Chungang Gu

发表

Surface-induced dissociation of singly and multiply protonated polypropylenamine dendrimers

V. Wysocki, Á. Somogyi, T. Weeding, 1999, Journal of the American Society for Mass Spectrometry.

CYP-Mediated Sulfoximine Deimination of AZD6738

G. Scarfe, B. Jones, Chungang Gu, 2017, Drug Metabolism and Disposition.

Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.

A. Ferguson, L. Drew, W. Shao, 2021, Journal of medicinal chemistry.

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

J. Bolton, P. Yao, Xuemei Liu, 2005, Journal of the American Society for Mass Spectrometry.

Mouse Red Blood Cell–Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate

Shenghua Wen, P. Doig, E. Gangl, 2017, Drug Metabolism and Disposition.

Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor.

S. Marsh, J. Stevens, P. Fan, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Implementation of low-energy surface-induced dissociation (eV SID) and high-energy collision-induced dissociation (keV CID) in a linear sector-TOF hybrid tandem mass spectrometer

V. Wysocki, Á. Somogyi, E. Nikolaev, 2001 .

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry.

Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325

R. Lewis, C. Elmore, Chungang Gu, 2018, Journal of labelled compounds & radiopharmaceuticals.

In vitro and in vivo metabolism of a selective δ-opioid receptor agonist

Diansong Zhou, S. Grimm, K. Bui, 2011 .

Dissociative and Reactive Hyperthermal Ion−Surface Collisions with Langmuir−Blodgett Films Terminated by CF3(CH2)n−, n-Perfluoroalkyl, or n-Alkyl Groups

V. Wysocki, A. Harada, Chungang Gu, 1999 .

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.

S. Kazmirski, Nancy Su, D. Ogg, 2015, ACS medicinal chemistry letters.

Absorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats

S. Grimm, Chungang Gu, Jian Guo, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.

M. Mingueneau, J. Lyssikatos, T. Bohnert, 2021, Journal of medicinal chemistry.

In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite

Diansong Zhou, S. Grimm, Minli Zhang, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of Protonated Sulfone and Aromatic Carboxylic Acid Functionalities in Organic Molecules by Using Ion-Molecule Reactions Followed by Collisionally Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer.

H. Kenttämaa, Minli Zhang, Huaming Sheng, 2017, Analytical chemistry.

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.

A. Ferguson, L. Drew, W. Shao, 2020, Journal of medicinal chemistry.

Identification of the carboxylic acid functionality in protonated drug metabolite model compounds by using tandem mass spectrometry based on ion-molecule reactions coupled with high performance liquid chromatography

H. Kenttämaa, Kawthar Z. Alzarieni, Xin Ma, 2021 .

Developmental Expression of the Major Human Hepatic CYP3A Enzymes

Ronald N. Hines, S. B. Koukouritaki, J. Manro, 2003, Journal of Pharmacology and Experimental Therapeutics.

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.

David A. Scott, S. Kazmirski, P. Lyne, 2016, Bioorganic & medicinal chemistry letters.

Elevated microRNA-145-5p increases matrix metalloproteinase-9 by activating the nuclear factor-κB pathway in rheumatoid arthritis

Mengchen Yang, Yuhua Yuan, Chungang Gu, 2019, Molecular medicine reports.

Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct

Diansong Zhou, S. Grimm, C. Elmore, 2012, Drug Metabolism and Disposition.

BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS.

Cathy Muste, Chungang Gu, 2021, Drug metabolism and pharmacokinetics.

Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase

G. S. Walker, R. Voorman, D. Holsworth, 2006, Drug Metabolism and Disposition.

Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

R. V. van Breemen, Natasa Pajkovic, Yan Wang, 2003, Analytical chemistry.

Fragmentation of protonated oligopeptides XLDVLQ (X=L, H, K or R) by surface induced dissociation: additional evidence for the 'mobile proton' model

Vicki H. Wysocki, Katalin F. Medzihradszky, K. Medzihradszky, 1999 .

Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance

Mark A. Smith, R. Lewis, J. Hall, 2018, Drug Metabolism and Disposition.

Lipid Peroxide–Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples

A. Wells, R. Lewis, V. Hosagrahara, 2015, Drug Metabolism and Disposition.

DMD065136 1441..1449

A. Wells, R. Lewis, V. Hosagrahara, 2015 .

In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor

Diansong Zhou, S. Grimm, K. Bui, 2011, Drug Metabolism and Disposition.

Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes

Jiansheng Huang, Joshua L. Johnson, Chungang Gu, 2021, Xenobiotica; the fate of foreign compounds in biological systems.

Clinical Parameters and Metabolomic Biomarkers That Predict Inhospital Outcomes in Patients With ST-Segment Elevated Myocardial Infarctions

Lei Huang, Chungang Gu, Shuye Liu, 2022, Frontiers in Physiology.

Selective gas-phase cleavage at the peptide bond C-terminal to aspartic acid in fixed-charge derivatives of Asp-containing peptides.

V. Wysocki, G. Tsaprailis, L. Breci, 2000, Analytical chemistry.

Surface-induced dissociation of singly and multiply protonated polypropylenamine dendrimers

V. Wysocki, Á. Somogyi, T. Weeding, 1999, Journal of the American Society for Mass Spectrometry.

CYP-Mediated Sulfoximine Deimination of AZD6738

G. Scarfe, B. Jones, Chungang Gu, 2017, Drug Metabolism and Disposition.