L. McGee

发表

Chiral enolate design

David A. Evans, M. D. Ennis, D. Mathre, 1981 .

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).

N. Jahchan, E. Jackson, J. Medina, 2018, Journal of medicinal chemistry.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus

D. W. Ovenall, F. Sariaslani, L. McGee, 1987, Applied and environmental microbiology.

INT131: a selective modulator of PPAR gamma.

M. Lindstrom, N. Walker, Zhulun Wang, 2009, Journal of Molecular Biology.

Small Molecule Therapeutics Preclinical Evaluation of AMG 925 , a FLT 3 / CDK 4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia

A. Kamb, Ji Ma, J. Medina, 2014 .

Gilvocarcin photobiology. Isolation and characterization of the DNA photoadduct

L. McGee, R. Misra, 1990 .

Light-induced modifications of DNA by gilvocarcin V and its aglycone.

Y. Tse‐Dinh, L. McGee, 1987, Biochemical and biophysical research communications.

Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors

D. Whittington, Yi Chen, K. Miner, 2012 .

Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quino

J. McCarter, D. Whittington, Iain D. G. Campuzano, 2016, Journal of medicinal chemistry.

Synthesis and SAR study of potent and selective PI3Kδ inhibitors.

J. McCarter, D. Metz, S. Wong, 2015, Bioorganic & medicinal chemistry letters.

From Peptide to Non-Peptide. Part 2. The de novo Design of Potent, Non- Peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold.

Mark Reynolds, M. Venuti, E. Thorsett, 1994 .

The photobiology of the gilvocarcins. Total synthesis of defucogilvocarcin V and a related photoactive vinyl phenol

P. Confalone, L. McGee, 1988 .

Practical Total Synthesis of the Anti-Influenza Drug GS-4104

K. Kent, J. Rohloff, Lijun Zhang, 1998 .

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors.

D. Whittington, Yi Chen, K. Miner, 2012, Journal of medicinal chemistry.

Synthesis of novel biaryl 2-benzimidazoles and 2-benzothiazoles

K. Pattabiraman, L. McGee, D. Chow, 2009 .

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Y. Wang, J. Canon, J. Oliner, 2014, Journal of medicinal chemistry.

Aldol diastereoselection via zirconium enolates. Product-selective, enolate structure independent condensations.

Davidr . Evans, L. McGee, D. A. Evans, 1980 .

Enantioselective aldol condensations. 3. Erythro-selective condensations via zirconium enolates

D. Evans, L. McGee, 1981 .

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

Thomas Rawson, E. Thorsett, T. Gadek, 1994 .

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.

J. McCarter, D. Whittington, D. Metz, 2016, Journal of medicinal chemistry.

An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.

J. Medina, S. Olson, L. McGee, 2012, Journal of the American Chemical Society.

Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.

B. Lemon, T. Sullivan, G. Tonn, 2008, Bioorganic & medicinal chemistry letters.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

On the Photobiology of the Gilvocarcins. Total Synthesis of Defucogilvocarin V and a Related Photoactive Vinyl Phenol.

P. Confalone, L. McGee, 1989 .

Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Xiaolin Hao, Ben Fisher, Andreas Reichelt, 2015, Journal of medicinal chemistry.

INT131: A Selective Modulator of PPARγ

M. Lindstrom, N. Walker, Zhulun Wang, 2009 .

Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia

Alexander Kamb, John Eksterowicz, C. Quéva, 2014, Molecular Cancer Therapeutics.

Is a Dual FLT 3 / CDK 4 Inhibitor with the Potential to Overcome FLT 3 Inhibitor Resistance in Acute Myeloid Leukemia

A. Kamb, K. Dai, L. Liang, 2015 .

AMG 925 Is a Dual FLT3/CDK4 Inhibitor with the Potential to Overcome FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

A. Kamb, K. Dai, L. Liang, 2014, Molecular Cancer Therapeutics.

PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.

D. Whittington, D. Metz, L. McGee, 2012, Journal of medicinal chemistry.

Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.

O. Plotnikova, Zhulun Wang, Jinsong Liu, 2013, Bioorganic & medicinal chemistry letters.

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

M. Kuehl, Y. Demchenko, Zhihong Li, 2014, Oncotarget.

Mass spectral data for gas chromatograph-mass spectral identification of some irregular monoterpenes

C. Poulter, W. Epstein, L. McGee, 1976 .

Inhibition of HIV-1 RNase H Activity by Nucleotide Dimers and Monomers

J. Cherrington, S. Krawczyk, N. Bischofberger, 1996 .

Mostueine: synthesis and structure revision☆

P. Confalone, G. Reddy, L. McGee, 1984 .

Imidazo-pyrazine derivatives as potent CXCR3 antagonists.

B. Lemon, Zhulun Wang, S. Miao, 2009, Bioorganic & medicinal chemistry letters.

Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.

M. Lindstrom, N. Walker, P. Timmermans, 2013, Bioorganic & medicinal chemistry.