M. Flavin

发表

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.

D. Zembower, R. Buckheit, A. Khilevich, 1998, Bioorganic & medicinal chemistry letters.

A Versatile Approach for Synthesis of 2,3-Dimethyl Chroman-4-ones, Intermediate for Calanolide Anti-HIV Agents, VIA Aldol/Mitsunobu Reactions

A. Khilevich, Lin Lin, M. Flavin, 1996 .

Novel approach for synthesis of (±)-calanolide a and its anti-HIV activity

A. Khilevich, M. Flavin, J. Rizzo, 1995 .

Biflavonoids as novel antituberculosis agents.

C. Cassidy, Y. M. Lin, M. Flavin, 2001, Bioorganic & medicinal chemistry letters.

Macrolides and Ketolides

M. Flavin, Ze-Qi Xu, D. Eiznhamer, 2012 .

Pyranocoumarin, a novel anti-TB pharmacophore: synthesis and biological evaluation against Mycobacterium tuberculosis.

K. Pupek, L. Enache, M. Flavin, 2006, Bioorganic & medicinal chemistry.

Development of an Image-Based HCS-Compatible Method for Endothelial Barrier Function Assessment

S. Dudek, L. Chan, Oleksii Dubrovskyi, 2021, SLAS discovery : advancing life sciences R & D.

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

W. Cance, A. Dementiev, T. Marlowe, 2019, BMC Molecular and Cell Biology.

Antiviral Activities of Biflavonoids

R. Sidwell, J. Huffman, E. Kern, 1999, Planta medica.

Effective attenuation of endotoxin-induced acute lung injury by 2,3-diacetyloxybenzoic acid in two independent animal models.

K. Burhop, G. Jesmok, D. Nelson, 2004, Pulmonary pharmacology & therapeutics.

Cethromycin versus Clarithromycin for Community-Acquired Pneumonia: Comparative Efficacy and Safety Outcomes from Two Double-Blinded, Randomized, Parallel-Group, Multicenter, Multinational Noninferiority Studies

Nancy A Milanesio, M. Flavin, Ze-Qi Xu, 2012, Antimicrobial Agents and Chemotherapy.

Efficacy of Post Exposure Administration of Doxycycline in a Murine Model of Inhalational Melioidosis

H. C. Gelhaus, D. Sanford, M. Flavin, 2013, Scientific Reports.

Sensitivity and Resistance to (+)-Calanolide a of Wild-Type and Mutated Forms of HIV-1 Reverse Transcriptase

M. Wainberg, M. Parniak, R. Buckheit, 1998, Antiviral therapy.

Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis.

W. W. Barrow, M. Flavin, Ze-Qi Xu, 2004, Bioorganic & medicinal chemistry.

Synthesis and antiviral activities of fluorinated acyclic nucleoside phosphonates

Wei Chen, R. Filler, M. Flavin, 1998 .

Introduction of α-fluorophosphonomethyl ether functionality and its application to the synthesis of fluorinated acyclic phosphonate nucleosides

Wei Chen, R. Filler, M. Flavin, 1996 .

Chalcones and flavonoids as anti-tuberculosis agents.

Li-Ming Zhou, Li-Ming Zhou, Yuh-Meei Lin, 2002, Bioorganic & medicinal chemistry.

Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.

S. Hughes, J. Pezzuto, T. Pengsuparp, 1996, Journal of medicinal chemistry.

Plant-Derived and Semi-Synthetic Calanolide Compounds with in Vitro Activity against Both Human Immunodeficiency Virus Type 1 and Human Cytomegalovirus

R. Buckheit, E. Kern, Z. Q. Xu, 2000, Antiviral chemistry & chemotherapy.

Safety and Pharmacokinetic Profile of Multiple Escalating Doses of (+)-Calanolide A, a Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy HIV-Negative Volunteers

M. Flavin, Ze-Qi Xu, J. Ruckle, 2002, HIV clinical trials.

Coumarins and Pyranocoumarins, Potential Novel Pharmacophores for Inhibition of Measles Virus Replication

D. Smee, D. Barnard, R. Sidwell, 2002, Antiviral chemistry & chemotherapy.

Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects

M. Flavin, Ze-Qi Xu, J. Ruckle, 2001, Antimicrobial Agents and Chemotherapy.

Anti-HIV-1 Activity of Calanolides Used in Combination with other Mechanistically Diverse Inhibitors of HIV-1 Replication

R. Buckheit, Z. Q. Xu, M. Flavin, 2000, Antiviral chemistry & chemotherapy.

Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.

