Qianqian Qiu

发表

A novel mitochondria‐targeting fluorescent probe for hydrogen sulfide in living cells

Wen-long Huang, Hai Qian, Liang Ge, 2017, Chemical biology & drug design.

Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8+ T cells.

Wen-long Huang, Hai Qian, W. Guo, 2020, European journal of medicinal chemistry.

Evaluation of Anti‐inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen

Wen-long Huang, Hai Qian, Xin Deng, 2015, Chemical biology & drug design.

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents.

Wen-long Huang, Hai Qian, Qianqian Qiu, 2020, Bioorganic & medicinal chemistry.

Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy

Wen-long Huang, Hai Qian, W. Shi, 2021, Journal for ImmunoTherapy of Cancer.

pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications.

Wen-long Huang, Hai Qian, B. Zhang, 2018, Biomaterials science.

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.

Wen-long Huang, Hai Qian, W. Shi, 2016, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents.

Wen-long Huang, Hai Qian, Qianqian Qiu, 2014, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

Wen-long Huang, Hai Qian, Bo Zhang, 2016 .

Novel HLA-A2 restricted antigenic peptide derivatives with high affinity for the treatment of breast cancer expressing NY-ESO-1.

Wen-long Huang, Hai Qian, W. Guo, 2020, Bioorganic chemistry.

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.

Wen-long Huang, Hai Qian, W. Shi, 2021, Bioorganic chemistry.

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors.

Wen-long Huang, Hai Qian, W. Guo, 2020, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of novel 4,4‐difluoro‐1‐methyl‐N, 6‐diphenyl‐5, 6‐dihydro‐4H‐pyrimido [4, 5‐b] [1, 2, 4] triazolo [4, 3‐d] [1, 4] diazepin‐8‐amine derivatives as potential BRD4 inhibitors

Wen-long Huang, Hai Qian, W. Shi, 2021, Chemical biology & drug design.

Design, Synthesis, and Biological Evaluation of Novel Cholesteryl Peptides with Anticancer and Multidrug Resistance‐Reversing Activities

Wen-long Huang, Hai Qian, Xin Deng, 2016, Chemical biology & drug design.

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Wen-long Huang, Hai Qian, Ziyu Yin, 2022, European journal of medicinal chemistry.

Discovery of potent inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue.

Hai Qian, Zhe-Sheng Chen, Xiduan Wei, 2020, Journal of medicinal chemistry.

Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis.

Wen-long Huang, Hai Qian, Huiting Jia, 2022, European journal of medicinal chemistry.

Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.

Wen-long Huang, Hai Qian, Ziyu Yin, 2021, Journal of medicinal chemistry.

A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells

Wen-long Huang, Hai Qian, Fanfei Meng, 2015, Chemical biology & drug design.

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.

Wen-long Huang, Hai Qian, B. Zhang, 2017, Journal of medicinal chemistry.

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.

Wen-long Huang, Hai Qian, B. Zhang, 2017, Journal of medicinal chemistry.

Advances in Tumor Antigen‐Based Anticancer Immunotherapy: Recent Progress, Prevailing Challenges, and Future Perspective

Hao Zhang, Hai Qian, W. Shi, 2022, Advanced Therapeutics.

Discovery of Novel P‐Glycoprotein‐Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry

Wen-long Huang, Hai Qian, Yunman Li, 2014, Chemical biology & drug design.

Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice

Wen-long Huang, Hai Qian, Xin Deng, 2015, Archiv der Pharmazie.

Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities.

Wen-long Huang, Hai Qian, Xin Deng, 2015, European journal of medicinal chemistry.

Phenylbutazone, a New Long‐Acting Agent that can Improve the Peptide Pharmacokinetic Based on Serum Albumin as a Drug Carrier

Wen-long Huang, Hai Qian, Xiao-yun Zhu, 2016, Chemical biology & drug design.

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Wen-long Huang, Hai Qian, Cheng Jiang, 2019, Bioorganic & medicinal chemistry.

Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability.

Wen-long Huang, Hai Qian, Xin Deng, 2015, Organic & biomolecular chemistry.

6,7‐Dimethoxy‐2‐{2‐[4‐(1H‐1,2,3‐triazol‐1‐yl)phenyl]ethyl}‐1,2,3,4‐tetrahydroisoquinolines as Superior Reversal Agents for P‐Glycoprotein‐Mediated Multidrug Resistance

Wen-long Huang, Hai Qian, Yunman Li, 2015, ChemMedChem.

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, Miaobo Pan, 2015, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.

Wen-long Huang, Hai Qian, W. Shi, 2016, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Wen-long Huang, Hai Qian, Baowei Yang, 2015, Bioorganic & medicinal chemistry.

Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists

Wen-long Huang, Hai Qian, Lin Yan, 2016, Chemical biology & drug design.

Design, Synthesis and in vivo Evaluation of Novel C‐Aryl Glucosides as Potent Sodium‐Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes

Wen-long Huang, Hai Qian, Qianqian Qiu, 2015, Chemical biology & drug design.

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Wen-long Huang, Hai Qian, Qianqian Qiu, 2016, Expert opinion on investigational drugs.

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, W. Shi, 2017, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance.

Hai Qian, W. Shi, Qianqian Qiu, 2019, Bioorganic chemistry.

Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver.

Qianqian Qiu, Yanli Chen, Rongqing Geng, 2020, Bioorganic chemistry.

Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.

Hai Qian, Ziyu Yin, W. Shi, 2023, Journal of medicinal chemistry.

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

Wen-long Huang, Hai Qian, W. Shi, 2019, Archiv der Pharmazie.

Design, synthesis and evaluation of a novel series of inhibitors reversing P‐glycoprotein‐mediated multidrug resistance

Wen-long Huang, Hai Qian, Qianqian Qiu, 2018, Chemical biology & drug design.

Synthesis and in vitro anti-cancer evaluation of luteinizing hormone-releasing hormone-conjugated peptide

Wen-long Huang, Hai Qian, Xin Deng, 2015, Amino Acids.

Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

Wen-long Huang, Qiutong Chen, Qianqian Qiu, 2019, Bioorganic chemistry.

Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.

Qianqian Qiu, Zheng Li, Q. Ren, 2019, Bioorganic chemistry.

Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo.

Wen-long Huang, Hai Qian, Yunman Li, 2015, Canadian journal of physiology and pharmacology.

Phenylbutazone, a New Long‐Acting Agent that can Improve the Peptide Pharmacokinetic Based on Serum Albumin as a Drug Carrier

Wen-long Huang, Hai Qian, Xiao-yun Zhu, 2016, Chemical biology & drug design.