Y. Uchida

发表

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

P. Elias, S. Kim, M. A. Mandal, 2007, Human molecular genetics.

Structural and biochemical basis for the UVB‐induced alterations in epidermal barrier function

P. Elias, W. Holleran, L. Halkier-Sørensen, 1997, Photodermatology, photoimmunology & photomedicine.

Lowered humidity produces human epidermal equivalents with enhanced barrier properties.

P. Elias, K. Feingold, D. Crumrine, 2015, Tissue engineering. Part C, Methods.

Water Extract of Gromwell (Lithospermum erythrorhizon) Enhances Migration of Human Keratinocytes and Dermal Fibroblasts with Increased Lipid Synthesis in an in vitro Wound Scratch Model

Y. Cho, W. Holleran, Y. Uchida, 2011, Skin Pharmacology and Physiology.

Glucosylceramide accumulates preferentially in lamellar bodies in differentiated keratinocytes

F. Otsuka, S. Hamanaka, Y. Uchida, 2005, The British journal of dermatology.

Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient

Hiroaki Yamada, Mujo Kim, Y. Uchida, 2019, Nutrition research and practice.

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.

P. Dubus, B. Monsarrat, A. Hovnanian, 2010, The Journal of clinical investigation.

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.

P. Elias, D. Bikle, Y. Oda, 2009, The Journal of investigative dermatology.

Infection and inflammation induce LDL oxidation in vivo.

K. Feingold, C. Grunfeld, A. Moser, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

K. Feingold, C. Grunfeld, A. Moser, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis

Yong-Moon Lee, S. Jeong, S. Kang, 2017, Biomolecules & therapeutics.

Aquatide Activation of SIRT 1 Reduces Cellular Senescence through a SIRT 1-FOXO 1-Autophagy Axis

Yong-Moon Lee, S. Jeong, S. Kang, 2017 .

Insights into the role of endoplasmic reticulum stress in skin function and associated diseases

Kyungho Park, Y. Uchida, Kyong-Oh Shin, 2019, The FEBS journal.

A Murine Model of Isolated Cardiac Steatosis Leads to Cardiomyopathy

D. Gardner, W. Holleran, Y. Yeghiazarians, 2011, Hypertension.

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex

H. Ikushiro, P. Elias, Yong-Moon Lee, 2016, Proceedings of the National Academy of Sciences.

Serine protease signaling of epidermal permeability barrier homeostasis.

P. Elias, K. Feingold, E. Choi, 2006, The Journal of investigative dermatology.

De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes.

P. Elias, W. Holleran, A. Nardo, 2003, The Journal of investigative dermatology.

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.

T. Willson, J. Auwerx, P. Chambon, 2004, The Journal of investigative dermatology.

Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope.

E. Sprecher, P. Elias, D. Roop, 2019, The Journal of investigative dermatology.

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

M. Setou, P. Elias, M. Ikawa, 2012, The Journal of investigative dermatology.

Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway*

P. Elias, T. Mauro, W. Holleran, 2011, The Journal of Biological Chemistry.

Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through Doxorubicin-Activated Sp1 in Drug-Resistant HL-60/ADR Cells

Y. Hirabayashi, S. Ichikawa, H. Umehara, 2004, Cancer Research.

Glucosylceramides stimulate mitogenesis in aged murine epidermis.

P. Elias, B. Brown, W. Holleran, 1998, The Journal of investigative dermatology.

Regulation of Glycosphingolipid Metabolism in Liver during the Acute Phase Response*

K. Feingold, C. Grunfeld, A. Moser, 1999, The Journal of Biological Chemistry.

Signaling roles of ceramide and its metabolites in cutaneous antimicrobial defense

Kyungho Park, Y. Uchida, Young il Kim, 2015 .

Ceramide Stimulates ABCA12 Expression via Peroxisome Proliferator-activated Receptor δ in Human Keratinocytes*

P. Elias, K. Feingold, C. Grunfeld, 2009, The Journal of Biological Chemistry.

Ceramides stimulate caspase‐14 expression in human keratinocytes

P. Elias, K. Feingold, C. Grunfeld, 2013, Experimental dermatology.

The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.

