Claus-Michael Lehr

发表

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

René Rietscher, Carolin Thum, Claus-Michael Lehr, 2014, Pharmaceutical Research.

Computational fluid dynamics of nanoparticle disposition in the airways: mucus interactions and mucociliary clearance

Claus-Michael Lehr, Marco Günther, Marc Schneider, 2011, Comput. Vis. Sci..

Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles

Claus-Michael Lehr, Marc Schneider, Stefan Schiller, 2015, Pharmaceutical Research.

Towards nanotechnology regulation — Publish the unpublishable

Claus-Michael Lehr, Albert Duschl, Steve Hankin, 2011 .

Integrating Case Studies on Methods and Materials

Claus-Michael Lehr, Jürgen Schnekenburger, Thomas A. J. Kuhlbusch, 2014 .

Biodegradable Systems in Tissue Engineering and Regenerative Medicine, Rui L. Reis (Ed.). CRC Press, Boca Raton (2005), 568 pp., $149, ISBN 0-8493-1936-6

Claus-Michael Lehr, Katharina Meier, 2005 .

Safety of Nanomaterials along Their Lifecycle : Release, Exposure, and Human Hazards

Claus-Michael Lehr, Thomas A. J. Kuhlbusch, Wendel Wohlleben, 2014 .

Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access.

Claus-Michael Lehr, Kevin J Edgar, Eva-Maria Collnot, 2010, Molecular pharmaceutics.

Improved input parameters for diffusion models of skin absorption.

Claus-Michael Lehr, Steffi Hansen, Ulrich F Schaefer, 2013, Advanced drug delivery reviews.

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models.

Claus-Michael Lehr, Nicole Schneider-Daum, C. Lehr, 2015, Advanced drug delivery reviews.

Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity

Claus-Michael Lehr, Andreas Luch, Sarah Mues, 2016, Nanotoxicology.

Interaction of metal oxide nanoparticles with lung surfactant protein A.

Claus-Michael Lehr, Wendel Wohlleben, Christine Schulze, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o–: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies

Carsten Kneuer, Claus-Michael Lehr, Kwang-Jin Kim, 2002, Cell and Tissue Research.

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier.

Claus-Michael Lehr, Peter Gehr, B. Rothen‐Rutishauser, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Cell culture models of biological barriers : in vitro test systems for drug absorption and delivery

Claus-Michael Lehr, C. Lehr, 2002 .

Models for Skin Absorption and Skin Toxicity Testing

Claus-Michael Lehr, Marc Schneider, Steffi Hansen, 2008 .

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.

René Rietscher, Claus-Michael Lehr, Marc Schneider, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs.

Karsten König, Claus-Michael Lehr, Marc Schneider, 2006, The Journal of investigative dermatology.

Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells.

Claus-Michael Lehr, Elias Fattal, Silvia Arpicco, 2009, Oligonucleotides.

Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations.

Claus-Michael Lehr, Ulrich F Schaefer, C. Lehr, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Developments in the area of bioadhesive drug delivery systems

Claus-Michael Lehr, C. Lehr, Jochen Haas, 2002, Expert opinion on biological therapy.

Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject.

Claus-Michael Lehr, Ulrich F Schaefer, C. Lehr, 2002, The Journal of investigative dermatology.

Carrier interactions with the biological barriers of the lung: advanced in vitro models and challenges for pulmonary drug delivery.

Claus-Michael Lehr, C. Lehr, Cristiane de Souza Carvalho, 2014, Advanced drug delivery reviews.

Dissolution Testing of Powders for Inhalation: Influence of Particle Deposition and Modeling of Dissolution Profiles

Claus-Michael Lehr, Marc Schneider, C. Lehr, 2014, Pharmaceutical Research.

Computational modeling of the sugar-lectin interaction.

Claus-Michael Lehr, Hans-Peter Lenhof, Oliver Kohlbacher, 2004, Advanced drug delivery reviews.

The Role of Corneocytes in Skin Transport Revised—A Combined Computational and Experimental Approach

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2009, Pharmaceutical Research.

