M. Lumb

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Peroxisomal Import of Human Alanine:glyoxylate Aminotransferase Requires Ancillary Targeting Information Remote from Its C Terminus*

Pia A J Huber, Graeme M Birdsey, Michael J Lumb, 2005, Journal of Biological Chemistry.

Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeting of AGT in primary hyperoxaluria type 1

H. Tabak, R. Wanders, A. Motley, 1995, The Journal of cell biology.

Context Dependency of the PTS1 Motif in Human Alanine:Glyoxylate Aminotransferase 1

M. Lumb, P. Jennings, C. Danpure, 1996, Annals of the New York Academy of Sciences.

Functional Synergism between the Most Common Polymorphism in Human Alanine:Glyoxylate Aminotransferase and Four of the Most Common Disease-causing Mutations*

C. Danpure, M. Lumb, 2000, The Journal of Biological Chemistry.

Cobalamin-folate interrelations: a critical review.

I. Chanarin, M. Lumb, R. Deacon, 1985 .

Role of Vitamin B12 in Folate Coenzyme Synthesis

I. Chanarin, E. Reynolds, M. Laundy, 1976, British journal of haematology.

Cobalamin-folate interrelations.

I. Chanarin, M. Lumb, R. Deacon, 1989, Blood reviews.

Molecular basis of the variable mitochondrial and peroxisomal localisation of alanine-glyoxylate aminotransferase.

M. Lumb, C. Danpure, P. Oatey, 1996, European journal of biochemistry.

Correction of an enzyme trafficking defect in hereditary kidney stone disease in vitro.

C. Danpure, G. Birdsey, M. Lumb, 2003, The Biochemical journal.

Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease.

Xiaoxuan Zhang, C. Danpure, G. Birdsey, 2003, Biochimica et biophysica acta.

Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.

M. Fox, S. Povey, C. Danpure, 1991, Genomics.

Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis.

A. Levi, M. Lumb, J. Perry, 1981, Gut.

The effect of nitrous oxide inactivation of vitamin B12 on rat hepatic folate. Implications for the methylfolate-trap hypothesis.

J. Nunn, I. Chanarin, M. Lumb, 1980, The Biochemical journal.

Cobalamin-folate interrelations: a critical review.

I. Chanarin, M. Lumb, R. Deacon, 1985, Blood.

Cobalamin and folate: recent developments.

I. Chanarin, M. Lumb, R. Deacon, 1992, Journal of clinical pathology.

Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged (cid:2) -Aminobutyric Acid Receptor, Type A (GABA A ), (cid:3) 2 Subunit Knock-in Mouse

S. Moss, T. Deeb, P. Davies, 2020 .

Vitamin B12 neuropathy is not due to failure to methylate myelin basic protein

I. Chanarin, M. Lumb, P. Purkiss, 1986, Journal of the Neurological Sciences.

Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition

R. Huganir, Zhen Yan, S. Moss, 2009, Proceedings of the National Academy of Sciences.

Effect of nitrous oxide-induced inactivation of vitamin B12 on glycinamide ribonucleotide transformylase and 5-amino-4-imidazole carboxamide transformylase.

I. Chanarin, M. Lumb, R. Deacon, 1983, Biochemical and biophysical research communications.

Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation.

S. Mauer, C. Danpure, S. Griffiths, 1993, American journal of human genetics.

Inactivation of methionine synthase by nitrous oxide.

J. Nunn, I. Chanarin, M. Lumb, 1980, European Journal of Biochemistry.

SELECTIVE INACTIVATION OF VITAMIN B12 IN RATS BY NITROUS OXIDE

J. Nunn, I. Chanarin, M. Lumb, 1978, The Lancet.

VITAMIN B12 REGULATES FOLATE METABOLISM BY THE SUPPLY OF FORMATE

I. Chanarin, M. Lumb, R. Deacon, 1980, The Lancet.

The effect of folate analogues on thymidine utilization by human and rat marrow cells and the effect on the deoxyuridine suppression test

I. Chanarin, M. Lumb, R. Deacon, 1981, Postgraduate medical journal.

Marrow Cells from Patients with Untreated Pernicious Anaemia Cannot Use Tetrahydrofolate Normally

I. Chanarin, M. Lumb, R. Deacon, 1980, British journal of haematology.

Folate polyglutamate synthetase activity in the cobalamin-inactivated rat.

I. Chanarin, M. Lumb, R. Deacon, 1985, The Biochemical journal.

Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.

I. Chanarin, M. Lumb, R. Deacon, 1983, The Journal of clinical investigation.

Studies on the haemopoietic toxicity of nitrous oxide in man

J. Nunn, I. Chanarin, P. Skacel, 1983, British journal of haematology.

Changes in tissue folates accompanying nitrous oxide-induced inactivation of vitamin B12 in the rat.

I. Chanarin, M. Lumb, R. Deacon, 1981, The American journal of clinical nutrition.

The effect of nitrous oxide-induced inactivation of vitamin B12 on thymidylate synthetase activity of rat bone marrow cells.

I. Chanarin, M. Lumb, R. Deacon, 1981, Biochemical and biophysical research communications.

Urinary folate loss following inactivation of vitamin B12 by nitrous oxide in rats

I. Chanarin, M. Lumb, R. Deacon, 1982, British journal of haematology.

Cobalamin andfolate: Recent developments

M. Lumb, R. Deacon, J. Perry, 1992 .

In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.

I. Chanarin, M. Lumb, R. Deacon, 1988, Journal of Clinical Pathology.

Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the feline gene.

P. Purdue, M. Lumb, C. Danpure, 1994, European journal of biochemistry.

Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes.

P. Purdue, M. Lumb, C. Danpure, 1992, European journal of biochemistry.

Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons

P. Oliver, N. Brandon, S. Moss, 2010, Molecular and Cellular Neuroscience.

Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.

