L. Podust

发表

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

A. Burlingame, J. Taunton, J. Gut, 2013, Beilstein journal of organic chemistry.

2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis.

P. Ortiz de Montellano, A. Ioanoviciu, L. Podust, 2008, Biochemistry.

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

D. Sherman, T. Pochapsky, D. Tietz, 2017, Biochemistry.

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

Brian M. Suzuki, J. McKerrow, W. Roush, 2017, PLoS neglected tropical diseases.

DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases.

U. Hübscher, V. Podust, L. Podust, 1995, Biochemistry.

The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2)*

Colin J Jackson, Douglas B Kell, D. Kell, 2002, The Journal of Biological Chemistry.

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

U. Hübscher, B. Ducommun, V. Podust, 1995, Biochemistry.

Assembly of DNA polymerase 6 and e holoenzymes depends on the geometry of the DNA template

U. Hübscher, V. Podust, L. Podust, 1994 .

Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole

B. Shing, A. Debnath, Vandna Sharma, 2020, Molecular Pharmacology.

Interaction of Mycobacterium tuberculosis CYP130 with Heterocyclic Arylamines*

P. Ortiz de Montellano, J. V. von Kries, L. Podust, 2009, The Journal of Biological Chemistry.

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.

K. Houk, D. Sherman, M. Garcia‐Borràs, 2020, ACS catalysis.

Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.

D. Kelly, S. Kelly, D. Lamb, 2002, The Biochemical journal.

Correction: The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

David L. Williams, Gregory R J Thatcher, L. Podust, 2016, PLoS neglected tropical diseases.

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

David L. Williams, Gregory R J Thatcher, L. Podust, 2015, PLoS neglected tropical diseases.

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.

D. Sherman, Shengying Li, L. Podust, 2007, Journal of the American Chemical Society.

Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives.

V. Vlassov, O. Fedorova, V. Zarytova, 1988, Gene.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.

P. Mäser, V. Summa, R. Di Santo, 2019, Journal of medicinal chemistry.

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

W. D. Nes, Wenxu Zhou, A. Debnath, 2018, PLoS pathogens.

Complementary addressed modification of double‐stranded DNA within a ternary complex

O. Fedorova, V. Zarytova, L. Podust, 1988, FEBS letters.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

P. Mäser, R. Di Santo, R. Costi, 2018, European journal of medicinal chemistry.

Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition.

J. Mccammon, M. Burkart, T. Davis, 2022, ACS chemical biology.

Estriol bound and ligand-free structures of sterol 14alpha-demethylase.

E. Dalmasso, M. Waterman, G. Lepesheva, 2004, Structure.

Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51.

G. Nienhaus, K. Nienhaus, Vandna Sharma, 2022, Biochemistry.

Application of tris(2,2'-bipyridyl)ruthenium(III) for the investigation of DNA spatial structure by a chemical modification method.

O. Fedorova, L. Podust, 1988, Journal of inorganic biochemistry.

Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2

A. Poso, C. Craik, R. S. Ferreira, 2022, J. Chem. Inf. Model..

Diversity of P450 enzymes in the biosynthesis of natural products.

D. Sherman, L. Podust, 2012, Natural product reports.

Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

T. Poulos, M. Waterman, L M Podust, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi.

W. Gerwick, R. Payne, J. McKerrow, 2022, Journal of medicinal chemistry.

Intramolecular interactions enhance the potency of gallinamide A analogs against Trypanosoma cruzi

W. Gerwick, R. Payne, J. McKerrow, 2021, bioRxiv.

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.

R. Abagyan, J. McKerrow, S. Reed, 2016, Journal of structural biology.

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.

J. McKerrow, M. Cameron, W. Roush, 2013, Journal of medicinal chemistry.

Drug Strategies Targeting CYP51 in Neglected Tropical Diseases

W. Roush, L. Podust, J. Choi, 2014, Chemical reviews.

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

R. Abagyan, Wenxu Zhou, J. McKerrow, 2017, PLoS neglected tropical diseases.

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of medicinal chemistry.

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Michelle R. Arkin, Joseph Mulvaney, Jiri Gut, 2012, PLoS neglected tropical diseases.

