S. Shears

发表

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate

D. Armstrong, J. Putney, A. R. Hughes, 1991, Nature.

A Short Historical Perspective of Methods in Inositol Phosphate Research.

S. Shears, 2020, Methods in molecular biology.

The versatility of inositol phosphates as cellular signals.

S. Shears, 1998, Biochimica et biophysica acta.

Regulation of AP-3 Function by Inositides

G. Prestwich, J. Chen, J. Falck, 1997, The Journal of Biological Chemistry.

Inhibition of Clathrin Assembly by High Affinity Binding of Specific Inositol Polyphosphates to the Synapse-specific Clathrin Assembly Protein AP-3 (*)

M. Bembenek, E. Lafer, S. Shears, 1995, The Journal of Biological Chemistry.

Metabolic and signaling properties of an Itpk gene family in Glycine max

E. Grabau, A. R. Stiles, S. Shears, 2008, FEBS letters.

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

A. M. Riley, R. Xavier, S. Snyder, 2014, PLoS pathogens.

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.

Jeremy D. Weaver, A. Janoshazi, S. Shears, 2013, The Biochemical journal.

The Nucleolus Exhibits an Osmotically Regulated Gatekeeping Activity That Controls the Spatial Dynamics and Functions of Nucleolin*

C. Bortner, Jaiesoon Cho, Ling Yang, 2008, Journal of Biological Chemistry.

Signaling by Higher Inositol Polyphosphates

X. Pesesse, S. Shears, Kuicheon Choi, 2004, Journal of Biological Chemistry.

Inositol 1,3,4-Trisphosphate Acts in Vivo as a Specific Regulator of Cellular Signaling by Inositol 3,4,5,6-Tetrakisphosphate*

A. M. Riley, C. Schultz, M. Yoshida, 1999, The Journal of Biological Chemistry.

Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.

Xiaonian Yang, X. Yang, S. Shears, 2000, The Biochemical journal.

Inositol 3,4,5,6-Tetrakisphosphate Inhibits Insulin Granule Acidification and Fusogenic Potential*

E. Renström, S. Shears, Rosita Ivarsson, 2002, The Journal of Biological Chemistry.

Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

C. Gu, S. Riazuddin, Z. Ahmed, 2018, PLoS genetics.

Identification of a functional nuclear translocation sequence in hPPIP5K2

Manoj N. Krishnan, C. Bortner, Jason G. Williams, 2015, BMC Cell Biology.

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Huanchen Wang, Jeremy D. Weaver, S. Shears, 2012, Bioscience reports.

Inositol Pentakisphosphate: A Signal Transduction Hub

S. Shears, 2010 .

scyllo‐Inositol Pentakisphosphate as an Analogue of myo‐Inositol 1,3,4,5,6‐Pentakisphosphate: Chemical Synthesis, Physicochemistry and Biological Applications

A. M. Riley, M. Borkovec, B. Potter, 2006, Chembiochem : a European journal of chemical biology.

Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool.

M. Sulis, R. Parsons, X. Pesesse, 2006, Cellular signalling.

The Inositol Hexakisphosphate Kinase Family

S. Snyder, A. Saiardi, J. Caffrey, 2000, Journal of Biological Chemistry.

Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae

S. Snyder, A. Saiardi, J. Caffrey, 2000, FEBS letters.

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

S. Frye, K. Pearce, Huanchen Wang, 2016, PloS one.

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

A. M. Riley, L. Perera, Huanchen Wang, 2022, Nature Communications.

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

Huanchen Wang, D. Fiedler, H. Jessen, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family

Huanchen Wang, R. London, E. DeRose, 2014, Nature Communications.

InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

C. Gu, Huanchen Wang, D. Fiedler, 2020, Proceedings of the National Academy of Sciences.

Signal transduction during environmental stress: InsP8 operates within highly restricted contexts.

S. Shears, Kuicheon Choi, E. Mollapour, 2005, Cellular signalling.

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP 8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

Huanchen Wang, H. Jessen, Nikolaus Jork, 2020 .

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

Huanchen Wang, H. Jessen, Nikolaus Jork, 2020, Chemical science.

