J. Fletcher

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Antibodies having markedly different effects on enzymatic activity and induction of acetylcholine release by two presynaptically-acting phospholipase A2 neurotoxins.

J. Fletcher, M. Jiang, J. Middlebrook, 1995, Biochemical pharmacology.

Presynaptically acting snake venom phospholipase A2 enzymes attack unique substrates.

J. Fletcher, M. Jiang, 1995, Toxicon : official journal of the International Society on Toxinology.

Phenytoin increases specific triacylglycerol fatty esters in skeletal muscle from horses with hyperkalemic periodic paralysis.

J. Fletcher, K. Erwin, J. Beech, 1993, Biochimica et biophysica acta.

Involvement of Lipid Metabolism in the Action of Phospholipase A2 Neurotoxins

J. Fletcher, 1992 .

Snake venom cardiotoxins and bee venom melittin activate phospholipase C activity in primary cultures of skeletal muscle.

L. Smith, Q. Gong, J. Fletcher, 1991, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Interactions of fatty acids with the calcium release channel in malignant hyperthermia.

H. Rosenberg, J. Fletcher, J. Beech, 1991, Advances in experimental medicine and biology.

Interactions in red blood cells between fatty acids and either snake venom cardiotoxin or halothane.

L. Smith, J. Fletcher, M. Jiang, 1990, Toxicon : official journal of the International Society on Toxinology.

Lipid analysis of skeletal muscle from pigs susceptible to malignant hyperthermia.

H. Rosenberg, K. Michaux, J. Fletcher, 1988, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Dantrolene and mepacrine antagonize the hemolysis of human red blood cells by halothane and bee venom phospholipase A2.

H. Rosenberg, K. Michaux, J. Fletcher, 1987, Toxicology and applied pharmacology.

Failure to identify the ryanodine receptor G1021A mutation in a large North American population with malignant hyperthermia

H. Rosenberg, J. Fletcher, S. L. Stewart, 1998, Clinical genetics.

Calcium accumulation by sarcoplasmic reticulum in whole muscle homogenate preparations of malignant hyperthermia diagnostic patients and pigs

H. Rosenberg, J. Fletcher, K. S. Cheah, 1990, Acta anaesthesiologica Scandinavica.

Importance of fasting in the lymphocyte calcium test for malignant hyperthermia

H. Rosenberg, J. Fletcher, G. Allen, 1990, Acta anaesthesiologica Scandinavica.

Erythrocyte Fragility Screening Is Not a Tool for Diagnosis of Human Malignant Hyperthermia

H. Rosenberg, J. Fletcher, P. Kistler, 1987, Anesthesia and analgesia.

Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin.

J. Fletcher, M. Jiang, 1993, Toxicon : official journal of the International Society on Toxinology.

Masseter Muscle Rigidity and Malignant Hyperthermia Susceptibility

H. Rosenberg, J. Fletcher, 1986, Anesthesia and analgesia.

Effects of a cardiotoxin from Naja naja kaouthia venom on skeletal muscle: involvement of calcium-induced calcium release, sodium ion currents and phospholipases A2 and C.

Q. Gong, J. Fletcher, M. Jiang, 1991, Toxicon : official journal of the International Society on Toxinology.

Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data.

G. Oliva, R. Garratt, H. Selistre‐de‐Araujo, 1999, Archives of biochemistry and biophysics.

Cardiotoxin 1 from cobra (Naja naja atra) venom causes necrosis of skeletal muscle in vivo.

C. Ownby, J. Fletcher, T. Colberg, 1993, Toxicon : official journal of the International Society on Toxinology.

Basic phospholipase A2 from Naja nigricollis snake venom: phospholipid hydrolysis and effects on electrical and contractile activity of the rat heart.

C. Yang, J. Fletcher, P. Rosenberg, 1982, Toxicology and applied pharmacology.

Contracture induction by snake venom cardiotoxin in skeletal muscle from humans and rats.

J. Fletcher, F. Lizzo, 1987, Toxicon : official journal of the International Society on Toxinology.

Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis.

