John D. Williams

发表

Small molecule inhibitors of anthrax lethal factor toxin.

N. Peet, T. Bowlin, John D. Williams, 2014, Bioorganic & medicinal chemistry.

Survey of Solvents for the Conrad–Limpach Synthesis of 4-Hydroxyquinolones

N. Peet, John D. Williams, Jean-Christophe Brouet, 2009, Synthetic communications.

Efficient Synthesis of 7-Amino-3-hydroxyindan-1-one

N. Peet, John D. Williams, H. Kim, 2009 .

A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF

J. Mecsas, D. Moir, D. M. Mills, 2020, Journal of Bacteriology.

Biosynthesis and half-life of MBX-2168-triphosphate in herpes virus-infected cells.

T. Bowlin, John D. Williams, B. Gentry, 2020, Antiviral research.

Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions

S. Chou, N. Peet, Gloria Komazin-Meredith, 2013, Antimicrobial Agents and Chemotherapy.

Cytomegalovirus Mutants Resistant to Ganciclovir and Cidofovir Differ in Susceptibilities to Synguanol and Its 6-Ether and 6-Thioether Derivatives

S. Chou, Gloria Komazin-Meredith, T. Bowlin, 2013, Antimicrobial Agents and Chemotherapy.

Synthesis and Antiviral Activities of Methylenecyclopropane Analogs with 6-Alkoxy and 6-Alkylthio Substitutions That Exhibit Broad-Spectrum Antiviral Activity against Human Herpesviruses

N. Peet, Gloria Komazin-Meredith, M. Prichard, 2013, Antimicrobial Agents and Chemotherapy.

Identiﬁcation of a Small-Molecule Entry Inhibitor for Filoviruses (cid:1)

R. Ray, D. Moir, M. Farzan, 2011 .

Novel Broad-Spectrum Bis-(Imidazolinylindole) Derivatives with Potent Antibacterial Activities against Antibiotic-Resistant Strains

R. Ulrich, R. Gussio, D. Moir, 2009, Antimicrobial Agents and Chemotherapy.

Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS).

Carson M. Brown, D. Moir, D. Aiello, 2015, Bioorganic & medicinal chemistry.

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

D. Moir, S. Bavari, N. Peet, 2010, Bioorganic & medicinal chemistry.

Aryl Rhodanines Speciﬁcally Inhibit Staphylococcal and Enterococcal Bioﬁlm Formation (cid:1) †

D. Moir, N. Peet, T. Opperman, 2009 .

Human Herpesvirus 6 U69 Kinase Phosphorylates the Methylenecyclopropane Nucleosides Cyclopropavir, MBX 2168, and MBX 1616 to Their Monophosphates

N. Peet, Gloria Komazin-Meredith, M. Prichard, 2013, Antimicrobial Agents and Chemotherapy.

Novel bis-indole agents active against multidrug-resistant Acinetobacter baumannii.

R. Bonomo, N. Peet, A. Endimiani, 2011, Diagnostic microbiology and infectious disease.

An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections

Angela M. Zaino, D. Caridha, P. Hergenrother, 2022, ACS central science.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

D. Moir, S. Nguyen, S. Bavari, 2013, Bioorganic & medicinal chemistry.

Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

Marc G. Busch, Gloria Komazin-Meredith, T. Bowlin, 2019, Antimicrobial Agents and Chemotherapy.

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

H. Nikaido, N. Peet, T. Opperman, 2015, Bioorganic & medicinal chemistry.

Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

D. Moir, S. Bavari, N. Peet, 2010, Antimicrobial Agents and Chemotherapy.

D‐Ribonolactone and 2,3‐Isopropylidene(D‐Ribonolactone)

V. Kamath, P. Morris, L. Townsend, 2005 .

Reactions of Cp* Ru(η6-C6H5CHO)+ OSO2CF3− (Cp* = C5Me5) with substituted anilines forming ruthenium Schiff base complexes

D. E. Wheeler, S. Hill, Steven Milos, 1997 .

Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds.

S. Nguyen, N. Peet, T. Opperman, 2015, Bioorganic & medicinal chemistry.

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

S. Nguyen, N. Peet, D. M. Mills, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of novel erythrofuranosyl imidazo[1,2-a]pyridine C-nucleosides constructed via palladium coupling of iodoimidazo[1,2-a]pyridines and dihydrofuran.

K. Gudmundsson, L. Townsend, J. Drach, 2003, Journal of medicinal chemistry.

Synthesis and characterization of and complexes

D. E. Wheeler, S. Hill, John D. Williams, 1995 .

Syntheses of Benzo[b]furan-6-carbonitrile and 6-Cyanobenzo[b]furan-2-boronic Acid Pinacol Ester

N. Peet, John D. Williams, Xiaoyuan Ding, 2013, Synthetic communications.

Design, Synthesis, and Antiviral Evaluation of Some Polyhalogenated Indole C-nucleosides

Yuan Wei, L. Townsend, J. Drach, 2005, Nucleosides, nucleotides & nucleic acids.

Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.

S. Biswas, D. Moir, D. Aiello, 2009, Bioorganic & medicinal chemistry.

A comparison of N- versus O-alkylation of substituted 2-pyridones under Mitsunobu conditions

N. Peet, John D. Williams, Matthew C. Torhan, 2013 .

Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion

S. Lory, D. Moir, D. Aiello, 2010, Antimicrobial Agents and Chemotherapy.

Diels-Alder reactions of five-membered heterocycles containing one heteroatom.

