaloids and Their Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors

T. Sasaoka, N. Toyooka, H. Nemoto, 2007 .

Acetylcholine-induced biphasic effect on the maximum upstroke velocity of action potential in mouse right atria: interaction with beta-adrenergic signaling cascade.

H. Nojima, I. Kimura, M. A. Islam, 1998, Japanese journal of pharmacology.

Dependence of cholecystokinin-8-stimulated insulin release on high glucose levels is evidenced by pseudo-alpha-D-glucose in rat pancreas and islets.

I. Kimura, M. Kimura, T. Komori, 1994, Japanese journal of pharmacology.

Independent regulation of activation and inactivation phases in non-contractile Ca2+ transients by nicotinic receptor at the mouse neuromuscular junction

H. Tsuneki, I. Kimura, M. Kimura, 1994, Brain Research.

Inhibitory effect of molecular moiety in papaverine structure on cyclic AMP-phosphodiesterase of smooth and cardiac muscles.

I. Kimura, M. Kimura, I. Waki, 1978 .

Relationship between cyclic AMP-dependent protein kinase activation and Ca uptake increase of sarcoplasmic reticulum fraction of hog biliary muscles relaxed by cholecystokinin-C-terminal peptides.

S. Kobayashi, I. Kimura, M. Kimura, 1982, Biochemical pharmacology.

Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans

T. Sasaoka, M. Terasawa, Jin-bin Wu, 2004, BMC pharmacology.

Postsynaptic nicotinic receptor desensitized by non‐contractile Ca2+ mobilization via protein kinase‐C activation at the mouse neuromuscular junction

K. Dezaki, H. Tsuneki, I. Kimura, 1995, British journal of pharmacology.

DIFFERENCE BETWEEN ADRENERGIC /91 AND (2-BLOCKING EFFECTS ON ISOPROTERENOL-INDUCED Ca SPIKE SUPPRESSION IN GUINEA-PIG TAENIA COLI

I. Kimura, M. Kimura, 2006 .

Difference between adrenergic beta 1- and beta 2-blocking effects on isoproterenol-induced Ca spike suppression in guinea-pig taenia coli.

H. Katoh, I. Kimura, M. Kimura, 1983, Japanese journal of pharmacology.

Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.

S. Kobayashi, I. Kimura, M. Kimura, 1993, Japanese journal of pharmacology.

Interferon-γ-activated macrophages enhance angiogenesis from endothelial cells of rat aorta

I. Kimura, M. Kimura, Shinjiro Kobayashi, 1994 .

Interferon-gamma-activated macrophages enhance angiogenesis from endothelial cells of rat aorta.

S. Kobayashi, I. Kimura, M. Kimura, 1994, Immunopharmacology.

Inhibitory actions of phospholipase A2 and saponins including ginsenoside Rb1 and glycyrrhizin on the formation of nicotinic acetylcholine receptor clusters on cultured mouse myotubes

Kentarou Takahashi, I. Kimura, M. Kimura, 1990 .

Calcium-dependent regulation of phospholipase A2 and its inhibitors, including tetracaine, for acetylcholine receptor cluster formation in mouse myotubes co-cultured with spinal cord explant

I. Kimura, M. Kimura, K. Takahashi, 1987, International Journal of Developmental Neuroscience.

Synthesis of a magnosalin derivative, 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine, and the anti-angiogenic and anti-rheumatic effect on mice by oral administration.

M. Kiniwa, I. Kimura, Y. Kuraishi, 2002, Bioorganic & medicinal chemistry letters.

Salivary peptide P-C potentiates insulin release and inhibits glucagon release from isolated perfused pancreas of the diabetic GK rat.

I. Kimura, M. Kimura, N. Nakashima, 1995, Japanese journal of pharmacology.

The essential amino acid domains in salivary peptide P-C that potentiate glucose-induced insulin release and inhibit arginine-induced glucagon release from perfused rat pancreas.

I. Kimura, M. Kimura, N. Nakashima, 1995, Japanese journal of pharmacology.

Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions.

