E. Mezeiova

发表

Profiling donepezil template into multipotent hybrids with antioxidant properties

K. Kuča, D. Jun, D. Maliňák, 2018, Journal of enzyme inhibition and medicinal chemistry.

From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia.

J. Konečný, M. Benkova, O. Soukup, 2020, Bioorganic chemistry.

Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods

K. Kuča, J. Konečný, M. Benkova, 2018, Molecules.

A systematic review on donepezil-based derivatives as potential cholinesterase inhibitors for Alzheimer's disease.

D. Kaping, O. Soukup, J. Korábečný, 2018, Current medicinal chemistry.

Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.

D. Jun, M. Benkova, O. Soukup, 2020, European journal of medicinal chemistry.

Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders

K. Musílek, O. Soukup, J. Korábečný, 2022, Medicinal research reviews.

Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides.

J. Pejchal, D. Jun, R. Doležal, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

D. Kaping, K. Kuča, D. Jun, 2017, Molecules.

Recent advances with 5-HT3 modulators for neuropsychiatric and gastrointestinal disorders.

K. Musílek, O. Soukup, J. Korábečný, 2020, Medicinal research reviews.

Total synthesis of pachastrissamine together with its 4-epi-congener via [3,3]-sigmatropic rearrangements and antiproliferative/cytotoxic evaluation.

M. Pilátová, J. Mojžiš, E. Mezeiova, 2015, Carbohydrate research.

Total synthesis and antiproliferative/cytotoxic profiling of 2-epi-jaspine B.

M. Pilátová, E. Mezeiova, J. Gonda, 2016, Carbohydrate research.

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

D. Kaping, K. Kuča, D. Jun, 2017, Molecules.

Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease.

M. Bartolini, M. Bolognesi, J. Pejchal, 2021, ACS chemical neuroscience.

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.

D. Kaping, K. Kuča, D. Jun, 2018, European journal of medicinal chemistry.

Total synthesis of (−)-jaspine B and its 4-epi-analogue from d-xylose

E. Mezeiova, J. Gonda, M. Martinková, 2014 .

Jaspine B Hydrochloride-induced Apoptosis in HeLa Cells Is Associated With Disrupted Sphingolipid Metabolism and Ceramide Overload

P. Takáč, P. Gál, M. Pilátová, 2021, AntiCancer Research.

Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.

K. Wanner, G. Höfner, B. Malawska, 2021, European journal of medicinal chemistry.

Donepezil Derivatives Targeting Amyloid-β cascade in Alzheimer's Disease.

K. Kuča, D. Maliňák, O. Soukup, 2019, Current Alzheimer Research.

Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.

H. Stark, A. Bojarski, T. Petrásek, 2022, European journal of medicinal chemistry.

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

K. Kuča, D. Jun, D. Maliňák, 2020, Journal of enzyme inhibition and medicinal chemistry.

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

M. Valis, M. Bartolini, M. Bolognesi, 2019, European journal of medicinal chemistry.

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.

J. Čapek, J. Pejchal, M. Valko, 2020, European journal of medicinal chemistry.

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

K. Kuča, D. Jun, D. Maliňák, 2015, Molecules.

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

D. Jun, O. Soukup, J. Marco-Contelles, 2019, Biomolecules.

Orexin supplementation in narcolepsy treatment: A review

A. Stuchlik, K. Kuča, K. Valeš, 2018, Medicinal research reviews.

Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment.

D. Jun, O. Soukup, L. Prchal, 2021, Bioorganic & medicinal chemistry letters.

Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease.

K. Kuča, O. Soukup, R. Doležal, 2017, Current topics in medicinal chemistry.

Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

K. Kuča, J. Korábečný, E. Nepovimova, 2017, Neuroscience.

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D2 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole

T. Petrásek, W. Dehaen, K. Musílek, 2021, Biomolecules.

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.

V. Spiwok, S. Bősze, Jiří Janoušek, 2023, European journal of medicinal chemistry.

1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats.

K. Kuča, J. Korábečný, J. Zdarova Karasova, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Morphing Cholinesterase Inhibitor Amiridine into Multipotent Drugs for the Treatment of Alzheimer’s Disease

O. Soukup, L. Prchal, A. Misiachna, 2024, bioRxiv.