M. Akhtar

发表

Phosphorylatio of solubilised dark‐adapted rhodopsin

K. R. Dean, M. Akhtar, 1993 .

Studies on the regeneration of rhodopsin from all-trans-retinal in isolated rat retinae.

M. Akhtar, S. Amer, 1973, Nature: New biology.

A convenient synthesis of labelled rhodopsin and studies on its active site.

M. Akhtar, M. Hirtenstein, 1970, The Biochemical journal.

Chromophore-environment interaction of visual pigments in model system.

M. Akhtar, M. Hirtenstein, 1971, Nature: New biology.

The regeneration of rhodopsin from all-trans-retinal: solubilization of an enzyme system involved in the completion of the visual cycle.

M. Akhtar, S. Amer, 1972, The Biochemical journal.

A unified mechanistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzymes.

M. Akhtar, J. N. Wright, J. Wright, 1991, Natural product reports.

Studies on estrogen biosynthesis using radioactive and stable isotopes

M. Akhtar, J. N. Wright, J. Wright, 1990, Steroids.

Mechanistic studies on aromatase and related CC bond cleaving P-450 enzymes

V. Njar, M. Akhtar, J. N. Wright, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis of 19-functionalised derivatives of 16α-hydroxy-testosterone: mechanistic studies on oestriol biosynthesis

D. Stevenson, M. Akhtar, J. N. Wright, 1985 .

Mechanistic consideration of P-450 dependent enzymic reactions: studies on oestriol biosynthesis

D. Stevenson, M. Akhtar, J. N. Wright, 1988 .

Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments.

P. Cohen, M. Akhtar, C. Fowles, 1989, Biochemistry.

Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin.

R. Sharma, M. Akhtar, C. Fowles, 1992, European journal of biochemistry.

Isolation and properties of protein phosphatase type 2A in photoreceptors.

M. Akhtar, A. King, N. E. McCarthy, 2000, Methods in enzymology.

Topography of the rhodopsin molecule. Identification of the domain phosphorylated.

G. J. Sale, P. Towner, M. Akhtar, 1978, The Biochemical journal.

A review of 18O labelling Studies to probe the mechanism of aromatase (CYP191A)

M. Akhtar, J. N. Wright, J. Wright, 2021, The Journal of Steroid Biochemistry and Molecular Biology.

The impact of aromatase mechanism on other P450s

M. Akhtar, J. N. Wright, P. Lee-Robichaud, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase).

A. Z. Shyadehi, M. Akhtar, J. N. Wright, 1995, Biochemistry.

A transition from ionic to free-radical mechanisms in chemistry and enzymology

A. Z. Shyadehi, M. Akhtar, J. N. Wright, 1994 .

Incorporation of label from 18O2 into acetate during side-chain cleavage catalysed by cytochrome P-45017α(17α-hydroxylase-17,20-lyase)

A. Z. Shyadehi, M. Akhtar, J. N. Wright, 1994 .

Mechanism of rhodopsin kinase regulation by recoverin

K. Koch, I. I. Senin, M. Akhtar, 2009, Journal of neurochemistry.

Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: studies on cytochrome P-450(17)alpha.

S. Miller, A. Z. Shyadehi, M. Akhtar, 1994, Biochemistry.

Functional rhodopsin complex consisting of three noncovalently linked fragments.

G. J. Sale, P. Towner, M. Akhtar, 1977, Biochemistry.

Studies on a missing reaction in the visual cycle.

M. Akhtar, S. Amer, 1972, Nature: New biology.

Chemistry of the active site of rhodopsin.

M. Akhtar, M. Hirtenstein, 1969, Biochemical Journal.

Activation of rhodopsin kinase.

M. Akhtar, N. E. McCarthy, 2002, The Biochemical journal.

Identification of the active site polypeptide in labeled photoreceptor membranes digested with papain

G. J. Sale, P. Towner, M. Akhtar, 1977, FEBS letters.

Obtaining and characterization of EF‐hand mutants of recoverin

S. Shulga-Morskaya, V. Lipkin, I. I. Senin, 1998, FEBS letters.

Rhodopsin phosphorylation in bovine rod outer segments is more sensitive to the inhibitory action of recoverin at the low rhodopsin bleaching than it is at the high bleaching

I. I. Senin, M. Akhtar, P. P. Philippov, 1997, FEBS letters.

Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: a possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction.

I. I. Senin, K. R. Dean, M. Akhtar, 1997, The Biochemical journal.

The biochemical role of vitamin B12.

M. Akhtar, 1969, Comparative biochemistry and physiology.

A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17)

M. Akhtar, P. Lee-Robichaud, J. Wright, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1.

M. Akhtar, J. Wright, 2015, Advances in experimental medicine and biology.

The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b 5-dependent acyl-carbon cleavage activities

Q. I. Sheikh, M. Akhtar, P. Lee-Robichaud, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins?

M. Akhtar, 1996 .

The involvement of an O2-derived nucleophilic species in acyl–carbon cleavage, catalysed by cytochrome P-45017α: implications for related P-450 catalysed fragmentation reactions

M. Akhtar, P. Robichaud, J. Wright, 1994 .

Rhodopsin kinase: studies on the sequence of and the recognition motif for multiphosphorylations.

N. Pullen, M. Akhtar, 1994, Biochemistry.

Steroidal C-19 sulphur and nitrogen derivatives designed as aromatase inhibitors

M. Calder, M. Akhtar, J. Wright, 1985 .

Cooperativity during multiple phosphorylations catalyzed by rhodopsin kinase: supporting evidence using synthetic phosphopeptides.

N. Pullen, N Pullen, R P Sharma, 1993, Biochemistry.

Novel mechanism for the activation of rhodopsin kinase: implications for other G protein-coupled receptor kinases (GRK's).

K. R. Dean, M. Akhtar, 1996, Biochemistry.

Phosphorylation of solubilised dark-adapted rhodopsin. Insights into the activation of rhodopsin kinase.

K. R. Dean, M. Akhtar, 1993, European journal of biochemistry.

The asymmetric distribution of enzymic activity between the six subunits of bovine liver glutamate dehydrogenase. Use of D- and L-glutamyl alpha-chloromethyl ketones (4-amino-6-chloro-5-oxohexanoic acid.

C. Rasool, S. Nicolaidis, M. Akhtar, 1976, The Biochemical journal.

Mechanistic and stereochemical studies on 3-oxo steroid delta 4-delta 5-isomerase from human placenta.

M. Calder, M. Akhtar, T. Smith, 1980, Biochemical Journal.

The phospho-opsin phosphatase from bovine rod outer segments. An insight into the mechanism of stimulation of type-2A protein phosphatase activity by protamine.

B. Hemmings, M. Akhtar, N. Andjelkovic, 1994, European journal of biochemistry.

Structural studies on membrane-bound bovine rhodopsin.

M. Akhtar, E. Mullen, 1983, The Biochemical journal.

An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).

M. Akhtar, P. Lee-Robichaud, M. Akhtar, 1998, The Biochemical journal.

Function of the farnesyl moiety in visual signalling.

M. Akhtar, N. E. McCarthy, 2000, The Biochemical journal.

Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin.

M. Akhtar, C. Fowles, N. G. Brown, 1993, European Journal of Biochemistry.

Activation of rhodopsin kinase

M. Akhtar, N. E. McCarthy, 2002 .