M. Domalski

发表

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, T. Kowalski, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, K. O'neill, 2006, Bioorganic & medicinal chemistry letters.

Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.

W. Greenlee, R. Bertorelli, A. Reggiani, 2007, Journal of medicinal chemistry.

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.

J. Clader, G. Scapin, J. Voigt, 2016, Bioorganic & medicinal chemistry.

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Jinsong Hao, A. Stamford, G. Scapin, 2016, ACS medicinal chemistry letters.

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2013, Bioorganic & medicinal chemistry letters.

Inhibitors of acyl CoA:cholesterol acyltransferase.

R. Burrier, J. Clader, J. Berger, 1996, Journal of medicinal chemistry.

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

R. Burrier, J. Clader, H. Zhao, 1996, Journal of medicinal chemistry.

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

J. Clader, D. Burnett, S. Dugar, 1995 .

Synthesis of Fluorescent Biochemical Tools Related to the 2‐Azetidinone Class of Cholesterol Absorption Inhibitors.

J. Clader, H. Davis, D. Burnett, 2002 .

Reactions of allylic Grignard reagents and unsaturated amines

M. Domalski, H. G. Richey, W. Erickson, 1981 .

Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.

P. Chiu, S. Wong, D. Blythin, 1986, Journal of medicinal chemistry.

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

W. Greenlee, R. Xu, J. Clader, 2012, ACS medicinal chemistry letters.

Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.

R. Burrier, J. Clader, H. Davis, 1995, Journal of medicinal chemistry.

Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines.

H. Guzik, S. Wong, A. J. Elliott, 1985, Journal of medicinal chemistry.

SAR of tricyclic sulfones as γ-secretase inhibitors

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2011 .

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

W. Greenlee, Mark D. McBriar, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, T. Kowalski, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.

W. Greenlee, D. Tulshian, R. Bertorelli, 2012, Bioorganic & medicinal chemistry letters.

Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogues.

H. Guzik, B. Pramanik, A. J. Elliott, 1987, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.

D. Burnett, A. Fawzi, Hongtao Zhang, 2002, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists.

A. Stamford, C. Foster, L. Arik, 1999, Bioorganic & medicinal chemistry letters.