I. Kimura, 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Platelet-derived growth factor (PDGF) accelerates induction of competence, and heparin does not inhibit PDGF-induced competence in primary cultured smooth muscle cells of rat aorta.

M. Okabe, I. Kimura, M. Kimura, 1992, Japanese journal of pharmacology.

Diabetic GK rat plasma but not normal Wistar rat plasma induces insulin-stimulated DNA synthesis in primary cultured smooth muscle cells in GK rat aorta.

M. Okabe, I. Kimura, M. Kimura, 1994, Japanese journal of pharmacology.

Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells.

S. Kobayashi, K. Notoya, I. Kimura, 1992, Japanese journal of pharmacology.

Complementary effects of paeoniflorin and glycyrrhizin on intracellular Ca2+ mobilization in the nerve-stimulated skeletal muscle of mice.

K. Dezaki, I. Kimura, M. Kimura, 1995, Japanese journal of pharmacology.

Forskolin‐ and diacylglycerol‐like potentiation of isoproterenol‐induced positive inotropic effect in guinea pig papillary muscles by the musk component, musclide

T. Uwano, I. Kimura, M. Kimura, 1989 .

Immunochemical evidence for interaction between cholecystokinin C-terminal peptides and the protein inhibitor of adenosine 3',5'-cyclic monophosphate dependent protein kinase in hog terminal bile ducts.

S. Kobayashi, I. Kimura, M. Kimura, 1986, Journal of pharmacobio-dynamics.

Evidence that relaxation of hog biliary muscle is mediated by the interaction between the protein inhibitor of cyclic AMP dependent protein kinase and cholecystokinin C-terminal peptides.

S. Kobayashi, I. Kimura, M. Kimura, 1983, Biochemical pharmacology.

Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria.

Y. Takamura, M. Islam, M. Makino, 1994, Japanese journal of pharmacology.

Immunohistochemical localization of neuronal nicotinic receptor subtypes at the pre- and postjunctional sites in mouse diaphragm muscle

C. Sala, K. Dezaki, G. Fumagalli, 1995, Neuroscience Letters.

Diabetes mellitus-induced enhancement of prostaglandin F2 alpha-responses is inhibited by lipoxygenase- but not cyclooxygenase-inhibitors in mesenteric veins and arteries of mouse and rat.

I. Kimura, M. Kimura, M. A. Islam, 1994, Japanese journal of pharmacology.

The diabetic state increases the activity but not the number of peritoneal macrophages in the GK rat promoting the tube formation of cultured endothelial cells in rat aorta.

S. Kobayashi, M. Okabe, I. Kimura, 1996, Biological & pharmaceutical bulletin.

The effects of the serotonin1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats.

Y. Sugimoto, J. Yamada, I. Kimura, 1992, Japanese journal of pharmacology.

Potent reduction of intraocular pressure by nipradilol plus latanoprost in ocular hypertensive rabbits.

H. Tsuneki, I. Kimura, Yuichiro Shima, 2005, Biological & pharmaceutical bulletin.

Monoclonal antibody to β2 subunit of neuronal nicotinic receptor depresses the postjunctional non-contractile Ca2+ mobilization in the mouse diaphragm muscle

H. Nojima, K. Dezaki, H. Tsuneki, 1994, Neuroscience Letters.

Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice.

H. Matsuura, I. Kimura, M. Kimura, 1993, Journal of natural products.

Antiangiogenic activity of β-eudesmol in vitro and in vivo

Kouji Maekawa, Min-wei Wang, T. Sasaoka, 2005 .

Potentiating effects of beta-eudesmol-related cyclohexylidene derivatives on succinylcholine-induced neuromuscular block in isolated phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice.

H. Nojima, S. Yanagi, I. Kimura, 1995, Biological & pharmaceutical bulletin.

Structural components of beta-eudesmol essential for its potentiating effect on succinylcholine-induced neuromuscular blockade in mice.

