M. Hitchcock

发表

In vitro antiviral activity of didanosine compared with that of other dideoxynucleoside analogs against laboratory strains and clinical isolates of human immunodeficiency virus.

M. Hitchcock, 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.

J. Starrett, W. Prusoff, T. Lin, 1989, Journal of medicinal chemistry.

Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.

J. C. Martin, H. Ho, H. de Boeck, 1992, Molecular pharmacology.

Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication

William A. Lee, E. Kern, A. Holý, 2003, Antimicrobial Agents and Chemotherapy.

Transcriptome analysis reveals that fertilization with cryopreserved sperm downregulates genes relevant for early embryo development in the horse

Wei Yan, Weibing Qin, Yunge Tang, 2022 .

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Z. H. Li, K. Kent, D. Mendel, 1994, Antimicrobial Agents and Chemotherapy.

Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides.

E. De Clercq, W. Prusoff, M. Hitchcock, 2010, Antiviral research.

2′,3′-Didehydro-2′,3′-dideoxythymidine (D4T), an anti-HIV Agent

M. Hitchcock, 1991 .

Comparative Studies of 2′,3′‐Didehydro‐2′,3′‐Dideoxythymidine (D4T) with other Pyrimidine Nucleoside Analogues

S. Kaul, A. Fridland, L. Dunkle, 1990, Annals of the New York Academy of Sciences.

Biochemical Pharmacology of 2′-Fluoro-2′,3′-Dideoxyarabinosyladenine, an Inhibitor of HIV with Improved Metabolic and Chemical Stability over 2′,3′-Dideoxyadenosine

H. Ho, H. de Boeck, M. Hitchcock, 1990 .

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

T. Cihlar, D. Greenwalt, G. Birkuš, 2002, Antiviral research.

Suppression of murine retroviral disease by 2',3'-didehydro-2',3'-dideoxythymidine (D4T).

R. Sidwell, R. Warren, J. Morrey, 1992, Antiviral research.

Translation of human immune interferon messenger RNA in Xenopus laevis oocytes.

S. L. Berger, D. Wallace, M. Hitchcock, 1981, Biochemical and biophysical research communications.

Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus.

E. Katz, M. Hitchcock, D. Brown, 1986, Canadian journal of microbiology.

Cilastatin-sensitive dehydropeptidase I enzymes from three sources all catalyze carbapenem hydrolysis and conversion of leukotriene D4 to leukotriene E4.

N. Allegretto, C. Farrell, M. Hitchcock, 1987, Archives of biochemistry and biophysics.

Preparation of oocytes for microinjection of RNA and DNA.

M. Hitchcock, C. Marcus-Sekura, 1987, Methods in enzymology.

Cellular metabolism and enzymatic phosphorylation of 9-(2-phosphonylmethoxyethyl) guanine (PMEG), a potent antiviral agent.

H. Ho, H. de Boeck, M. Hitchcock, 1992, Advances in experimental medicine and biology.

In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine

H. McClure, S. Kaul, J. Sommadossi, 1993, Antimicrobial Agents and Chemotherapy.

Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.

William A. Lee, P. Tellier, K. Cundy, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.

J. C. Martin, J. Bronson, M. Hitchcock, 1990, Journal of medicinal chemistry.

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

J. C. Martin, J. Starrett, D. Tortolani, 1994, Journal of medicinal chemistry.

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.

J. C. Martin, J. Starrett, D. Tortolani, 1992, Antiviral research.

Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors

T. Cihlar, Tomas Cihlar, G. Birkuš, 2002, Antimicrobial Agents and Chemotherapy.

Synthesis and Antiviral Activity of Nucleotide Analogues Bearing the ( S)-(3-Hydroxy-2-phosphonylmethoxy)propyl Moiety Attached to Adenine, Guanine, and Cytosine

R. Webb, E. Kern, J. Bronson, 1991 .

Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.

J. C. Martin, R. Webb, J. Bronson, 1989, Journal of medicinal chemistry.

Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity

J. C. Martin, H. Jaffe, R. Stagg, 1996 .

Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits.

J. Shaw, K. Cundy, M. Hitchcock, 1996, Current eye research.

Susceptibility of Human Cytomegalovirus to Cidofovir Is Unchanged after Limited In Vivo Exposure to Various Clinical Regimens of Drug

J. Cherrington, J. Lalezari, W. Drew, 1996 .

Purification and characterization of tryptophan dioxygenase from Streptomyces parvulus.

E. Katz, M. Hitchcock, Michael J. M. Hitchcock, 1988, Archives of biochemistry and biophysics.

Distinct kynureninase and hydroxykynureninase enzymes in an actinomycin-producing strain of Streptomyces parvulus.

T. Troost, E. Katz, M. Hitchcock, 1980, Biochimica et biophysica acta.

Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.

J. C. Martin, J. Bronson, M. Hitchcock, 1990, Journal of medicinal chemistry.

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

H. Ho, M. Hitchcock, 1989, Antimicrobial Agents and Chemotherapy.

Synthesis and Antiviral Evaluation of 3′-Branched Nucixoside Analogues

M. Wittman, M. Hitchcock, Hyekyung Yang, 1991 .

Synthesis and in vitro activity of C-2 quaternary heterocyclic alkylthio carbapenems.