J. Beech, J. Fletcher, L. Tripolitis, 1995, Research in veterinary science.

Effects of phenytoin in two myotonic horses with hyperkalemic periodic paralysis

J. Beech, J. Fletcher, L. Tripolitis, 1992, Muscle & nerve.

Dissociation of enzymatic activity from lethality and pharmacological properties by carbamylation of lysines in Naja nigricollis and Naja naja atra snake venom phospholipases A2.

C. Yang, B. Rapuano, J. Fletcher, 1981, Toxicon : official journal of the International Society on Toxinology.

ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine.

H. Reyford, H. Rosenberg, J. Fletcher, 1999, Anesthesiology.

Bovine serum albumin does not completely block synaptosomal cholinergic activities of presynaptically acting snake venom phospholipase A2 enzymes.

J. Fletcher, M. Jiang, R. Storella, 1995, Toxicon : official journal of the International Society on Toxinology.

Preliminary evidence for a postsynaptic action of beta-bungarotoxin in mammalian skeletal muscle.

L. Smith, J. Fletcher, M. Jiang, 1992, Toxicon : official journal of the International Society on Toxinology.

Effects of beta-bungarotoxin and Naja naja atra snake venom phospholipase A2 on acetylcholine release and choline uptake in synaptosomes.

J. Fletcher, J. Middlebrook, 1986, Toxicon : official journal of the International Society on Toxinology.

Comparison of sensitivity of sodium currents to tetrodotoxin in equine muscle specimens with that in murine and human muscle specimens.

J. Fletcher, K. Erwin, J. Beech, 2000, American journal of veterinary research.

Fatty Acids: Potentially Crucial Modulators of the Malignant Hyperthermia Syndrome

J. Fletcher, S. Wieland, 1996 .

Masseter Muscle Rigidity Associated with Glycine1306-to- Alanine Mutation in the Adult Muscle Sodium Channel α-Subunit Gene

A. George, A. Olckers, A. Jedlicka, 1995 .

Altered sodium current response to intracellular fatty acids in halothane-hypersensitive skeletal muscle.

Q. Gong, H. Rosenberg, J. Fletcher, 1996, The American journal of physiology.

Fatty acids modulate calcium-induced calcium release from skeletal muscle heavy sarcoplasmic reticulum fractions: implications for malignant hyperthermia.

H. Rosenberg, J. Fletcher, K. Erwin, 1990, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Effects of arginine modification of Naja nigricollis and Naja naja atra snake venom phospholipases A2 on enzymatic activity, lethality and anticoagulant action.

C. Yang, B. Rapuano, J. Fletcher, 1981, Toxicon : official journal of the International Society on Toxinology.

Fatty acids markedly lower the threshold for halothane-induced calcium release from the terminal cisternae in human and porcine normal and malignant hyperthermia susceptible skeletal muscle.

H. Rosenberg, J. Fletcher, L. Tripolitis, 1991, Life sciences.

Halothane‐caffeine contracture testing in neuromuscular diseases

T. Heiman-Patterson, H. Rosenberg, J. Fletcher, 1988, Muscle & nerve.

Malignant hyperthermia susceptibility in X-linked muscle dystrophies.

T. Heiman-Patterson, H. Rosenberg, H. Natter, 1986, Pediatric neurology.

Masseter Muscle Rigidity and Malignant Hyperthermia Susceptibility in Pediatric Patients An Update on Management and Diagnosis

J. G. Shutack, H. Rosenberg, J. Fletcher, 1994, Anesthesiology.

Malignant hyperthermia: halothane- and calcium-induced calcium release in skeletal muscle.

H. Rosenberg, J. Fletcher, J. Beech, 1993, Biochemistry and molecular biology international.

Malignant hyperthermia: slow sodium current in cultured human muscle cells.

Q. Gong, H. Rosenberg, J. Fletcher, 1989, The American journal of physiology.

Q. Gong, J. Fletcher, M. Jiang, 1996, Toxicon : official journal of the International Society on Toxinology.

Myotoxin a reduces the threshold for calcium-induced calcium release in skeletal muscle.

J. Fletcher, J. Beech, M. Yudkowsky, 1994, Toxicon : official journal of the International Society on Toxinology.

Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo.