H. Nojima, S. Yano, I. Kimura, 1994, Biological & pharmaceutical bulletin.

Loxiglumide, L-364,718 and L-365,260 prevent the inhibition of spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rat peripherally administered with cholecystokinin-8S.

I. Kimura, M. Kimura, M. Kimura, 1995, Japanese journal of pharmacology.

Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.

Y. Sugimoto, J. Yamada, I. Kimura, 1990, Japanese journal of pharmacology.

Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice.

H Nojima, H. Nojima, A Kato, 1998, Journal of natural products.

Expression of two neuronal nicotinic receptor subunits in innervated and denervated adult rat muscle

C. Sala, G. Fumagalli, I. Kimura, 1996, Neuroscience Letters.

Calcium-dependent desensitizing function of the postsynaptic neuronal-type nicotinic acetylcholine receptors at the neuromuscular junction.

I. Kimura, 1998, Pharmacology & therapeutics.

Effects of pollen-extract components, diamines and derivatives of feruloylputrescine on isolated bladder and urethral smooth muscles of mice.

I. Kimura, M. Kimura, K. Nakase, 1990, Japanese journal of pharmacology.

Inhibitory effect of rehmaionoside B, a constituent of rehmaniae radix, on isolated bladder and urethral smooth muscle of mice

I. Kitagawa, I. Kimura, M. Kimura, 1991 .

Neuromuscular blocking action of alkaloids from a Japanese crude drug "Shin-l" (Flos Magnoliae) in frog skeletal muscle.

S. Kadota, T. Kikuchi, I. Kimura, 1983, Planta medica.

Absolute stereostructures of polypodane-type triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resin (the resin of Balsamodendron mukul).

H. Matsuda, T. Morikawa, M. Yoshikawa, 2004, Chemical & pharmaceutical bulletin.

New Triterpenes, Myrrhanol A and Myrrhanone A, from Guggul—Gum Resins, and Their Potent Antiinflammatory Effect on Adjuvant-Induced Air-Pouch Granuloma of Mice.

Miho Suzuki, H. Matsuda, M. Yoshikawa, 2001 .

New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice.

H. Matsuda, M. Yoshikawa, T. Murakami, 2001, Bioorganic & medicinal chemistry letters.

Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors.

J. A. Dani, T. Sasaoka, N. Toyooka, 2005, Biological & pharmaceutical bulletin.

Combined potentiating effect of byakko-ka-ninjin-to, its constituents, rhizomes of Anemarrhena asphodeloides, tomosaponin A-III, and calcium on pilocarpine-induced saliva secretion in streptozocin-diabetic mice.

I. Kimura, M. Kimura, F. J. Chem, 1996, Biological & pharmaceutical bulletin.

Paeoniflorigenone, a new monoterpene from paeony roots

H. Noguchi, Toshimitsu Hayashi, U. Sankawa, 1981 .

Positive inotropic action and conformation difference of lupin alkaloids in isolated cardiac muscle of guinea pig and bullfrog

S. Okuda, I. Kimura, M. Kimura, 1989 .

Potentiating effects on pilocarpine-induced saliva secretion, by extracts and N-containing sugars derived from mulberry leaves, in streptozocin-diabetic mice.

I. Kimura, F. Chen, N. Nakashima, 1995, Biological & pharmaceutical bulletin.

The streptozocin-diabetic state depresses saliva secretion stimulated by pilocarpine and noradrenaline in mice.

I. Kimura, F. Chen, M. Kimura, 1996, Biological & pharmaceutical bulletin.

Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin.

H. Nojima, I. Kimura, M. Kimura, 1985, Japanese journal of pharmacology.

Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse.

M. Muroi, I. Kitagawa, I. Kimura, 1984, Japanese journal of pharmacology.

Depolarizing effects of glycyrrhizin-derivatives relating to the blend effects with paeoniflorin in mouse diaphragm muscle.

S. Shibata, M. Muroi, I. Kimura, 1986, Japanese journal of pharmacology.

Decreasing effects by glycyrrhizin and paeoniflorin on intracellular Ca2+-aequorin luminescence transients with or without caffeine in directly stimulated-diaphragm muscle of mouse.

