D. Oksenberg

发表

Antagonism of 5-hydroxytryptamine1A (5-HT1A) receptor-mediated modulation of adenylate cyclase activity by pindolol and propranolol isomers.

S. Peroutka, D. Oksenberg, 1988, Biochemical pharmacology.

Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor

K. Bridges, K. Dufu, J. Howard, 2016 .

Increased hemoglobin–oxygen affinity ameliorates bleomycin‐induced hypoxemia and pulmonary fibrosis

K. Dufu, Qingbang Xu, Chien-Ming Li, 2016, Physiological reports.

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

S. Almo, Y. Patskovsky, K. Dufu, 2016, British journal of haematology.

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

C. Derian, A. Pandey, D. McComsey, 2001, Journal of medicinal chemistry.

A High-Throughput Turbidometric Assay for Screening Inhibitors of Protein Disulfide Isomerase Activity

Li-Ping Gao, R. Urfer, Shu-Gui Huang, 2004, Journal of biomolecular screening.

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

C. Johnson, S. Almo, Lan Hua, 2017, ACS medicinal chemistry letters.

Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.

C. Derian, D. McComsey, B. Maryanoff, 2001, Bioorganic & medicinal chemistry letters.

Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules

S. Baranzini, J. Oksenberg, L. Gan, 2012, Neuroscience.

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

C. Derian, D. McComsey, B. Maryanoff, 2003, Bioorganic & medicinal chemistry letters.

GBT 1118 , a potent allosteric modifier of hemoglobin oxygen affinity increases 1 tolerance to severe hypoxia in mice

P. Cabrales, P. Cabrales, K. Dufu, 2017 .

Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).

D. McComsey, B. Maryanoff, D. Oksenberg, 1999, Bioorganic & medicinal chemistry letters.

Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

V. Sheehan, D. Oksenberg, Danitza Nébor, 2020, Frontiers in Physiology.

Functional Interactions between Colony-stimulating Factors and the Insulin Family Hormones for Human Myeloid Leukemic Cells1

P. Greenberg, D. Oksenberg, B. Dieckmann, 2006 .

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia

M. Shamloo, P. Lombroso, Jian Xu, 2008, The European journal of neuroscience.

Characterization of the human 5-hydroxytryptamine1B receptor.

R. Rozmahel, J. Palacios, G. Mengod, 1992, The Journal of biological chemistry.

Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia*

M. Shamloo, T. Wieloch, K. Nikolich, 2005, Journal of Biological Chemistry.

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

C. Washington, A. Hutchaleelaha, D. Oksenberg, 2019, British journal of clinical pharmacology.

GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

K. Dufu, D. Oksenberg, 2018, Hematology reports.

Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells.

P. Greenberg, D. Oksenberg, B. Dieckmann, 1990, Cancer research.

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.

C. Derian, D. McComsey, B. Maryanoff, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers

D. Oksenberg, Mira P Patel, Zhe Li, 2018, Drug design, development and therapy.

The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia

K. Dufu, D. Rees, J. Brewin, 2019, Physiological reports.

GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

K. Dufu, D. Oksenberg, E. Ramos, 2016, Hematology reports.

Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid.

M. Pavani, J. Ferreira, G. Cordano, 1994, Biochemical pharmacology.

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

P. Cabrales, K. Dufu, D. Oksenberg, 2018, Clinical hemorheology and microcirculation.

Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)

K. Nikolich, R. Urfer, Karoly Nikolich, 2006, The European journal of neuroscience.

Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites

C. Fischette, S. Peroutka, A. Hamik, 1990, Biological Psychiatry.

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif.

D. McComsey, B. Maryanoff, R. Scarborough, 1998, Bioorganic & medicinal chemistry letters.

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

B. O'dowd, S. Marsters, A. Ashkenazi, 1992, Nature.

endothelial hypoxic stress protein Identification of protein disulfide isomerase as an

A. Harris, Tsonwin Hai, R. Poulsom, 2005 .

Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies.

G. Leo, D. McComsey, B. Maryanoff, 1999, Bioorganic & medicinal chemistry.

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.

H. Toresson, I. Ladunga, B. Johansson, 2011, Brain : a journal of neurology.

Cardiomyocyte Apoptosis Induced by G&agr;q Signaling Is Mediated by Permeability Transition Pore Formation and Activation of the Mitochondrial Death Pathway

John W. Adams, R. Armstrong, D. Oksenberg, 2000, Circulation research.

A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke

M. Shamloo, K. Nikolich, R. Urfer, 2013, PloS one.

GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease

K. Dufu, J. Howard, P. Telfer, 2015 .

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

B. Metcalf, A. Hutchaleelaha, D. Oksenberg, 2015 .

The Third Intracellular Loop of the 5‐Hydroxytryptamine2A Receptor Determines Effector Coupling Specificity

A. Ashkenazi, S. Peroutka, D. Oksenberg, 1995, Journal of neurochemistry.

Anti‐Migraine Drug Interactions with Cloned Human 5‐Hydroxytryptamine 1 , Receptor Subtypes

S. Peroutka, D. Oksenberg, S. Havlik, 1993 .

Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion

Steven C. Strutt, J. Benz, R. Mihaila, 2020 .

Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide.

R. Scarborough, B. Blackhart, D. Oksenberg, 2000, Molecular pharmacology.

GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice.

P. Cabrales, K. Dufu, O. Yalcin, 2017, American journal of physiology. Heart and circulatory physiology.

GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model

Alexander T. Williams, Steven C. Strutt, C. Muller, 2023, British journal of haematology.

PS1522 CENTRAL PHYSIOLOGIC MECHANISMS WHICH AUGMENT OXYGEN RELEASE (BOHR EFFECT AND 2,3-DPG BINDING) ARE PRESERVED IN THE PRESENCE OF VOXELOTOR AT THE THERAPEUTIC TARGET OF 30% HB MODIFICATION

K. Dufu, D. Oksenberg, Vincent Siu, 2019, HemaSphere.

RESEARCH ARTICLE Integrative Cardiovascular Physiology and Pathophysiology GBT1118, a potent allosteric modiﬁer of hemoglobin O 2 afﬁnity, increases tolerance to severe hypoxia in mice

P. Cabrales, K. Dufu, O. Yalcin, 2022 .