J. Middlebrook

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Antibodies having markedly different effects on enzymatic activity and induction of acetylcholine release by two presynaptically-acting phospholipase A2 neurotoxins.

J. Fletcher, M. Jiang, J. Middlebrook, 1995, Biochemical pharmacology.

Ion-conducting channels produced by botulinum toxin in planar lipid membranes.

J. J. Donovan, J. Middlebrook, 1986, Biochemistry.

Specific antibodies against the Zn(2+)-binding domain of clostridial neurotoxins restore exocytosis in chromaffin cells treated with tetanus or botulinum A neurotoxin.

H. Bigalke, J. Middlebrook, J. Halpern, 1994, The Journal of biological chemistry.

Association of diphtheria toxin with Vero cells. Demonstration of a receptor.

S. Leppla, J. Middlebrook, R. B. Dorland, 1978, The Journal of biological chemistry.

Binding of myotoxin a to cultured muscle cells.

A. Tu, B. Baker, J. Middlebrook, 1993, Toxicon : official journal of the International Society on Toxinology.

Cellular regulation of diphtheria toxin cell surface receptors.

B. Rönnberg, J. Middlebrook, 1989, Toxicon : official journal of the International Society on Toxinology.

Specific association of T-2 toxin with mammalian cells.

J. Middlebrook, D. L. Leatherman, 1989, Biochemical pharmacology.

CHAPTER 5 – Cell Surface Receptors for Protein Toxins

J. Middlebrook, 1989 .

Monoclonal antibodies against Vero cells that protect against diphtheria toxin.

B. Rönnberg, J. Middlebrook, B. Lidgerding, 1989, Toxicon : official journal of the International Society on Toxinology.

Binding of T-2 toxin to eukaryotic cell ribosomes.

J. Middlebrook, D. L. Leatherman, 1989, Biochemical pharmacology.

Chapter 33: Botulinum Toxins

D. Franz, J. Middlebrook, 1996 .

Cellular Mechanism of Action of Botulinum Neurotoxin

J. Middlebrook, 1986 .

RECEPTOR-MEDIATED INTERNALIZATION OF DIPHTHERIA TOXIN

J. Middlebrook, R. Dorland, 1981 .

RECEPTOR-MEDIATED BINDING AND INTERNALIZATION OF PSEUDOMONAS EXOTOXIN A AND DIPHTHERIA EXOTOXIN BY MAMMALIAN CELLS

Stephen H. Leppla, J. D. White, J. Middlebrook, 1980 .

Production of vaccines against leading biowarfare toxins can utilize DNA scientific technology.

J. Middlebrook, 2005, Advanced drug delivery reviews.

Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc.

M. Oshima, M. Atassi, J. Middlebrook, 1998, Immunology letters.

Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855–1296 with antitoxin antibodies from three host species

M. Oshima, M. Atassi, M. Hayakari, 1996, Journal of protein chemistry.

Protection of mammalian cells from diphtheria toxin by exogenous nucleotides.

J. Middlebrook, R. Dorland, 1979, Canadian journal of microbiology.

Differential chemical protection of mammalian cells from the exotoxins of Corynebacterium diphtheriae and Pseudomonas aeruginosa

J. Middlebrook, R. Dorland, 1977, Infection and immunity.

Contributions of the U.S. Army to Botulinum Toxin Research

J. Middlebrook, 1993 .

Differential sensitivity of reticulocytes to nicked and unnicked diphtheria toxin.

J. Middlebrook, D. L. Leatherman, 1982, Experimental cell research.

Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.

S. Leppla, J. Middlebrook, R. Dorland, 1980, The Journal of biological chemistry.

Effects of lectins on the interaction of diphtheria toxin with mammalian cells.

S. Leppla, J. Middlebrook, R. Dorland, 1979, Experimental cell research.

Effect of ammonium chloride on receptor-mediated uptake of diphtheria toxin by Vero cells.

S. Leppla, J. Middlebrook, R. Dorland, 1981, Experimental cell research.

Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects.

I. I. Kaiser, L. Simpson, J. Middlebrook, 1993, Toxicon : official journal of the International Society on Toxinology.

Effects of myonecrotic snake venom phospholipase A2 toxins on cultured muscle cells.

T. V. Gowda, J. Middlebrook, 1993, Toxicon : official journal of the International Society on Toxinology.

Effects of beta-bungarotoxin and Naja naja atra snake venom phospholipase A2 on acetylcholine release and choline uptake in synaptosomes.

J. Fletcher, J. Middlebrook, 1986, Toxicon : official journal of the International Society on Toxinology.

Protective vaccination with a recombinant fragment of Clostridium botulinum neurotoxin serotype A expressed from a synthetic gene in Escherichia coli

D. Brown, J. Middlebrook, M. A. Clayton, 1995, Infection and immunity.

[12] Isolation and characterization of the Botulinum neurotoxins

L. Simpson, J. Middlebrook, J. Schmidt, 1988 .

Epitope mapping studies of snake venom phospholipase A2 using monoclonal antibodies.

B. Stiles, J. Middlebrook, 1991, Advances in experimental medicine and biology.

Effects of Botulinum Neurotoxin a on Protein Phosphorylation in Synaptosomes

J. Middlebrook, D. L. Leatherman, 1993 .

Immune recognition of botulinum neurotoxin type A: regions recognized by T cells and antibodies against the protective H(C) fragment (residues 855-1296) of the toxin.

