P. Forkert

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PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1

R. Baldwin, D. Putt, L. Lash, 2005, Drug Metabolism and Disposition.

Gap junctional intercellular communication in cells isolated from urethane-induced tumors in A/J mice.

A. Malkinson, A. Vultur, L. Raptis, 2003, DNA and cell biology.

Improved procedure for examination of gap junctional intercellular communication by in situ electroporation on a partly conductive slide.

L. Raptis, E. Tomai, K. Firth, 2000, BioTechniques.

Lung injury induced by trichloroethylene.

J. Poland, P. Forkert, P. Sylvestre, 1985, Toxicology.

Pulmonary toxicity of trichloroethylene in mice. Covalent binding and morphological manifestations.

P. Forkert, D. W. Birch, 1989, Drug metabolism and disposition: the biological fate of chemicals.

Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice.

P. Forkert, 1997, Toxicology and applied pharmacology.

Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: analysis by in situ hybridization and immunohistochemical methods.

S. Chen, A. Parkinson, P. Forkert, 1996, American journal of respiratory cell and molecular biology.

Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice.

P. Forkert, R. P. Lee, 1995, The Journal of pharmacology and experimental therapeutics.

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.

A. Okey, H. Bradlow, D. S. Riddick, 1993, Biochemical pharmacology.

Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.

T. Dowsley, J. Ulreich, P. Forkert, 1996, The Journal of pharmacology and experimental therapeutics.

Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.

A. Parkinson, P. Forkert, J. Lord, 1996, Carcinogenesis.

Expression and inducibility of alpha, pi, and Mu glutathione S-transferase protein and mRNA in murine lung.

P. Forkert, M. El‐Mestrah, D. D'Costa, 1999, American journal of respiratory cell and molecular biology.

Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone.

P. Premdas, P. Forkert, R. Bowers, 2000, The Journal of pharmacology and experimental therapeutics.

Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs.

P. Premdas, P. Forkert, R. Bowers, 2000, American journal of respiratory cell and molecular biology.

1,1-Dichloroethylene-induced Clara cell damage is associated with in situ formation of the reactive epoxide. Immunohistochemical detection of its glutathione conjugate.

P. Forkert, 1999, American journal of respiratory cell and molecular biology.

CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.

J. Bolton, T. Dowsley, S. S. Park, 1996, Toxicology and applied pharmacology.

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes.

T. Dowsley, R. Fisher, J. Ulreich, 1999, The Journal of pharmacology and experimental therapeutics.

Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes.

W. J. Racz, P. Forkert, M. Hofley, 1987, Canadian journal of physiology and pharmacology.

Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.

W. J. Racz, P. Forkert, V. Stringer, 1986, Experimental and molecular pathology.

Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.

A. Malkinson, P. Rice, P. Forkert, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Resistance of murine lung tumors to xenobiotic-induced cytotoxicity.

A. Malkinson, L. Thaete, A. Parkinson, 1992, Cancer research.

P. Forkert, A. P. Titis, A. Titis, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate

P. Forkert, 2010, Drug metabolism reviews.

Inhibition of vinyl carbamate-induced lung tumors and Kras2 mutations by the garlic derivative diallyl sulfone.

L. G. Hernández, P. Forkert, Lya G. Hernández, 2009, Mutation research.

In vivo mutagenicity of vinyl carbamate and ethyl carbamate in lung and small intestine of F1 (Big Blue® × A/J) transgenic mice

L. G. Hernández, P. Forkert, Lya G. Hernández, 2007, International journal of cancer.

Inhibition of vinyl carbamate-induced mutagenicity and clastogenicity by the garlic constituent diallyl sulfone in F1 (Big Blue x A/J) transgenic mice.

L. G. Hernández, P. Forkert, Lya G. Hernández, 2007, Carcinogenesis.

Oxidation of Vinyl Carbamate and Formation of 1,N6-Ethenodeoxyadenosine in Murine Lung

Glenville Jones, Ashish Sharma, K. Collins, 2007, Drug Metabolism and Disposition.

CARBAMATE METABOLISM IN HUMAN LUNG MICROSOMES

P. Forkert, K. Reid, Ray Lee, 2001 .

Inactivation of cytochrome P-450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes by vinyl carbamate in murine pulmonary microsomes.

