T. Shinozuka

发表

Arylamine based cathepsin K inhibitors: investigating P3 heterocyclic substituents.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & medicinal chemistry.

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

R. Koishi, Yasuyuki Abe, Tomoko Sakakura, 2020, Journal of medicinal chemistry.

Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.

H. Takakusa, Masakazu Hirouchi, T. Shinozuka, 2012, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents.

D. Nakai, S. Naito, Y. Nagai, 2013, Bioorganic & medicinal chemistry.

CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate

K. Yoshinari, N. Watanabe, H. Zahir, 2021, Drug Metabolism and Disposition.

First total synthesis of sterenins A, C and D

T. Hasegawa, S. Naito, T. Shinozuka, 2008 .

Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase

K. Yoshinari, N. Watanabe, T. Shinozuka, 2021, Xenobiotica; the fate of foreign compounds in biological systems.

Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.

Masakazu Hirouchi, T. Shinozuka, M. Ikeda, 2013, Bioorganic & medicinal chemistry letters.

4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & medicinal chemistry letters.

AN EFFICIENT METHOD FOR THE PREPARATION OF 4-ALKOXY-SUBSTITUTED THIENO[2,3-b]PYRIDINES

S. Naito, T. Shinozuka, Keiji Saito, 2014 .

Synthesis and structure-activity relationship of 4-alkoxy-thieno[2,3-b]pyridine derivatives as potent alkaline phosphatase enhancers for osteoporosis treatment.

T. Kunikata, S. Naito, Y. Nagai, 2019, Bioorganic & medicinal chemistry letters.

An Efficient Method for the Preparation of 4‐Alkoxy‐Substituted Thieno[2,3‐b]pyridines.

S. Naito, T. Shinozuka, Keiji Saito, 2014 .

A Practical Method for the Preparation of 4-Nitrogen-substituted Benzoic Acids

S. Naito, T. Shinozuka, A. Nakao, 2006 .

Investigation of the Selectivity of the Palladium-Catalyzed Aroylation and Arylation of Stannyl Glycals with Aroyl Chlorides

T. Shinozuka, 2021, ACS omega.

Generation of silyl group stabilized amide homoenolates by utilizing the complex-induced proximity effect (CIPE)

T. Shinozuka, M. Asaoka, Tomoko Utsumi, 1999 .

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

Potent and selective cathepsin K inhibitors.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & Medicinal Chemistry.

Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver

K. Yoshinari, H. Takakusa, N. Watanabe, 2022, Drug Metabolism and Disposition.

Discovery of a Novel Class of ERRα Agonists.

S. Ito, K. Wakabayashi, T. Shinozuka, 2021, ACS medicinal chemistry letters.

Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.

K. Tamaki, R. Koishi, Y. Kitano, 2015, Bioorganic & medicinal chemistry letters.

N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors

R. Koishi, Tomoko Sakakura, Y. Kitano, 2023, ACS Medicinal Chemistry Letters.