A. Volckmar

发表

RNA-Based Detection of Gene Fusions in Formalin-Fixed and Paraffin-Embedded Solid Cancer Samples

P. Schirmacher, A. Stenzinger, D. Kazdal, 2019, Cancers.

Spatial and temporal heterogeneity of panel-based tumor mutational burden (TMB) in pulmonary adenocarcinoma: separating biology from technical artifacts.

S. Fröhling, M. Kriegsmann, A. Warth, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

KRAS/GNAS‐testing by highly sensitive deep targeted next generation sequencing improves the endoscopic ultrasound‐guided workup of suspected mucinous neoplasms of the pancreas

P. Schirmacher, A. Stenzinger, D. Kazdal, 2021, Genes, chromosomes & cancer.

Risk stratification of EGFR+ lung cancer diagnosed with panel-based next-generation sequencing.

M. Kriegsmann, P. Schirmacher, A. Stenzinger, 2020, Lung cancer.

In depth analysis of obesity candidate genes in the chromosomal

A. Volckmar, 2013 .

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants

H. Wichmann, T. Illig, H. Grallert, 2012, BMC Medical Genomics.

Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities

M. Kloor, J. Cheville, M. Manns, 2020, Hepatology.

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

E. Zeggini, D. Collier, H. Hakonarson, 2017, Molecular Psychiatry.

Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma

M. Kriegsmann, J. Kriegsmann, R. Longuespée, 2021, Translational lung cancer research.

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K–AKT pathway

W. Weichert, P. Schirmacher, A. Stenzinger, 2017, Genes, chromosomes & cancer.

Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA

A. Stenzinger, D. Kazdal, M. Schlesner, 2020, EBioMedicine.

Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma

A. Warth, P. Schirmacher, A. Stenzinger, 2017, Genes, chromosomes & cancer.

PARP inhibition in BRCA2-mutated prostate cancer.

D. Jäger, A. Stenzinger, D. Bonekamp, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Evidence for correlations between BMI-associated SNPs and circRNAs

C. Dieterich, J. Hebebrand, A. Hinney, 2022, Scientific Reports.

Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deﬁcit/hyperactivity disorder

S. Cichon, H. Wichmann, K. Jöckel, 2013 .

RREB1-MKL2 fusion in a spindle cell sinonasal sarcoma: biphenotypic sinonasal sarcoma or ectomesenchymal chondromyxoid tumor in an unusual site?

C. Antonescu, A. Stenzinger, M. Andrulis, 2021, Genes, chromosomes & cancer.

Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing

S. Fröhling, D. Kazdal, J. Budczies, 2022, British Journal of Cancer.

The Fatty Acid Amide Hydrolase (FAAH) Gene Variant rs324420 AA/AC is not Associated with Weight Loss in a 1-Year Lifestyle Intervention for Obese Children and Adolescents

M. Kleber, J. Hebebrand, A. Hinney, 2011, Hormone and Metabolic Research.

Decreased melanocortin‐4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene

J. Hebebrand, A. Hinney, H. Biebermann, 2016, Obesity.

22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts

J. N. Fidalgo, Jimmy D Bell, L. S. Silveira, 2015, Obesity Facts.

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

Olaf Neumann, Michael Thomas, Ivo Buchhalter, 2019, International journal of cancer.

Genetic variation at the CELF1 (CUGBP, elav‐like family member 1 gene) locus is genome‐wide associated with Alzheimer's disease and obesity

I. Heid, D. Harold, R. Sims, 2014, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Immunotherapy with ipilimumab plus nivolumab in a stage IV melanoma patient during pregnancy.

A. Enk, D. Jäger, E. Richtig, 2018, European journal of cancer.

Common obesity risk alleles in childhood attention‐deficit/hyperactivity disorder

S. Cichon, M. Nöthen, B. Neale, 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genome‐wide association study in German patients with attention deficit/hyperactivity disorder

S. Cichon, B. Franke, C. Freitag, 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genes and the hypothalamic control of metabolism in humans.

A. Hinney, J. Antel, A. Volckmar, 2014, Best practice & research. Clinical endocrinology & metabolism.

Molecular genetic aspects of weight regulation.

J. Hebebrand, A. Hinney, A. Scherag, 2013, Deutsches Arzteblatt international.

Chipping Away the ‘Missing Heritability’: GIANT Steps Forward in the Molecular Elucidation of Obesity – but Still Lots to Go

J. Hebebrand, A. Hinney, A. Volckmar, 2010, Obesity Facts.

Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine

S. Fröhling, P. Schirmacher, A. Stenzinger, 2021, Genes, chromosomes & cancer.

Targeted next‐generation sequencing enables reliable detection of HER2 (ERBB2) status in breast cancer and provides ancillary information of clinical relevance

Jan Budczies, Nicole Pfarr, Volker Endris, 2017, Genes, chromosomes & cancer.

