N. Saito

发表

Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.

I. Abe, P. Chanvorachote, K. Suwanborirux, 2013, Journal of natural products.

Ecteinascidin 770, a tetrahydroisoquinoline alkaloid, sensitizes human lung cancer cells to anoikis.

P. Chanvorachote, K. Suwanborirux, N. Saito, 2013, Anticancer research.

Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells

M. Velarde, G. Concepcion, K. Suwanborirux, 2019, Marine drugs.

Apoptosis-inducing Effect of Hydroquinone 5-O-Cinnamoyl Ester Analog of Renieramycin M on Non-small Cell Lung Cancer Cells.

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2017, Anticancer research.

Bishydroquinone Renieramycin M Induces Apoptosis of Human Lung Cancer Cells Through a Mitochondria-dependent Pathway.

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2016, Anticancer research.

Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.

K. Suwanborirux, A. Kubo, N. Saito, 2002, Journal of natural products.

Synthesis of 6,6-dimethyltricyclo[5.4.0.02,8]undecane-2,9-diol for (ent-)longipinane-type sesquiterpenoids using two types of radical cyclization reactions

H. Kogen, N. Saito, K. Takatori, 2018, Tetrahedron Letters.

Chemistry of renieramycins. Part 12: An improved total synthesis of (±)-renieramycin G

Saiko Yoshida, N. Saito, M. Yokoya, 2012 .

Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

Natchanun Sirimangkalakitti, N. Saito, M. Yokoya, 2018, Marine drugs.

Chemistry of Ecteinascidins. Part 5: An Additional Proof of Cytotoxicity Evaluation of Ecteinascidin 770 Derivatives.

K. Suwanborirux, Toshihiro Suzuki, N. Saito, 2016, Chemical & pharmaceutical bulletin.

Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.

K. Suwanborirux, Panithi Saktrakulkla, N. Saito, 2011, Bioorganic & medicinal chemistry.

Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms

T. Owa, K. Suwanborirux, N. Saito, 2009, Marine drugs.

Chemistry of renieramycins. Part 7: Renieramycins T and U, novel renieramycin–ecteinascidin hybrid marine natural products from Thai sponge Xestospongia sp. ☆

K. Suwanborirux, N. Saito, S. Amnuoypol, 2009 .

Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues.

T. Owa, K. Suwanborirux, N. Saito, 2009, Bioorganic & medicinal chemistry.

Synthesis of 1,2,3,4,5,6,7,10-Octahydro-1,5-imino-7,10-dioxo-3-benzazocine-4-carbonitrile Derivative and Evaluation of Antitumor Activity Related to Saframycin and Renieramycin Isoquinolinequinones

A. Kubo, N. Saito, Yu-ichi Koizumi, 2006 .

Chemistry of ecteinascidins. Part 2. Preparation of 6'-O-acyl derivatives of stable ecteinascidin and evaluation of cytotoxicity.

K. Suwanborirux, A. Kubo, N. Saito, 2006, Chemical & pharmaceutical bulletin.

Structure of Saframycin R

A. Kubo, N. Saito, N. Kameyama, 2000 .

Chemistry of Renieramycins. 17. A New Generation of Renieramycins: Hydroquinone 5-O-Monoester Analogues of Renieramycin M as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells.

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2017, Journal of natural products.

Chemistry of Renieramycins. 15. Synthesis of 22-O-Ester Derivatives of Jorunnamycin A and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cells.

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2016, Journal of natural products.

Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2019, Marine drugs.

A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis

K. Yazawa, Y. Mikami, Ken-ichiro Suzuki, 1990, Mycopathologia.

Naturally occurring biflavonoids with amyloid β aggregation inhibitory activity for development of anti-Alzheimer agents.

K. Kinoshita, K. Koyama, Natchanun Sirimangkalakitti, 2019, Bioorganic & medicinal chemistry letters.

Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-O-Amino Ester and Hydroquinone 5-O-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2020, Marine drugs.

A Concise Route to 3-Hydroxy-4-Methoxy-5-Methylbenzaldehyde Derivative

A. Kubo, N. Saito, M. Tachi, 2000 .

Chemistry of renieramycins. Part 6: Transformation of renieramycin M into jorumycin and renieramycin J including oxidative degradation products, mimosamycin, renierone, and renierol acetate ☆

K. Suwanborirux, A. Kubo, N. Saito, 2004 .

Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol.

