A. Venkatesan

发表

Inhibition of OXA-1 β-Lactamase by Penems

R. Bonomo, K. Hujer, A. Hujer, 2008, Antimicrobial Agents and Chemotherapy.

Recent Developments in β-Lactamases and Inhibitors

T. Mansour, P. Bradford, A. Venkatesan, 2008 .

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.

A. Agarwal, T. Mansour, Youjun Yang, 2008, Bioorganic & medicinal chemistry.

Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489

T. Mansour, P. Bradford, S. Projan, 2008, Antimicrobial Agents and Chemotherapy.

On the Absolute Configuration in 1,4‐Dihydrothiazepine Covalent Complexes Derived from Inhibition of Class A and C β‐Lactamases with 6‐Methylidene Penems

A. Agarwal, T. Mansour, Youjun Yang, 2007, ChemMedChem.

Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-α converting enzyme and matrix metalloproteinase inhibitors

J. Skotnicki, J. Levin, J. Ellingboe, 2004 .

Molecular Engineering of Surface Functional Groups Enabling Clinical Translation of Nanoparticle–Drug Conjugates

F. Chen, U. Wiesner, M. Bradbury, 2022, Chemistry of Materials.

5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.

M. Reich, J. Dusza, H. Mazandarani, 1998, Journal of medicinal chemistry.

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

R. Talaat, A. Mutlib, J. Scatina, 2011, Drug Metabolism and Disposition.

The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.

F. C. Nelson, R. Black, J. Skotnicki, 2001, Bioorganic & medicinal chemistry letters.

(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators.

A. Failli, J. Coupet, P. Chan, 2005, Bioorganic & medicinal chemistry letters.

Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor

R. Abraham, N. Brooijmans, L. Feldberg, 2010 .

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

R. Bonomo, A. Hujer, A. Agarwal, 2004, Journal of medicinal chemistry.

Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.

N. Brooijmans, L. Feldberg, R. Mallon, 2010, Journal of medicinal chemistry.

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

B. Harrison, J. Ellingboe, L. Schechter, 2010, Bioorganic & medicinal chemistry letters.

The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

J. Levin, A. Katocs, P. Chan, 1994 .

Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.

N. Brooijmans, Steven C. Kim, L. Feldberg, 2010, Bioorganic & medicinal chemistry letters.

6-SUBSTITUTED QUINAZOLINONE ANGIOTENSIN II RECEPTOR ANTAGONISTS

J. Levin, J. Coupet, P. Chan, 1994 .

5-ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.

N. Brooijmans, N. Zhang, R. Mallon, 2010, Bioorganic & medicinal chemistry letters.

Selective hydrolysis of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate and ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate as a key step in the large-scale synthesis of bicyclic heteroaryl carboxyaldehydes

A. Venkatesan, G. Khafizova, D. Blum, 2006 .

6-ISOXAZOLINYL AND ISOXAZOLIDINYL SUBSTITUTED QUINAZOLINONES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS

J. Levin, J. Coupet, P. Chan, 1994 .

Novel imidazole substituted 6-methylidene-penems as broad-spectrum beta-lactamase inhibitors.

A. Agarwal, T. Mansour, J. Ryan, 2004, Bioorganic & medicinal chemistry.

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

A. Agarwal, T. Mansour, J. Knox, 2006, Journal of medicinal chemistry.

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.

J. Skotnicki, J. Levin, Weixin Xu, 2005, Bioorganic & medicinal chemistry letters.

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.

A. Clark, P. Parsons, M. Kitamura, 2017, Organic letters.

In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors

J. O'Connell, T. Mansour, P. Bradford, 2004, Antimicrobial Agents and Chemotherapy.

Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

R. Abraham, N. Brooijmans, L. Feldberg, 2010, Journal of medicinal chemistry.

Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

L. Feldberg, R. Mallon, J. Lucas, 2011, Clinical Cancer Research.

Cancer Therapy : Preclinical Antitumor Efficacy of PKI-587 , a Highly Potent Dual PI 3 K / mTOR Kinase Inhibitor

L. Feldberg, R. Mallon, J. Lucas, 2011 .

PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

L. Feldberg, R. Mallon, J. Lucas, 2010, Bioorganic & medicinal chemistry letters.

Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor

L. Feldberg, R. Mallon, J. Gibbons, 2010, Molecular Cancer Therapeutics.

Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.

N. Brooijmans, L. Feldberg, R. Mallon, 2011, Bioorganic & medicinal chemistry letters.

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.

R. Abraham, N. Brooijmans, L. Feldberg, 2010, Bioorganic & medicinal chemistry letters.

Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

Judy Lucas, Irwin Hollander, Robert Mallon, 2010, Journal of medicinal chemistry.

Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.

M. Follettie, N. Brooijmans, J. Lucas, 2010, Journal of medicinal chemistry.

2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer.

J. Lucas, T. Mansour, K. Arndt, 2009, Bioorganic & medicinal chemistry letters.

Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection

P. Bradford, P. Petersen, A. Venkatesan, 2009, Antimicrobial Agents and Chemotherapy.

Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate.

R. Bonomo, T. Mansour, J. Knox, 2003, Biochemistry.

Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer.

F. Chen, G. Adams, M. Bradbury, 2022, ACS nano.

Prodrugs of CL316243: a selective beta3-adrenergic receptor agonist for treating obesity and diabetes.

M. Malamas, Z. Chen, J. Ellingboe, 1999, Bioorganic & medicinal chemistry letters.

Mechanism of Inactivation of β-Lactamases by Novel 6-Methylidene Penems Elucidated Using Electrospray Ionization Mass Spectrometry

T. Mansour, M. Siegel, Xidong Feng, 2004 .

Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179.

T. Mansour, S. Ayral-Kaloustian, L. McDonald, 2010, The Journal of organic chemistry.

An efficient method to prepare a-sulfonyl hydroxamic acid derivatives

A. Zask, V. Sandanayaka, A. Venkatesan, 2001 .

An Efficient Method to Prepare α-Sulfonyl Hydroxamic Acid Derivatives.

A. Zask, V. Sandanayaka, A. Venkatesan, 2001 .

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

R. Talaat, A. Mutlib, J. Scatina, 2011, Drug Metabolism and Disposition.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Journal of medicinal chemistry.

Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Journal of medicinal chemistry.

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Bioorganic & medicinal chemistry letters.

In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.

T. Mansour, P. Bradford, S. Projan, 2004, Antimicrobial agents and chemotherapy.