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

J. McKerrow, G. De Muylder, W. Roush, 2015, PLoS neglected tropical diseases.

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)*♦

S. Kaufmann, J. V. von Kries, L. Podust, 2008, Journal of Biological Chemistry.

Mycobacterium tuberculosis CYP130

P. D. de Montellano, L. Podust, H. Ouellet, 2008, Journal of Biological Chemistry.

Expanding the Binding Envelope of CYP51 Inhibitors Targeting Trypanosoma cruzi with 4‐Aminopyridyl‐Based Sulfonamide Derivatives

W. Roush, J. Choi, L. Podust, 2014, Chembiochem : a European journal of chemical biology.

Folding Requirements Are Different between Sterol 14α-Demethylase (CYP51) from Mycobacterium tuberculosis and Human or Fungal Orthologs*

M. Waterman, A. Bellamine, G. Lepesheva, 2001, The Journal of Biological Chemistry.

FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specific.

A. Archakov, A. Ivanov, A. Molnar, 2010, ACS chemical biology.

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.

Rommie E. Amaro, Jacob D Durrant, Rommie E Amaro, 2017, ACS chemical biology.

A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Matthew P. Jacobson, M. Jacobson, Chiung-Kuang J. Chen, 2010, Antimicrobial Agents and Chemotherapy.

Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate.

J. F. Aparicio, Javier Santos-Aberturas, L. Podust, 2010, Chemistry & biology.

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

K. Houk, J. N. Sanders, Song Yang, 2019, The Journal of Biological Chemistry.

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

J. McKerrow, B. Shing, A. Debnath, 2020, Antimicrobial Agents and Chemotherapy.

Identification of four amoebicidal non-toxic compounds by a molecular docking screen of Naegleria fowleri sterol Δ8-Δ7-isomerase and phenotypic assays.

R. Abagyan, J. McKerrow, L. Nothias, 2019, ACS infectious diseases.

Structural control of cytochrome P450-catalyzed ω-hydroxylation.

P. Ortiz de Montellano, Jonathan B. Johnston, L. Podust, 2011, Archives of biochemistry and biophysics.

Biochemical and structural characterization of CYP124: A methyl-branched lipid ω-hydroxylase from Mycobacterium tuberculosis

P. Ortiz de Montellano, Jonathan B. Johnston, L. Podust, 2009, Proceedings of the National Academy of Sciences.

Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

Raghunath O. Ramabhadran, Alison R. H. Narayan, K. Houk, 2015, Nature Chemistry.

Two approaches to discovering and developing new drugs for Chagas disease.

I D Kerr, C. Craik, R. S. Ferreira, 2009, Memorias do Instituto Oswaldo Cruz.

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of medicinal chemistry.

Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways

S. Kelly, D. Lamb, M. Waterman, 2004, Protein science : a publication of the Protein Society.

The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1

Benjamin A. Neely, S. Kelly, D. Lamb, 2003, The Journal of Biological Chemistry.

Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation

Alison R. H. Narayan, D. Sherman, J. Montgomery, 2014, Journal of the American Chemical Society.

The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*

Youngchang Kim, David H Sherman, M. Waterman, 2006, Journal of Biological Chemistry.

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

D. Sherman, A. N. Lowell, Sung Ryeol Park, 2016, ACS chemical biology.

[Affinity modification of Escherichia coli ribosomes with photoactivated analogs of mRNA].

M. Zenkova, G. Karpova, L. Podust, 1984, Molekuliarnaia biologiia.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

R. Abagyan, K. Jarnagin, G. A. Lemieux, 2017, PLoS neglected tropical diseases.

A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.

S. Kelly, D. Lamb, M. Waterman, 2006, Structure.

Identification of amino acids in rat pregnane X receptor that determine species-specific activation.

R. Kim, R. Tirona, B. Leake, 2004, Molecular pharmacology.

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes

D. Sherman, Shengying Li, Y. Anzai, 2011, Nature chemistry.

Selective oxidation of carbolide C–H bonds by an engineered macrolide P450 mono-oxygenase

D. Sherman, J. Montgomery, Shengying Li, 2009, Proceedings of the National Academy of Sciences.

New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners

L. Yao, D. Sherman, Jinyong Yan, 2014, Journal of the American Chemical Society.

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae *

D. Sherman, Shengying Li, L. Podust, 2009, Journal of Biological Chemistry.

Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA

U. Hübscher, J. Sogo, V. Podust, 1995, Molecular and cellular biology.

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Siegfried S. F. Leung, Matthew P. Jacobson, Christophe Guilbert, 2010, PLoS neglected tropical diseases.

