A. Bihlet

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The impact of clinical trial monitoring approaches on data integrity and cost—a review of current literature

Faidra Kalakou, Rasmus Olsen, Asger Reinstrup Bihlet, 2016, European Journal of Clinical Pharmacology.

Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

L. Edwards, R. Zuwallack, J. Wedzicha, 2017, BMC Pulmonary Medicine.

Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial.

M. Karsdal, H. B. Nielsen, M. Boesen, 2021, Osteoarthritis and cartilage.

Effect of adrenaline on serum mid‐regional pro‐atrial natriuretic peptide and central blood volume

N. Secher, J. Goetze, H. Nielsen, 2022, Experimental physiology.

An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion

N. Secher, A. Mackey, H. Nielsen, 2022, Frontiers in Physiology.

Blood levels of matrix metalloproteinase generated C-reactive protein metabolite (CRPM) are a sensitive measure of chronic inflammation in OA

M. Karsdal, C. Christiansen, C. Ladel, 2020 .

Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design

M. Karsdal, C. Bager, A. Bihlet, 2019, BMC Musculoskeletal Disorders.

Use of extracellular matrix biomarkers in clinical research

M. Karsdal, C. Bager, A. Bihlet, 2019, Biochemistry of Collagens, Laminins and Elastin.

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study

F. Eckstein, M. Hochberg, P. Conaghan, 2021, Annals of the Rheumatic Diseases.

Associations between single-question Visual Analogue Scale pain score and weight-bearing and non–weight-bearing domains of Western Ontario and McMaster Universities Arthritis Index pain: data from 2 phase 3 clinical trials

M. Karsdal, A. Bihlet, J. Andersen, 2022, Pain Reports.

Protein biomarkers associated with pain mechanisms in osteoarthritis.

M. Karsdal, A. Bihlet, H. Löfvall, 2019, Journal of proteomics.

Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover

M. Karsdal, A. Mackey, M. Boesen, 2020, Osteoarthritis and cartilage open.

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future.

M. Karsdal, C. Christiansen, V. Kraus, 2016, Osteoarthritis and cartilage.

Cohort Profile: The Prospective Epidemiological Risk Factor (PERF) study.

M. Karsdal, C. Christiansen, P. Alexandersen, 2016, International journal of epidemiology.

Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

R. Bowler, M. Karsdal, W. White, 2017, Respiratory Research.

A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D.

M. Karsdal, C. Christiansen, P. Alexandersen, 2016, Bone.

Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD—VIVIAD

P. Scheltens, P. Alexandersen, N. Prins, 2021, Alzheimer's Research & Therapy.

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

M. Karsdal, J. Vestbo, B. Miller, 2016, Respiratory Research.

Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD.

M. Karsdal, J. Vestbo, P. Lange, 2015, Chest.

Symptomatic and structural benefit of cathepsin K inhibition by MIV-711 in a subgroup with unilateral pain: post-hoc analysis of a randomised phase 2a clinical trial.

P. Conaghan, F. Öberg, M. Bowes, 2022, Clinical and experimental rheumatology.

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials.

M. Karsdal, C. Christiansen, P. Alexandersen, 2015, Osteoarthritis and cartilage.

OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.

M. Karsdal, C. Christiansen, P. Alexandersen, 2015, Osteoarthritis and cartilage.

Clinical and biochemical factors associated with risk of total joint replacement and radiographic progression in osteoarthritis: Data from two phase III clinical trials.

M. Karsdal, A. Bihlet, I. Byrjalsen, 2020, Seminars in arthritis and rheumatism.

Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

M. Karsdal, C. Christiansen, B. Riis, 2019, Arthritis Research & Therapy.

The impact of clinical trial monitoring approaches on data integrity and cost—a review of current literature

Rasmus Olsen, A. Bihlet, Faidra Kalakou, 2016, European Journal of Clinical Pharmacology.

Impact of source data verification on data quality in clinical trials: an empirical post hoc analysis of three phase 3 randomized clinical trials.

Jeppe Ragnar Andersen, Inger Byrjalsen, Asger Bihlet, 2015, British journal of clinical pharmacology.

The Efficacy and Safety of Multiple Dose Regimens of Kudzu (Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms

M. Karsdal, C. Christiansen, B. Riis, 2021, Frontiers in Pharmacology.

Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects

M. Karsdal, C. Christiansen, K. Henriksen, 2021 .

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

M. Karsdal, C. Christiansen, C. Ladel, 2021, Scientific Reports.

Segregating OA patients with and without joint inflammation using two biomarkers of connective tissue inflammation

M. Karsdal, C. Christiansen, B. Riis, 2015 .

The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial.

F. Eckstein, M. Hochberg, P. Conaghan, 2021, Seminars in arthritis and rheumatism.

Trial design of SB-061 in osteoarthritis of the knee. The modify-OA trial

A. Bihlet, I. Byrjalsen, J. Andersen, 2017 .

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

M. Karsdal, C. Christiansen, J. Svendsen, 2018, Scientific Reports.

A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study

K. Henriksen, A. Bihlet, M. Karsdal, 2023, The Journal of Prevention of Alzheimer's Disease.

P. Scheltens, P. Alexandersen, N. Prins, 2021, Alzheimer's research & therapy.

The acute and long‐term impact of physical activity on biochemical markers and MRI measures in osteoarthritis—Perspectives for clinical osteoarthritis research

M. Karsdal, H. Bliddal, M. Boesen, 2020 .

A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study

M. Karsdal, A. Mackey, M. Boesen, 2021, European Journal of Applied Physiology.

Reflections from the OARSI 2022 clinical trials symposium: The pain of OA-Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design.

V. Kraus, C. Ladel, N. Nikolov, 2023, Osteoarthritis and cartilage.

Joint biomarker response to mechanical stimuli in osteoarthritis – a scoping review

Y. Henrotin, A. Bihlet, C. Thudium, 2023, Osteoarthritis and Cartilage Open.

A novel diclofenac gel (AMZ001) applied once or twice daily in subjects with painful knee osteoarthritis: A randomized, placebo-controlled clinical trial.

L. Simon, A. Bihlet, I. Byrjalsen, 2020, Seminars in arthritis and rheumatism.

Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis

M. Karsdal, C. Christiansen, M. Hochberg, 2018, BMC Musculoskeletal Disorders.

Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD.

M. Karsdal, J. Vestbo, P. Lange, 2015, Chest.

The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial.

R. Moots, P. Conaghan, A. Bihlet, 2024, Osteoarthritis and cartilage.

Safety, Tolerability, and Pharmacodynamics of the ADAMTS‐5 Nanobody M6495: Two Phase 1, Single‐Center, Double‐Blind, Randomized, Placebo‐Controlled Studies in Healthy Subjects and Patients With Osteoarthritis

T. Balchen, A. Bihlet, H. Guehring, 2024, ACR open rheumatology.

A Phase 2b double-blind placebo-controlled randomized clinical trial of SB-061, an aggrecan mimetic, in patients with symptomatic knee osteoarthritis.

A. Bihlet, I. Byrjalsen, Kamilla Mundbjerg, 2024, Osteoarthritis and cartilage.