J. Powell, C. Ownby, Jennifer R. Powell, 1997, Toxicon : official journal of the International Society on Toxinology.

Contribution of bee venom phospholipase A2 contamination in melittin fractions to presumed activation of tissue phospholipase A2.

K. Michaux, J. Fletcher, M. Jiang, 1990, Toxicon : official journal of the International Society on Toxinology.

Factors influencing the hemolysis of human erythrocytes by cardiotoxins from Naja naja kaouthia and Naja naja atra venoms and a phospholipase A2 with cardiotoxin-like activities from Bungarus fasciatus venom.

Leonard A. Smith, L. Smith, J. Fletcher, 1989, Toxicon : official journal of the International Society on Toxinology.

Enhancement of halothane action at the ryanodine receptor by unsaturated fatty acids.

J. Fletcher, V. E. Welter, 1994, Advances in pharmacology.

Comparison of European and North American malignant hyperthermia diagnostic protocol outcomes for use in genetic studies.

H. Rosenberg, J. Fletcher, M. Aggarwal, 1999, Anesthesiology.

Malignant Hyperthermia Susceptibility in Neuroleptic Malignant Syndrome

T. Heiman-Patterson, S. Caroff, H. Rosenberg, 1987, Anesthesiology.

Pathologic changes induced by phospholipase A2 isolated from the venom of Collett's snake, Pseudechis colletti: a light and electron microscopic study.

C. Brown, L. Smith, R. C. Bell, 1992, Toxicon : official journal of the International Society on Toxinology.

Modulation of Human Muscle Sodium Channels by Intracellular Fatty Acids Is Dependent on the Channel Isoform*

R. Kallen, Q. Gong, J. Fletcher, 1996, The Journal of Biological Chemistry.

Relationship between catalysis and toxicological properties of three phospholipases A2 from elapid snake venoms.

C. Yang, B. Rapuano, J. Fletcher, 1981, Toxicology and applied pharmacology.

Effect of modification of one histidine residue on the enzymatic and pharmacological properties of a toxic phospholipase A2 from Naja nigricollis snake venom and less toxic phospholipases A2 from Hemachatus haemachatus and Naja atra snake venoms.

C. Yang, B. Rapuano, J. Fletcher, 1981, Toxicon : official journal of the International Society on Toxinology.

Comparison of a relatively toxic phospholipase A2 from Naja nigricollis snake venom with that of a relatively non-toxic phospholipase A2 from Hemachatus haemachatus snake venom--II. Pharmacological properties in relationship to enzymatic activity.

C. Yang, B. Rapuano, J. Fletcher, 1980, Biochemical pharmacology.

Effects of divalent cations on snake venom cardiotoxin-induced hemolysis and 3H-deoxyglucose-6-phosphate release from human red blood cells.

L. Smith, J. Fletcher, M. Jiang, 1989, Toxicon : official journal of the International Society on Toxinology.

Phospholipase A and B activities of reptile and hymenoptera venoms.

J. Ishay, J. Fletcher, W. Elliott, 1979, Toxicon : official journal of the International Society on Toxinology.

Skeletal muscle mitochondrial respiration of malignant hyperthermia-susceptible patients. Ca2+-induced uncoupling and free fatty acids.

H. Rosenberg, J. Fletcher, K. S. Cheah, 1989, The International journal of biochemistry.

Caffeine contractures, twitch characteristics and the threshold for Ca(2+)-induced Ca2+ release in skeletal muscle from horses with chronic intermittent rhabdomyolysis.

J. Beech, K. Braund, J. Fletcher, 1993, Research in veterinary science.

The importance of calcium ions forin vitro malignant hyperthermia testing

H. Rosenberg, J. Fletcher, F. Huggins, 1990, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Caffeine and halothane contracture testing in swine using the recommendations of the North American Malignant Hyperthermia Group.

H. Rosenberg, J. Fletcher, G. Allen, 1990, Anesthesiology.

Laboratory Methods for Malignant Hyperthermia Diagnosis

H. Rosenberg, J. Fletcher, 1988 .

Low molecular weight proteins in human malignant hyperthermia muscle.