A. Kubo, N. Saito, Chigusa Oyama, 2004, Chemical & pharmaceutical bulletin.

Chemistry of Renieramycins. Part 14: Total Synthesis of Renieramycin I and Practical Synthesis of Cribrostatin 4 (Renieramycin H)

N. Saito, M. Yokoya, K. Kobayashi, 2015, Marine drugs.

Preparation of renieramycin left-half model compounds

N. Saito, K. Kubo, M. Yokoya, 2014 .

Synthesis of renieramycins: construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate.

Hiroshi Ito, N. Saito, M. Yokoya, 2011, Chemical & pharmaceutical bulletin.

A stereocontrolled total synthesis of (±)-saframycin A

N. Saito, S. Kimura, 2018 .

Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W–Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide

G. Concepcion, K. Suwanborirux, H. D. Magpantay, 2012 .

Chemistry of renieramycins. Part 9: Stereocontrolled total synthesis of (±)-renieramycin G

N. Saito, M. Yokoya, Kimiko Shinada-Fujino, 2011 .

Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris.

K. Suwanborirux, A. Kubo, N. Saito, 2007, Chemical & pharmaceutical bulletin.

Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.

K. Suwanborirux, A. Kubo, N. Saito, 2003, Journal of natural products.

Chemistry of renieramycins. Part 2. Partial reduction and nucleophilic substitution of hexahydro-1,5-imino-4-oxo-3-benzazocine-7,10-dione: Promising method to construct renieramycin J from renieramycin G via renieramycin E

K. Suwanborirux, A. Kubo, N. Saito, 2002 .

Synthesis of saframycins. VII, The synthesis of novel renieramycin congeners

A. Kubo, N. Saito, R. Yamaguchi, 1991 .

Isolation, Structure Characterization, and Synthesis of Stabilized 1,2,3,4-Tetrahydroisoquinoline Marine Natural Product from Potassium Cyanide Pretreated Thai Tunicate, Ecteinascidia thurstoni

K. Suwanborirux, N. Saito, P. Puthongking, 2014 .

Chemistry of Renieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol.

A. Kubo, N. Saito, Chigusa Oyama, 2004 .

Stereoselective Total Synthesis of (-)-Renieramycin T.

Robert M. Williams, Toshihiro Suzuki, V. Le, 2016, The Journal of organic chemistry.

Chemistry of renieramycins. Part 11: Total synthesis of (±)-cribrostatin 4

Hiroshi Ito, N. Saito, M. Yokoya, 2011 .

Synthesis of Tetrahydroisoquinoline Antitumor Natural Products: Construction of Tricyclic Lactams Through Pictet—Spengler-Type Cyclization of N-Methyl-3-arylmethylpiperazine-2,5-dione with Ethyl Diethoxyacetate.

N. Saito, M. Yokoya, O. Kawachi, 2009 .

13C NMR Spectral Assignment of 5-Hydroxy-1,5-imino-3-benzazocin-4,7,10-trione Derivatives: The Revised Structure of Renieramycin H

K. Suwanborirux, A. Kubo, N. Saito, 2001 .

Synthesis and Antitumor Evaluation of Octahydro-5-hydroxy-1,5-imino-3-benzazocin-4,7,10-triones.

K. Yazawa, Y. Mikami, A. Kubo, 1998 .

Synthesis of saframycins. XII. 1 total synthesis of (-)-N-acetylsaframycin Mx 2 and Its epi-(+)-enantiomer

K. Yamaguchi, A. Kubo, N. Saito, 1995 .

Synthesis of saframycins. V. Selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocin-7,10-dione; a useful method for constructing saframycins C and D from saframycin B

N. Wada, A. Kubo, N. Saito, 1990 .

Synthesis of saframycins. II. Preparations and reactions of N-methyl-2,5-piperazinediones.

A. Kubo, N. Saito, S. Inoue, 1988, Chemical & pharmaceutical bulletin.

Synthesis of Renieramycins: Construction of the Core Ring System of Cribrostatin 4 Through Modified Pictet—Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-dione with Diethoxyethyl Benzoate.

Hiroshi Ito, N. Saito, M. Yokoya, 2011 .