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest‐4‐en‐3‐one

S. Guan, A. Burlingame, E. Chow, 2010, Molecular microbiology.

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

M. Waterman, S. Kaufmann, H. Oschkinat, 2007, Antimicrobial Agents and Chemotherapy.

Expansion of Substrate Specificity of Cytochrome P450 2A6 by Random and Site-directed Mutagenesis*

F. Guengerich, Z. Wu, P. Guengerich, 2005, Journal of Biological Chemistry.

Tyrosine 114 is essential for the trimeric structure and the functional activities of human proliferating cell nuclear antigen.

Z. Jónsson, U. Hübscher, V. Podust, 1995, The EMBO journal.

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

K. Ang, Chiung-Kuang J. Chen, J. McKerrow, 2009, PLoS neglected tropical diseases.

Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2*

Bradley S Moore, F Peter Guengerich, Tsutomu Shimada, 2005, Journal of Biological Chemistry.

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.

R. Abagyan, Shantanu Roy, A. Debnath, 2020, ACS chemical neuroscience.

Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase.

B. Hoffman, R. Davydov, L. Podust, 2019, Archives of biochemistry and biophysics.

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

A. Poso, C. Craik, R. S. Ferreira, 2022, bioRxiv.

Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1.

P. Ortiz de Montellano, Larissa M Podust, Hugues Ouellet, 2011, Bioorganic & medicinal chemistry letters.

A highly conserved mycobacterial cholesterol catabolic pathway.

J. García, B. Galán, P. Ortiz de Montellano, 2013, Environmental microbiology.

Crystal Structure of the CCAAT Box/Enhancer-binding Protein β Activating Transcription Factor-4 Basic Leucine Zipper Heterodimer in the Absence of DNA*

Youngchang Kim, L M Podust, A M Krezel, 2001, The Journal of Biological Chemistry.

R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.

J. McKerrow, M. Cameron, W. Roush, 2014, ACS medicinal chemistry letters.

Identification of Small‐Molecule Scaffolds for P450 Inhibitors

J. V. Kries, L. Podust, Thulasi Warrier, 2010, Current protocols in microbiology.

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

M. Jaremko, M. Burkart, T. Davis, 2020, RSC chemical biology.

Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.

Stefânia N Lavorato, A. Poso, R. S. Ferreira, 2023, Future medicinal chemistry.

Estriol Bound and Ligand-free Structures of Sterol 14α-Demethylase

E. Dalmasso, M. Waterman, G. Lepesheva, 2004 .

Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

T. Poulos, M. Waterman, J. Stojan, 2001, Journal of inorganic biochemistry.

Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions*

D. Sherman, Shengying Li, Y. Anzai, 2012, The Journal of Biological Chemistry.

Assembly of DNA polymerase delta and epsilon holoenzymes depends on the geometry of the DNA template.

U. Hübscher, V. Podust, L. Podust, 1994, Nucleic acids research.

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of Medicinal Chemistry.

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

David L. Williams, Gregory R J Thatcher, L. Podust, 2015, PLoS neglected tropical diseases.

2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis.

P. Ortiz de Montellano, A. Ioanoviciu, L. Podust, 2008, Biochemistry.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

R. Abagyan, K. Jarnagin, G. A. Lemieux, 2017, PLoS neglected tropical diseases.

chemical and functional characterization of cyclic 4 (PDE4) as a potential anthelmintic drug target.

K. Jarnagin, G. A. Lemieux, Kaveh Ashrafi, 2017 .

Mycobacterium Tuberculosis Cyp130:Crystal Mycobacterium Tuberculosis Cyp130: Crystal Structure, Biophysical Characterization, and Interactions with Antifungal Azole Drugs.

L. Podust, P. O. D. Montellano, H. Ouellet, 2007 .