A. Lespine

发表

Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line.

M. Alvinerie, L. Mselli-Lakhal, P. Balaguer, 2012, Biochemical pharmacology.

Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.

R. Havel, J. Kane, J. Rapp, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

In silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1

S. Orlowski, R. Prichard, F. André, 2016, International journal for parasitology. Drugs and drug resistance.

ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics.

M. Alvinerie, P. Geldhof, J. Vercruysse, 2008, Trends in parasitology.

Ivermectin interacts with human ABCG2.

E. Kis, P. Krajcsi, P. Szabó, 2011, Journal of pharmaceutical sciences.

Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin.

J. Sutra, M. Alvinerie, A. Lespine, 2003, Veterinary parasitology.

Impaired secretion of heart lipoprotein lipase in cyclophosphamide-treated rabbit.

B. Perret, H. Chap, A. Lespine, 1997, Biochimica et biophysica acta.

Lipoprotein lipase regulation in the cyclophosphamide-treated rabbit: dependence on nutritional status.

B. Perret, H. Chap, J. Manent, 1993, Journal of lipid research.

Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations.

G. Durrieu, S. Cunat, F. André, 2020, The New England journal of medicine.

P-glycoproteins play a role in ivermectin resistance in cyathostomins☆

G. Pinchbeck, L. Peachey, G. von Samson-Himmelstjerna, 2017, International journal for parasitology. Drugs and drug resistance.

Persistent coma in Strongyloides hyperinfection syndrome associated with persistently increased ivermectin levels.

D. van Westerloo, R. Prichard, L. Visser, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

P-glycoprotein Dysfunction Contributes to Hepatic Steatosis and Obesity in Mice

H. Guillou, J. Bertrand-Michel, X. Collet, 2011, PloS one.

The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes.

J. Sutra, M. Alvinerie, A. Lespine, 2006, Journal of veterinary pharmacology and therapeutics.

Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.

J. Sutra, M. Alvinerie, A. Lespine, 2006, Journal of veterinary pharmacology and therapeutics.

Total parenteral nutrition decreases liver oxidative metabolism and antioxidant defenses in healthy rats: comparative effect of dietary olive and soybean oil.

A. Galinier, J. Thouvenot, A. Lespine, 2001, JPEN. Journal of parenteral and enteral nutrition.

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

B. Pillot, X. Prieur, C. Le May, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Kinetic evidence for phosphatidylethanolamine and triacylglycerol as preferential substrates for hepatic lipase in HDL subfractions: modulation by changes in the particle surface, or in the lipid core.

G. Simard, B. Perret, P. Marques-Vidal, 1990, Biochimica et biophysica acta.

Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells.

M. Alvinerie, C. Ménez, A. Lespine, 2010, Chemico-biological interactions.

A device to simulate contaminant transfer and surface and subsurface flow through intact soil monoliths

J. Sutra, C. Legoût, G. Nord, 2022, Vadose Zone Journal.

Influence of Dyslipidemia on Moxidectin Distribution in Plasma Lipoproteins and on its Pharmacokinetics

Pascal G. P. Martin, M. Alvinerie, B. Perret, 2006, Pharmaceutical Research.

Ivermectin as a potential treatment for COVID-19?

J. Changeux, B. Giraudeau, Z. Amoura, 2021, PLoS neglected tropical diseases.

Decreases in retinol and retinol-binding protein during total parenteral nutrition in rats are not due to a vitamin A deficiency.

J. Thouvenot, S. Jaconi, M. C. Alexandre, 1996, Journal of lipid research.

Retinol and retinyl ester concentrations in rat tissues during total parenteral nutrition

J. Thouvenot, A. Lespine, J. Garcia, 1998 .

Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration

M. Alvinerie, A. Lespine, Mohamad Firas Bassissi, 2004, Parasitology Research.

Accumulation of large VLDL in cyclophosphamide treated rabbits. Relationship with lipoprotein lipase deficiency.

L. Douste-Blazy, B. Perret, H. Chap, 1988, Biochemical and biophysical research communications.

Lack of efficacy of topical administration of eprinomectin against gastrointestinal nematode in a French dairy sheep farm: A case of underexposure of worms

J. Sutra, P. Jacquiet, A. Lespine, 2022, Veterinary Record Case Reports.

Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (−/−) Mice and Effects on Mammalian GABA(A) Channel Activity

J. Sutra, R. Prichard, C. Ménez, 2012, PLoS neglected tropical diseases.

Moxidectin and the avermectins: Consanguinity but not identity.

R. Prichard, C. Ménez, A. Lespine, 2012, International journal for parasitology. Drugs and drug resistance.

Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France.

J. Sutra, T. Marcotty, A. Lespine, 2016, Veterinary parasitology.

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

P. Hunt, R. Kaminsky, A. Jex, 2014, International journal for parasitology. Drugs and drug resistance.

S0031182022000853jra 1439..1449

J. Sutra, B. Dumont, N. Mach, 2022 .

First report of multiple resistance to eprinomectin and benzimidazole in Haemonchus contortus on a dairy goat farm in France.