Cystic Fibrosis Airway Epithelial Ca2+i Signaling

R. Boucher, A. M. Paradiso, S. Shears, 2005, Journal of Biological Chemistry.

Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

R. Michell, R. Irvine, S. Shears, 1987, The Biochemical journal.

Flavored E-liquids Increase Cytoplasmic Ca2+ Levels in Airway Epithelia.

G. Glish, R. Tarran, J. E. Keating, 2019, American journal of physiology. Lung cellular and molecular physiology.

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells

C. Gu, J. Gromada, M. Köhler, 2018, Cellular signalling.

Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling

S. Shears, 2018, Journal of cellular physiology.

Cellular Energetic Status Supervises the Synthesis of Bis-Diphosphoinositol Tetrakisphosphate Independently of AMP-Activated Protein Kinase

S. Shears, Kuicheon Choi, Jae H. Choi, 2008, Molecular Pharmacology.

Metabolism of the inositol phosphates produced upon receptor activation.

S. Shears, S. B. Shears, 1989, The Biochemical journal.

Long-term uncoupling of chloride secretion from intracellular calcium levels by lns(3,4,5,6)P4

R. Tsien, C. Schultz, K. Barrett, 1994, Nature.

D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways.

R. Tsien, M. Kagnoff, L. Eckmann, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate.

D. J. Storey, A. B. Cubitt, A. Morris, 1987, The Biochemical journal.

The Effects of Mastoparan on the Carrot Cell Plasma Membrane Polyphosphoinositide Phospholipase C

C. Erneux, W. Boss, M. Cho, 1995, Plant physiology.

Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6‐pentakisphosphate 3‐phosphatase activity

M. Wenk, J. Caffrey, S. Shears, 2001, FEBS letters.

Regulation of a Human Chloride Channel A PARADIGM FOR INTEGRATING INPUT FROM CALCIUM, TYPE II CALMODULIN-DEPENDENT PROTEIN

D. Armstrong, M. Kaetzel, S. Shears, 2001 .

27 – Measurement of Receptor-Activated Accumulation of Inositol Phosphates as an Index of Phospholipase C Activity

S. Shears, 1994 .

Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate

Huanchen Wang, H. Jessen, A. Janoshazi, 2018, Bioscience reports.

Inositol pyrophosphates: why so many phosphates?

S. Shears, 2015, Advances in biological regulation.

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA

G. Mayr, Jason G. Williams, M. Brehm, 2013, Journal of Cell Science.

Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.

F. Menniti, J. Putney, R. Miller, 1993, The Journal of biological chemistry.

Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling

Huanchen Wang, D. Fiedler, H. Jessen, 2020, Proceedings of the National Academy of Sciences.

Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages

W. Glasgow, T. Eling, S. Shears, 1995, Journal of virology.

Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain.

S. Shears, N. Gokhale, A. Zaremba, 2011, The Biochemical journal.

Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis

S. Gabriel, Ling Yang, S. Shears, 2006, Journal of Cell Science.

An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function

M. Gentzsch, D. Nelson, S. Shears, 2008, Current Biology.

Can intervention in inositol phosphate signalling pathways improve therapy for cystic fibrosis?

S. Shears, 2005, Expert opinion on therapeutic targets.

Regulation of Ins(3,4,5,6)P4 Signaling by a Reversible Kinase/Phosphatase

A. M. Riley, B. Potter, Yong‐Uk Kwon, 2002, Current Biology.

myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line.

C. Schultz, X. Yang, S. Shears, 2000, The Journal of biological chemistry.

Signalling by inositides : a practical approach

S. Shears, 1997 .

Inositol 3,4,5,6-Tetrakisphosphate Inhibits the Calmodulin-dependent Protein Kinase II-activated Chloride Conductance in T84 Colonic Epithelial Cells*

M. Kaetzel, J. Dedman, K. Bruzik, 1996, The Journal of Biological Chemistry.

Origins of myo-inositol tetrakisphosphates in agonist-stimulated rat pancreatoma cells. Stimulation by bombesin of myo-inositol 1,3,4,5,6-pentakisphosphate breakdown to myo-inositol 3,4,5,6-tetrakisphosphate.

F. Menniti, J. Putney, J. Obie, 1990, The Journal of biological chemistry.

The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.

