R. Jacamo

发表

Protein Kinase D Mediates Mitogenic Signaling by Gq-coupled Receptors through Protein Kinase C-independent Regulation of Activation Loop Ser744 and Ser748 Phosphorylation*

S. H. Young, E. Rozengurt, R. Waldron, 2009, Journal of Biological Chemistry.

G Protein-coupled Receptor Activation Rapidly Stimulates Focal Adhesion Kinase Phosphorylation at Ser-843

E. Rozengurt, J. Sinnett-Smith, R. Fan, 2005, Journal of Biological Chemistry.

AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth.

R. Davis, A. Rao, M. Konopleva, 2017, JCI insight.

Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton.

E. Rozengurt, Steven S. Wu, S. K. Vong, 2006, Cellular signalling.

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment.

A. Reinisch, D. Strunk, M. Konopleva, 2012, Blood.

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia

R. Davis, Min Zhang, S. Lowe, 2017, Oncotarget.

Preferential Phosphorylation of Focal Adhesion Kinase Tyrosine 861 Is Critical for Mediating an Anti-apoptotic Response to Hyperosmotic Stress*

E. Rozengurt, J. A. Lunn, R. Jacamo, 2007, Journal of Biological Chemistry.

FAK phosphorylation at Ser‐843 inhibits Tyr‐397 phosphorylation, cell spreading and migration

E. Rozengurt, J. A. Lunn, Xiaohua Jiang, 2007, Journal of cellular physiology.

Transcription and RNA Replication of Tacaribe Virus Genome and Antigenome Analogs Require N and L Proteins: Z Protein Is an Inhibitor of These Processes

N. López, R. Jacamo, M. T. Franze-Fernández, 2001, Journal of Virology.

Apoptosis repressor with caspase recruitment domain modulates second mitochondrial‐derived activator of caspases mimetic‐induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia

M. Andreeff, H. Kantarjian, S. Kornblau, 2014, British journal of haematology.

The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.

K. Coombes, G. Calin, Nianxiang Zhang, 2014, Biochimica et biophysica acta.

signaling and microRNA expression in acute myeloid leukemia cells

M. Konopleva, M. Andreeff, S. Kornblau, 2014 .

Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.

James M. Bogenberger, K. Coombes, M. Andreeff, 2014, Journal of the National Cancer Institute.

Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization

S. H. Young, E. Rozengurt, J. Sinnett-Smith, 2017, The Journal of Biological Chemistry.

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival

M. Konopleva, M. Andreeff, E. Shpall, 2018, Haematologica.

Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas

T. Link, K. Young, M. Barton, 2020 .

MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway.

E. Reed, E. Rozengurt, P. Jindra, 2008, Biochemical and biophysical research communications.

Reversal of Acquired Drug Resistance in FLT3-Mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies

M. Konopleva, M. Andreeff, J. Cortes, 2014, Clinical Cancer Research.

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

M. Konopleva, L. Platanias, T. Fujimura, 2015, Oncotarget.

Therapeutic Targeting of the Hypoxic Microenvironment in Acute Lymphocytic Leukemia.

D. Campana, M. Konopleva, M. Andreeff, 2009 .

Tacaribe Virus Z Protein Interacts with the L Polymerase Protein To Inhibit Viral RNA Synthesis

M. Wilda, N. López, R. Jacamo, 2003, Journal of Virology.

Hypoxia regulates CD9 expression and dissemination of B lymphoblasts.

V. Praloran, M. Galibert, M. Troadec, 2022, Leukemia research.

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing

T. Link, R. Kanagal-Shamanna, S. Kornblau, 2022, NAR cancer.

Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML

M. Andreeff, S. Kornblau, Y. Shi, 2013, Apoptosis.

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferative disease in mice via altered Runx1 splicing

T. Link, R. Kanagal-Shamanna, S. Kornblau, 2021, bioRxiv.

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia

T. Link, R. Kanagal-Shamanna, S. Post, 2021 .

Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis.

G. Hortobagyi, M. Andreeff, A. Sahin, 2012, The Journal of clinical investigation.

Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition

S. H. Young, M. Moyer, E. Rozengurt, 2010, Journal of cellular physiology.

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

J. Velez, Y. Qi, Xiaoping Su, 2016, Oncotarget.

Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML

Lauren E. Heese, R. Davis, S. Lindquist, 2021, Leukemia.

p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.