Bioadhesive Drug Delivery Systems : Fundamentals, Novel Approaches, and Development

Claus-Michael Lehr, Donald E. Chickering, Edith Mathiowitz, 1999 .

A Design of Experiment Study of Nanoprecipitation and Nano Spray Drying as Processes to Prepare PLGA Nano- and Microparticles with Defined Sizes and Size Distributions

Claus-Michael Lehr, Eva-Maria Collnot, Steffi Hansen, 2015, Pharmaceutical Research.

In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients.

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition.

Claus-Michael Lehr, Stefan Tenzer, Alexander Rurainski, 2015, ACS nano.

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo.

Claus-Michael Lehr, Eva-Maria Collnot, Dejan Djuric, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

Claus-Michael Lehr, Julian Kirch, Jennifer Herrmann, 2012, PloS one.

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.

Claus-Michael Lehr, Nicole Schneider-Daum, Brigitta Loretz, 2018, ALTEX.

PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease.

Claus-Michael Lehr, Christian Lautenschläger, Andreas Stallmach, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Non-invasive determination of cellular oxygen consumption as novel cytotoxicity assay for nanomaterials

Michael Veith, Claus-Michael Lehr, C. Lehr, 2014, Nanotoxicology.

Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa

Claus-Michael Lehr, Alf Lamprecht, A. Lamprecht, 2001, Pharmaceutical Research.

Modeling the human skin barrier--towards a better understanding of dermal absorption.

Claus-Michael Lehr, Steffi Hansen, Ulrich F Schaefer, 2013, Advanced drug delivery reviews.

Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.

Claus-Michael Lehr, Marc Schneider, Ulrich F Schaefer, 2007, Nanomedicine : nanotechnology, biology, and medicine.

Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data

Claus-Michael Lehr, C. Lehr, K. Kostka, 2000, Pharmaceutical Research.

Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions.

Claus-Michael Lehr, Wendel Wohlleben, Christine Schulze, 2012, ACS nano.

A Model for the Transient Subdiffusive Behavior of Particles in Mucus.

Claus-Michael Lehr, Christian Wagner, Ulrich F Schaefer, 2017, Biophysical journal.

Dual flow bioreactor with ultrathin microporous TEER sensing membrane for evaluation of nanoparticle toxicity

Claus-Michael Lehr, Arti Ahluwalia, Tommaso Sbrana, 2016 .

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Claus-Michael Lehr, Bruno Sarmento, B. Sarmento, 2019, Acta biomaterialia.

Bioadhesive polymers for the peroral delivery of peptide drugs

Claus-Michael Lehr, Hans E. Junginger, H. L. Lueßen, 1994 .

The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier.

Claus-Michael Lehr, Carsten Ehrhardt, C. Ehrhardt, 2014, Molecular pharmaceutics.

Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell.

Claus-Michael Lehr, Thomas Eichinger, Ulrich F Schaefer, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Claus-Michael Lehr, Marc Schneider, Julian Kirch, 2012, Proceedings of the National Academy of Sciences.

Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion.

Claus-Michael Lehr, Dirk Neumann, Alf Lamprecht, 2006, Journal of nanoscience and nanotechnology.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Sangeeta Khare, Carsten Kneuer, Uwe Marx, 2015, ALTEX.

An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop

Claus-Michael Lehr, Hans E. Junginger, Josef J. Tukker, 1991 .

In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers

Claus-Michael Lehr, Hans E. Junginger, Etienne Schacht, 1992 .

In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters.

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Claus-Michael Lehr, Marcus Koch, Brigitta Loretz, 2018, Journal of Nanobiotechnology.

Nanoparticles--an efficient carrier for drug delivery into the hair follicles.

Claus-Michael Lehr, Heike Richter, Ulrike Blume-Peytavi, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

Bioadhesion by Means of Specific Binding of Tomato Lectin

Claus-Michael Lehr, Hans E. Junginger, H. Junginger, 1992, Pharmaceutical Research.

Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Claus-Michael Lehr, William Doub, Per Bäckman, 2016 .

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products.

Claus-Michael Lehr, Nicole Schneider-Daum, C. Lehr, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2008, Alternatives to laboratory animals : ATLA.