Debra L. Taylor

发表

Anti-HIV Activity of MDL 74968, a Novel Acyclonucleotide Derivative of Guanine: Drug Resistance and Drug Combination Effects in Vitro

D. Taylor, P. Casara, Debra L. Taylor, 1996 .

Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors

S. Rees, M. Wigglesworth, A. Davenport, 2013, Journal of biomolecular screening.

Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action

G. Milligan, S. Nicklin, A. Mackenzie, 2012, Journal of Pharmacology and Experimental Therapeutics.

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

A. Holder, B. Clough, K. Ansell, 2013, Bioorganic & medicinal chemistry letters.

New anti-tuberculosis agents amongst known drugs.

R. Buxton, S. Osborne, J. Bryans, 2009, Tuberculosis.

Synergistic Inhibition of Human Immunodeficiency Virus Type 1 in vitro by 6-0-butanoylcastanospermine (MDL 28574) in Combination with Inhibitors of the Virus-Encoded Reverse Transcriptase and Proteinase

D. Taylor, M. Kang, Debra L. Taylor, 1995 .

Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2′-Deoxy-3′-Oxa-4′-Thiocytidine

M. Wainberg, H. Gourdeau, N. Nguyen-ba, 1999, Antimicrobial Agents and Chemotherapy.

Enzymes by6-0-Butanoyl Castanospermine (MDL28,574) andIts Consequences inHumanImmunodeficiency Virus-Infected T Cells

P. Sunkara, Debra L. Taylor, T. Brennan, 1994 .

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

S. Smerdon, T. J. Nott, R. Buxton, 2011, Tuberculosis.

Action of Celgosivir (6 O-Butanoyl Castanospermine) against the Pestivirus BVDV: Implications for the Treatment of Hepatitis C

K. Whitby, Debra L. Taylor, A. Tyms, 2004, Antiviral chemistry & chemotherapy.

ACTH Antagonists

A. Clark, Li Chan, J. Jerman, 2016, Front. Endocrinol..

Drug Resistance and Drug Combination Features of the Human Immunodeficiency Virus Inhibitor, BCH-10652 [(±)-2′-Deoxy-3′-Oxa-4′-Thiocytidine, dOTC]

J. Bédard, L. Kelly, P. Chambers, 2000, Antiviral chemistry & chemotherapy.

Synthesis and antiviral activity of rigid acyclonucleotide analogs

M. Kenny, P. Casara, Debra L. Taylor, 1995 .

Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

M. Kenny, P. Casara, Debra L. Taylor, 1996 .

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

V. Perry, A. Prescott, J. Obst, 2020, Frontiers in Immunology.

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

V. Perry, A. Prescott, J. Obst, 2020, bioRxiv.

High-Throughput Identification and Characterization of Novel, Species-selective GPR35 Agonists

Graeme Milligan, G. Milligan, A. Mackenzie, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

S. Jackson, A. Lau, M. O’Connor, 2005, Nature Cell Biology.

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

S. Smerdon, R. Buxton, S. Osborne, 2012, Bioorganic & medicinal chemistry letters.

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

A. Holder, B. Clough, K. Ansell, 2014, Journal of medicinal chemistry.

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

J. Jerman, A. Clark, Debra L. Taylor, 2022, Endocrine connections.

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

Ankit K. Rochani, S. Howell, M. Grainger, 2015, Antimicrobial Agents and Chemotherapy.

Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

A. Holder, R. Moon, B. Clough, 2014, Antimicrobial Agents and Chemotherapy.

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1.

D. Alessi, S. Lewis, Debra L. Taylor, 2019, Bioorganic & medicinal chemistry letters.

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

A. Holder, B. Clough, K. Ansell, 2013, Bioorganic & medicinal chemistry letters.

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3

M. Perretti, J. Jerman, Debra L. Taylor, 2016, Cellular and Molecular Life Sciences.

Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16)

R. Cowan, M. Carr, R. Bayliss, 2016, The Journal of Biological Chemistry.

GPR35 as a Novel Therapeutic Target

D. Taylor, G. Milligan, S. Nicklin, 2011, Front. Endocrin..

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

P. Cohen, J. Arthur, J. Bryans, 2012, Bioorganic & medicinal chemistry letters.