K. Shimada

发表

Arylamine based cathepsin K inhibitors: investigating P3 heterocyclic substituents.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & medicinal chemistry.

Heterolytic oxygen-oxygen bond cleavage of peroxy acid and effective alkane hydroxylation in hydrophobic solvent mediated by an iron porphyrin coordinated by thiolate anion as a model for cytochrome P-450

M. Hirobe, N. Maruyama, T. Higuchi, 1993 .

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents.

D. Nakai, S. Naito, Y. Nagai, 2013, Bioorganic & medicinal chemistry.

A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.

M. Yokoyama, Kenjiro Ueda, K. Yabe, 2021, Bioorganic & medicinal chemistry letters.

4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & medicinal chemistry letters.

Total synthesis of leustroducsin B.

T. Fukuyama, K. Shimada, Yosuke Kaburagi, 2003, Journal of the American Chemical Society.

Chemical transformation of Leustroducsins: synthesis of Leustroducsin B

K. Shimada, H. Matsuhashi, 2002 .

Natural products reveal cancer cell dependence on oxysterol-binding proteins.

John A. Tallarico, M. Schirle, J. Tallarico, 2011, Nature chemical biology.

Chemical modification by trinitrobenzenesulfonate of a lipid and proteins of intracytoplasmic membranes isolated from Chromatium vinosum and Azotobacter vinelandii.

K. Shimada, N. Murata, 1976, Biochimica et biophysica acta.

Studies on the surface structure of the intracytoplasmic membrane in the photosynthetic purple bacterium Chromatium vinosum by means of chemical modification.

K. Shimada, N. Murata, 1977, Journal of biochemistry.

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

Potent and selective cathepsin K inhibitors.

T. Fukuda, S. Naito, T. Shinozuka, 2006, Bioorganic & Medicinal Chemistry.

Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists.

Y. Nagai, Yasuyuki Abe, K. Shimada, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.

Y. Nagai, Yasuyuki Abe, K. Shimada, 2015, Bioorganic & medicinal chemistry.

Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration.

K. Shimada, Kazuhiro Yoshida, Hisashi Takahashi, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.

K. Shimada, Nobuo Machinaga, Y. Domon, 2019, Bioorganic & medicinal chemistry letters.

Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.

K. Shimada, Nobuo Machinaga, Y. Domon, 2019, Bioorganic & medicinal chemistry letters.

4-(tert-Butyldimethylsilyloxy)benzylidene acetal: a novel benzylidene-type protecting group for 1,2-diols

H. Tokuyama, T. Fukuyama, K. Shimada, 2004 .

Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships.

K. Shimada, Masanori Izumi, Y. Arai, 2019, Bioorganic & medicinal chemistry letters.

Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit.

Y. Hiroaki, Y. Fujiyoshi, H. Hanzawa, 2023, Journal of molecular biology.

Chemical Transformation of Leustroducsins: Synthesis of Leustroducsin B.

K. Shimada, H. Matsuhashi, 2002 .