Z. Q. Xu, M. Flavin, D. S. Weinberg, 2000, Journal of chromatography. B, Biomedical sciences and applications.

In vivo anti-HIV activity of (+)-calanolide A in the hollow fiber mouse model.

M. Hollingshead, S. Borgel, A. Khilevich, 1999, Bioorganic & medicinal chemistry letters.

An efficient and scalable method for the isolation of costatolide, a naturally-occurring anti-HIV agent, from the latex of Calophyllum teysmannii var. Inophylloide

Michael J. Williams, M. Flavin, Ze-Qi Xu, 1999 .

Synthesis of dual 14C-labeled (+)-calanolide A, a naturally occurring anti-HIV agent

A. Khilevich, M. Flavin, J. Rizzo, 1997 .

Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products

Wei Chen, D. Zembower, S. Liao, 1996 .

Synthesis, Chromatographic Resolution, and Anti‐Human Immunodeficiency Virus Activity of (.+‐.)‐Calanolide A and Its Enantiomers.

Wei Chen, S. Hughes, J. Pezzuto, 1996 .

Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).

D. Zembower, R. Buckheit, S. Liao, 1997, Journal of medicinal chemistry.

Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).

D. Zembower, R. Buckheit, S. Liao, 1997, Journal of medicinal chemistry.

anti‐HIV Natural Product (+)‐Calanolide A Is Active Against Both Drug‐Susceptible and Drug‐Resistant Strains of Mycobacterium tuberculosis.

W. W. Barrow, M. Flavin, Ze-Qi Xu, 2004 .

Calanolides, the naturally occurring anti-HIV agents.

Z. Q. Xu, M. Flavin, T. Jenta, 2000, Current opinion in drug discovery & development.

Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids.

William P. Flavin, A. Koohang, M. Flavin, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of a novel hexahydrofuro[3,4-b]furan derivative

M. Flavin, Matthias C. Lu, 1983 .

Preparation of New Wittig Reagents and Their Application to the Synthesis of alpha,beta-Unsaturated Phosphonates.

M. Flavin, Ze-Qi Xu, Yibo Xu, 1996, The Journal of organic chemistry.

AN IMPROVED SYNTHESIS OF 9-[2-(DIETHOXYPHOSPHONOMETHOXY)ETHYL]ADENINE AND ITS ANALOGUES WITH OTHER PURINE BASES UTILIZING THE MITSUNOBU REACTION

Wei Chen, R. Filler, M. Flavin, 1996 .

In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.

R F Schinazi, J M Pezzuto, S. Hughes, 1997, Journal of natural products.

Robustaflavone, a potential non-nucleoside anti-hepatitis B agent.

D. Zembower, B. Korba, Y. M. Lin, 1998, Antiviral research.

Combating multidrug-resistant Gram-negative bacterial infections

J. Flavin, M. Flavin, Ze-Qi Xu, 2014, Expert opinion on investigational drugs.

Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro

D. Zembower, B. Korba, M. Flavin, 1997 .

Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones.

A. Koohang, M. Flavin, A. Mar, 2009, Bioorganic & medicinal chemistry letters.

Structures of human plasma β-factor XIIa cocrystallized with potent inhibitors.

H. Sham, J. Partridge, A. Dementiev, 2018, Blood advances.

Amyloid fibril formation in microwell plates for screening of inhibitors

C. Cassidy, F. Stevens, R. Raffen, 2001, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Automated Process Research. An Example of Accelerated Optimization of the Friedel−Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A

D. Zembower, M. Flavin, P. Sen, 2000 .

Synthesis and cytotoxicity of 28-carboxymethoxy lupane triterpenoids. Preference of 28-O-acylation over 28-O-alkylation of betulin by ethyl bromoacetate

A. Koohang, M. Flavin, A. Mar, 2009 .

Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine.

E. Thompson, M. Flavin, H. Bhargava, 1987, Journal of medicinal chemistry.

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

W. Cance, A. Dementiev, T. Marlowe, 2019, BMC molecular and cell biology.

Preparation of New Wittig Reagents and Their Application to the Synthesis of α,β-Unsaturated Phosphonates.

M. Flavin, Y. Xu, Z.‐Q. Xu, 1997 .