P. Forkert, R. P. Lee, 1999, Drug metabolism and disposition: the biological fate of chemicals.

PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE : RELATIVE CONTRIBUTIONS OF CYP 2 E 1 , CYP 2 F , AND CYP 2 B 1

R. Baldwin, D. Putt, L. Lash, 2005 .

Evidence That 1,1-Dichloroethylene Induces Apoptotic Cell Death in Murine Liver

P. Forkert, E. Martin, 2004, Journal of Pharmacology and Experimental Therapeutics.

Lung injury and repair: DNA synthesis following 1,1-dichloroethylene.

M. Farooqui, E. Reynolds, L. Forkert, 1985, Toxicology.

Structure of sinuses in the human lymph node

J. Thliveris, P. Forkert, F. Bertalanffy, 1977, Cell and Tissue Research.

1,1-Dichloroethylene-Induced Mitochondrial Damage Precedes Apoptotic Cell Death of Bronchiolar Epithelial Cells in Murine Lung

P. Forkert, E. Martin, 2005, Journal of Pharmacology and Experimental Therapeutics.

Differential formation of 1,1-dichloroethylene-metabolites in the lungs of adult and weanling male and female mice: correlation with severities of bronchiolar cytotoxicity.

T. Dowsley, J. Ulreich, P. Forkert, 1996, The Journal of pharmacology and experimental therapeutics.

Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies.

H. Gelboin, S. S. Park, P. Forkert, 1988, Molecular pharmacology.

Bromobenzene causes Clara cell damage in mice.

P. Forkert, 1985, Canadian journal of physiology and pharmacology.

Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes.

A. Parkinson, P. Forkert, R. P. Lee, 1998, Drug metabolism and disposition: the biological fate of chemicals.

CYP2E1 is preferentially expressed in Clara cells of murine lung: localization by in situ hybridization and immunohistochemical methods.

P. Forkert, 1995, American journal of respiratory cell and molecular biology.

Lactate dehydrogenase activity in mouse lung following 1,1-dichloroethylene: index of airway injury.

G. Ansari, A. Alpert, E. Reynolds, 1982, Experimental lung research.

Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.

C. Vandevoort, N. Tanphaichitr, R. Tardif, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Trichloroethylene induces pulmonary fibrosis in mice.

L. Forkert, P. Forkert, 1994, Canadian journal of physiology and pharmacology.

Histochemical localization of glutathione in fixed tissues

P. Forkert, M. Moussa, 1989, The Histochemical Journal.

Lung volume maintenance prevents lung injury during high frequency oscillatory ventilation in surfactant-deficient rabbits.

A. Froese, P. Forkert, P. R. McCulloch, 1988, The American review of respiratory disease.

Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung

Ashish Sharma, C. Reilly, Christopher A Reilly, 2004, Journal of Pharmacology and Experimental Therapeutics.

Bioactivation of 1 , 1-Dichloroethylene by CYP 2 E 1 and CYP 2 F 2 in Murine

Ashish Sharma, C. Reilly, G. Yost, 2004 .

Mitochondrial Dysfunction Is an Early Manifestation of 1,1-Dichloroethylene-Induced Hepatotoxicity in Mice

Erik J Martin, William J Racz, Poh-Gek Forkert, 2003, Journal of Pharmacology and Experimental Therapeutics.

MECHANISMS OF 1,1-DICHLOROETHYLENE-INDUCED CYTOTOXICITY IN LUNG AND LIVER*,†

P. Forkert, 2001, Drug metabolism reviews.

In vivo formation and localization of 1,1-dichloroethylene epoxide in murine liver: identification of its glutathione conjugate 2-S-glutathionyl acetate.

P. Forkert, 1999, The Journal of pharmacology and experimental therapeutics.

Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.

J. Bolton, T. Dowsley, P. Forkert, 1995, Chemico-biological interactions.

In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice.

P. Forkert, R. P. Lee, 1994, The Journal of pharmacology and experimental therapeutics.

1,1‐dichloroethylene‐induced alterations in glutathione and covalent binding in murine lung: Morphological, histochemical, and biochemical studies

P. Forkert, M. Moussa, 1992, The Journal of pathology.

Pulmonary toxicity of 1,1-dichloroethylene: correlation of early changes with covalent binding.