I. Kimura, M. Kimura, 1985, Japanese journal of pharmacology.

Combined effects of Japanese‐Sino medicine ‘Kakkon‐to‐ka‐senkyu‐shin'i’ and its related combinations and component drugs on adjuvant‐induced inflammation in mice

I. Kimura, M. Kimura, Shinjiro Kobayashi, 1992 .

Antiinflammatory effect of Japanese‐Sino medicine ‘Keishi‐ka‐jutsubu‐to’ and its component drugs on adjuvant air pouch granuloma of mice

I. Kimura, M. Kimura, Shinjiro Kobayashi, 1991 .

Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins.

H. Matsuda, T. Morikawa, M. Yoshikawa, 2004, Bioorganic & medicinal chemistry.

Muscarinic M1 receptor activation reduces maximum upstroke velocity of action potential in mouse right atria.

H. Nojima, I. Kimura, M. A. Islam, 1998, European journal of pharmacology.

Effects of papaverine on the relative distribution of 45Ca ions in subcellular fractions of hog biliary muscles.

S. Kobayashi, I. Kimura, M. Kimura, 1984, Biochemical pharmacology.

Interferon-γ-activated macrophages release interleukin-1 α to increase tube formation from endothelial cells of rat aorta

M. Okabe, I. Kimura, M. Kimura, 1995 .

A quantitative assay for angiogenesis of cultured choroidal tissues in streptozotocin-diabetic Wistar and spontaneously diabetic GK rats.

S. Kobayashi, I. Kimura, H. Kontani, 1998, Japanese journal of pharmacology.

Glycated serum stimulation of macrophages in GK- and streptozotocin-rats for the proliferation of primary cultured smooth muscle cells of the aorta.

S. Kobayashi, I. Kimura, Shinjiro Kobayashi, 1998, Immunopharmacology.

Inhibitory effects of anti-rheumatic drugs containing magnosalin, a compound from 'Shin-i' (Flos magnoliae), on the proliferation of synovial cells in rheumatoid arthritis models.

H. Matsuno, H. Kobayashi, S. Kobayashi, 1998, Immunopharmacology.

Basic fibroblast growth factor stimulates the competence phase of subcultured endothelial cells and the progression phase of primary cultured smooth muscle cells from rat aorta.

S. Kobayashi, M. Okabe, I. Kimura, 1994, Biological & pharmaceutical bulletin.

Heparin inhibits the progression phase of subcultured endothelial cell proliferation in rat aorta.

S. Kobayashi, I. Kimura, M. Kimura, 1992, Japanese journal of pharmacology.

Selective inhibition by magnosalin and magnoshinin, compounds from 'shin-i' (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch.

S. Kobayashi, I. Kimura, M. Kimura, 1990, International archives of allergy and applied immunology.

Inhibitory effects of tryptamine on tolbutamide-induced hypoglycemia in mice: Mediation by 5-HT receptors

Y. Sugimoto, J. Yamada, I. Kimura, 2004, Neurochemical Research.

Effects of tetrodotoxin on relaxation of pig duodenal circular muscle induced by C‐terminal fragments of cholecystokinin

T. Kondoh, I. Kimura, M. Kimura, 1989, British journal of pharmacology.

Calcium-based evaluation of dose-response curves of papaverine-like relaxants in guinea-pig taenia coli.

H. Katoh, M. Kimura, I. Kimura, 1981, Archives internationales de pharmacodynamie et de therapie.

Enhancement by calcitonin gene‐related peptide of nicotinic receptor‐operated noncontractile Ca2+ mobilization at the mouse neuromuscular junction

K. Dezaki, H. Tsuneki, I. Kimura, 1993, British journal of pharmacology.

Proglumide peptides and CCK antagonistic action in hog duodenal circular muscle.

T. Kondoh, I. Kimura, M. Kimura, 1987, European journal of pharmacology.

Potassium induces relaxation and hyperpolarization of circular muscles but contraction of longitudinal muscles of pig duodenum

I. Kimura, M. Kimura, 1984, British journal of pharmacology.

Relaxation and Ca-spike suppression in circular and longitudinal muscles of hog bile duct ampulla by CCK-C-terminal peptides.

