Mian Zhou

发表

Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis

Jeremy M. Stark, J. Stark, Xiaochun Yu, 2019, Oncogene.

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

Qin M. Chen, Zhigang Guo, Li Zheng, 2010, Nature chemical biology.

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates and defective in myopathy

D. Bogenhagen, Zhigang Guo, Huiming Lu, 2008, Molecular cell.

Role of FEN1 S187 phosphorylation in counteracting oxygen‐induced stress and regulating postnatal heart development

Jian Xu, Juan Du, Y. Hua, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice.

B. Shen, Hong Xu, Mian Zhou, 2012, Mutation research.

Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation.

J. Turchi, B. Shen, Mian Zhou, 2003, Biochemistry.

Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.

Na Liu, Zhigang Guo, B. Shen, 2012, Molecular cell.

Human DNA polymerase β polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity

Zhigang Guo, B. Shen, Hong Xu, 2009, Nucleic acids research.

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.

A. Tomkinson, Chen Wu, D. Lin, 2012, DNA repair.

JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells

Dustin E. Schones, Juan Du, P. Chu, 2018, Cell reports.

Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity

Mian Zhou, Qin Huang, Binghui Shen, 2013, The EMBO journal.

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

Qin Huang, Mian Zhou, Binghui Shen, 2012, Nature Communications.

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity

B. Shen, C. Kowolik, Judith L Campbell, 2019, Nucleic acids research.

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

Xiwei Wu, Zhiyuan Shen, Zhengke Li, 2018, The EMBO journal.

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy

K. Schlacher, Zhengke Li, Hongzhi Li, 2016, EBioMedicine.

Error-prone, stress-induced 3′ flap–based Okazaki fragment maturation supports cell survival

Jinhui Wang, Xiwei Wu, B. Shen, 2021, Science.

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

G. Pfeifer, Xiwei Wu, S. Mitra, 2011, Cell Research.

Nucleolar Localization and Dynamic Roles of Flap Endonuclease 1 in Ribosomal DNA Replication and Damage Repair

Zhigang Guo, B. Shen, Mian Zhou, 2008, Molecular and Cellular Biology.

Fen1 mutations result in autoimmunity, chronic inflammation and cancers

D. Lin, B. Shen, K. Kernstine, 2007, Nature Medicine.

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Jay Z. Parrish, David J. Chen, J. Parrish, 2005, EMBO reports.

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.

J. Bachant, B. Shen, D. Thrower, 2003, DNA repair.

Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice

Y. Hua, B. Shen, Hong Xu, 2010, Oncogene.

SUMO-1 modification of FEN1 facilitates its interaction with Rad9–Rad1–Hus1 to counteract DNA replication stress

Y. Hua, Zhigang Guo, B. Shen, 2018, Journal of molecular cell biology.

Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma

B. Shen, K. Kernstine, C. Kowolik, 2011, Melanoma research.

The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers

A. Nicolas, Yate-Ching Yuan, Weihang Chai, 2014, Oncogene.

Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells

Lufen Chang, Xufeng Chen, B. Shen, 2017, Molecular and Cellular Biology.

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

G. Pfeifer, Xiwei Wu, Xiaojin Li, 2012, Nature Communications.

JMJD1B mediates H4R3me2s reprogramming to maintain DNA demethylation status in neural progenitor cells during embryonic development

Q. Lu, B. Shen, Mian Zhou, 2023, Cell insight.