M. Aggarwal

发表

Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.

C. D. Boone, D. Silverman, R. McKenna, 2012, Protein engineering, design & selection : PEDS.

Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2013, Biochemistry.

Structural annotation of human carbonic anhydrases

C. D. Boone, R. McKenna, M. Aggarwal, 2013, Journal of enzyme inhibition and medicinal chemistry.

Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

R. McKenna, G. Wennemuth, J. Deitmer, 2012, The Journal of physiology.

Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.

C. Supuran, A. Scozzafava, E. Masini, 2012, Journal of medicinal chemistry.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.

C. Supuran, A. Scozzafava, F. Carta, 2012, Chemical communications.

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.

C. Supuran, A. Scozzafava, R. McKenna, 2011, Bioorganic & medicinal chemistry.

Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review

R. McKenna, M. Aggarwal, Bhargav Kondeti, 2013, Expert opinion on therapeutic patents.

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

R. McKenna, M. Aggarwal, 2012, Expert opinion on therapeutic patents.

Insights towards sulfonamide drug specificity in α-carbonic anhydrases.

R. McKenna, M. Aggarwal, Bhargav Kondeti, 2013, Bioorganic & medicinal chemistry.

Triplex-forming MicroRNAs Form Stable Complexes With HIV-1 Provirus and Inhibit its Replication

O. Bagasra, N. Panasik, M. Kanak, 2010, Applied immunohistochemistry & molecular morphology : AIMM.

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.

C. Supuran, F. Carta, R. McKenna, 2014, ACS medicinal chemistry letters.

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.

C. Supuran, A. Scozzafava, R. McKenna, 2010, Chemical communications.

Structural Mapping of Anion Inhibitors to β‐Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa

C. Supuran, D. Vullo, R. McKenna, 2018, ChemMedChem.

Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase.

R. McKenna, M. Pinard, M. Aggarwal, 2015, Biochemistry.

Insights into human carbonic anhydrase inhibitor design

M. Aggarwal, 2013 .

Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.

C. Supuran, A. Scozzafava, M. Bialer, 2011, Journal of medicinal chemistry.

Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.

D. Silverman, R. McKenna, S. Z. Fisher, 2012, Journal of the American Chemical Society.

Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex.

C. D. Boone, D. Silverman, R. McKenna, 2013, Acta crystallographica. Section D, Biological crystallography.

"To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.

Jeremy C. Smith, M. Cuneo, Hector A Velazquez, 2018, Structure.

TIME TO ADD PROCALCITONIN AS AN ADJUNCT BIOMARKER IN DIAGNOSING BURN SEPSIS: A TERTIARY LEVEL CARE EXPERIENCE

M. Aggarwal, G. Kalra, Sushrut Kalra, 2022, INDIAN JOURNAL OF APPLIED RESEARCH.

Neutron protein crystallography reveals unique details of clinical drug binding to a human target enzyme

D. Silverman, R. McKenna, A. Kovalevsky, 2013 .

A large number of the human microRNAs target lentiviruses, retroviruses, and endogenous retroviruses.

O. Bagasra, S. Saleem, M. Aggarwal, 2008, Biochemical and biophysical research communications.

Abdominal Wall Reconstruction Using Pedicled Antero Lateral Thigh Flap

M. Aggarwal, Samarth Gupta, Amit Sharma, 2022, World journal of plastic surgery.

Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug

Jeremy C. Smith, Hector A Velazquez, R. McKenna, 2016, IUCrJ.

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

D. Silverman, R. McKenna, C. M. Maupin, 2014, IUCrJ.

Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

R. McKenna, G. Wennemuth, J. Deitmer, 2012, The Journal of physiology.

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

R. McKenna, C. Tu, B. Mahon, 2015, Acta crystallographica. Section F, Structural biology communications.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2013, Biochemistry.