S. Shears, 1989, The Journal of biological chemistry.

Inhibition by inositoltetrakisphosphates of calcium- and volume-activated Cl– currents in macrovascular endothelial cells

B. Nilius, T. Voets, G. Droogmans, 1998, Pflügers Archiv.

Ins(3,4,5,6)P4 specifically inhibits a receptor-mediated Ca2+-dependent Cl- current in CFPAC-1 cells.

A. S. French, K. Bruzik, S. Shears, 1997, The American journal of physiology.

Chapter 160 - Ins(1,3,4,5,6)P 5 : A Signal Transduction Hub

S. Shears, 2003 .

Properties of the Inositol 3,4,5,6-Tetrakisphosphate 1-Kinase Purified from Rat Liver

K. Bruzik, S. Shears, Z. Tan, 1997, The Journal of Biological Chemistry.

Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase.

C. Erneux, A. Craxton, S. Shears, 1994, The Journal of biological chemistry.

Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity.

J. Putney, P. Hughes, M. E. Hodgson, 1991, The Journal of biological chemistry.

Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo

H. Chi, J. Puzas, P. Reynolds, 2000, Molecular and Cellular Biology.

Faculty Opinions recommendation of Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.

S. Shears, 2011 .

Regulation of Ca2+‐dependent Cl− conductance in a human colonic epithelial cell line (T84): cross‐talk between Ins(3,4,5,6)P4 and protein phosphatases

S. Freeman, M. Kaetzel, K. Bruzik, 1998, The Journal of physiology.

Turnover of bis‐diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by β2‐adrenergic receptors through a cAMP‐mediated, A‐kinase‐independent mechanism

S. Safrany, S. Shears, Stephen B. Shears, 1998, The EMBO journal.

Is Intervention in Inositol Phosphate Signaling a Useful Therapeutic Option for Cystic Fibrosis

S. Gabriel, Ling Yang, Carla M. P. Ribeiro, 2005 .

Metabolism of inositol phosphates.

S. Shears, 1992, Advances in second messenger and phosphoprotein research.

Regulation of the metabolism of 1,2-diacylglycerols and inositol phosphates that respond to receptor activation.

S. Shears, 1991, Pharmacology & therapeutics.

Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.

Huanchen Wang, D. Fiedler, N. Veiga, 2016, Chemistry.

Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation.

Huanchen Wang, H. Jessen, Samanta Capolicchio, 2014, Angewandte Chemie.

The mitochondrial protonic electrochemical potential difference as a point of hormone action. II. New proposals for the activity of glucagon.

S. Shears, 1981, Journal of theoretical biology.

Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells

Sindura B. Ganapathi, F. Lamb, S. Shears, 2013, Hypertension.

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

J. Locasale, Ji Luo, Huanchen Wang, 2021, Proceedings of the National Academy of Sciences.

The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity

J. Caffrey, S. Shears, Tong Zhang, 2001, FEBS letters.

Inositol phosphate metabolism: further problems and some solutions.

S. Shears, 1989, Cellular signalling.

The influence of thyroxine administered in vivo on the transmembrane protonic electrochemical potential difference in rat liver mitochondria.

J. R. Bronk, S. Shears, 1979, The Biochemical journal.

Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.

S. Fleischer, D. Palmer, J. Xie, 1994, The Journal of biological chemistry.

CHAPTER 13 – REGULATION OF THE METABOLISM OF 1,2-DIACYLGLYCEROLS AND INOSITOL PHOSPHATES THAT RESPOND TO RECEPTOR ACTIVATION

S. Shears, 1993 .

Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?

S. Safrany, J. Caffrey, X. Yang, 1999, Biological chemistry.

The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.

H. Takeuchi, M. Hirata, T. Kanematsu, 2003, Experimental cell research.

Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2.

J. Caffrey, S. Shears, 2001, Gene.

A novel context for the ‘MutT’ module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase

Xiaonian Yang, S. Safrany, M. Moyer, 1998, The EMBO journal.

Synthesis and Metabolism of Bis-diphosphoinositol Tetrakisphosphate in Vitro and in Vivo(*)

M. Bembenek, A. Craxton, S. Shears, 1995, The Journal of Biological Chemistry.

Ion transport in liver mitochondria from normal and thyroxine-treated rats

J. R. Bronk, S. Shears, 1980, Journal of bioenergetics and biomembranes.

Telomere maintenance by intracellular signals: new kid on the block?

