E. Ab

发表

Application of Fragment-Based Drug Discovery to Membrane Proteins: Identification of Ligands of the Integral Membrane Enzyme DsbB

Gregg Siegal, Eiso Ab, G. Siegal, 2015 .

Solution structure and characterization of the DNA-binding activity of the B3BP-Smr domain.

R. Kaptein, G. Folkers, M. Daniels, 2008, Journal of molecular biology.

Target Immobilization as a Strategy for NMR-Based Fragment Screening

G. Siegal, K. Retra, H. Irth, 2010, Journal of biomolecular screening.

Catalysis by a rigid enzyme

A. Volkov, M. Ubbink, C. Waudby, 2019, bioRxiv.

NMR in structure-based drug design.

G. Siegal, Stephan Theisgen, M. Carneiro, 2017, Essays in biochemistry.

Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis

A. W. Tuin, G. Siegal, P. Keizers, 2014 .

Correlation of the15N(i+ 1),13Cα(i), and1Hα(i) Backbone Resonances in13C/15N-Labeled Proteins by the (CO)N(CO)CAH Experiment

J. Kemmink, R. Scheek, G. Kroon, 1997 .

Dynamics of Ligand Binding to a Rigid Glycosidase**

H. Ingen, A. Volkov, M. Ubbink, 2020, Angewandte Chemie.

X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor

K. H. Kalk, J. Drenth, B. Dijkstra, 1990, Nature.

Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory.

Gregg Siegal, T Reid Alderson, Matteo T Degiacomi, 2017, Journal of the American Chemical Society.

DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways

D. Rees, A. Faro, E. Ab, 2006, BMC Structural Biology.

Atomic-resolution three-dimensional structure of HET-s(218-289) amyloid fibrils by solid-state NMR spectroscopy.

B. Meier, A. Loquet, A. Lange, 2010, Journal of the American Chemical Society.

Structure and DNA binding of the human Rtf1 Plus3 domain.

R. Kaptein, G. Folkers, M. Daniels, 2008, Structure.

NMR in target driven drug discovery: why not?

G. Siegal, G. Müller, Stephan Theisgen, 2020, Journal of Biomolecular NMR.

Fragment-derived modulators of an industrial β-glucosidase

James D. Firth, G. Siegal, R. Hubbard, 2020, The Biochemical journal.

Structure of the DNA-bound BRCA1 C-terminal Region from Human Replication Factor C p140 and Model of the Protein-DNA Complex

G. Siegal, A. Bonvin, E. Ab, 2010, The Journal of Biological Chemistry.

Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS)

G. Siegal, I. D. de Esch, J. Luirink, 2019, International journal of molecular sciences.

Solution structure of a chemosensory protein from the desert locust Schistocerca gregaria.

A. Scaloni, R. Boelens, P. Pelosi, 2006, Biochemistry.

Solution Structure of RING Finger-like Domain of Retinoblastoma-binding Protein-6 (RBBP6) Suggests It Functions as a U-box*

J. Moolman-Smook, D. Rees, A. Faro, 2011, The Journal of Biological Chemistry.

The high resolution NMR structure of the third SH3 domain of CD2AP

A. Azuaga, M. L. Romero Romero, A. Ora, 2007, Journal of biomolecular NMR.

Solution Structure of the Human Ubiquitin-specific Protease 15 DUSP Domain*

R. Kaptein, G. Folkers, M. Daniëls, 2006, Journal of Biological Chemistry.

The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.

R. Kaptein, G. Folkers, R. Boelens, 2005, Structure.

Structural Characterization of Spo0E-like Protein-aspartic Acid Phosphatases That Regulate Sporulation in Bacilli*

R. Kaptein, G. Folkers, M. Perego, 2006, Journal of Biological Chemistry.

The NMR side‐chain assignments and solution structure of enzyme HBcellobiose of the phosphoenolpyruvate‐dependent phosphotransferase system of Escherichia coli

M. Saier, G. Robillard, J. Reizer, 1997, Protein science : a publication of the Protein Society.

The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation in Bacillus*

R. Kaptein, G. Folkers, K. Wilson, 2005, Journal of Biological Chemistry.

Integration of fragment screening and library design.

Jan Schultz, Gregg Siegal, Eiso Ab, 2007, Drug discovery today.

NMR structure of cysteinyl-phosphorylated enzyme IIB of the N,N'-diacetylchitobiose-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli.

M. Saier, G. Robillard, R. Scheek, 2001, Journal of molecular biology.

The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3

N. V. van Nuland, S. Casares, O. López-Mayorga, 2007, BMC Structural Biology.

DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.

D. Rees, A. Faro, E. Ab, 2006, BMC structural biology.

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.

G. Siegal, S. Sligar, Yunpeng Zhou, 2010, Chemistry & biology.