M. Kimura, I. Kimura, N. Nakayama, 1983, Archives internationales de pharmacodynamie et de therapie.

The mode of action of contractile effects induced by external calcium and its related bivalent cations in the KCl-depolarized rat uterus.

M. Kimura, M. Maekawa, I. Kimura, 1978, Japanese journal of pharmacology.

Succinylcholine-induced acceleration and suppression of electrically evoked acetylcholine release from mouse phrenic nerve-hemidiaphragm muscle preparation.

T. Uwano, S. Kobayashi, I. Kimura, 1991, Japanese journal of pharmacology.

Different Modes of Blockade by p‐Phenylene‐polymethylene Bis‐ammonium Compounds of the Nicotinic Acetylcholine Receptor Channel in Skeletal Muscle Cells of Mice

M. Muroi, I. Kimura, M. Kimura, 1993, The Journal of pharmacy and pharmacology.

Postsynaptic nicotinic ACh receptor-operated Ca2+ transients with neostigmine in phrenic nerve-diaphragm muscles of mice

T. Kondoh, I. Kimura, M. Kimura, 1990, Brain Research.

8-Eudesmol (a Main Component of Atractylodes lancea)-Induced Potentiation of Depolarizing Neuromuscular Blockade in Diaphragm Muscles of Normal and Diabetic Mice

M. Muroi, I. Kimura, Katsunao Tanaka, 2006 .

Streptozocin-diabetes modifies acetylcholine release from mouse phrenic nerve terminal and presynaptic sensitivity to succinylcholine.

I. Kimura, M. Kimura, M. Okazaki, 1993, Japanese journal of pharmacology.

Different modes of potentiation by beta-eudesmol, a main compound from Atractylodes lancea, depending on neuromuscular blocking actions of p-phenylene-polymethylene bis-ammonium derivatives in isolated phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice.

T. Uwano, H. Nojima, M. Muroi, 1992, Japanese journal of pharmacology.

beta-eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.

M. Muroi, I. Kimura, M. Kimura, 1989, Japanese journal of pharmacology.

Counter Effects of Higenamine and Coryneine, Components of Aconite Root, on Acetylcholine Release from Motor Nerve Terminal in Mice

M. Okazaki, I. Kimura, H. Nojima, 2000, Journal of Asian natural products research.

Aconitine-induced increase and decrease of acetylcholine release in the mouse phrenic nerve-hemidiaphragm muscle preparation.

I. Kimura, M. Kimura, M. Okazaki, 1994, Japanese journal of pharmacology.

Mechanism of the blocking action of β-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal muscles

H. Nojima, M. Muroi, I. Kimura, 1991, Neuropharmacology.

Acetylcholine sensitivity in myotubes of nerve-muscle co-culture cultured with anti-muscle antibodies, α-bungarotoxin and d-tubocurarine

H. Nojima, I. Kimura, M. Kimura, 1986, International Journal of Developmental Neuroscience.

Reversed effect of caffeine on non-contractile and contractile Ca2+ mobilization operated by acetylcholine receptor in mouse diaphragm muscle

T. Kondoh, H. Tsuneki, I. Kimura, 1991, Neuroscience Letters.

Blocking action of succinylcholine with β-eudesmol on acetylcholine-activated channel activity at endplates of single muscle cells of adult mice

H. Nojima, I. Kimura, M. Kimura, 1992, Brain Research.

External Ca2+ dependence of acetylcholine- and succinylcholine-induced changes in channel conductance, open time and frequency at endplates of single muscle cells of adult mice

H. Nojima, I. Kimura, M. Kimura, 1991, Neuropharmacology.

Changes in Intracellular CaL

T. Kondoh, I. Kimura, M. Kimura, 2010 .

Changes in Intracellular Ca2+ Produced in the Mouse Diaphragm by Neuromuscular Blocking Drugs

T. Kondoh, I. Kimura, M. Kimura, 1990, The Journal of pharmacy and pharmacology.

Interventional Evaluation of Monoammonium Glycyrrhizinate-Glycine/DLMethionine Combination Tablets in Mild Alopecia Areata

I. Kimura, T. Nogita, K. Sakakibara, 2015 .

Aconitine‐induced bradycardia, centrally acting muscarinic effects are inhibited peripherally by higenamine in conscious mice

T. Matsui, M. Makino, I. Kimura, 1994 .

Peroral TAS-202 reduced vessel density in rats with adjuvant-induced arthritis.