S. Shears, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

D. McCormick, A. Lüthi, R. Flavell, 1999, Cell.

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis".

P. Reynolds, J. Petitte, Jaiesoon Cho, 2006, Journal of biotechnology.

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

C. Brearley, P. Bailey, A. Hemmings, 2014, Cell reports.

Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration*

P. Berggren, B. Leibiger, I. Leibiger, 2003, Journal of Biological Chemistry.

Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Huanchen Wang, Michael K. Johnson, H. Jessen, 2015, Biochemistry.

Diphosphoinositol Polyphosphates: Metabolic Messengers?

S. Shears, 2009, Molecular Pharmacology.

Microsoft Word-38259283-file00

S. Shears, Inositide, 2009 .

Assessing the omnipotence of inositol hexakisphosphate.

S. Shears, S. B. Shears, 2001, Cellular signalling.

Pregnenolone efflux from mitochondria of bovine adrenal cortex.

G. S. Boyd, S. Shears, 1982, European journal of biochemistry.

The effect of azastene, cyanoketone and trilostane upon respiration and cleavage of the cholesterol side chain in mitochondria from bovine adrenal cortex.

G. S. Boyd, S. Shears, 2005, European journal of biochemistry.

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Ryan P. McNabb, J. Rotter, Y. Rabinowitz, 2019, Scientific Reports.

Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.

Huanchen Wang, S. Shears, 2019, Advances in biological regulation.

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.

Tobias M. H. Schenk, G. Mayr, M. Nalaskowski, 2007, The Biochemical journal.

Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7

A. M. Riley, Huanchen Wang, B. Potter, 2019, MedChemComm.

How versatile are inositol phosphate kinases?

S. Shears, 2004, The Biochemical journal.

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

D. J. Storey, R. Michell, S. Shears, 1984, Nature.

Regulation of calcium-activated chloride channels by inositol 3,4,5,6 tetrakisphosphate

S. Shears, M. Ho, 2002 .

The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?

Y. Hayakawa, S. Shears, 2018, Cytokine.

Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP

H. Matsumoto, Masasuke Ryuda, S. Tsuzuki, 2014, Nature Communications.

Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

A. M. Riley, Solomon H. Snyder, Ramnik J. Xavier, 2014, PLoS Pathogens.

The effects of thyroxine treatment, in vivo and in vitro, on Ca2+ efflux from rat liver mitochondria

J. R. Bronk, S. Shears, 1981, FEBS letters.

Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells.

R. Michell, C. J. Barker, S. Shears, 1988, The Biochemical journal.

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells

F. Granucci, S. Schurmans, M. Garrè, 2021, Science Signaling.

In Saccharomyces cerevisiae, the Inositol Polyphosphate Kinase Activity of Kcs1p Is Required for Resistance to Salt Stress, Cell Wall Integrity, and Vacuolar Morphogenesis*

E. Dubois, F. Messenguy, B. Scherens, 2002, The Journal of Biological Chemistry.

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Thomas M. Haas, A. Saiardi, D. Fiedler, 2020, Nature Communications.

Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway.

D. Burstein, M. Lisanti, C. Chu, 2004, Cellular signalling.

Discovery of Molecular and Catalytic Diversity among Human Diphosphoinositol-Polyphosphate Phosphohydrolases

Xiaonian Yang, S. Safrany, J. Caffrey, 2000, The Journal of Biological Chemistry.

Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates

Huanchen Wang, R. Rolfes, H. Jessen, 2018, The Journal of Biological Chemistry.

Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs

R. S. Kilari, Jeremy D. Weaver, S. Safrany, 2013, FEBS letters.

Structural insight into inositol pyrophosphate turnover.

Huanchen Wang, Jeremy D. Weaver, S. Shears, 2013, Advances in biological regulation.

Diphosphoinositol polyphosphates: what are the mechanisms?

Huanchen Wang, S. Shears, N. Gokhale, 2011, Advances in enzyme regulation.

The Metabolism and the Functions of Diphosphoinositol Polyphosphates

S. Shears, 2009 .

Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress*

J. Falck, Jaiesoon Cho, Jason G. Williams, 2007, Journal of Biological Chemistry.

Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.