I. Chanarin, M. Lumb, R. Deacon, 1985, The Biochemical journal.

Increased urinary excretion of formiminoglutamic acid in nitrous-oxide-treated rats and its reduction by methionine.

I. Chanarin, M. Lumb, R. Deacon, 2005, European journal of biochemistry.

Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat.

I. Chanarin, M. Lumb, P. Jennings, 1983, Biochimica et biophysica acta.

Changes in plasma folate levels in rats inhaling nitrous oxide.

I. Chanarin, M. Lumb, R. Deacon, 2009, Scandinavian journal of haematology.

Recovery of tissue folates after inactivation of cobalamin by nitrous oxide. The significance of dietary folate.

I. Chanarin, M. Lumb, R. Deacon, 1981, The American journal of clinical nutrition.

The effect of nitrous oxide-induced inactivation of vitamin B12 on the activity of formyl-methenyl-methylenetetrahydrofolate synthetase, methylene-tetrahydrofolate reductase and form iminotetrahydrofolate transferase

I. Chanarin, M. Lumb, R. Deacon, 1980 .

The effect of nitrous oxide-induced inactivation of vitamin B12 on serine transhydroxymethylase.

I. Chanarin, M. Lumb, R. Deacon, 1980, Biochemical and biophysical research communications.

Impaired deoxyuridine utilization in the B12-inactivated rat and its correction by folate analogues.

I. Chanarin, M. Lumb, R. Deacon, 1980, Biochemical and biophysical research communications.

The substrate for folate polyglutamate biosynthesis in the vitamin B12-inactivated rat.

I. Chanarin, M. Lumb, R. Deacon, 1979, Biochemical and biophysical research communications.

The biochemical lesion in vitamin-B12 deficiency in man.

I. Chanarin, M. Lumb, J. Perry, 1974, Lancet.

A comparison of tetrahydrofolate and 5-formyltetrahydrofolate in correcting the impairment of thymidine synthesis in pernicious anaemia.

I. Chanarin, M. Lumb, R. Deacon, 2009, Scandinavian journal of haematology.

Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.

I. Chanarin, M. Lumb, R. Deacon, 1989, The Biochemical journal.

Cobalamin inactivation induces formyltetrahydrofolate synthetase

I. Chanarin, M. Lumb, R. Deacon, 1990, FEBS letters.

Regulation of 5-methyltetrahydrofolate synthesis.

T. Bottiglieri, I. Chanarin, M. Lumb, 1989, The Biochemical journal.

Turnover of the methyl moiety of 5-methyltetrahydropteroylglutamic acid in the cobalamin-inactivated rat.

I. Chanarin, M. Lumb, R. Deacon, 1985, Blood.

Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-asenosylmethionine metabilism in the rat

I. Chanarin, M. Lumb, P. Jennings, 1983 .

Folinic acid protection against nitrous oxide teratogenicity in the rat.

J. Nunn, M. Halsey, D. Rocke, 1986, British journal of anaesthesia.

Characterization of endogenous folate and incorporation of labelled folates into the brain of the South African fruit bat.

I. Chanarin, M. Lumb, J. H. van der Westhuyzen, 1979, Biochimica et biophysica acta.

Methylation of DNA in megaloblastic anaemia.

I. Chanarin, M. Lumb, R. Deacon, 1990, Journal of Clinical Pathology.

Formate metabolism in the cobalamin‐inactivated rat

M. Lumb, R. Deacon, J. Perry, 1990, British journal of haematology.

Benzodiazepines Modulate GABAA Receptors by Regulating the Preactivation Step after GABA Binding

T. Smart, M. Gielen, M. Lumb, 2012, The Journal of Neuroscience.

Molecular characterization and clinical use of a polymorphic tandem repeat in an intron of the human alanine: Glyoxylate aminotransferase gene

G. Rumsby, C. Danpure, G. Birdsey, 1994, Human Genetics.

An intronic duplication in the alanine: glyoxylate aminotransferase gene facilitates identification of mutations in compound heterozygote patients with primary hyperoxaluria type 1

C. Danpure, P. Purdue, M. Lumb, 1991, Human Genetics.

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

Zhen Yan, P. Rostaing, A. Triller, 2010, Neuron.

Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory

M. Pangalos, P. Haydon, S. Moss, 2014, The Journal of Neuroscience.

Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse*

S. Moss, T. Deeb, P. Davies, 2016, The Journal of Biological Chemistry.

Effect of N-terminal α-Helix Formation on the Dimerization and Intracellular Targeting of Alanine:Glyoxylate Aminotransferase*

A. Drake, C. Danpure, M. Lumb, 1999, The Journal of Biological Chemistry.

A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1.

P. Purdue, M. Lumb, J. Allsop, 1992, Genomics.

Targeting of Alanine: Glyoxylate Aminotransferase in Normal Individuals and Its Mistargeting in Patients with Primary Hyperoxaluria Type 1

J. Leiper, C. Danpure, M. Lumb, 1996, Annals of the New York Academy of Sciences.

How can the mood stabilizer VPA limit both mania and depression?

L. Polgár, A. Mudge, Lili Cheng, 2005, Molecular and Cellular Neuroscience.

Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid type-A receptors

F. Cacucci, S. Moss, A. Dickenson, 2018 .

Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.

I. Chanarin, M. Lumb, R. Deacon, 1985, Journal of Clinical Pathology.

The effect of nitrous oxide-induced inactivation of cobalamin on plasma amino acid levels in the rat.

I. Chanarin, M. Lumb, P. Jennings, 2009, Scandinavian journal of haematology.

HOW VITAMIN B12 ACTS

I. Chanarin, M. Lumb, R. Deacon, 1981, British journal of haematology.