G. V. D. van der Zon

发表

OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

R. Slieker, Jiang Ren, P. ten Dijke, 2022, Signal Transduction and Targeted Therapy.

The insulin receptor tyrosine kinase domain in a chimaeric epidermal growth factor-insulin receptor generates Ca2+ signals through the PLC-gamma1 pathway.

P. Willems, W. Frankhuizen, J. Maassen, 1999, Biochimica et biophysica acta.

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

W. Alkema, W. Fleuren, D. Ouwens, 2013, Archives of physiology and biochemistry.

TGF-β-Induced Endothelial to Mesenchymal Transition Is Determined by a Balance Between SNAIL and ID Factors

M. Gonçalves, P. ten Dijke, G. Sánchez-Duffhues, 2021, Frontiers in Cell and Developmental Biology.

Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes.

Rob C. G. van de Ven, M. Bazuine, G. V. D. van der Zon, 2004, Biochemical pharmacology.

Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice

K. Clément, J. Pépin, P. Lévy, 2016, Scientific Reports.

Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats

J. Eckel, D. Ouwens, M. Diamant, 2006, Diabetes.

Chronic Intermittent Hypoxia Impairs Insulin Sensitivity but Improves Whole-Body Glucose Tolerance by Activating Skeletal Muscle AMPK

B. Viollet, J. Pépin, P. Lévy, 2017, Diabetes.

Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.

R. Schwenk, A. Bonen, D. Ouwens, 2009, The Journal of endocrinology.

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

J. Heitman, C. Alarcón, M. Cárdenas, 1997, Biochemical and biophysical research communications.

An Insulin Receptor Mutant (Asp707 → Ala), Involved in Leprechaunism, Is Processed and Transported to the Cell Surface but Unable to Bind Insulin*

L. Hart, D. Lindhout, W. Kleijer, 1996, The Journal of Biological Chemistry.

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

H. van Dam, D. Ouwens, J. Maassen, 2006, Molecular endocrinology.

A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface.

W. Möller, J. Maassen, G. V. D. van der Zon, 1991, Biochemistry.

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

C. Kahn, J. Maassen, J. Bos, 1994, The Journal of biological chemistry.

Improper expression of insulin receptors on fibroblasts from a leprechaun patient.

H. Sips, W. Möller, J. Maassen, 1988, European journal of biochemistry.

The role of ras proteins in insulin signal transduction.

R. Medema, J. Bos, W. Möller, 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance.

E. Tobias, J. Maassen, F. Féry, 2003, The Journal of clinical endocrinology and metabolism.

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

D. Ouwens, M. Diamant, B. Guigas, 2010, Cellular signalling.

An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.

D. Lindhout, W. Möller, J. Maassen, 1992, The Journal of biological chemistry.

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

R. Medema, J. Bos, A. M. D. de Vries-Smits, 1993, Molecular and cellular biology.

Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact.

D. Ouwens, J. Dorrestijn, J. Maassen, 1996, Biochemistry.