Synthesis of tetrahydroisoquinoline antitumor natural products: construction of tricyclic lactams through Pictet-Spengler-type cyclization of N-methyl-3-arylmethylpiperazine-2,5-dione with ethyl diethoxyacetate

N. Saito, M. Yokoya, O. Kawachi, 2008 .

Stereoselective total synthesis of (±)-saframycin B

A. Kubo, N. Saito, Madoka Nakamura, 1988 .

Preparations and Reactions of (Z) -3-Arylidene-6-arylmethyl-2, 5-piperazinediones Having Highly Oxygenated Benzene Rings

A. Kubo, N. Saito, H. Yamato, 1987 .

Synthesis of saframycins. IX.

N. Saito, Y. Shida, S. Harada, 1994 .

6-Cyanotetracyclo[5.5.0.02,4.03,5]dodeca-6,8,10,12-tetraene

I. Murata, N. Saito, Y. Sugihara, 1986 .

Demonstration of isospecific free radical polymerization of acrylate controlled by conformation and chirality of monomer

Tatsuya Kibayashi, N. Saito, Hitoshi Tanaka, 2015 .

Erratum to: Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

K. Suwanborirux, Jutamas Jiaranaikulwanitch, J. Pratuangdejkul, 2017, Journal of Natural Medicines.

Synthesis and Absolute Configuration of Acanthodendrilline, a New Cytotoxic Bromotyrosine Alkaloid from the Thai Marine Sponge Acanthodendrilla sp.

P. Chanvorachote, K. Suwanborirux, S. Chamni, 2016, Chemical & pharmaceutical bulletin.

Total Synthesis of (±)-Marsupellins A and B via Acetoxymarsupellone Using an Intramolecular Reductive Cyclization of Epoxycyanohydrin Derivative with Cp2TiI.

H. Kogen, N. Saito, K. Takatori, 2019, Organic letters.

Inactivation of Kanamycin A by Phosphorylation in Pathogenic Nocardia

T. Kudo, K. Yazawa, Y. Mikami, 1991, Microbiology and immunology.

Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

K. Suwanborirux, Jutamas Jiaranaikulwanitch, J. Pratuangdejkul, 2017, Journal of Natural Medicines.

5-O-Acetyl-Renieramycin T from Blue Sponge Xestospongia sp. Induces Lung Cancer Stem Cell Apoptosis

Wipa Chantarawong, P. Chanvorachote, K. Suwanborirux, 2019, Marine drugs.

Transformation of Renieramycin M into Renieramycins T and S by Intramolecular Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione Derivatives.

K. Suwanborirux, S. Chamni, N. Saito, 2023, Journal of natural products.

Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells

T. Rungrotmongkol, P. Chanvorachote, B. Nutho, 2020, Cancers.

Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T

N. Saito, S. Kimura, 2018, ChemistryOpen.

Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide.

K. Suwanborirux, A. Kubo, N. Saito, 2004, Journal of natural products.

SYNTHETIC APPROACHES TOWARD ECTEINASCIDINS. PART 1. PREPARATION OF AN (E)-2-ARYLIDENE-3-BENZYL-1,5-IMINO-3-BENZAZOCIN-4-ONE HAVING A PROTECTED PHENOL IN THE E-RING

K. Yamaguchi, A. Kubo, N. Saito, 1997 .

Synthesis of saframycins. 3. Preparation of a key tricyclic lactam intermediate to saframycin A

A. Kubo, Satoko Ida, N. Saito, 1989 .

A Synthesis of the Derivatives of 1,2,3,5,10,10a‐Hexahydrobenz(f) indolizine‐6,9‐dione Having Antifungal Activity as a Simple Model of Saframycin A.

K. Yazawa, Y. Mikami, A. Kubo, 1996 .

A Synthesis of the Derivative of 1,2,3,5,10,10a-Hexahydrobenz[f]indolizine-6,9-dione Having Antifungal Activity as a Simple Model of SaframycinA

K. Yazawa, Y. Mikami, A. Kubo, 1996 .

The Partial Syntheses of Reserpiline and Isoreserpiline

N. Hirose, N. Saito, S. Sakai, 1982 .

Chemical Research on Antitumor Isoquinoline Marine Natural Products and Related Compounds.

N. Saito, 2021, Chemical & pharmaceutical bulletin.

Synthesis of saframycins. X. Transformation of (-)-saframycin A to (-)-saframycin Mx type compound with the structure proposed for saframycin E.

A. Kubo, N. Saito, M. Nishida, 1995, Chemical and pharmaceutical bulletin.

A practical synthesis of the ABC ring model of ecteinascidins.