L. D. Barnes, X. Pesesse, S. Shears, 2003, The Biochemical journal.

An Adjacent Pair of Human NUDT Genes on Chromosome X Are Preferentially Expressed in Testis and Encode Two New Isoforms of Diphosphoinositol Polyphosphate Phosphohydrolase*

L. D. Barnes, L. Carrel, J. Falck, 2002, The Journal of Biological Chemistry.

Site-directed Mutagenesis of Diphosphoinositol Polyphosphate Phosphohydrolase, a Dual Specificity NUDT Enzyme That Attacks Diadenosine Polyphosphates and Diphosphoinositol Polyphosphates*

Xiaonian Yang, S. Safrany, S. Shears, 1999, The Journal of Biological Chemistry.

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.

G. Mayr, J. Falck, J. Falck, 1997, The Biochemical journal.

The interaction of coatomer with inositol polyphosphates is conserved in Saccharomyces cerevisiae.

R. Duden, M. Bembenek, S. Shears, 1995, The Biochemical journal.

Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytes.

S. Shears, M. C. Glennon, M. Glennon, 1993, The Biochemical journal.

Respiration and pregnenolone synthesis in bovine adrenal cortex mitochondria

G. S. Boyd, S. Shears, 1982, FEBS letters.

A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization

L. Hernandez, J. Galán, Daoguo Zhou, 2001, Molecular microbiology.

α1-Adrenergic Receptors Mediate LH-Releasing Hormone Secretion through Phospholipases C and A2 in Immortalized Hypothalamic Neurons.

W. Wetsel, S. Collins, S. Fillo, 2001, Endocrinology.

Transcriptional regulation: a new dominion for inositol phosphate signaling?

S. Shears, 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

Defining signal transduction by inositol phosphates.

Tobias M. H. Schenk, Huanchen Wang, Jeremy D. Weaver, 2012, Sub-cellular biochemistry.

On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate

A. M. Riley, B. Potter, S. Adelt, 2006, FEBS letters.

Regiospecific phosphohydrolases from Dictyostelium as tools for the chemoenzymatic synthesis of the enantiomers D-myo-inositol 1,2,4-trisphosphate and D-myo-inositol 2,3,6-trisphosphate: non-physiological, potential analogues of biologically active D-myo-inositol 1,3,4-trisphosphate.

G. Dallmann, O. Plettenburg, S. Adelt, 2001, Bioorganic & medicinal chemistry letters.

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport–Luebering glycolytic shunt

A. Harwood, Jaiesoon Cho, J. King, 2008, Proceedings of the National Academy of Sciences.

KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype

Huanchen Wang, D. Ganini, Zhaowei Chen, 2017, Proceedings of the National Academy of Sciences.

Metabolism of Ins(1,3,4)P3 by Rat Liver Homogenates

R. Michell, R. Irvine, S. Shears, 1989 .

Preferential localization of rat liver D-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and 'late' endosomal vesicles.

W. H. Evans, R. Michell, S. Shears, 1988, The Biochemical journal.

Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress

J. Putney, Huanchen Wang, H. Matsumoto, 2017, Proceedings of the National Academy of Sciences.

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

D. Fiedler, J. Gordon, R. Stanley, 2023, Biomolecules.

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

A. Gruzdev, B. Bengsch, H. Jessen, 2022, bioRxiv.

Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Huanchen Wang, S. Shears, 2020, Molecules.

A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase.

Huanchen Wang, T. Randall, S. Shears, 2019, Advances in biological regulation.

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels

A. Saiardi, H. Jessen, S. Shears, 2016, PloS one.

Ca2+ transport and Ca2+-dependent ATP hydrolysis by Golgi vesicles from lactating rat mammary glands.

S. Shears, S. S. Virk, C. Kirk, 1985, The Biochemical journal.

Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme.

A. Craxton, S. Shears, N. Ali, 1995, The Biochemical journal.

Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity.

H. Takeuchi, M. Hirata, H. Yagisawa, 1996, The Biochemical journal.

Calcium uptake by intracellular compartments in permeabilised enterocytes. Effect of inositol 1,4,5 trisphosphate.

R. Michell, P. S. Lazo, S. Shears, 1986, Biochemical and biophysical research communications.

The thyroid gland and the liver mitochondrial protonic electrochemical potential difference: a novel hormone action?

