Jing Qu

发表

Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii.

Yu-huan Li, Shuang-Gang Ma, Lu-Lu Li, 2020, Phytochemistry.

Lycojaponicumins A-C, three alkaloids with an unprecedented skeleton from Lycopodium japonicum.

N. Chen, X. Bao, Dan Zhang, 2012, Organic letters.

Structural characterization of constituents with molecular diversity in fractions from Lysidice brevicalyx by liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance.

Zeper Abliz, Shi-shan Yu, Z. Abliz, 2008, Rapid communications in mass spectrometry : RCM.

Structural characterization of trace stilbene glycosides in Lysidice brevicalyx Wei using liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry.

Jin-Lan Zhang, Jianbei Li, Yuanyan Liu, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Novel phloroglucinol derivatives from the roots of Lysidice rhodostegia.

Shishan Yu, Jing Qu, Song Gao, 2006, Organic letters.

Resveratrol/phloroglucinol glycosides from the roots of Lysidice rhodostegia.

De-Quan Yu, Shishan Yu, Jing Qu, 2007, Planta medica.

Rapid structural determination of modified pregnane glycosides from Cynanchum forrestii by liquid chromatography-diode-array detection/electrospray ionization multi-stage tandem mass spectrometry.

Z. Abliz, Jianbei Li, Shishan Yu, 2008, Analytica chimica acta.

The antibacterial mechanism of berberine against Actinobacillus pleuropneumoniae

Xin Lai, Xu Song, R. Jia, 2015, Natural product research.

A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire

Shuang-Gang Ma, Shishan Yu, Yong Li, 2012 .

Four new minor alkaloids from the seeds of Strychnos nux-vomica

Shuang-Gang Ma, Shishan Yu, Yong Li, 2014 .

A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma

H. Lv, Shuang-Gang Ma, Shishan Yu, 2018, RSC advances.

Antiviral spirooliganones C and D with a unique spiro[bicyclo[2.2.2]octane-2,2′-bicyclo[3.1.0]hexane] carbon skeleton from the roots of Illicium oligandrum

Rongmei Gao, Shuang-Gang Ma, Shishan Yu, 2022, Chinese Chemical Letters.

Nine new lycopodine-type alkaloids from Lycopodium japonicum Thunb.

X. Bao, Dan Zhang, Shuang-Gang Ma, 2013 .

Neolignans and glycosides from the stem bark of Illicium difengpi.

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2010, Journal of natural products.

Bioactive sesquiterpenoids from the roots of Artabotrys hexapetalus

Fengmin Xi, Xiaoguang Chen, Yu-huan Li, 2017 .

Phenolic constituents with anti-inflammatory and cytotoxic activities from the rhizomes of Iris domestica.

Ying Dong, Ming Dai, Jing Qu, 2022, Phytochemistry.

Sesquiterpenes from the Endophyte Glomerella cingulata.

Zhen Liu, J. Dai, Shuang-Gang Ma, 2017, Journal of natural products.

Bioactive megastigmane glucosides and monoterpenes from Lyonia ovalifolia

Yu-huan Li, Dan Zhang, Shuang-Gang Ma, 2018, Journal of Asian natural products research.

Terpenoids from the roots of Alangium chinense

Jian-Dong Jiang, Xiao-guang Chen, Dan Zhang, 2015, Journal of Asian natural products research.

Dimeric prenylated C6-C3 compounds from the stem bark of Illicium oligandrum.

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2011, Journal of natural products.

Micranthanosides I and II, two novel 1,10-secograyanane diterpenoids and their antinociceptive analogues from the leaves and twigs of Rhododendron micranthum

Yong Li, Jing Qu, Hui Yan, 2019, RSC advances.

Pierisketolide A and Pierisketones B and C, Three Diterpenes with an Unusual Carbon Skeleton from the Roots of Pieris formosa.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2017, Organic letters.

Chiral resolution and absolute configuration of a pair of rare racemic spirodienone sesquineolignans from Xanthium sibiricum.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2014, Organic letters.

Prenylated C6-C3 compounds from the roots of Illicium henryi.

Dan Zhang, Shuang-Gang Ma, Shishan Yu, 2013, Phytochemistry.