A. Kubo, N. Saito, M. Tachi, 2000, Chemical & pharmaceutical bulletin.

Synthesis of saframycins. VIII: Synthesis of the ABC ring of safracins

A. Kubo, N. Saito, Yasuko Obara, 1992 .

Synthesis of saframycins. I. Total synthesis (+/-)-saframycin B and its congeners.

A. Kubo, N. Saito, R. Yamauchi, 1987, Chemical & pharmaceutical bulletin.

An Improved Synthesis of the ABC Ring Model of Ecteinascidins

A. Kubo, N. Saito, M. Tachi, 1999 .

A promising cyclization of the 3-arylidene-6-arylmethyl-2,5-piperazinedione to construct tricyclic lactam as an intermediate to saframycin synthesis

A. Kubo, N. Saito, S. Sakai, 1987 .

Inhibition of BACE1 and amyloid β aggregation by polyketide from Streptomyces sp.

Y. Kino, T. Sugita, N. Saito, 2021, Chemical biology & drug design.

Some Preparation Methods of a Tricyclo[4.1.0.02,7]Hept-4-En-3-One Skeleton

T. Sugimura, I. Murata, N. Saito, 1995 .

Some Preparation Methods of a Tricyclo(4.1.0.02,7)hept‐4‐en‐3‐one Skeleton.

T. Sugimura, I. Murata, N. Saito, 1995 .

Unusual thermal behaviour of tricyclo[4.1.0.02,7]hept-4-en-3-one (tropovalene)

T. Sugimura, I. Murata, N. Saito, 1989 .

Synthesis of Novel Octahydro-1, 5-imino-3-benzazocin-4, 7, 10-trione Derivatives Having a Methyl Group at the C-2 Position as ABC Ring Models of Saframycins

A. Kubo, N. Saito, M. Tanitsu, 1997 .

Erratum to: Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

K. Suwanborirux, Jutamas Jiaranaikulwanitch, J. Pratuangdejkul, 2017, Journal of Natural Medicines.

Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T

N. Saito, S. Kimura, 2018, ChemistryOpen.

Chemistry of Renieramycins. Part 10. Structure of Renieramycin V, a Novel Renieramycin Marine Natural Product Having a Sterol Ether at C-14 Position.

K. Suwanborirux, Miho Yoshino, N. Saito, 2012 .

Synthesis of saframycins. XI. Synthetic studies toward a total synthesis of safracin A

K. Yamaguchi, A. Kubo, Takeshi Saito, 1995 .

Synthetic approaches toward ecteinascidins. Part 2. Preparation of the ABCDE ring system of ecteinascidins having characteristic substituents in both benzene rings.

A. Kubo, N. Saito, N. Kameyama, 2003, Chemical & pharmaceutical bulletin.

Synthesis of Saframycins. Part 11. Synthetic Studies Toward a Total Synthesis of Safracin A (I).

K. Yamaguchi, A. Kubo, N. Saito, 1995 .

CHEMISTRY OF RENIERAMYCINS (PART 10) STRUCTURE OF RENIERAMYCIN V, A NOVEL RENIERAMYCIN MARINE NATURAL PRODUCT HAVING A STEROL ETHER AT C-14 POSITION (Dedicated to Dr. Albert Padwa on his 75th birthday)

K. Suwanborirux, Miho Yoshino, N. Saito, 2012 .

A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

Yasuo Matsuyama, A. Kubo, N. Saito, 1988 .

Lipase-Catalyzed Site-Selective Deacetylation of 2-Methoxy-3-methylnaphthalene-1,4-diol Diacetate for Construction of Characteristic Substituted 1,2,3,4-Tetrahydroisoquinoline Derivative of Novel Ecteinascidin Marine Natural Product

N. Saito, M. Yokoya, R. Sato, 2022, HETEROCYCLES.

Synthesis of Isoquinolinequinone Antibiotics.

S. Nakahara, A. Kubo, N. Saito, 1982 .

Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

K. Suwanborirux, Jutamas Jiaranaikulwanitch, J. Pratuangdejkul, 2017, Journal of Natural Medicines.

Simple Strategy for Benzo[g]chromene Synthesis via a Photochemical Intramolecular Cyclization Reaction.

Ryo Fujimoto, Tomoki Kato, N. Saito, 2023, The Journal of organic chemistry.

SYNTHESIS OF SAFRAMYCINS. VI. THE USEFUL TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN Mx TYPE COMPOUND

A. Kubo, N. Saito, M. Nishida, 1991 .

Total synthesis of isoquinolinequinone antibiotics.

A. Kubo, N. Saito, 1988 .