A. Portale

P. Stock, S. Gitelman, A. Posselt, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The clinical impact of humoral immunity in pediatric renal transplantation.

M. Sarwal, E. Kamil, T. Sigdel, 2013, Journal of the American Society of Nephrology : JASN.

Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency.

R. Morris, B. Halloran, A. Portale, 1984, The Journal of clinical investigation.

Persistent secondary hyperparathyroidism after renal transplantation in children

J. Neuhaus, A. Portale, M. Matsuda-Abedini, 2006, Pediatric Nephrology.

Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice.

H. Tenenhouse, T. Yamashita, Martin Y. H. Zhang, 2005, Endocrinology.

Nutritional management of chronic renal disease.

M. Holliday, A. Portale, K. McHenry-Richardson, 1979, The Medical clinics of North America.

Dietary potassium influences kidney maintenance of serum phosphorus concentration.

R. Morris, A. Sebastian, J. Colman, 1990, Kidney international.

Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men.

E. Lonergan, B. Halloran, D. Tanney, 1997, The American journal of physiology.

Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro.

W. Miller, Xuemei Wang, Martin Y. H. Zhang, 2002, The Journal of clinical endocrinology and metabolism.

Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels.

S. T. Harris, D. Bikle, B. Halloran, 1992, The Journal of clinical endocrinology and metabolism.

Vitamin D metabolism: the effects of aging.

D. Feldman, B. Halloran, A. Portale, 1997 .

A Randomized, Double‐Blind, Placebo‐Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti‐FGF23 Antibody, in Adults With X‐Linked Hypophosphatemia: Week 24 Primary Analysis

J. S. San Martin, R. Lachmann, H. Cheong, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families.

M. Labuda, W. Miller, G. K. Fu, 1998, American journal of human genetics.

Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency.

R. Morris, H. Tsai, A. Portale, 1982, Kidney international.

The Mechanism of 1,25-Dihydroxyvitamin D3Autoregulation in Keratinocytes*

W. Miller, D. Bikle, N. Huang, 2002, The Journal of Biological Chemistry.

Dietary Phosphorus Transcriptionally Regulates 25-Hydroxyvitamin D-1α-Hydroxylase Gene Expression in the Proximal Renal Tubule.

Jonathan T. Wang, W. Miller, Xuemei Wang, 2002, Endocrinology.

Human 25-hydroxyvitamin D-1α-hydroxylase: cloning, mutations, and gene expression

W. Miller, A. Portale, 2000, Pediatric Nephrology.

Reduced expression of the renal calcium-sensing receptor in rats with experimental chronic renal insufficiency.

H. T. Nguyen, M. Y. Zhang, A. Portale, 1998, Journal of the American Society of Nephrology : JASN.

Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study

R. Eastell, S. Ralston, M. Brandi, 2022, Calcified Tissue International.

Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial

F. Glorieux, H. Cheong, E. Sochett, 2019, The Lancet.

A review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial

M. Mitsnefes, S. Mendley, I. Salusky, 2022, Pediatric Nephrology.

Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial

J. S. San Martin, F. Rauch, T. Kubota, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Burosumab Therapy in Children with X‐Linked Hypophosphatemia

J. S. San Martin, M. Whyte, A. Linglart, 2018, The New England journal of medicine.

Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.

F. Glorieux, M. Peacock, J. Humphrey, 2015, The Journal of clinical endocrinology and metabolism.

Association Between Chronic Kidney Disease–Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study

J. Yokoyama, S. Hooper, S. Furth, 2020, Kidney medicine.

Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men.

T. Yamashita, A. Portale, D. Antoniucci, 2006, The Journal of clinical endocrinology and metabolism.

Correction to: An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis

H. Zhang, S. Shahinfar, I. Salusky, 2018, Pediatric nephrology (Berlin, West).

An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis

S. Shahinfar, I. Salusky, Edward Lee, 2018, Pediatric Nephrology.

Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial

F. Glorieux, H. Cheong, E. Sochett, 2019, The Lancet.

Fibroblast growth factor 23 regulates renal 1,25‐dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice

Martin Y. H. Zhang, Daniel Ranch, A. Portale, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Emerging topics in pediatric bone and mineral disorders 2008.

C. McKay, A. Portale, 2009, Seminars in nephrology.

Genetic causes of rickets.

W. Miller, A. Portale, 1999, Current opinion in pediatrics.

Burosumab versus continuation of conventional therapy in children with X-linked hypophosphatemia: a randomised, active-controlled, open-label, phase 3 trial

Farzana, F. Glorieux, H. Cheong, 2020 .

Burosumab Therapy for X-Linked Hypophosphatemia and Therapeutic Implications for CKD.

A. Portale, Farzana Perwad, 2019, Clinical journal of the American Society of Nephrology : CJASN.

Pharmacokinetics and pharmacodynamics of a human monoclonal anti‐FGF23 antibody (KRN23) in the first multiple ascending‐dose trial treating adults with X‐linked hypophosphatemia

F. Glorieux, M. Peacock, J. Humphrey, 2015, Journal of clinical pharmacology.

Aging and renal responsiveness to parathyroid hormone in healthy men.