New alkaloids from the seeds of Strychnos nux-vomica

Li‐jun Wu, N. Chen, Shuang-Gang Ma, 2012 .

Cytotoxic cassaine diterpenoid-diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii.

Xiao-guang Chen, Shuang-Gang Ma, Shishan Yu, 2010, Phytochemistry.

Progress on Cassaine-Type Diterpenoid Ester Amines and Amides (Erythrophleum Alkaloids)

Jing Liu, Shishan Yu, Jing Qu, 2006 .

New Approaches to Identification and Direct Isolation of Novel Bioactive Compounds from Natural Products: New Approaches to Identification and Direct Isolation of Novel Bioactive Compounds from Natural Products

De-Quan Yu, Shishan Yu, Jing Qu, 2009 .

Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense.

Xiaoguang Chen, Shuang-Gang Ma, Shishan Yu, 2016, Phytochemistry.

Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum.

Yu-Sheng Shi, Li Li, Yong Li, 2015, Journal of natural products.

Diterpenoid glycosides and monoterpenoid glycosides from the fruits of Xanthium chinense

Lu-Lu Li, Long Chen, Jing Qu, 2018, Journal of Asian natural products research.

A Novel Asymmetric Synthesis of (+)-Deoxytylophorinine

H. Lv, Shuang-Gang Ma, Shishan Yu, 2015, Synthesis.

Bisindole alkaloids with neural anti-inflammatory activity from Gelsemium elegans.

X. Bao, Dan Zhang, Shuang-Gang Ma, 2013, Journal of natural products.

Indole alkaloids and quassinoids from the stems of Brucea mollis.

Xiao-guang Chen, Shuang-Gang Ma, Shishan Yu, 2011, Journal of natural products.

Sesquiterpenes and alkaloids from the roots of Alangium chinense.

Dan Zhang, Yong Li, Li Li, 2013, Journal of natural products.

Claoxylones A–I, prenylbisabolane diterpenoids with anti-Coxsackie B virus activity from the branches and leaves of Claoxylon polot

H. Lv, Yu-huan Li, Yadan Wang, 2014 .

Illisimonin A, a Caged Sesquiterpenoid with a Tricyclo[5.2.1.01,6]decane Skeleton from the Fruits of Illicium simonsii.

Q. Hou, Mingbao Lin, Shuang-Gang Ma, 2017, Organic letters.

Oxygenated pentacyclic triterpenoids from the stems and branches of Enkianthus chinensis.

Yu-huan Li, Dan Zhang, Shuang-Gang Ma, 2021, Bioorganic chemistry.

Phenolic constituents from the roots of Alangium chinense

Jian-Dong Jiang, Dan Zhang, Shuang-Gang Ma, 2017 .

Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect.

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2022, Phytochemistry.

Total synthesis of illicidione A and illihendione A

Shuang-Gang Ma, Shishan Yu, Yong Li, 2015 .

Bioactive quassinoids from the seeds of Brucea javanica.

Li‐jun Wu, Xiao-guang Chen, Shuang-Gang Ma, 2012, Journal of natural products.

Thiodiketopiperazines produced by the endophytic fungus Epicoccum nigrum.

J. Dai, Xiao-guang Chen, Yinghong Wang, 2010, Journal of natural products.

Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity†

K. Houk, Rongmei Gao, Yu-huan Li, 2021, Chemical science.

Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia

Nan Jiang, Jing Ma, R. Tan, 2011 .

Bioactive constituents from toxic seed plants in China

Yadan Wang, Shishan Yu, Jing Qu, 2013 .

Cytotoxic cardenolides from the stems of Periploca forrestii

H. Lv, Xiao-guang Chen, Shuang-Gang Ma, 2012, Steroids.

Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents

H. Lv, Jinhong Ren, Shuang-Gang Ma, 2012, PloS one.

Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii.

Yuanyan Liu, H. Lv, Shuang-Gang Ma, 2011, Planta medica.

New vernocuminosides from the stem barks of Vernonia cumingiana Benth

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2009, Steroids.

New Sesquiterpene Lactone and Neolignan Glycosides with Antioxidant and Anti-Inflammatory Activities from the Fruits of Illicium oligandrum

Shishan Yu, Jing Qu, Yunbao Liu, 2007, Planta medica.