P. Forkert, K. Troughton, V. Stringer, 1986, Canadian journal of physiology and pharmacology.

1,1-Dichloroethylene-induced pulmonary injury.

E. Reynolds, P. Forkert, 1982, Experimental lung research.

Pulmonary bioactivation of 1,1-dichloroethylene is associated with CYP2E1 levels in A/J, CD-1, and C57BL/6 mice.

S. Boyd, J. Ulreich, P. Forkert, 2001, The Journal of pharmacology and experimental therapeutics.

Pulmonary toxicity of trichloroethylene: induction of changes in surfactant phospholipids and phospholipase A2 activity in the mouse lung.

M. Oulton, J. Scott, M. Fraser, 1988, Experimental and molecular pathology.

Localization of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in mouse lung with monoclonal antibodies.

S. Cole, J. Elce, H. Gelboin, 1986, Research communications in chemical pathology and pharmacology.

Cytochrome P-450-Dependent Bioactivation of 1 , 1-Dichloroethylene to a Reactive Epoxide in Human Lung and Liver Microsomes 1

T. Dowsley, R. Fisher, J. Ulreich, 1999 .

Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.

P. Forkert, 1998, Experimental lung research.

Immunochemical assay for recognition of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene-epoxide.

T. Dowsley, K. Collins, P. Forkert, 1997, The Journal of pharmacology and experimental therapeutics.

Conjugation of glutathione with the reactive metabolites of 1,1‐dichloroethylene in murine lung and liver

P. Forkert, 1997, Microscopy research and technique.

Chemically-Induced Respiratory Toxicities

P. Forkert, 2019, Encyclopedia of Environmental Health.

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

R. Baldwin, C. Reilly, G. Yost, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration.

Z. M. Redza, S. S. Park, S. Mangos, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Temporal effects of 1,1-dichloroethylene on nonprotein sulfhydryl content in murine lung and liver.

P. Forkert, M. Moussa, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Morphologic changes and covalent binding of 1,1-dichloroethylene in Clara and alveolar type II cells isolated from lungs of mice following in vivo administration.

T. Massey, P. Forkert, D. W. Birch, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Isolation of nonciliated bronchiolar epithelial (Clara) cells and alveolar type II cells from mouse lungs.

T. Massey, P. Forkert, B. A. Geddes, 1987, Canadian journal of physiology and pharmacology.

Metabolism and toxicity of trichloroethylene in epididymis and testis.

Robert Tardif, Lawrence H Lash, R. Tardif, 2002, Toxicology and applied pharmacology.

Differential metabolism of 1,1-dichloroethylene in livers of A/J, CD-1, and C57BL/6 mice.

S. Boyd, P. Forkert, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozymes: involvement of CYP2E1 and hydrolase A.

P. Forkert, R. P. Lee, 1997, Toxicology and applied pharmacology.

Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration.

L. Anderson, T. Massey, H. Gelboin, 1991, Carcinogenesis.

Mechanisms of chemically induced respiratory toxicities

P. Forkert, 2010 .

Detection of Early Stages of Carcinogenesis in Adenomas of Murine Lung by 5‐Aminolevulinic Acid‐Induced Protoporphyrin IX Fluorescence

J. Kennedy, R. Pottier, D. L. Campbell, 1996, Photochemistry and photobiology.

Distinct forms of hepatic androgen 6β-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile

C. Martucci, P. Forkert, P. Jellinck, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Cytochromes P-450 in murine lung. An immunohistochemical study with monoclonal antibodies.

S. Cole, H. Gelboin, S. S. Park, 1989, Drug metabolism and disposition: the biological fate of chemicals.

Pulmonary Bronchiolar Cytotoxicity and Formation of Dichloroacetyl Lysine Protein Adducts in Mice Treated with Trichloroethylene

D. Putt, L. Lash, B. Ghanayem, 2006, Journal of Pharmacology and Experimental Therapeutics.

Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.

P. Forkert, K. Reid, R. P. Lee, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice.

M. Wade, N. Tanphaichitr, R. Vincent, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Phase II enzymes and bioactivation.

J. Hinson, J A Hinson, P G Forkert, 1995, Canadian journal of physiology and pharmacology.