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis.

A. Hinney, A. Volckmar, N. Knoll, 2013, Progress in molecular biology and translational science.

Variant classification in precision oncology

Melanie Boerries, Olaf Neumann, Michael Thomas, 2019, International journal of cancer.

The BRCA2 mutation status shapes the immune phenotype of prostate cancer

D. Jäger, P. Schirmacher, A. Stenzinger, 2019, Cancer Immunology, Immunotherapy.

Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real‐life analysis of three larger gene panels

Olaf Neumann, Michael Thomas, Ivo Buchhalter, 2019, International journal of cancer.

Size matters: Dissecting key parameters for panel‐based tumor mutational burden analysis

Olaf Neumann, Michael Thomas, Ivo Buchhalter, 2018, International journal of cancer.

Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians.

Olaf Neumann, Michael Thomas, Jan Budczies, 2018, Translational lung cancer research.

Genetic profiling of melanoma in routine diagnostics: assay performance and molecular characteristics in a consecutive series of 274 cases.

A. Enk, S. Fröhling, P. Schirmacher, 2018, Pathology.

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology

M. Kloor, W. Weichert, P. Schirmacher, 2016, Genes, chromosomes & cancer.

High prevalence of DNA damage repair gene defects and TP53 alterations in men with treatment-naïve metastatic prostate cancer -Results from a prospective pilot study using a 37 gene panel.

D. Jäger, P. Schirmacher, A. Stenzinger, 2020, Urologic oncology.

Mutations in BRCA2 and taxane resistance in prostate cancer

D. Jäger, P. Schirmacher, A. Stenzinger, 2017, Scientific Reports.

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing

S. Haas, H. Grallert, J. Hebebrand, 2016, PloS one.

Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2

T. Illig, H. Grallert, J. Hebebrand, 2015, PloS one.

Targeting rare and non-canonical driver variants in NSCLC - An uncharted clinical field.

S. Fröhling, M. Kriegsmann, P. Schirmacher, 2021, Lung cancer.

Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report

A. Warth, P. Schirmacher, A. Stenzinger, 2016, Diagnostic Pathology.

Detection of TP53 Mutations in Tissue or Liquid Rebiopsies at Progression Identifies ALK+ Lung Cancer Patients with Poor Survival

P. Schirmacher, A. Stenzinger, J. Budczies, 2019, Cancers.

Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder

S Cichon, S. Cichon, C. Freitag, 2012, Molecular Psychiatry.

Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy

D. Jäger, A. Stenzinger, M. Schlesner, 2017, Oncotarget.

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

E. Zeggini, D. Collier, H. Hakonarson, 2017, Molecular Psychiatry.

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

E. Zeggini, D. Collier, H. Hakonarson, 2017, Molecular Psychiatry.

A Novel SP1/SP3 Dependent Intronic Enhancer Governing Transcription of the UCP3 Gene in Brown Adipocytes

H. Jarrett, A. Hinney, M. Klingenspor, 2013, PloS one.

Knowledge bases and software support for variant interpretation in precision oncology

S. Fröhling, R. Eils, D. Jäger, 2021, Briefings Bioinform..

Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary

W. Weichert, P. Schirmacher, A. Stenzinger, 2020, International journal of cancer.

Comparative genetic profiling aids diagnosis and clinical decision making in challenging cases of CUP syndrome

P. Schirmacher, A. Stenzinger, A. Krämer, 2019, International journal of cancer.

Genetics of Eating Disorders

A. Hinney, A. Volckmar, 2013, Current Psychiatry Reports.

Oncogenic driver mutations, treatment, and EGFR-TKI resistance in a Caucasian population with non-small cell lung cancer: survival in clinical practice

A. Stenzinger, M. Faehling, A. Volckmar, 2017, Oncotarget.

Feasibility and Challenges for Sequential Treatments in ALK-Rearranged Non-Small-Cell Lung Cancer

M. Kriegsmann, A. Stenzinger, D. Kazdal, 2021, Frontiers in Oncology.

Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer

M. Kriegsmann, P. Schirmacher, A. Stenzinger, 2021, Therapeutic advances in medical oncology.

EGFR T790M mutation testing of non-small cell lung cancer tissue and blood samples artificially spiked with circulating cell-free tumor DNA: results of a round robin trial

P. Schirmacher, A. Stenzinger, M. Dietel, 2017, Virchows Archiv.

High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation

E. Zeggini, D. Collier, T. Illig, 2018, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

D. Meyre, J. Hebebrand, A. Hinney, 2018, Obesity reviews : an official journal of the International Association for the Study of Obesity.