M. Konopleva, M. Andreeff, E. Shpall, 2011, Blood.

Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients

S Hanash, S. Hanash, A. Maitra, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia.

C. Croce, R. Garzon, M. Konopleva, 2013, The Journal of clinical investigation.

Bone Marrow Microenvironment-mediated Resistance to Chemotherapy in Leukemia

M. Andreeff, R. Jacamo, 2015 .

CXCR 4 downregulation of let-7 a drives chemoresistance in acute myeloid leukemia

C. Croce, R. Garzon, M. Konopleva, 2013 .

MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications

M. Andreeff, F. Marini, E. Spaeth, 2013 .

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

K. Ikeo, M. Konopleva, M. Andreeff, 2021, Blood advances.

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

Jing Wang, M. Konopleva, M. Andreeff, 2019, Haematologica.

Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia

Jing Wang, C. Mullighan, M. Konopleva, 2018, Oncotarget.

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

M. Andreeff, S. Arold, J. Ladbury, 2016, Oncotarget.

Oxygen Sensing Mesenchymal Progenitors Promote Neo-Vasculogenesis in a Humanized Mouse Model In Vivo

A. Reinisch, D. Strunk, M. Andreeff, 2012, PloS one.

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

M. Konopleva, M. Andreeff, H. Kantarjian, 2012, Cancer biology & therapy.

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

J. Velez, R. Davis, M. Protopopova, 2015, Clinical Cancer Research.

A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals.

E. Rozengurt, R. Jacamo, 2005, Biochemical and biophysical research communications.

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.

R. Davis, D. Strunk, M. Konopleva, 2014, Blood.

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

K. Coombes, A. Letai, Nianxiang Zhang, 2015, Cell reports.

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

M. Konopleva, M. Andreeff, G. Borthakur, 2015, PloS one.

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

Michael L. Wang, R. Davis, T. McDonnell, 2016, Science Signaling.

The Nuclear Import of Protein Kinase D3 Requires Its Catalytic Activity*

J. Lippincott-Schwartz, S. H. Young, E. Rozengurt, 2006, Journal of Biological Chemistry.

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

R. Bast, D. Etemadmoghadam, D. Bowtell, 2010, Cancer cell.

Protein kinase D1 inhibition interferes with mitosis progression

E. Rozengurt, O. Rey, G. Amable, 2019, Journal of cellular physiology.

Sequential Protein Kinase C (PKC)-dependent and PKC-independent Protein Kinase D Catalytic Activation via Gq-coupled Receptors

E. Rozengurt, R. Waldron, J. Sinnett-Smith, 2008, Journal of Biological Chemistry.

Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas.

T. Link, K. Young, M. Barton, 2019, Journal of the National Cancer Institute.

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

R. Davis, T. McDonnell, M. Konopleva, 2014 .

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

M. Andreeff, H. Saya, S. Kornblau, 2017, Blood.

Acquired Point Mutations of TKD Are Responsible for Sorafenib Resistance in FLT3-ITD Mutant AML,

M. Konopleva, M. Andreeff, J. Cortes, 2011 .

Proteomic, Gene Expression, and Micro-RNA Analysis Of Bone Marrow Mesenchymal Stromal Cells In Acute Myeloid Leukemia Identifies Pro-Inflammatory, Pro-Survival Signatures In Vitro and In Vivo

S. Lowe, C. Croce, R. Garzon, 2013 .

Targeting CXCR4, SDF1 and Beta-Adrenergic Receptors In the AML Microenvironment by Novel Antagonist POL6326, G-CSF and Isoproterenol

M. Konopleva, M. Andreeff, P. Frenette, 2010 .

Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models

M. Konopleva, M. Andreeff, H. Kantarjian, 2016 .

RNA interference reveals a differential role of FAK and Pyk2 in cell migration, leading edge formation and increase in focal adhesions induced by LPA in intestinal epithelial cells

E. Rozengurt, J. Sinnett-Smith, E. Zhukova, 2006, Journal of cellular physiology.