P. Elias, Yong-Moon Lee, W. Holleran, 2014, The Journal of nutritional biochemistry.

A Method to Investigate the Epidermal Permeability Barrier In Vitro.

A. Celli, Y. Uchida, 2020, Methods in molecular biology.

Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis).

A. Christiano, P. Elias, K. Feingold, 2004, The Journal of investigative dermatology.

Topical 11&bgr;-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice

P. Elias, W. Holleran, A. Tiganescu, 2018, Endocrinology.

PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

Y. Ramot, R. Paus, M. Bertolini, 2019, Experimental dermatology.

An Endoplasmic Reticulum Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates Epithelial Innate Immunity by Stimulating β-Defensin Production

P. Elias, Yong-Moon Lee, W. Holleran, 2014, Molecular and Cellular Biology.

An ER Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates 2

P. Elias, Yong-Moon Lee, W. Holleran, 2014 .

Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes.

P. Elias, D. Crumrine, W. Holleran, 2000, The Journal of investigative dermatology.

Local blockade of glucocorticoid activation reverses stress‐ and glucocorticoid‐induced delays in cutaneous wound healing

P. Elias, T. Mauro, W. Holleran, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

CELLULAR CHANGES THAT ACCOMPANY SHEDDING OF HUMAN CORNEOCYTES

P. Elias, D. Crumrine, R. Rice, 2012, The Journal of investigative dermatology.

Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus

W. Greene, P. Elias, B. Closs, 2019, Experimental dermatology.

A Novel Role of a Lipid Species, Sphingosine-1-Phosphate, in Epithelial Innate Immunity

A. Borkowski, P. Elias, Yong-Moon Lee, 2012, Molecular and Cellular Biology.

Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production.

P. Elias, T. Mauro, Yong-Moon Lee, 2015, Journal of dermatological science.

Resveratrol Stimulates Sphingosine-1-Phosphate Signaling of Cathelicidin Production

A. Borkowski, P. Elias, Yong-Moon Lee, 2013, The Journal of investigative dermatology.

Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation and epidermal organelles

A. Borkowski, R. Gallo, Kyungho Park, 2013, The Journal of investigative dermatology.

Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.

H. Ikushiro, Young‐Hee Kang, Yong-Moon Lee, 2019, The Journal of investigative dermatology.

UVB induces epidermal 11β‐hydroxysteroid dehydrogenase type 1 activity in vivo

P. Elias, T. Mauro, W. Holleran, 2015, Experimental dermatology.

Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.

K. Feingold, C. Grunfeld, A. Moser, 2001, Journal of lipid research.

Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines.

P. Elias, D. Crumrine, Yong-Moon Lee, 2018, The American journal of pathology.

Effect of a chemically-synthesized acylglucosylceramide, epidermoside, on normal human keratinocyte differentiation.

F. Otsuka, S. Hamanaka, Y. Uchida, 1996, Journal of dermatological science.

Formation and functions of the corneocyte lipid envelope (CLE).

P. Elias, G. Menon, W. Holleran, 2014, Biochimica et biophysica acta.

Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome.

M. Akiyama, H. Shimizu, P. Elias, 2010, The Journal of investigative dermatology.

Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation

P. Elias, C. Baudouin, P. Msika, 2012, Experimental dermatology.

Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome.

M. Akiyama, H. Shimizu, M. Ujihara, 2010, Journal of dermatological science.

Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.

V. Rogiers, P. Elias, K. Feingold, 2005, The Journal of investigative dermatology.

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes.

P. Elias, W. Holleran, R. C. Dickson, 1998, Journal of lipid research.

P. Kim, S. Kang, Sung-il Yoon, 2020, Cells.

UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response.

R. Yasuda, P. Elias, M. Schmuth, 1997, The Journal of investigative dermatology.

Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.

Y. Hannun, P. Elias, N. Radin, 2010, The Journal of investigative dermatology.

Murine atopic dermatitis responds to peroxisome proliferator-activated receptor α , β / δ (but not γ ), and liver-X-receptor activators

Debra, P. Elias, K. Feingold, 2010 .

Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.

P. Elias, K. Feingold, T. Mauro, 2010, The Journal of allergy and clinical immunology.

Human epidermal glucosylceramides are major precursors of stratum corneum ceramides.

F. Otsuka, A. Suzuki, S. Hamanaka, 2002, The Journal of investigative dermatology.

Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.

P. Elias, K. Feingold, Seung Ho Lee, 2008, The Journal of investigative dermatology.

Intrinsically aged epidermis displays diminished UVB-induced alterations in barrier function associated with decreased proliferation.

P. Elias, W. Holleran, Y. Uchida, 1997, The Journal of investigative dermatology.

Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway

Kyungho Park, Y. Uchida, Kyong-Oh Shin, 2022, International journal of molecular sciences.

Epithelial and Mesenchymal Cell Biology Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis , Dermal Angiogenesis , and the Development of Epidermal Hyperplasia Implications for the Pathogenesis of Psoriasis

E. Tschachler, J. Arbiser, P. Elias, 2010 .

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

P. Elias, K. Feingold, T. Mauro, 2009, The Journal of investigative dermatology.

Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures.

P. Elias, W. Holleran, M. Behne, 2001, The Journal of investigative dermatology.

A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

S. Jane, J. Cunningham, P. Elias, 2005, Science.

Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism.

Y. Jeong, Kyungho Park, S. Choe, 2018, Journal of medicinal food.

Kinetic Characteristics of Acidic and Alkaline Ceramidase in Human Epidermis

T. Vanhaecke, V. Rogiers, W. Holleran, 2007, Skin Pharmacology and Physiology.

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides.

P. Elias, E. Sidransky, F. Otsuka, 2000, Journal of lipid research.

Epidermal sphingolipids: Metabolism, function, and roles in skin disorders

W. Holleran, Y. Takagi, Y. Uchida, 2006, FEBS letters.

Stratum Corneum Ceramides: Function, Origins and Therapeutic Applications

S. Hamanaka, Y. Uchida, 2005 .

Omega-O-acylceramide, a lipid essential for mammalian survival.

W. Holleran, Y. Uchida, 2008, Journal of dermatological science.

Basis for the permeability barrier abnormality in lamellar ichthyosis

P. Elias, K. Feingold, R. Rice, 2002, Experimental dermatology.

Ceramides in Skin Health and Disease: An Update

Kyungho Park, Y. Uchida, 2021, American Journal of Clinical Dermatology.

SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.

T. Mauro, D. Bikle, A. Celli, 2016 .

SERCA2-controlled Ca2+-dependent Keratinocyte Adhesion and Differentiation is Mediated via the Sphingolipid Pathway- a Novel Therapeutic Target for Darier’s Disease

T. Mauro, W. Holleran, D. Bikle, 2011, The Journal of investigative dermatology.

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis Published, JLR Papers in Press, February 13, 2006.

V. Rogiers, P. Elias, L. Obeid, 2006, Journal of Lipid Research.

Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity

P. Elias, R. Rice, R. Gruber, 2005, Archives of Dermatological Research.

Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function.

P. Elias, P. R. Montellano, W. Holleran, 2000, The Journal of investigative dermatology.

Euphorbia supina Extracts Block NADPH Oxidase-Mediated, Ceramide-Induced Apoptosis Initiated by Diesel Particulate Matter

H. Cho, Kyungho Park, Y. Uchida, 2022, Pharmaceuticals.

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis.

Robert H. Brown, S. Yasuda, K. Hanada, 2002, The Journal of clinical investigation.

4.04 – Skin Glycobiology

W. Holleran, Y. Uchida, 2007 .

Chapter 41 – Skin Lipids

Y. Uchida, 2017 .

Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death

Radha Ayyagari, Peter M. Elias, P. Elias, 2007 .