S. Shears, 1980, Journal of theoretical biology.

Inositol phosphates and cell signaling: new views of InsP5 and InsP6.

K G Oliver, F. Menniti, J. Putney, 1993, Trends in biochemical sciences.

Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.

Huanchen Wang, D. Kireev, H. Jessen, 2019, Structure.

Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities

Huanchen Wang, S. Shears, 2017, The Journal of Biological Chemistry.

Synthesis of an alpha-phosphono-alpha , alpha-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7.

A. M. Riley, Huanchen Wang, B. Potter, 2019 .

Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery

A. M. Riley, Huanchen Wang, H. Y. Godage, 2014, Chemistry & biology.

Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

S. Frye, K. Pearce, Huanchen Wang, 2019, Journal of medicinal chemistry.

Towards pharmacological intervention in inositol pyrophosphate signalling.

S. Shears, 2016, Biochemical Society transactions.

Synthetic tools for studying the chemical biology of InsP8 † †Electronic supplementary information (ESI) available: Data deposition: atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID codes 5BYA and 5BYB). See DOI: 10.1039/c5cc05017k

A. M. Riley, Huanchen Wang, S. Shears, 2015, Chemical communications.

Identification of a functional nuclear translocation sequence in hPPIP5K2

Manoj N. Krishnan, C. Bortner, S. Yong, 2015, BMC Cell Biology.

Inositol pentakis- and hexakisphosphate metabolism adds versatility to the actions of inositol polyphosphates. Novel effects on ion channels and protein traffic.

S. Shears, 1996, Sub-cellular biochemistry.

Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs

Huanchen Wang, S. Shears, G. Zong, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family.

Huanchen Wang, Brandi M Baughman, S. Shears, 2017, Advances in biological regulation.

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Huanchen Wang, J. Falck, J. Falck, 2011, Nature chemical biology.

Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases*

J. York, G. Mayr, J. Falck, 2009, Journal of Biological Chemistry.

Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').

S. Shears, 2007, Biochemical Society symposium.

Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress

Y. Hayakawa, S. Shears, 2019, Front. Physiol..

Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

Huanchen Wang, Y. Hayakawa, Shilan Wu, 2012, The Biochemical journal.

A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging

Eui Jae Sung, S. Shears, 2018, BMC Research Notes.

Integration of Inositol Phosphate Signaling Pathways via Human ITPK1*

G. Spraggon, S. Lesley, David H. Jones, 2007, Journal of Biological Chemistry.

The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.

R. Petrovich, Sung-Jen Wei, Jason G. Williams, 2005, The Biochemical journal.

The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cells.

J. Putney, J. Obie, S. Shears, 1992, The Journal of biological chemistry.

Cell signaling by a physiologically reversible inositol phosphate kinase/phosphatase.

Ling Yang, S. Shears, Xun Qian, 2004, Advances in enzyme regulation.

Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1.

S. Shears, 2009, Advances in enzyme regulation.

Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.

S. Safrany, A. Craxton, W. Burkhart, 1997, The Biochemical journal.

Hepatic Ins(1,3,4,5)P4 3-phosphatase is compartmentalized inside endoplasmic reticulum.

A. Craxton, S. Shears, N. Ali, 1993, The Journal of biological chemistry.

Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P.

M. Moyer, G. Czirják, P. Enyedi, 1999, Biochimica et biophysica acta.

Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column.

G. Prestwich, P. Hughes, J. Marecek, 1992, The Journal of biological chemistry.

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular-fractionation technique. Alpha-adrenergic agonists do not mobilize mitochondrial Ca2+.

S. Shears, C. Kirk, 1984, The Biochemical journal.

The regulation of the phosphorylation of inositol 1,3,4-trisphosphate in cell-free preparations and its relevance to the formation of inositol 1,3,4,6-tetrakisphosphate in agonist-stimulated rat parotid acinar cells.

J. Putney, P. Hughes, A. R. Hughes, 1989, The Journal of biological chemistry.

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular fractionation technique. Vasopressin stimulates mitochondrial Ca2+ uptake.

S. Shears, C. Kirk, 1984, Biochemical Journal.

Regulation of a Human Chloride Channel

D. Armstrong, M. Kaetzel, S. Shears, 2001, The Journal of Biological Chemistry.

Phosphatidylinositol and inositol phosphate metabolism.