New cassaine diterpenoid amides with cytotoxic activities from the bark of Erythrophleum fordii.

Xiao-guang Chen, Shishan Yu, Jing Qu, 2006, Planta medica.

Identification of cardiac glycosides in fractions from Periploca forrestii by high-performance liquid chromatography/diode-array detection/electrospray ionization multi-stage tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance.

Jing Liu, Haining Lv, Zeper Abliz, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Minor terpenoids from the leaves of Craibiodendron yunnanense.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2022, Journal of Asian natural products research.

New stilbenes and phenolic constituents from the rhizomes of Belamcanda chinensis

Jing Qu, Shijie Sun, Jiang Fu, 2022, Journal of Asian natural products research.

New lignans and diterpenoid glycosides from the fruits of Xanthium italicum Moretti

Shuang-Gang Ma, Shishan Yu, Yong Li, 2021, Journal of Asian natural products research.

Diterpenoids with diverse carbon skeletons from the roots of Pieris formosa and their analgesic and antifeedant activities.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2019, Bioorganic chemistry.

Diverse epoxy grayanane diterpenoids with analgesic activity from the roots of Pieris formosa.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2019, Fitoterapia.

Grayanane diterpenoids with diverse bioactivities from the roots of Pieris formosa

Fei Liu, Shuang-Gang Ma, Shishan Yu, 2018 .

Diterpenoids from the fruits of Rhododendron molle, potent analgesics for acute pain

Shuang-Gang Ma, Shishan Yu, Yong Li, 2017 .

Biological and chemical guided isolation of 3,4-secograyanane diterpenoids from the roots of Pieris formosa

Fei Liu, Shuang-Gang Ma, Shishan Yu, 2017 .

Isopimarane and nor-diterpene glucosides from the twigs and leaves of Lyonia ovalifolia

Shuang-Gang Ma, Shishan Yu, Yong Li, 2017 .

Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

H. Lv, Yu-huan Li, Shuang-Gang Ma, 2016, Scientific Reports.

Analgesic diterpenoids from the twigs of Pieris formosa

Shuang-Gang Ma, Shishan Yu, Yong Li, 2016 .

Antinociceptive Grayanoids from the Roots of Rhododendron molle.

H. Lv, Shuang-Gang Ma, Shishan Yu, 2015, Journal of natural products.

Mollanol A, a diterpenoid with a new C-nor-D-homograyanane skeleton from the fruits of Rhododendron molle.

Shuang-Gang Ma, Shishan Yu, Chen Wang, 2014, Organic letters.

Mollolide A, a diterpenoid with a new 1,10:2,3-disecograyanane skeleton from the roots of Rhododendron molle.

Jian-Dong Jiang, H. Lv, Yu-huan Li, 2013, Organic letters.

Analgesic grayanoids from Craibiodendron henryi

Shuang-Gang Ma, Shishan Yu, Yong Li, 2022, Tetrahedron.

Sesquiterpenes from an Endophytic Aspergillus flavus.

Zhen Liu, Hai-tao Liu, Yong Li, 2019, Journal of natural products.

Four new phenolic diglycosides from the roots of Illicium oligandrum.

Xiao-guang Chen, Shuang-Gang Ma, Shishan Yu, 2011, Carbohydrate research.

Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans.

Cai-xia Zang, Shuang-Gang Ma, Shishan Yu, 2015, Journal of natural products.

Cnidimonins A-C, Three Types of Hybrid Dimer from Cnidium monnieri: Structural Elucidation and Semisynthesis.

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2017, Organic letters.

Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2019, Tetrahedron.

Triterpenoids from the Roots of Craibiodendron henryi W. W. Smith

Shishan Yu, Jing Qu, You-cai Hu, 2007 .

Five new fawcettimine-related alkaloids from Lycopodium japonicum Thunb.

Yadan Wang, Shuang-Gang Ma, Shishan Yu, 2013, Fitoterapia.

Sesquiterpenes from the roots of Illicium oligandrum

Shuang-Gang Ma, Shishan Yu, Yong Li, 2015, Journal of Asian natural products research.

Anti-Coxsackie virus B diterpenes from the roots of Illicium jiadifengpi

Jian-Dong Jiang, Yu-huan Li, De-Quan Yu, 2013 .