M. Kiniwa, I. Kimura, Y. Kuraishi, 2003, European journal of pharmacology.

Novel G423S Mutation of Human α7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism

M. Kurachi, M. Tsunoda, T. Sasaoka, 2007, Molecular Pharmacology.

Serotonin-induced hypoglycemia and increased serum insulin levels in mice.

Y. Sugimoto, J. Yamada, I. Kimura, 1989, Life sciences.

Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese population

K. Yamazaki, H. Ishihara, T. Sasaoka, 2003, FEBS letters.

Blood-Pressure Lowering, Positive Chronotropy and Inotropy by the Veratrum Alkaloids Germidine and Germerine but Negative Chronotropy by Veratridine in Mice

H. Nojima, Y. Tezuka, M. Islam, 2000, Journal of Asian natural products research.

Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root).

M. Muroi, I. Kitagawa, I. Kimura, 1988, Japanese journal of pharmacology.

Increase of nascent protein synthesis in neuromuscular junction of rat diaphragm induced by denervation.

I. Kimura, M. Kimura, 1973, Nature: New biology.

Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice

M. Muroi, I. Kimura, M. Kimura, 1990, Neuropharmacology.

Pharmacological evidence for an interaction between constituents (blend effect) of the Japanese‐Sino medicine “Keishi‐ka‐zyutubu‐tō” in neuromuscular blockade in diabetic mice

M. Muroi, H. Hikino, I. Kimura, 1987 .

Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin.

I. Kimura, M. Kimura, M. A. Islam, 1996, Biological & pharmaceutical bulletin.

External Ca2+-dependent Ca2+ release in directly stimulated diaphragm muscles of mice.

I. Kimura, M. Kimura, 1987, Japanese journal of pharmacology.

Endothelium-dependent potentiation of prostaglandin F2alpha-induced contractions by (+/-)-[6]-gingerol is inhibited by cyclooxygenase- but not lipoxygenase-inhibitors in mouse mesenteric veins.

H. Nojima, I. Kimura, L. R. Pancho, 1998, Biological & pharmaceutical bulletin.

Modification by dantrolene, procaine and suxamethonium of caffeine‐induced changes in aequorin luminescence transients and twitch tensions of directly‐stimulated diaphragm muscle of mouse

I. Kimura, M. Kimura, M. Kimura, 1985, British journal of pharmacology.

Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.

H. Ishihara, T. Sasaoka, H. Hori, 2003, Endocrinology.

The activation of cyclic 3',5'-adenosine monophosphate-dependent protein kinase on sarcoplasmic reticulum fractions of various smooth muscles and its related novel relaxants.

S. Kobayashi, I. Kimura, M. Kimura, 1977, Biochemical pharmacology.

Enhancement by calcitonin gene‐related peptide of non‐contractile Ca2+‐induced nicotinic receptor desensitization at the mouse neuromuscular junction

K. Dezaki, H. Tsuneki, I. Kimura, 1996, British journal of pharmacology.

The effects of the serotonin1A receptor agonist buspirone on tolbutamide-induced hypoglycemia in rats.

Y. Sugimoto, J. Yamada, I. Kimura, 1995, Biological and Pharmaceutical Bulletin.

The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglycemia in rats.

Y. Sugimoto, J. Yamada, I. Kimura, 1995, Life sciences.

Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2 alpha-induced contraction in isolated mesenteric veins of mice.