R. Anderson, S. Shears, R. Anderson, 2001, Journal of cell science.

Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands.

P. Hughes, S. Shears, 1990, Journal of Biological Chemistry.

Changes in Phosphatidylinositol Metabolism in Response to Hyperosmotic Stress in Daucus carota L. Cells Grown in Suspension Culture

W. Boss, M. Cho, S. Shears, 1993, Plant physiology.

Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5) trisphosphate and inositol (1,3,4,5) tetrakisphosphate in liver. Different effects upon the 3- and 5-phosphatases.

S. Shears, 1990, Cellular signalling.

Signals | The Inositol Pyrophosphate Signaling Family

S. Shears, Soumyadip Sahu, 2021 .

A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis

Shaomeng Wang, Xin Song, Z. Fan, 2011, Molecular Carcinogenesis.

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis*

Xuming Dai, Huanchen Wang, Huanchen Wang, 2017, The Journal of Biological Chemistry.

The Diadenosine Hexaphosphate Hydrolases fromSchizosaccharomyces pombe andSaccharomyces cerevisiae Are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase

L. D. Barnes, A. McLennan, J. Falck, 1999, The Journal of Biological Chemistry.

Permeability properties of isolated enterocytes from rat small intestine.

P. Domínguez, P. S. Lazo, S. Shears, 1986, Biochimica et biophysica acta.

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Huanchen Wang, P. Berggren, C. J. Barker, 2018, Cellular signalling.

Nomenclature and terminology of inositol phosphates: clarification and a glossary of terms.

Benjamin L Turner, A. Richardson, S. Shears, 2007 .

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

P. Berggren, B. Leibiger, I. Leibiger, 2023, Biomolecules.

HIV‐1 envelope protein, gp120, has no effects on inositol phosphate production and metabolism in the Jurkat T‐cell line either in the presence or absence of receptor stimulation

S. Shears, M. Sumner, Stephen B Shears, 1997, FEBS letters.

Pathogenicity of Salmonella: SopE‐mediated membrane ruffling is independent of inositol phosphate signals

S. Shears, S. Deleu, J. Reece, 2006, FEBS letters.

Cystic Fibrosis Airway Epithelial Ca 2 i Signaling THE MECHANISM FOR THE LARGER AGONIST-MEDIATED Ca

R. Boucher, A. M. Paradiso, S. Shears, 2005 .

The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up‐regulated during endochondral ossification

M. Matsuda, M. Hirata, J. Caffrey, 1999, FEBS letters.

Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling

D. McCormick, H. Horvitz, E. Jorgensen, 2000, The Journal of cell biology.

Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.

K. Pearce, Huanchen Wang, M. Chakraborty, 2022, Journal of medicinal chemistry.

Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C.

C. Erneux, C. Moreau, S. Shears, 2000, The Biochemical journal.

A Novel, Phospholipase C-independent Pathway of Inositol 1,4,5-Trisphosphate Formation in Dictyostelium and Rat Liver (*)

P. V. van Haastert, C. Erneux, A. Craxton, 1995, The Journal of Biological Chemistry.

Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors

S. Frye, K. Pearce, Huanchen Wang, 2018, SLAS discovery : advancing life sciences R & D.

Polarized subcellular distribution of the 1-, 4- and 5-phosphatase activities that metabolize inositol 1,4,5-trisphosphate in intestinal epithelial cells.

P. S. Lazo, S. Shears, C. Rubiera, 1990, Biochemical Journal.

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

C. Brearley, P. Bailey, A. Hemmings, 2014, Cell reports.

The effects of some mitochondrial translocase inhibitors on the activity of rat liver transhydrogenase.

S. Shears, H. Matarira, P. Jocelyn, 1982, Biochemical pharmacology.

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport–Luebering glycolytic shunt

A. Harwood, Jaiesoon Cho, J. King, 2008, Proceedings of the National Academy of Sciences.

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.

Jeremy D. Weaver, A. Janoshazi, S. Shears, 2013, The Biochemical journal.

Near-equilibrium model is insufficient

S. Shears, 1979 .

IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight.

Huanchen Wang, S. Shears, Xingyao Li, 2023, Advances in biological regulation.

Transcriptional regulation: a new dominion for inositol phosphate signaling?

S. Shears, 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.