Study on absolute configurations of α/α′ chiral carbons of thiodiketopiperazines by experimental and calculated circular dichroism spectra

Nan Jiang, Jing Ma, R. Tan, 2013 .

Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum.

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2009, Journal of natural products.

Structures and absolute configurations of penicillactones A-C from an endophytic microorganism, Penicillium dangeardii Pitt.

Yi Tang, J. Dai, H. Lv, 2013, Organic letters.

New C-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy-3-methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2018, Bioorganic chemistry.

3-Hydroxy-3-methylglutaryl flavone glycosides from the leaves of Turpinia arguta.

Q. Hou, Shaopeng Yuan, Shuang-Gang Ma, 2018, Fitoterapia.

A new glycoside from the leaves of Neoalsomitra integrifoliola

De-Quan Yu, Shuang-Gang Ma, Shishan Yu, 2008 .

Novel Sesquiterpenoid Glycosides and Sesquiterpenes from the Roots of Illicium henryi

N. Chen, Shuang-Gang Ma, Shishan Yu, 2013, Planta Medica.

New sesquiterpenes from the roots of Coriaria nepalensis

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2012 .

Sesquiterpenes from the roots of Illicium dunnianum.

Wenjing Wang, Shuang-Gang Ma, Shishan Yu, 2012, Phytochemistry.

Prenylated C6-C3 compounds with molecular diversity from the roots of Illicium oligandrum.

Yi Zhang, Xiao-guang Chen, Shuang-Gang Ma, 2011, Phytochemistry.

Rapid structural determination of new trace cassaine-type diterpenoid amides in fractions from Erythrophleum fordii by liquid chromatography-diode-array detection/electrospray ionization tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance.

Jing Qu, Ying-Hong Wang, Jian-Bei Li, 2007, Rapid communications in mass spectrometry : RCM.

Antinociceptive grayanane-derived diterpenoids from flowers of Rhododendron molle

Zhao Zhang, Shuang-Gang Ma, Shishan Yu, 2019, Acta pharmaceutica Sinica. B.

Dothiorelone derivatives from an endophyte Diaporthe pseudomangiferaea inhibit the activation of human lung fibroblasts MRC-5 cells.

X. Liang, Zhen Liu, Yong Li, 2018, Fitoterapia.

Targeted isolation and structure elucidation of stilbene glycosides from the bark of Lysidice brevicalyx Wei guided by biological and chemical screening.

Jianbei Li, Shuang-Gang Ma, Shishan Yu, 2008, Journal of natural products.

The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin

Cai-xia Zang, Dan Zhang, Shishan Yu, 2023, Signal Transduction and Targeted Therapy.

Diterpenoids and sesquiterpenoids from the roots of Illicium majus.

Jian-Dong Jiang, H. Lv, Yu-huan Li, 2013, Journal of natural products.

Sesquiterpenes from the Roots of Illicium jiadifengpi

Shuang-Gang Ma, Shishan Yu, Dequan Yu, 2013, Planta Medica.

Diterpenoids and Sesquiterpenoids from the Twigs and Leaves of Illicium majus

Shuang-Gang Ma, Shishan Yu, Hui Chen, 2012, Planta Medica.

Antiviral mono- and bis-prenylated C6–C3 derivatives from the roots of Illicium oligandrum

H. Lv, Yu-huan Li, Hui-qiang Wang, 2016 .

New prenylated C6–C3 compounds from the roots of Illicium henryi

Q. Hou, Shuang-Gang Ma, Shishan Yu, 2013 .

Diterpenes and sesquiterpenes with anti-Coxsackie virus B3 activity from the stems of Illicium jiadifengpi

Jian-Dong Jiang, Yu-huan Li, De-Quan Yu, 2014 .

Metabonomics and the NF-κB Pathway

Haibo Zhu, Jianbei Li, Yuanyan Liu, 2015 .

A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by 1H NMR-Based Metabonomics and the NF-κB Pathway

Haibo Zhu, Jianbei Li, Yuanyan Liu, 2013, Evidence-based complementary and alternative medicine : eCAM.

Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo.