M. Kimura, I. Kimura, L. R. Pancho, 1989, Journal of pharmacobio-dynamics.

Methyllycaconitine-sensitive neuronal nicotinic receptor-operated slow Ca2+ signal by local application or perfusion of ACh at the mouse neuromuscular junction

K. Dezaki, H. Tsuneki, I. Kimura, 1999, Neuroscience Research.

Ca2+-dependent regulation by calcitonin gene-related peptide of neuronal type nicotinic acetylcholine receptor in neuromuscular pre- and postsynapse

K. Dezaki, I. Kimura, 1998, Journal of Physiology-Paris.

Calcitonin gene‐related peptide potentiates nicotinic acetylcholine receptor‐operated slow Ca2+ mobilization at mouse muscle endplates

K. Dezaki, A. Abdel-Zaher, H. Tsuneki, 1998, British journal of pharmacology.

Acetylcholine sensitivity of biphasic Ca2+ mobilization induced by nicotinic receptor activation at the mouse skeletal muscle endplate

K. Dezaki, I. Kimura, Katsuya Dezaki, 1998, British journal of pharmacology.

[Slow Ca2+ (RAMIC) mobilization operated by postsynaptic neuronal nicotinic receptor regulates synaptic function at the mouse neuromuscular junction].

K. Dezaki, H. Tsuneki, I. Kimura, 1997, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Neuronal nicotinic receptor operates slow Ca2+ mobilization at mouse muscle endplate

K. Dezaki, H. Tsuneki, I. Kimura, 1997, Neuroscience Letters.

Modulation of eicosanoid-induced contraction of mouse and rat blood vessels by gingerols.

I. Kimura, L. R. Pancho, M. Kimura, 1989, Japanese journal of pharmacology.

Vascular endothelial growth factor promotes cell-cycle transition from G0 to G1 phase in subcultured endothelial cells of diabetic rat thoracic aorta.

M. Okabe, I. Kimura, R. Honda, 2000, Japanese journal of pharmacology.

Methyllycaconitine‐, α‐Bungarotoxin‐Sensitive Neuronal Nicotinic Receptor Operates Slow Calcium Signal in Skeletal Muscle End Plate

I. Kimura, KATSUYA DEZAKI, 1999, Annals of the New York Academy of Sciences.

Alloxan-diabetic state-induced suppression of Ca2+-dependent slow action potentials in mouse diaphragm muscle.

I. Kimura, M. Kimura, T. Nakamura, 1988, Japanese journal of pharmacology.

The 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT) induces hyperglucagonemia in rats.

Y. Sugimoto, J. Yamada, I. Kimura, 2001, Biological & pharmaceutical bulletin.

Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig.

I. Kimura, M. Kimura, N. Mori, 1986, Planta medica.

Antiproliferative effects of magnosalin derived from ‘Shin'i’ (Flos Magnoliae), a Japanese Sino‐medicine, on cultured synovial cells of MRL/1 and C57BL/6J mice

K. Terasawa, Hideo Kobayashi, I. Kimura, 1996 .

Diabetes-induced enhancement of prostanoid-stimulated contraction in mesenteric veins of mice.

I. Kimura, L. R. Pancho, M. Kimura, 1989, Japanese journal of pharmacology.

Correlation of clustering peak density and total amount of acetylcholine receptor on cultured mouse myotubes

I. Kimura, M. Kimura, K. Shikada, 1987, International Journal of Developmental Neuroscience.

Theoretical pharmacological effects in single herb and polyherbal therapies: influences of processing on the constituents, and their synergistic/modulatory interactions

H. Tsuneki, I. Kimura, 2005 .

Inhibitory effects of tetrandrine and related synthetic compounds on angiogenesis in streptozotocin-diabetic rodents.

S. Kobayashi, M. Niwa, I. Kimura, 1999, Biological and Pharmaceutical Bulletin.

Inotropic effects of (+/-)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional sino-Japanese medicines "bushi" and "shin-i" in isolated guinea pig papillary muscle.

