R. Billinghurst

发表

Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.

H. V. Van Wart, A. Poole, L. Dahlberg, 2000, Arthritis and rheumatism.

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.

D. Zukor, A. Poole, J. Antoniou, 2002, Arthritis & Rheumatism.

Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.

D. Frisbie, C. McIlwraith, G. Trotter, 2001, American journal of veterinary research.

Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses.

D. Frisbie, R. Arthur, R. Billinghurst, 2010, Equine veterinary journal.

Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses.

P. R. van Weeren, P. Brama, C. McIlwraith, 2003, Osteoarthritis and cartilage.

Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.

A. Hollander, A. Poole, W. B. van den Berg, 1999, Arthritis and rheumatism.

Secretory Leukocyte Protease Inhibitor Suppresses the Inflammation and Joint Damage of Bacterial Cell Wall–Induced Arthritis

S. Wahl, A. Poole, D. Mizel, 1999, The Journal of experimental medicine.

The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases.

A. Poole, M. Fitzcharles, M. Ionescu, 2004, Journal of immunological methods.

Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.

A. Hollander, A. Poole, W. B. van den Berg, 2001, Osteoarthritis and cartilage.

Use of an antineoepitope antibody for identification of type-II collagen degradation in equine articular cartilage.

C. McIlwraith, R. Billinghurst, E. Buxton, 2001, American journal of veterinary research.

Induction of intra-articular tumour necrosis factor during acute inflammatory responses in equine arthritis.

J. Gordon, R. Billinghurst, P. Fretz, 1995, Equine veterinary journal.

Proteolysis of the collagen fibril in osteoarthritis.

A. Poole, E. Tchetina, T. Kojima, 2003, Biochemical Society symposium.

Novel Biologic Therapies—Metalloproteinase Inhibitors

C. McIlwraith, R. Billinghurst, 2001 .

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).

D. Zukor, H. V. Van Wart, A. Poole, 2000, Arthritis and rheumatism.

Inhibition of Articular Cartilage Degradation in Culture by a Novel Nonpeptidic Matrix Metalloproteinase Inhibitor

A. Poole, C. McIlwraith, R. Billinghurst, 1999, Annals of the New York Academy of Sciences.

Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals.

P. R. van Weeren, P. Brama, C. McIlwraith, 2004, American journal of veterinary research.

Chapter 10.6 – Biomarkers of Joint Disease

R. Billinghurst, 2003 .

Changes in collagen turnover in early acute respiratory distress syndrome.

D. Thickett, L. Armstrong, A. Millar, 1999, American journal of respiratory and critical care medicine.

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

C. Rorabeck, H. V. Van Wart, A. Poole, 1997, The Journal of clinical investigation.

Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses.

C. Kawcak, D. Frisbie, C. McIlwraith, 2008, Osteoarthritis and cartilage.

Immunoassays for collagens in chondrocyte and cartilage explant cultures.

A. Hollander, F. Mwale, A. Robin Poole, 2004, Methods in molecular medicine.

Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis

S. Laverty, I. Pidoux, Y. Rossier, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Immunoassay for collagenase-mediated cleavage of types I and II collagens.

A. Robin Poole, M. Ionescu, R. Billinghurst, 2001, Methods in molecular biology.

Current and Future Diagnostic Means to Better Characterize Osteoarthritis in the Horse—Routine Synovial Fluid Analysis and Synovial Fluid and Serum Markers

D. Frisbie, C. McIlwraith, R. Billinghurst, 2001 .

The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone

H. Birkedal‐Hansen, P. Bianco, S. Yamada, 2005, Journal of Cell Science.

Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.

M. Markel, A. Poole, K. Hayashi, 2002, Osteoarthritis and cartilage.

Joint dependent concentrations of bone alkaline phosphatase in serum and synovial fluids of horses with osteochondral injury: an analytical and clinical validation.

R. Billinghurst, T. Trumble, K. Merritt, 2008, Osteoarthritis and cartilage.

Correlation of prostaglandin E2 concentrations in synovial fluid with ground reaction forces and clinical variables for pain or inflammation in dogs with osteoarthritis induced by transection of the cranial cruciate ligament.

C. McIlwraith, R. Billinghurst, T. Trumble, 2004, American journal of veterinary research.

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.

Alexander Fraser, Mirela Ionescu, Paul Emery, 2003, Arthritis and rheumatism.

Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.

P. Libby, G. Sukhova, U. Schönbeck, 1999, Circulation.

Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.

A R Poole, I. Pidoux, F Nelson, 2006, Osteoarthritis and cartilage.

Evaluation of changes in vertical ground reaction forces as indicators of meniscal damage after transection of the cranial cruciate ligament in dogs.

A. Bendele, C. McIlwraith, R. Billinghurst, 2005, American journal of veterinary research.

Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection.

A. Hollander, W. B. van den Berg, P. Buma, 2000, Arthritis and rheumatism.