E. Lonergan, B. Halloran, A. Portale, 1996, The Journal of clinical endocrinology and metabolism.

Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease

S. Furth, J. Fadrowski, B. Warady, 2018, Pediatric Nephrology.

Effect of KRN23, a fully human anti-FGF23 monoclonal antibody, on rickets in children with X-linked hypophosphatemia (XLH): 40-week interim results from a randomized, open-label phase 2 study

S. Agarwal, M. Whyte, W. Hoff, 2016 .

Blood calcium, phosphorus, and magnesium

A. Portale, 1993 .

Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency.

Amita Sharma, W. Miller, N. Huang, 2007, The Journal of clinical endocrinology and metabolism.

Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation.

J. Sorof, M. Koerper, K. Desantes, 1995, Transplantation.

Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats.

T. Kurtz, R. Morris, A. Portale, 1986, Hypertension.

Vitamin D 1 alpha-hydroxylase.

W. Miller, A. Portale, 2000, Trends in endocrinology and metabolism: TEM.

Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease

K. Johansen, A. Portale, Aalia Akber, 2014, Pediatric Nephrology.

Renal osteodystrophy in children: the role of vitamin D, phosphorus, and parathyroid hormone.

R. Chesney, J. Mahan, O. Mehls, 1986, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Comparison of continuous ambulatory peritoneal dialysis and hemodialysis in children.

A. Portale, D. Potter, E. San Luis, 1986, Kidney international. Supplement.

Complete Structure of the Human Gene for the Vitamin D 1α-Hydroxylase, P450c1α

W. Miller, G. K. Fu, A. Portale, 1997 .

Rickets Due to Hereditary Abnormalities of Vitamin D Synthesis or Action

W. Miller, A. Portale, Farzana Perwad, 2012 .

CHAPTER 24 – Rickets Due to Hereditary Abnormalities of Vitamin D Synthesis or Action

W. Miller, A. Portale, 2003 .

Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure.

B. Hoppe, M. Kemper, C. Langman, 1999, Kidney international.

Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.

R. Morris, B. Halloran, A. Portale, 1989, The Journal of clinical investigation.

K/DOQI clinical practice guidelines for bone metabolism and disease in children with chronic kidney disease: Work group membership

B. Jaber, N. Powe, G. Eknoyan, 2005 .

Pathogenesis of secondary hyperparathyroidism in chronic renal insufficiency.

R. Morris, A. Portale, 1991, Mineral and electrolyte metabolism.

Foscarnet-induced hypocalcemia and effects of foscarnet on calcium metabolism.

M. Jacobson, F. Aweeka, J. Gambertoglio, 1991, The Journal of clinical endocrinology and metabolism.

Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1.

W. Miller, C. Shackleton, D. Lin, 1997, Molecular endocrinology.

Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha.

W. Miller, G. K. Fu, A. Portale, 1997, DNA and cell biology.

Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.

H. Tenenhouse, Martin Y. H. Zhang, A. Portale, 2007, American journal of physiology. Renal physiology.

Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone

M. Schambelan, R. Recker, Q. Duh, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Altered diurnal regulation of blood ionized calcium and serum parathyroid hormone concentrations during parenteral nutrition.

J. Veldhuis, W. Goodman, I. Salusky, 2000, The American journal of clinical nutrition.

Nephrogenic syndrome of inappropriate antidiuresis.

S. Gitelman, W. Miller, R. Lustig, 2005, The New England journal of medicine.

Are blood transfusions beneficial in the cyclosporine era?

O. Salvatierra, M. Garovoy, N. Feduska, 2004, Pediatric Nephrology.

Complete Steroid Avoidance Is Effective and Safe in Children With Renal Transplants: A Multicenter Randomized Trial With Three‐Year Follow‐Up

M. Sarwal, E. Kamil, T. Sigdel, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A Peripheral Blood Diagnostic Test for Acute Rejection in Renal Transplantation

A. Butte, P. Khatri, M. Sarwal, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Fibroblast Growth Factor 23 and Risk of CKD Progression in Children.

M. Wolf, S. Messinger, S. Furth, 2016, Clinical journal of the American Society of Nephrology : CJASN.

Genetics of vitamin D biosynthesis and its disorders.

W. Miller, A. Portale, 2001, Best practice & research. Clinical endocrinology & metabolism.

Factors and Microalbuminuria in Adolescents Being Overweight Modifies the Association between Cardiovascular Risk

C. McCulloch, Chi-yuan Hsu, A. Portale, 2022 .

Genetics of Vitamin D 1α-Hydroxylase Deficiency in 17 Families

Jonathan T. Wang, M. Labuda, W. Miller, 1998 .

Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation

A. Quan, J. Lavine, A. Portale, 1995, Pediatric Nephrology.

Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age.

R. Morris, E. Lonergan, B. Halloran, 1990, The Journal of clinical endocrinology and metabolism.

Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans.

R. Morris, B. Halloran, A. Portale, 1986, The Journal of clinical investigation.

Serum concentration of 1,25-dihydroxyvitamin D in the human: diurnal variation.

R. Morris, B. Halloran, R. Goldsmith, 1985, The Journal of clinical endocrinology and metabolism.

Liquid-chromatographic measurements of inosine, hypoxanthine, and xanthine in studies of fructose-induced degradation of adenine nucleotides in humans and rats.

T. Kurtz, R. Morris, H. Tsai, 1986, Clinical chemistry.

Hemoperfusion in a child who ingested diquat and died from pontine infarction and hemorrhage.

S. Pond, A. Portale, D. Powell, 1983, Journal of toxicology. Clinical toxicology.

Chapters and Other Papers 1-6-2018 FGF 23 and Left Ventricular Hypertrophy in Children with CKD .

M. Wolf, A. Betoko, S. Furth, 2019 .

Waist-to-height ratio, body mass index, and cardiovascular risk profile in children with chronic kidney disease

S. Furth, M. Mitsnefes, B. Warady, 2018, Pediatric Nephrology.

FGF23 and Left Ventricular Hypertrophy in Children with CKD.

M. Wolf, A. Betoko, S. Furth, 2018, Clinical journal of the American Society of Nephrology : CJASN.

Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD.

D. Glidden, K. Johansen, Chi-yuan Hsu, 2016, Journal of the American Society of Nephrology : JASN.

Pedometer-assessed physical activity in children and young adults with CKD.

K. Johansen, A. Portale, Aalia Akber, 2012, Clinical journal of the American Society of Nephrology : CJASN.

Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia

F. Glorieux, H. Cheong, Hiroyuki Tanaka, 2021, Calcified Tissue International.

Vitamin D 1α-Hydroxylase Gene Mutations in Patients with 1α-Hydroxylase Deficiency

Amita Sharma, W. Miller, N. Huang, 2007 .

Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study.

Thomas O Jemielita, M. Leonard, S. Furth, 2016, Journal of the American Society of Nephrology : JASN.

Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule

W. Gu, V. David, Y. Jiao, 2015, PloS one.

Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia

F. Glorieux, M. Peacock, J. Humphrey, 2016, Bone reports.

Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia

J. Merritt, M. Peacock, T. Weber, 2022, The Journal of clinical endocrinology and metabolism.

Effect of Burosumab Compared With Conventional Therapy on Younger vs Older Children With X-linked Hypophosphatemia

F. Glorieux, H. Cheong, M. Whyte, 2022, The Journal of clinical endocrinology and metabolism.

Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period

R. Eastell, J. S. San Martin, S. Ralston, 2019, Calcified Tissue International.

Vitamin D 1α-Hydroxylase

W. Miller, A. Portale, 2000, Trends in Endocrinology & Metabolism.

Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D.

R. Morris, B. Halloran, A. Portale, 1987, The Journal of clinical investigation.

Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia

M. Whyte, A. Linglart, W. Högler, 2021, The Journal of clinical endocrinology and metabolism.

Fibroblast Growth Factor 23 and Phosphate Homeostasis

M. Fukagawa, A. Portale, 2005 .

Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease.

A. Muñoz, S. Furth, D. Ng, 2018, Annals of epidemiology.

Hereditary rickets revealed.

W. Miller, A. Portale, 1998, Kidney international.

Vitamin D Biosynthesis and Vitamin D 1α-Hydroxylase Deficiency

W. Miller, A. Portale, 2003 .

Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression.

W. Miller, A. Portale, 2000, Pediatric nephrology.

Effect of Immigration Status on Outcomes in Pediatric Kidney Transplant Recipients

P. Stock, A. Posselt, M. Tavakol, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Genetic disorders of vitamin D biosynthesis.

W. Miller, A. Portale, 1999, Endocrinology and metabolism clinics of North America.

Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.

R. Morris, D. Bikle, B. Halloran, 1992, American Journal of Physiology.

Endocrine Regulation of Phosphate Homeostasis

H. Jüppner, A. Portale, 2009 .

Fibroblast growth factor 23 regulates renal 1,25‐dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice

Martin Y. H. Zhang, Daniel Ranch, A. Portale, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Being Overweight Modifies the Association Between Cardiovascular Risk Factors and Microalbuminuria in Adolescents

C. McCulloch, Chi-yuan Hsu, A. Portale, 2008, Pediatrics.

H. Zhang, S. Shahinfar, I. Salusky, 2018, Pediatric Nephrology.

Liquid-ChromatographicMeasurementsof Inosine,Hypoxanthine,and Xanthinein Studiesof Fructose-InducedDegradationof AdenineNucleotides in Humansand Rats

Anthony, Beverley, R., 2004 .