A field guide for cancer diagnostics using cell‐free DNA: From principles to practice and clinical applications

P. Schirmacher, A. Stenzinger, T. Fioretos, 2018, Genes, chromosomes & cancer.

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

H. Grallert, J. Hebebrand, A. Hinney, 2018, Obesity Facts.

Relevance of polymorphisms in MC4R and BDNF in short normal stature

S. Grant, J. Hebebrand, A. Hinney, 2018, BMC Pediatrics.

Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus

J. Hebebrand, A. Hinney, A. Scherag, 2010, PloS one.

Gene Set of Nuclear-Encoded Mitochondrial Regulators Is Enriched for Common Inherited Variation in Obesity

C. Gieger, A. Peters, H. Wichmann, 2013, PloS one.

Genome-wide analysis of rare copy number variations reveals PARK 2 as a candidate gene for attention-deficit / hyperactivity disorder

S. Cichon, C. Freitag, K. Lesch, 2013 .

Therapeutic and Prognostic Implications of Immune-Related Adverse Events in Advanced Non-Small-Cell Lung Cancer

M. Kriegsmann, A. Stenzinger, D. Kazdal, 2021, Frontiers in Oncology.

Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies

M. Kriegsmann, A. Stenzinger, D. Kazdal, 2021, Translational lung cancer research.

Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1–ALK-rearranged lung cancer

A. Stenzinger, M. Schlesner, Michael Thomas, 2019, Cold Spring Harbor molecular case studies.

First proficiency testing for NGS‐based and combined NGS‐ and FISH‐based detection of FGFR2 fusions in intrahepatic cholangiocarcinoma

W. Weichert, D. Kazdal, M. Kirchner, 2023, The journal of pathology. Clinical research.

Structure and content of the EU-IVDR

W. Weichert, D. Kazdal, R. Penzel, 2023, Pathologie.

Validating Comprehensive Next-Generation Sequencing Results for Precision Oncology: The NCT/DKTK Molecularly Aided Stratification for Tumor Eradication Research Experience.

Melanie Boerries, Mario Lamping, Damian T. Rieke, 2018, JCO precision oncology.

Complete Metabolic Response in FDG-PET-CT Scan before Discontinuation of Immune Checkpoint Inhibitors Correlates with Long Progression-Free Survival

A. Enk, A. Stenzinger, A. Dimitrakopoulou-Strauss, 2021, Cancers.

Digital PCR After MALDI–Mass Spectrometry Imaging to Combine Proteomic Mapping and Identification of Activating Mutations in Pulmonary Adenocarcinoma

R. Casadonte, M. Kriegsmann, J. Kriegsmann, 2018, Proteomics. Clinical applications.

Immuno‐oncology gene expression profiling of formalin‐fixed and paraffin‐embedded clear cell renal cell carcinoma: Performance comparison of the NanoString nCounter technology with targeted RNA sequencing

P. Schirmacher, A. Stenzinger, D. Kazdal, 2020, Genes, chromosomes & cancer.

Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Case Report

M. Kriegsmann, A. Stenzinger, D. Kazdal, 2021, Case Reports in Oncology.

Next generation sequencing of the cellular and liquid fraction of pancreatic cyst fluid supports discrimination of IPMN from pseudocysts and reveals cases with multiple mutated driver clones: First findings from the prospective ZYSTEUS biomarker study

P. Schirmacher, A. Stenzinger, R. Penzel, 2018, Genes, chromosomes & cancer.

Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.

P. Schirmacher, A. Stenzinger, R. Penzel, 2017, Pathology.

Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility

M. Kriegsmann, A. Warth, P. Schirmacher, 2018, Genes, chromosomes & cancer.

[Genetic and epigenetic mechanisms in obesity].

A. Hinney, A. Volckmar, L. Schonnop, 2015, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

Analysis of rare fusions in NSCLC: genomic architecture and clinical implications

D. Kazdal, J. Budczies, F. Herth, 2023, Lung Cancer.

PARP inhibition in BRCA2-mutated prostate cancer.

D. Jäger, A. Stenzinger, D. Bonekamp, 2017 .

Mitochondrial DNA Variants in Obesity

C. Gieger, H. Völzke, H. Wichmann, 2014, PloS one.

[Structure and content of the EU-IVDR : Current status and implications for pathology].

W. Weichert, D. Kazdal, R. Penzel, 2022, Pathologie.

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology

M. Kloor, W. Weichert, P. Schirmacher, 2016, Genes, chromosomes & cancer.

Varianteninterpretation in der molekularen Pathologie und Onkologie

S. Fröhling, P. Schirmacher, A. Stenzinger, 2021, Der Pathologe.

Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.

J. Hebebrand, A. Hinney, A. Scherag, 2013, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.