S. Nguyen, N. Peet, John D. Williams, 2014, Tetrahedron letters.

Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication

R. Sanchez, D. Tortorella, N. Lurain, 2016, Journal of Virology.

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

N. Peet, M. Prichard, Geraldine M. Jefferson, 2012, Bioorganic & medicinal chemistry.

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

R. Ptak, L. Townsend, J. Drach, 2004, Journal of medicinal chemistry.

Design and Synthesis of Acyclic Nucleoside Analogs with Chlorinated Imidazo[1,2-a]pyridine Bases

L. Townsend, J. Drach, John D. Williams, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives.

L. Townsend, J. Drach, John D. Williams, 2004, Journal of medicinal chemistry.

Design and Synthesis of Acyclic Nucleoside Analogues with Chlorinated Imidazo[1,2-a]pyridine Bases.

L. Townsend, J. Drach, John D. Williams, 2004 .

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

Gloria Komazin-Meredith, T. Opperman, M. Prichard, 2015, Antiviral research.

Pentostatin Antagonizes the Antiviral Activity of MBX-2168 by Inhibiting the Biosynthesis of the Active Compound.

T. Bowlin, John D. Williams, B. Gentry, 2021, Antiviral research.

Identification of a Small-Molecule Entry Inhibitor for Filoviruses

R. Ray, D. Moir, M. Farzan, 2011, Journal of Virology.

Ecology and Status of Piscivores in Guri, an Oligotrophic Tropical Reservoir

K. Winemiller, D. Taphorn, L. Balbás, 1998 .

New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion

D. Moir, A. Basu, Lijun Rong, 2013, Journal of Virology.

Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection

D. Moir, A. Hauser, Katherine R. Murphy, 2017, Antimicrobial Agents and Chemotherapy.

Novel Small Molecule Entry Inhibitors of Ebola Virus.

J. Dye, A. Herbert, K. Chandran, 2015, The Journal of infectious diseases.

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

D. Moir, N. Peet, T. Opperman, 2009, Antimicrobial Agents and Chemotherapy.

Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay

C. Rock, D. Moir, D. M. Mills, 2015, Antimicrobial Agents and Chemotherapy.

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

T. Opperman, R. Darouiche, M. Mansouri, 2012, Antimicrobial Agents and Chemotherapy.

Efficient Synthesis of a Benzo[b]furan Building Block

N. Peet, John D. Williams, S. P. Khanapure, 2010 .

Walleye Movement, Distribution, and Habitat Use in Laurel River Lake, Kentucky

N. Hwy, John D. Williams, 2001 .

Synthesis and Antiviral Evaluation of Some Novel Tricyclic Pyrazolo[3,4‐b]indole Nucleosides

L. Townsend, J. Drach, John D. Williams, 2004, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides.

L. Townsend, J. Drach, John D. Williams, 2004, Journal of medicinal chemistry.

Synthesis and Antiviral Evaluation of Some Novel Tricyclic Pyrazolo[3,4-b]indole Nucleosides.

L. Townsend, J. Drach, John D. Williams, 2004 .

Synthesis and Antiviral Activity of Some 2-Substituted 3-Formyl-and 3-Cyano-5,6-Dichloroindole Nucleosides

L. Townsend, J. Drach, John D. Williams, 2005, Nucleosides, nucleotides & nucleic acids.

Two concise total syntheses of the wasabi phytoalexin methyl 1-methoxyindole-3-carboxylate

N. Peet, John D. Williams, Bing Li, 2013 .

Studies on the mechanism of the Cadogan–Sundberg indole synthesis

N. Peet, John D. Williams, Helena Majgier-Baranowska, 2012 .

4β-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4β-methyl-5-(3-hydroxyphenyl)morphan pure antagonist.

B. Roth, James B. Thomas, S. Mascarella, 2013, Journal of medicinal chemistry.

New Small Molecule Entry Inhibitors Targeting 1 Hemagglutinin-mediated Influenza A Virus Fusion 2 3

Barnard, D. Moir, A. Basu, 2013 .

Mutations in the Pseudomonas aeruginosa Needle Protein Gene pscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System

J. Mecsas, D. Moir, D. Aiello, 2014, Antimicrobial Agents and Chemotherapy.

DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

D. Moir, D. Aiello, E. Long, 2016, Antimicrobial Agents and Chemotherapy.

Concise Synthesis of 6-Cyanobenzo[b]furan, a Useful Building Block

S. Nguyen, N. Peet, John D. Williams, 2014 .

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

D. Moir, S. Nguyen, S. Bavari, 2013, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Activities of Methylenecyclopropane Analogs with 6-Alkoxy and 6-Alkylthio Substitutions That Exhibit Broad-Spectrum Antiviral Activity against Human Herpesviruses

N. Peet, Gloria Komazin-Meredith, M. Prichard, 2013, Antimicrobial Agents and Chemotherapy.

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

T. Opperman, R. Darouiche, M. Mansouri, 2012, Antimicrobial Agents and Chemotherapy.

Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.

S. Biswas, D. Moir, D. Aiello, 2009, Bioorganic & medicinal chemistry.

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

Gloria Komazin-Meredith, T. Opperman, M. Prichard, 2015, Antiviral research.

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

H. Nikaido, N. Peet, T. Opperman, 2015, Bioorganic & medicinal chemistry.