Zhuo-wei Hu, H. Lv, Yadan Wang, 2013, Journal of medicinal chemistry.

Analgesic corynanthe-type alkaloids from Strychnos angustiflora

Shuang-Gang Ma, Shishan Yu, Yong Li, 2016 .

Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata

Z. Zou, Shuang-Gang Ma, Shishan Yu, 2019, Journal of Asian natural products research.

[Chemical constituents from leaves of Craibiodendron yunnanense].

Cheng Zhou, Rong-Tao Li, Shuang-Gang Ma, 2012, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2016, Bioorganic & medicinal chemistry letters.

Steroidal glycosides from Dregea sinensis var. corrugata screened by liquid chromatography-electrospray ionization tandem mass spectrometry.

Jin-Lan Zhang, Shishan Yu, Yong Li, 2009, Journal of natural products.

Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var. corrugata

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2008, Steroids.

Eight new C-21 steroidal glycosides from Dregea sinensis var. corrugata

Shishan Yu, Jing Qu, Yunbao Liu, 2007, Steroids.

Seven new steroidal glycosides from the roots of Cynanchum forrestii

Shishan Yu, Jing Qu, You-cai Hu, 2007, Steroids.

Sesquiterpenes and neolignans from the roots of Illicium dunnianum

Shuang-Gang Ma, Shishan Yu, Hui Chen, 2012, Journal of Asian natural products research.

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

Shuang-Gang Ma, Yong Li, Jing Qu, 2021, Molecules.

Antiviral spirooliganones A and B with unprecedented skeletons from the roots of Illicium oligandrum.

Jian-Dong Jiang, Ning-bo Gong, Rongmei Gao, 2013, Organic letters.

Antiviral Triterpenes from the Twigs and Leaves of Lyonia ovalifolia.

Yu-huan Li, Dan Zhang, Shuang-Gang Ma, 2016, Journal of natural products.

Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae.

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2018, Journal of natural products.

Identification of new trace triterpenoid saponins from the roots of Panax notoginseng by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Jiuming He, Z. Abliz, Jianbei Li, 2009, Rapid communications in mass spectrometry : RCM.

Humulane-type and germacrane-type sesquiterpenoids from the fruits of Xanthium spinosum Linn.

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2021, Phytochemistry.

Lycojaponicumins D and E: two new alkaloids from Lycopodium japonicum.

H. Lv, Dan Zhang, Shuang-Gang Ma, 2012, Organic letters.

Three new alkaloids from Menispermum dauricum

Shuang-Gang Ma, Lu-Lu Li, Long Chen, 2020, Journal of Asian natural products research.

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Fei Liu, Yu-huan Li, Shuang-Gang Ma, 2017, Scientific Reports.

Xanthanoltrimer A–C: three xanthanolide sesquiterpene trimers from the fruits of Xanthium italicum Moretti isolated by HPLC-MS-SPE-NMR

Shuang-Gang Ma, Shishan Yu, Yong Li, 2021 .

New glycosides from the twigs and leaves of Rhododendron latoucheae

Yu-huan Li, Shuang-Gang Ma, Shishan Yu, 2019, Journal of Asian natural products research.

Antiviral Spirotriscoumarins A and B: Two Pairs of Oligomeric Coumarin Enantiomers with a Spirodienone-Sesquiterpene Skeleton from Toddalia asiatica.

Jian-Dong Jiang, Shuang-Gang Ma, Shishan Yu, 2016, Organic letters.

Analgesic Diterpenoids from the Twigs of Pieris formosa.

Shuang-Gang Ma, Shishan Yu, Yong Li, 2016 .

Diketopiperazines and Sesquilignans from the Branches and Leaves of Claoxylon polot

Shuang-Gang Ma, Shishan Yu, Jing Qu, 2015, Planta Medica.

Identification of new trace triterpenoid saponins from the roots of Panax notoginseng by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Jiuming He, Z. Abliz, Jianbei Li, 2009, Rapid communications in mass spectrometry : RCM.

Lignan glycosides from Neoalsomitra integrifoliola.

Shuang-Gang Ma, Shishan Yu, Dequan Yu, 2008, Journal of natural products.

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Fei Liu, Yu-huan Li, Shuang-Gang Ma, 2017, Scientific Reports.