J. Sutra, P. Jacquiet, A. Lespine, 2020, Parasitology international.

Kinetics and anthelmintic efficacy of topical eprinomectin when given orally to goats.

J. Sutra, C. Chartier, A. Lespine, 2015, Veterinary parasitology.

Characterisation of macrocyclic lactone resistance in two field-derived isolates of Cooperia oncophora.

J. Sutra, J. Matthews, D. Bartley, 2012, Veterinary parasitology.

Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate.

J. Sutra, M. Alvinerie, F. Jackson, 2012, Veterinary parasitology.

Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals.

J. Sutra, F. Reigner, G. Sallé, 2021, Veterinary parasitology.

P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance.

C. Bourguinat, R. Prichard, C. Ménez, 2012, International journal for parasitology. Drugs and drug resistance.

Efficacy of sainfoin (Onobrychis viciifolia) pellets against multi resistant Haemonchus contortus and interaction with oral ivermectin: Implications for on-farm control.

J. Sutra, F. Schelcher, H. Hoste, 2016, Veterinary parasitology.

The influence of parasitism on the pharmacokinetics of moxidectin in lambs

J. Sutra, M. Alvinerie, G. Aumont, 2004, Parasitology Research.

The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep.

M. Alvinerie, V. Bowles, S. Barber, 2003, Journal of veterinary pharmacology and therapeutics.

Efficacy of injectable and pour-on microdose ivermectin in the treatment of goat warble fly infestation by Przhevalskiana silenus (Diptera, Oestridae).

M. Alvinerie, C. Boulard, D. Otranto, 2003, Veterinary parasitology.

Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration

M. Alvinerie, F. Bassissi, A. Lespine, 2006, Parasitology Research.

Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

M. Alvinerie, P. Toutain, E. Lallemand, 2007, Journal of veterinary pharmacology and therapeutics.

D06 Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2 and 3)

M. Alvinerie, P. Krajcsi, T. Nagy, 2006 .

Multiple oral dosing of ketoconazole increases dog exposure to ivermectin.

M. Alvinerie, A. Lespine, C. Hugnet, 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

P-glycoprotein (ABCB1) is involved in vitamin K efflux.

C. Le May, Marielle Margier, E. Reboul, 2020, Food chemistry.

ABCB1 (P‐glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux

C. Defoort, Marielle Margier, E. Reboul, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

J. Sutra, O. Chosidow, K. Fischer, 2016, PLoS neglected tropical diseases.

Influence of the route of administration on efficacy and tissue distribution of ivermectin in goat.

J. Sutra, M. Alvinerie, C. Chartier, 2005, Veterinary parasitology.

Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance

R. Prichard, A. Lespine, E. Curry, 2022, Parasites & vectors.

The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12

R. Prichard, F. André, Thavy Long, 2020, Scientific Reports.

Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

S. Orlowski, R. Beech, T. Duguet, 2018, International journal for parasitology. Drugs and drug resistance.

Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs.

M. Alvinerie, S. Orlowski, P. Krajcsi, 2009, Current drug metabolism.

Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis) in sheep

M. Alvinerie, P. Lemercier, H. Hoste, 2004, Veterinary Record.

P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus

M. Alvinerie, F. Jackson, D. Bartley, 2009, Parasitology.

Ketoconazole increases the plasma levels of ivermectin in sheep.

J. Sutra, M. Alvinerie, A. Lespine, 2008, Veterinary parasitology.

Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship.

M. Alvinerie, T. Pineau, S. Orlowski, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).

M. Alvinerie, S. Orlowski, P. Krajcsi, 2006, Chemico-biological interactions.

Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis elegans

A. Blanchard, C. Ménez, A. Lespine, 2016, Antimicrobial Agents and Chemotherapy.

Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptes scabiei in the Porcine Scabies Model for Human Infestation

J. Sutra, O. Chosidow, K. Fischer, 2018, Antimicrobial Agents and Chemotherapy.

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

M. Alvinerie, P. Toutain, G. Chanoit, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

M. Alvinerie, X. Collet, C. Ménez, 2010, Drug Metabolism and Disposition.

D02 Influence of anthelmintic drugs on P‐glycoprotein transport activity in mdr1‐LLC‐PK1 cells

M. Alvinerie, A. Lespine, Jacques Dupuy, 2006 .

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients

J. Sutra, P. Toutain, A. Bousquet-Mélou, 2021, Frontiers in Pharmacology.

Title: Large Impact of obesity on the disposition of ivermectin, moxidectin and eprinomectin in a canine model: relevance for COVID-19 patients. Short running title: obesity and pharmacokinetics of ivermectin, moxidectin and eprinomectin Authors:

J. Sutra, P. Toutain, A. Bousquet-Mélou, 2021 .

Assessment of the long‐acting ivermectin formulation in sheep: Further insight into potential pharmacokinetic interactions

A. Lifschitz, G. Virkel, C. Lanusse, 2018, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics of ivermectin in the yak (Bos grunniens).

J. Sutra, M. Alvinerie, C. Boulard, 2003, Veterinary parasitology.