H. Kubota

发表

A Pyrazole Derivative Potently Inhibits Lymphocyte Ca2+ Influx and Cytokine Production by Facilitating Transient Receptor Potential Melastatin 4 Channel Activity

J. Kinet, R. Penner, A. Fleig, 2006, Molecular Pharmacology.

Development of a Practical and Scalable Synthesis of (R)- and (S)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block

M. Shibazaki, S. Yoshida, H. Kubota, 2012 .

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition.

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008, Bioorganic & medicinal chemistry.

Spiro-substituted piperidines as neurokinin receptor antagonists. II. Syntheses and NK2 receptor-antagonistic activities of N-[2-aryl-4-(spiro-substituted piperidin-1'-yl)butyl]carboxamides.

M. Takeuchi, Y. Isomura, T. Shibanuma, 1998, Chemical & pharmaceutical bulletin.

Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.

K. Ohno, M. Takeuchi, Keiko Suzuki, 2009, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.

M. Takeuchi, M. Ohta, T. Morokata, 2012, Bioorganic & medicinal chemistry letters.

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.

M. Takeuchi, Yoji Miyazaki, Y. Yonetoku, 2008, Bioorganic & medicinal chemistry.

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles.

M. Takeuchi, Y. Yonetoku, M. Ohta, 2006, Bioorganic & medicinal chemistry.

A novel dual antagonist of thromboxane A2 and leukotriene D4 receptors: synthesis and structure-activity relationships of chloroquinolylvinyl derivatives.

M. Takeuchi, H. Kubota, M. Yokota, 2006, Chemical & pharmaceutical bulletin.

RP67580, a neurokinin1 receptor antagonist, decreased restraint stress-induced defecation in rat

K. Tomioka, K. Ikeda, K. Miyata, 1995, Neuroscience Letters.

Synthesis and NK1 receptor antagonistic activity of (+/-)-1-acyl-3-(3,4- dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines.

M. Takeuchi, Y. Isomura, T. Shibanuma, 1998, Bioorganic & medicinal chemistry letters.

Spiro-substituted piperidines as neurokinin receptor antagonists. I. Design and synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro [isobenzofuran-1(3H),4'piperidin]-1'-yl)butyl]-N-methylbenzamide, YM-35375, as a new lead compound for novel neurokinin receptor antagonists.

M. Takeuchi, Y. Isomura, T. Shibanuma, 1998, Chemical & pharmaceutical bulletin.

LymphocytesInflux and IL-2 Production in T 2 + Inhibits Store-Operated Sustained Ca

A. Ichikawa, J. Ishikawa, H. Kubota, 2003 .

Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor.

H. Yamazaki, K. Ohno, M. Takeuchi, 2012, Journal of medicinal chemistry.

Synthesis of Optically Active Thromboxane A2 and Leukotriene D4 Receptor Antagonists

M. Takeuchi, M. Okada, T. Oriyama, 2014 .

6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor.

T. Furuya, K. Hidaka, M. Okada, 1994, Journal of medicinal chemistry.

A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes

A. Ichikawa, J. Ishikawa, H. Kubota, 2003, The Journal of Immunology.

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides.

M. Takeuchi, Y. Yonetoku, M. Ohta, 2006, Bioorganic & medicinal chemistry.

Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure−Activity Relationships of 6-(1H-Imidazol-1-yl)- 7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and Related Compounds

M. Okada, H. Kubota, S. Sakamoto, 1996 .

Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure-Activity Relationships of 6-(1H- Imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido(2,3-b)pyrazinedione and Related Compounds.

M. Okada, H. Kubota, S. Sakamoto, 1996 .

Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit.

H. Kubota, N. Nakagawa, Masataka Morita, 2019, Bioorganic & medicinal chemistry.

Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156]

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008 .