H. Rosenberg, J. Fletcher, 1985, Anesthesiology.

ELECTROPHORESIS OF SOLUBLE MUSCLE PROTEIN FROM MALIGNANT HYPERTHERMIA SUSCEPTIBLES

H. Rosenberg, J. Fletcher, M. Hilf, 1984 .

Sodium Channel in Human Malignant Hyperthermia

J. Beech, H. Rosenberg, J. Fletcher, 1997, Anesthesiology.

Phenotypes associated with malignant hyperthermia susceptibility in swine genotyped as homozygous or heterozygous for the ryanodine receptor mutation.

H. Rosenberg, J. Fletcher, P. A. Calvo, 1993, British journal of anaesthesia.

In vitro muscle contractures induced by halothane and suxamethonium. I: The rat diaphragm.

H. Rosenberg, J. Fletcher, 1986, British journal of anaesthesia.

In vitro muscle contractures induced by halothane and suxamethonium. II: Human skeletal muscle from normal and malignant hyperthermia susceptible patients.

H. Rosenberg, J. Fletcher, 1986, British journal of anaesthesia.

In vitro interaction between halothane and succinylcholine in human skeletal muscle: implications for malignant hyperthermia and masseter muscle rigidity.

H. Rosenberg, J. Fletcher, 1985, Anesthesiology.

The importance of calcium ions for in vitro malignant hyperthermia testing

J. Fletcher, F. Huggins, MO HenryRosenberg, 2008 .

Effects of lipid-soluble agents on sodium channel function in normal and MH-susceptible skeletal muscle cultures.

Q. Gong, H. Rosenberg, J. Fletcher, 1991, Advances in experimental medicine and biology.

IN VITRO STUDIES OF DROPERIDOL FOR USE IN HUMAN MALIGNANT HYPERTHERMIA

H. Rosenberg, J. Fletcher, M. Hilf, 1985 .

ELEVATED FATTY ACID PRODUCTION IN SKELETAL MUSCLE FROM MALIGNANT HYPERTHERMIA SUSCEPTIBLE PATIENTS

H. Rosenberg, J. Fletcher, L. Tripolitis, 1985 .

North American Malignant Hyperthermia Population: Screening of the Ryanodine Receptor Gene and Identification of Novel Mutations

T. Nelson, N. Sambuughin, Y. Sei, 2001, Anesthesiology.

More about masseter spasm and malignant hyperthermia.

H. Rosenberg, J. Fletcher, 1985, Anesthesiology.

CAFFEINE AND HALOTHANE CONTRACTURE TESTING IN MALIGNANT HYPERTHERMIA (MH) SUSCEPTIBLE SWINE USING THE NEW NORTH AMERICAN MH GROUP RECOMMENDATIONS

H. Rosenberg, J. Fletcher, G. Allen, 1989 .

Malignant hyperthermia in myotonia congenita

T. Heiman-Patterson, H. Rosenberg, J. Fletcher, 1988, Neurology.

Safety of general anesthesia in patients previously tested negative for malignant hyperthermia susceptibility.

H. Rosenberg, J. Fletcher, G. Allen, 1990, Anesthesiology.

Genotype and phenotype relationships for mutations in the ryanodine receptor in patients referred for diagnosis of malignant hyperthermia.

R. Levitt, H. Rosenberg, J. Fletcher, 1995, British journal of anaesthesia.

Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients

H. Rosenberg, J. Fletcher, Merrill Hilf, 1984, Canadian Anaesthetists' Society journal.

Masseter Muscle Rigidity Associated with Glycine sup 1306 ‐to‐ Alanine Mutation in the Adult Muscle Sodium Channel alpha‐Subunit Gene

A. George, A. Olckers, A. Jedlicka, 1995, Anesthesiology.

An update on the malignant hyperthermia syndrome.

H. Rosenberg, J. Fletcher, 1994, Annals of the Academy of Medicine, Singapore.

Lysine 49 phospholipase A2 proteins.