M. Oshima, M. Atassi, M. Hayakari, 1997, Molecular immunology.

Development of a Molecular Engineered Vaccine for C. Botulinum Neurotoxins

J. Brown, J. Middlebrook, M. A. Clayton, 1993 .

Protection strategies against botulinum toxin.

J. Middlebrook, 1995, Advances in experimental medicine and biology.

Vaccination of mice with DNA encoding a large fragment of botulinum neurotoxin serotype A.

J. Middlebrook, J. Clayton, 2000, Vaccine.

Optical and hydrodynamic studies of the structure of bacteriophage f2.

R. Henkens, J. Middlebrook, 1973, Biochemistry.

Effect of emetine on T-2 toxin-induced inhibition of protein synthesis in mammalian cells.

J. Middlebrook, D. L. Leatherman, 1993, The Journal of pharmacology and experimental therapeutics.

Response of cultured mammalian cells to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae: differential cytotoxicity.

J. Middlebrook, R. Dorland, 1977, Canadian journal of microbiology.

Purification, sequencing and characterization of pseudexin phospholipases A2 from Pseudechis porphyriacus (Australian red-bellied black snake).

J. J. Schmidt, J. Middlebrook, 1989, Toxicon : official journal of the International Society on Toxinology.

Effect of salt on reversibility of glucocorticoid receptor binding.

N. S. Krieger, J. Middlebrook, L. Aronow, 1976, Journal of steroid biochemistry.

Bacterial toxins: cellular mechanisms of action

J. Middlebrook, R. Dorland, 1984 .

Bacterial toxins: cellular mechanisms of action

J L Middlebrook, R B Dorland, J. Middlebrook, 1984, Microbiological reviews.

Epitope mapping of snake venom phospholipases A2 with pseudexin monoclonal antibodies

B. Stiles, J. Middlebrook, John L. Middlebrook, 1991, Journal of protein chemistry.

The secondary structure of staphylococcal enterotoxins A, B and C.

P. Argos, L. Spero, J. Middlebrook, 1980, Biochimica et biophysica acta.

Differential association of T-2 and T-2 tetraol with mammalian cells.

J. Middlebrook, D. L. Leatherman, 1989, The Journal of pharmacology and experimental therapeutics.

Effects of steroids on association of T-2 toxin with mammalian cells.

J. Middlebrook, D. L. Leatherman, 1994, Toxicon : official journal of the International Society on Toxinology.

Mosquito inoculation: an alternative bioassay for toxins.

M. Turell, J. Middlebrook, 1988, Toxicon : official journal of the International Society on Toxinology.

Subcellular distribution of glucocorticoid receptors in mouse fibroblasts.

D. Ishii, J. Middlebrook, L. Aronow, 1975, Biochemistry.

Immunodiagnosis and immunotherapy of tetanus and botulinum neurotoxins.

J. Brown, J. Middlebrook, 1995, Current topics in microbiology and immunology.

Cross-reactivity and neutralization by rabbit antisera raised against crotoxin, its subunits and two related toxins.

I. I. Kaiser, J. Middlebrook, M. Crumrine, 1986, Toxicon : official journal of the International Society on Toxinology.

Preparation of a crotoxin neutralizing monoclonal antibody.

I. I. Kaiser, J. Middlebrook, 1988, Toxicon : official journal of the International Society on Toxinology.

Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells.

Stephen H. Leppla, J. Middlebrook, R. Dorland, 1979, The Journal of biological chemistry.

Effect of single and double peptide bond scission by trypsin on the structure and activity of staphylococcal enterotoxin C.

L. Spero, J. Middlebrook, J. Metzger, 1976, The Journal of biological chemistry.

Cross-neutralizations of phospholipase A2 neurotoxins from snake venoms.

J. Middlebrook, 1991, Toxicon : official journal of the International Society on Toxinology.

Immunological relationships of phospholipase A2 neurotoxins from snake venoms.

I. I. Kaiser, J. Middlebrook, 1989, Toxicon : official journal of the International Society on Toxinology.

Monoclonal antibodies to VRV-PL-VIIIa, a basic multitoxic phospholipase A2 from Vipera russelli venom.

T. V. Gowda, J. Middlebrook, T. Gowda, 1994, Toxicon : official journal of the International Society on Toxinology.

Primary sequence determination of the most basic myonecrotic phospholipase A2 from the venom of Vipera russelli.

J. Middlebrook, V. Gowda, J. Schmidt, 1994, Toxicon : official journal of the International Society on Toxinology.

Preparation and characterization of monoclonal antibodies against pseudexin.

J. Middlebrook, 1991, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of the Botulinum neurotoxins.

L. Simpson, J. J. Schmidt, J. Middlebrook, 1988, Methods in enzymology.

Expression of a large, nontoxic fragment of botulinum neurotoxin serotype A and its use as an immunogen.

J. Middlebrook, M. A. Clayton, H. Lapenotiere, 1995, Toxicon : official journal of the International Society on Toxinology.

N-TIC N Differential Association of T-2 and T-2 Tetraol with ELECTE 00 Mammalian Cells 5 STRTEoMIT-i FEB 2 3 1990

J. Middlebrook, L. Dennis, 2022 .

Serum effects on the response of mammalian cells to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae.

J. Middlebrook, R. Dorland, 1977, Canadian journal of microbiology.

Physicochemical properties of glucocorticoid receptors from mouse fibroblasts.

J. Middlebrook, L. Aronow, 1977, Endocrinology.