M. Hitchcock, B. Luh, C. U. Kim, 1987, The Journal of antibiotics.

Radiolabeled quaternary carbapenems and their interactions with human serum albumin

K. Ogborne, M. Hitchcock, 1988, Antimicrobial Agents and Chemotherapy.

Affinity purification of renal dipeptidase solubilized with detergent.

S. Huybensz, D. J. Phelps, C. Farrell, 1987, Analytical biochemistry.

1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine. A Highly Potent and Selective Anti-HIV Agent.

J. Starrett, W. Prusoff, J. Sommadossi, 1989 .

Biochemical Pharmacology of Acyclic Nucleotide Analogues

H. Ho, J. Bronson, M. Hitchcock, 1990, Annals of the New York Academy of Sciences.

Characterization of interferon messenger RNA synthesis in Namalva cells.

R. Friedman, K. Zoon, E. Chang, 1980, The Journal of biological chemistry.

Side effects of feed restriction and compensatory growth in fish

M. Hitchcock, 2013 .

[29] Arylformamidase from streptomyces parvulus

E. Katz, M. Hitchcock, Dale Brown, 1987 .

Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

Wei Yan, Weibing Qin, Yunge Tang, 2021, Nature Communications.

A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.

J. C. Martin, M. Hitchcock, I. Ghazzouli, 1991, Journal of medicinal chemistry.

Metabolism of Antiviral Nucleosides and Nucleotides

A. Ray, M. Hitchcock, 2009 .

Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.

A. Ray, M. Fordyce, M. Hitchcock, 2016, Antiviral research.

Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys.

J. C. Martin, K. Soike, J. Y. Zhang, 1991, Antiviral research.

Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.

J. C. Martin, A. Patick, J. Bronson, 1992, Journal of medicinal chemistry.

Synthesis and Antiviral Activity of Phosphonylmethoxyethyl Derivatives of Purine and Pyrimidine Bases

E. Kern, J. Bronson, C. Kim, 1991 .

Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug.

Z. H. Li, K. Cundy, M. Hitchcock, 1996, Drug Metabolism And Disposition.

Cellular pharmacology of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) in human peripheral blood mononuclear cells.

H. Ho, J. Sommadossi, M. Hitchcock, 1990, Biochemical pharmacology.

Prodrugs of 2',3'-didehydro-3'-deoxythymidine (D4T): synthesis, antiviral activity, and rapid pharmacokinetic evaluation.

J. C. Martin, J. Starrett, D. Tortolani, 1994, Journal of pharmaceutical sciences.

Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus

J. C. Martin, J. Starrett, M. Hitchcock, 1990, Antimicrobial Agents and Chemotherapy.

Synthesis, Anti-Hiv Activity, and Biological Properties of 2′,3′-Didehydro-2′,3′-Dideoxythwidine (d4T)

J. Starrett, H. Ho, J. Sommadossi, 1989 .

Synthesis and Antiviral Activity of Methyl Derivatives of 9-(2-( Phosphonomethoxy)ethyl)guanine.

A. Patick, J. Bronson, R. Datema, 1992 .

Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.

J. C. Martin, A. Patick, J. Bronson, 1993, Journal of medicinal chemistry.

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

M. Polis, M. Wachsman, J. Lalezari, 1995, Antimicrobial agents and chemotherapy.

A preclinical and clinical overview of the nucleotide-based antiviral agent cidofovir (HPMPC).

J. Lalezari, W. Drew, R. Stagg, 1996, Advances in experimental medicine and biology.

(S)-1-(3-hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): a potent antiherpesvirus agent.

J. C. Martin, K. Soike, H. Ho, 1990, Advances in experimental medicine and biology.

Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9‐(2‐(Phosphonomethoxy)ethyl) adenine (PMEA).

J. Starrett, D. Tortolani, J. Russell, 1994 .

Synthesis and Antiviral Activity of the Nucleotide Analogue (S)-1-(3-Hydroxy-2-(phosphonylmethoxy)propyl)cytosine.

R. Webb, J. Bronson, M. Hitchcock, 1989 .

Metabolism and DNA interaction of 2',3'-didehydro-2',3'-dideoxythymidine in human bone marrow cells.

J. Sommadossi, M. Hitchcock, Z. Zhu, 1991, Molecular pharmacology.

a Nucleoside Analog Active against HumanImmunodeficiency Virus

M. Hitchcock, 1989 .

High-frequency fusion of Streptomyces parvulus or Streptomyces antibioticus protoplasts induced by polyethylene glycol

E. Katz, K. Ochi, M. Hitchcock, 1979, Journal of bacteriology.

Susceptibility of human cytomegalovirus to cidofovir is unchanged after limited in vivo exposure to various regimens of drug.

J. Cherrington, J. Lalezari, W. Drew, 1996, The Journal of infectious diseases.

Regulation of lysine- and lysine-plus-threonine-inhibitable aspartokinases in Bacillus brevis

M. Hitchcock, B. Hodgson, J. Linforth, 1980, Journal of bacteriology.

Actinomycin Biosynthesis by Protoplasts Derived from Streptomyces parvulus

E. Katz, M. Hitchcock, 1978, Antimicrobial Agents and Chemotherapy.

Preparation of interferon messenger RNAs with the use of ribonucleoside--vanadyl complexes.

S. L. Berger, G. Siegal, C. Birkenmeier, 1981, Methods in enzymology.