C. Ownby, J. Fletcher, S. P. White, 1999, Toxicon : official journal of the International Society on Toxinology.

Genotype and Phenotype Relationships for Mutations in the Ryanodine Receptor in Patients Referred for Diagnosis of Malignant Hyperthymia

R. Levitt, H. Rosenberg, J. Fletcher, 1996 .

Mn(2+) ions reduce the enzymatic and pharmacological activities of bothropstoxin-I, a myotoxic Lys49 phospholipase A(2) homologue from Bothrops jararacussu snake venom.

A. Soares, L. Rodrigues-Simioni, J. Giglio, 2002, The international journal of biochemistry & cell biology.

No role for enzymatic activity or dantrolene-sensitive Ca2+ stores in the muscular effects of bothropstoxin, a Lys49 phospholipase A2 myotoxin.

L. Rodrigues-Simioni, J. Giglio, A. Cintra, 1995, Toxicon.

LYS49 phospholipase A2 myotoxins lyse cell cultures by two distinct mechanisms.

J. Fletcher, M. Jiang, 1998, Toxicon : official journal of the International Society on Toxinology.

Species difference in modulation of calcium release by Naja naja kaouthia snake venom cardiotoxin in terminal cisternae from human and equine skeletal muscle.

J. Fletcher, J. Beech, L. Tripolitis, 1993, Toxicon : official journal of the International Society on Toxinology.

Modulation of Ca2+ release and Na+ channel function in skeletal muscle by fatty acids.

T. Heiman-Patterson, H. Rosenberg, J. Fletcher, 1992, Advances in Experimental Medicine and Biology.

Ethoxyformylation and guanidination of snake venom phospholipases A2: effects on enzymatic activity, lethality and some pharmacological properties.

C. Yang, B. Rapuano, J. Fletcher, 1983, Toxicon : official journal of the International Society on Toxinology.

Phenytoin alters transcript levels of hormone-sensitive lipase in muscle from horses with hyperkalemic periodic paralysis.

J. Fletcher, J. Beech, M. Yudkowsky, 1998, Archives of biochemistry and biophysics.

Effect of phenytoin on the clinical signs and in vitro muscle twitch characteristics in horses with chronic intermittent rhabdomyolysis and myotonia.

J. Beech, J. Fletcher, F. Lizzo, 1988, American journal of veterinary research.

Effect of a phospholipase A2 with cardiotoxin-like properties, from Bungarus fasciatus snake venom, on calcium-modulated potassium currents.

Q. Gong, J. Fletcher, M. Jiang, 1989, Toxicon : official journal of the International Society on Toxinology.

Effects of three myotoxins on membrane phospholipid hydrolysis in cell culture systems

C. Ownby, J. Fletcher, M. Jiang, 1995 .

Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids.

Q. Gong, J. Fletcher, S. Wieland, 1992, The American journal of physiology.

Bee venom melittin is a potent toxin for reducing the threshold for calcium-induced calcium release in human and equine skeletal muscle.

J. Fletcher, J. Beech, L. Tripolitis, 1992, Life sciences.

Altered [3H]ryanodine binding is not associated with malignant hyperthermia susceptibility in terminal cisternae preparations from swine.

H. Rosenberg, J. Fletcher, L. Tripolitis, 1991, Biochemistry International.

Triglycerides, not phospholipids, are the source of elevated free fatty acids in muscle from patients susceptible to malignant hyperthermia.

H. Rosenberg, K. Michaux, J. Fletcher, 1989, European journal of anaesthesiology.

MASSETER MUSCLE RIGIDITY (MMR) AND MALIGNANT HYPERTHERMIA SUSCEPTIBILITY (MHS): AN UPDATE ON MANAGEMENT AND DIAGNOSIS

H. Rosenberg, J. Fletcher, J. Do, 1992 .

Molecular genetics and malignant hyperthermia.

R. Levitt, H. Rosenberg, J. Fletcher, 1991, Anesthesiology.

Evidence for genetic heterogeneity in malignant hyperthermia susceptibility.

V. McKusick, J. G. Shutack, A. Jedlicka, 1991, Genomics.

Dissociation between enzymatic activity and pharmacological properties of snake venom phospholipases A2

B. Rapuano, J. Fletcher, P. Rosenberg, 1983 .