B. Spenkelink

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Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation

I. Rietjens, Qianrui Wang, K. Beekmann, 2020, Molecular nutrition & food research.

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

I. Rietjens, J. Louisse, A. Punt, 2020, Journal of applied toxicology : JAT.

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling

I. Rietjens, J. Louisse, J. Ning, 2017, Archives of Toxicology.

Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations.

P. van Bladeren, I. Rietjens, A. Punt, 2015, Toxicology and applied pharmacology.

Interactive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoids on proliferation and differentiation in cultured human keratinocytes: quantification of cross-linked envelope formation

A. Brouwer, B. Blaauboer, B. Spenkelink, 2009, Archives of Toxicology.

Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests.

L. Kamelia, J. Vervoort, I. Rietjens, 2019, Journal of ethnopharmacology.

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat.

P. van Bladeren, I. Rietjens, A. Punt, 2012, Toxicology and applied pharmacology.

An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats.

D. Bosch, G. Alink, I. Rietjens, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models.

A. Murk, I. Rietjens, A. Punt, 2014, Molecular nutrition & food research.

Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

P. van Bladeren, G. Williamson, I. Rietjens, 2010, Journal of agricultural and food chemistry.

The use of biochemical parameters in comparative toxicological studies with the cormorant () in the Netherlands

A. Brouwer, T. Sinnige, M. Berg, 1992 .

Biochemical and toxic effects of polychlorinated biphenyls (PCBs), dibenzo-P-dioxins (PCDDs) and dibenzofurans (PCDFs) in the cormorant (phalacrocorax carbo) after in ovo exposure

A. Brouwer, S. Dirksen, M. Gaag, 1994 .

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

J. Vervoort, I. Rietjens, S. Wesseling, 2020, BMC Complementary Medicine and Therapies.

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

L. Kamelia, I. Rietjens, S. Wesseling, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models.

H. Bouwmeester, L. Duivenvoorde, M. van der Zande, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Differential toxicity as a result of apical and basolateral treatment of LLC-PK1 monolayers with S-(1,2,3,4,4-pentachlorobutadienyl)glutathione and N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine.

P. van Bladeren, J. Temmink, J. Weijnen, 1988, Chemico-biological interactions.

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

R. Woutersen, I. Rietjens, A. Punt, 2013, Archives of Toxicology.

Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay.

R. Woutersen, I. Rietjens, A. Punt, 2012, Toxicology letters.

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids.

J. V. van Zanden, N. Cnubben, J. Koeman, 2002, Environmental toxicology and pharmacology.

Patterns of variability of retinol levels in a harbour porpoise population from an unpolluted environment

A. Brouwer, A. Aguilar, C. Lockyer, 1999 .

Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.

J. Vervoort, I. Rietjens, A. Punt, 2012, Chemical research in toxicology.

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

I. Rietjens, S. Wesseling, B. Spenkelink, 2021, Archives of Toxicology.

Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity

R. Woutersen, I. Rietjens, A. Punt, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.

Alicia Paini, Benoît Schilter, Eric Gremaud, 2012, Mutagenesis.

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat.

Ans Punt, Ivonne M C M Rietjens, Jacques Vervoort, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol

I. Rietjens, Qianrui Wang, B. Spenkelink, 2021, Journal of agricultural and food chemistry.

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

R. Woutersen, I. Rietjens, A. Punt, 2013, Archives of Toxicology.

Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.

J. J. van de Sandt, J. Groten, G. Alink, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

P. van Bladeren, H. Wortelboer, J. V. van Zanden, 2003, Chemical research in toxicology.

Detection of hormonal anabolic compounds in calf urine and unverified growth-promoting preparations: application of the AR-LUX bioassay for screening and determination of androgenic activity.

R. Rodenburg, B. Blankvoort, J. Aarts, 2003, The Analyst.

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Ans Punt, Ivonne M C M Rietjens, Ruud A Woutersen, 2016, Archives of Toxicology.

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro

J. Vervoort, I. Rietjens, J. Louisse, 2019, PloS one.

The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances

L. Kamelia, P. Boogaard, I. Rietjens, 2019, Journal of applied toxicology : JAT.

Cytotoxicity of S-(1,2,3,4,4-pentachlorobutadienyl)-L cysteine after apical and basolateral exposure of LLC-PK monolayers. Involvement of an amino acid transport system.

P. van Bladeren, J. Temmink, B. Spenkelink, 1990, Chemico-biological interactions.

Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats.

A. Brouwer, I. Lutke-Schipholt, B. Spenkelink, 2001, Toxicological sciences : an official journal of the Society of Toxicology.