T. Kikuchi, I. Kimura, M. Kimura, 1989, Japanese Journal of Pharmacology.

Diabetic state-induced modification of resting membrane potential and conductance in diaphragm muscle of alloxan and diabetic KK-CAy mice

H. Nojima, M. Kimura, I. Kimura, 1988, Diabetologia.

Antiangiogenic activity of beta-eudesmol in vitro and in vivo.

Min-wei Wang, T. Sasaoka, H. Tsuneki, 2005, European journal of pharmacology.

Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.

H. Ishihara, T. Sasaoka, T. Wada, 2005, The Journal of clinical endocrinology and metabolism.

Platelet-derived growth factor blocks the cell-cycle transition from the G0 to G1 phase in subcultured angiogenic endothelial cells in rat thoracic aorta.

M. Okabe, H. Tsuneki, I. Kimura, 1997, Japanese journal of pharmacology.

Inhibitory effect of magnosalin derived from Flos magnoliae on tube formation of rat vascular endothelial cells during the angiogenic process.

S. Kobayashi, I. Kimura, M. Kimura, 1996, Biological & pharmaceutical bulletin.

Aconitine, a main component of aconite, increases spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rats.

H. Nojima, I. Kimura, M. Kimura, 1996, Biological & pharmaceutical bulletin.

Inhibitory effects on angiogenesis and pouch fluid exudation by aconite alkaloids in adjuvant‐induced inflammation of the mouse

I. Kimura, M. Kimura, Shinjiro Kobayashi, 1991 .

T. Sakurai, M. Yanagisawa, T. Sasaoka, 2008, Diabetologia.

Self‐administered rhubarb‐free kyoseihatekigan has novel anti‐asthma effects: Two case reports

I. Kimura, S. Kagawa, K. Nishimura, 2017 .

Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells.

T. Sasaoka, H. Tsuneki, I. Kimura, 2004, Biological & pharmaceutical bulletin.

Activation by alpha 1-adrenergic agonists of the progression phase in the proliferation of primary cultures of smooth muscle cells in mouse and rat aorta.

I. Horikoshi, M. Okabe, I. Kimura, 1995, Biological and Pharmaceutical Bulletin.

Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice.

H. Nojima, I. Kimura, M. Takada, 1997, Biological & pharmaceutical bulletin.

Suppression of spontaneous calcium spikes and contraction in isolated portal veins of mice by gingerols and chemically related compounds.

I Kimura, L R Pancho, T Shiori, 1988, Japanese journal of pharmacology.

Pharmacology of Ginger

H. Tsuneki, I. Kimura, Leonara R. Pancho, 2016 .

The activation of serotonin receptors by tryptamine induces hyperinsulinemia in mice.

Y. Sugimoto, J. Yamada, I. Kimura, 1990, European journal of pharmacology.

Fluctuation of acetylcholine sensitivity in skeletal muscles with development, denervation and glycerol treatment.

H. Ohkura, I. Kimura, M. Kimura, 1978, Japanese journal of pharmacology.

Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.

H. Nojima, T. Hayashi, I. Kimura, 1984, Japanese journal of pharmacology.

Inhibitory effects of magnoshinin and magnosalin, compounds from "Shin-i" (Flos magnoliae), on the competence and progression phases in proliferation of subcultured rat aortic endothelial cells.

S. Kobayashi, I. Kimura, M. Kimura, 1992, Japanese journal of pharmacology.

Selective inhibition by magnosalin and magnoshinin, compounds from "Shin-i" (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch.

S. Kobayashi, I. Kimura, M. Kimura, 1991, Agents and actions. Supplements.

Inhibitory effects of tetrandrine on angiogenesis in adjuvant-induced chronic inflammation and tube formation of vascular endothelial cells.

S. Kobayashi, I. Kimura, M. Kimura, 1998, Biological & pharmaceutical bulletin.

Cluster Analysis of First-visit Patients' Answers for Japanese-Oriental Kampo Questionnaire Supporting the Empirical Decision of Sho-syndrome

Masaki Tsuda, T. Katoh, Hiroshi Tsuneki, 2004 .