Phenotypic overlap between atopic dermatitis and autism

P. Elias, K. Abuabara, Jason M. Meyer, 2020, BMC Neuroscience.

The role of fatty acid elongation in epidermal structure and function

Y. Uchida, 2011, Dermato-endocrinology.

655 Origin and functions of the corneocyte lipid envelope

E. Sprecher, P. Elias, D. Roop, 2018 .

Fatty Acid 2-Hydroxylase, Encoded by FA2H, Accounts for Differentiation-associated Increase in 2-OH Ceramides during Keratinocyte Differentiation*

P. Elias, D. Crumrine, N. L. Alderson, 2007, Journal of Biological Chemistry.

Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress DOI 10.1194/jlr.M100442-JLR200

P. Elias, M. Schmuth, Y. Hirabayashi, 2002, Journal of Lipid Research.

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation

Kyungho Park, Y. Uchida, K. Ishida, 2022, Cells.

Ceramide signaling in mammalian epidermis.

Y. Uchida, 2014, Biochimica et biophysica acta.

On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.

P. Elias, W. Holleran, Y. Uchida, 2008, Journal of dermatological science.

Decreased Ceramide Transport Protein (CERT) Function Alters Sphingomyelin Production following UVB Irradiation*

K. Hanada, Keigo Kumagai, M. Kawano, 2008, Journal of Biological Chemistry.

Increased glucocorticoid activation during mouse skin wound healing.

P. Elias, T. Mauro, W. Holleran, 2014, The Journal of endocrinology.

Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes

T. Willson, J. Auwerx, P. Chambon, 2004 .

Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing.

P. Elias, K. Feingold, M. Schmuth, 2006, The Journal of investigative dermatology.

Chapter 2 Stratum Corneum

Kyungho Park, Y. Uchida, 2019 .

Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.

P. Elias, Y. Obata, H. Sano, 2013, Journal of dermatological science.

Altered lipid profiles in the stratum corneum of Sjögren-Larsson syndrome.

M. Akiyama, H. Shimizu, S. Sano, 2011, Journal of dermatological science (Amsterdam).

Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice

P. Elias, M. Akiyama, Y. Hirabayashi, 2021, Skin Pharmacology and Physiology.

A Trial of Galactosylceramide Containing Cream to the Patients with Atopic Skin and Xerosis

M. Ujihara, S. Hamanaka, Y. Uchida, 1995 .

Roles of Epidermal Lipids in Barrier Formation

Y. Uchida, 2017 .

Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation.

J. Yeo, H. Seo, Yunhi Cho, 2014, International journal of molecular medicine.

Galactocerebroside and not glucocerebroside or ceramide stimulate epidermal beta-glucocerebrosidase activity.

S. Hamanaka, Y. Uchida, A. Haratake, 1998, Journal of dermatological science.

Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features.

P. Elias, W. Holleran, J. Takeda, 2004, The Journal of investigative dermatology.

The Epidermal Environment’s Influence on the Dermal Environment in Response to External Stress

Jin-Taek Hwang, Kyungho Park, Y. Uchida, 2023, Skin Pharmacology and Physiology.

Imaging Mass Spectrometry Visualizes Ceramides and the Pathogenesis of Dorfman-Chanarin Syndrome Due to Ceramide Metabolic Abnormality in the Skin

M. Setou, N. Goto-Inoue, W. Holleran, 2012, PloS one.

Modulation of Aryl Hydrocarbon Receptor Can Be a Strategy to Improve Epidermal Barrier Function by Increasing Glucosylceramide Synthesis.

Kyungho Park, Y. Uchida, 2023, The Journal of investigative dermatology.

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

K. Feingold, C. Grunfeld, A. Moser, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Increased glucocorticoid activation during mouse skin wound healing.

P. Elias, T. Mauro, W. Holleran, 2014, The Journal of endocrinology.

Exploring the human hair follicle microbiome *

A. Di Nardo, R. Paus, T. Bosch, 2020, The British journal of dermatology.

Local blockade of glucocorticoid activation reverses stress‐ and glucocorticoid‐induced delays in cutaneous wound healing

P. Elias, T. Mauro, W. Holleran, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis.

K. Feingold, M. Man, H. Rossiter, 2008, The American journal of pathology.

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production.

S. Itami, Mujo Kim, Kyungho Park, 2018, Journal of medicinal food.